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numerical Simulation of Turbulent diffusion Flames of a Biogas Enriched with hydrogen

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Fluid dynamics & Materials Processing 2024年第1期20卷 79-96页

作者： naima Krarraz Amina Sabeur Khadidja Safer Ahmed Ouadha Laboratoire des Science et Ingénierie Maritimes Facultéde Génie MécaniqueUniversitédes Sciences et de la Technologie d’Oran Mohamed BoudiafOranAlgérie Laboratoire des Carburants Gazeux et de l’Environnement Facultéde Génie MécaniqueUniversitédes Sciences et de la Laboratoire des Carburants Gazeux et de l’Environneme

Any biogas produced by the anaerobic fermentation of organic materials has the advantage of being an environmentally friendly ***,the relatively low calorific value of such gases makes their effective utilization in practical applications relatively *** present study considers the addition of hydrogen as a potential solution to mitigate this *** particular,the properties of turbulent diffusion jet flames and the related pollutant emissions are investigated numerically for different operating *** related numerical simulations are conducted by solving the RAnS equations in the frame of the Reynolds Stress Model in combination with the flamelet *** effects are also taken into account and the combustion kinetics are described via the GRI-Mech 3.0 reaction *** considered hydrogen fuel enrichment spans the range from 0%to 50%in terms of *** varies between 1 and 10 *** results show that both hydrogen addition and pressure increase lead to an improvement in terms of mixing quality and have a significant effect on flame temperature and *** also reduce CO_(2) emissions but increase nOx *** nO is shown to be the predominant nO formation mechanism.

关键词： Biogas hydrogen diffusion flame turbulence nO formation route pressure

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/dSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

A digital twin model-based approach to cost optimization of residential community microgrids

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Global Energy Interconnection 2024年第1期7卷 82-93页

作者： Mariem dellaly Sondes Skander-Mustapha Ilhem Slama-Belkhodja Université de Tunis El Manar Ecole Nationale d’Ingénieurs de TunisLR11ES15 Laboratoire de Systèmes Electriques1002TunisTunisie Université de Carthage Ecole Nationale d’Architecture et d’UrbanismeLaboratoire de Systèmes Electriques1002TunisTunisie

This paper presents a peer-to-peer community cost optimization approach based on a single-prosumer energy management *** objective is to optimize energy costs for prosumers in the community by enhancing the consumption *** study was conducted along two main *** first axis focuses on designing a digital twin for a residential community microgrid *** phase involves data collection,cleaning,exploration,and ***,it includes replicating the functionality of the real platform and validating the *** second axis involves the development of a novel approach that incorporates two distinct prosumer behaviors within the same community microgrid,while maintaining the concept of peer-to-peer energy *** without storage utilize their individual PV systems to fulfill their energy requirements and inject excess energy into a local ***,a single prosumer with a storage system actively engages in energy exchange to maximize the community’s *** is achieved by optimizing battery usage using a cost optimization *** proposed solution is validated using the developed digital twin.

关键词： Energy management system(EMS) Cost optimization digital twin Photovoltaic systems Microgrid

COVId-19 Vaccination Status and Severe Outcomes among Patients hospitalized for COVId-19 in West Africa, Togo, 2021

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Advances in Infectious diseases 2024年第1期14卷 87-104页

作者： Awèréou Kotosso Yao Rodion Konu Lidaw déassoua Bawe Sarakawabalo Assenouwe Yawovi Mawufemo Tsevi Koffi Atsu Aziagbe Akouda Akessiwe Patassi Bawoubadi Abaltou Gnimdou Tchamdja Lampouguini nebona Komi Séraphin Adjoh didier Ekouevi Majesté Ihou Wateba Faculté des Sciences de la Santé Université de Lomé Lomé Togo Centre hospitalier Régional Lomé Commune Lomé Togo service des Maladies Infectieuses Centre Hospitalier Universitaire Sylvanus-Olympio Lomé Togo Unité de Recherche Mixte 1219 Bordeaux Population Health Centre University of Bordeaux National Institute for Health and Medical Research (INSERM) Research Institute for Sustainable Development (IRD) Bordeaux France département de Santé Publique Université de Lomé Lomé Togo Faculté des Sciences de la Santé Université de Kara Kara Togo service d’Anesthésie et Réanimation Centre Hospitalier Universitaire Kara Kara Togo service de néphrologie et d’hémodialyse Centre Hospitalier Universitaire Sylvanus-Olympio Lomé Togo service de Pneumo-Phtisiologie Centre Hospitalier Universitaire Sylvanus-Olympio Lomé Togo

Objectives: More than a year after its introduction, COVId-19 vaccination coverage was low in the Togolese population and little data were available on its benefits for hospitalized patients. This study aimed to describe the impact of COVId-19 vaccination on the prognosis of hospitalized patients. Methods: This was a retrospective cohort study of patients admitted to the Centre hospitalier Régional Lomé Commune (Togo) between June 1, 2021 and May 31, 2022. Primary outcomes (admission to the intensive care unit and death) were presented with frequency and proportion. Mortality rates were presented by sociodemographic and clinical characteristics and compared by appropriate statistical tests. Factors associated with inpatient death were described by performing a Cox proportional hazard regression. Results: A total of 604 patients were hospitalized (50.0% women). The mean age was 54.03 ±17.1 years. Only 55 patients were fully vaccinated (9.1%). ICU admission was significantly more frequent in unvaccinated patients than in vaccinated ones (63.0% vs. 38.2%;p Conclusion: COVId-19 vaccination had a significant benefit for patients with COVId-19 infection in terms of reducing the risk of death. Based on real-world data from sub-Saharan Africa, this information can help optimize the benefit of COVId-19 vaccination by raising community awareness and increasing vaccine coverage while reducing hesitancy.

关键词： COVId-19 Vaccination Prognosis Mortality Sub-Saharan Africa

Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem Marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance service d’hématologie Biologique AP-HPHôpital LariboisièreParisFrance

neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(nTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECd)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75nTR ECd levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(nTR) ECd could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(nTR) ECd in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(nGFR) neurodegeneration p75^(nTR) schizophrenia

Risk Factors for neonatal Mortality at the Institute of nutrition and Child health of the donka/Guinea-Conakry national hospital

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Open Journal of Pediatrics 2024年第2期14卷 327-337页

作者： Bangoura Mmah Aminata Kolié Ouo Ouo Camara Salématou hassimiou Baldé Mariama Bangoura Kaba diop Mamadou Moustapha Camara Emmanuel diallo Fatoumata Binta doukouré Mamadou Aliou Mamadou Mouctar Sow Bémy Pé néabey Institut de nutrition et de Santé de l’Enfant Conakry Guinea service de Pédiatrie hô pital National Donka Conakry Guinea service de Pédiatrie hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. however, the neonatal period is a very delicate phase of life. neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. Methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de nutrition et de la Santé de l’Enfant (InSE) at donka national hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. Statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: neonatal mortality is a health problem in the InSE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： neonatal Mortality InSE Guinea-Conakry

Visceral Leishmaniasis at the national Reference University hospital Center of n’djamena (Chad): Epidemiological, Clinical, diagnostic, Therapeutic and Prognostic Aspects

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Advances in Infectious diseases 2024年第2期14卷 478-486页

作者： Joseph Mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat djarma Alifa Adjibera Philippe Ali Mahamat Moussa ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti djiddi Ali Sougoudi Mamissou didi Mahamat doungous Atim service des Maladies Infectieuses CHU de Référence Nationale N’Djamena Chad service de Gastroentérologie et Médecine Interne CHU de Référence Nationale N’Djamena Chad service de Pneumologie et Phtisiologie CHU de Référence Nationale N’Djamena Chad service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad service de Médecine CHU de la Renaissance N’Djamena Chad

Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious diseases department of the Centre hospitalier Universitaire de Référence nationale in n'djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishmaniasis Gold Mining Sites Chad

Stable,intense supercontinuum light generation at 1 khz by electric field assisted femtosecond laser filamentation in air

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Light(Science & Applications) 2024年第2期13卷 354-365页

作者： Yaoxiang Liu Fukang Yin Tie-Jun Wang Yuxin Leng Ruxin Li Zhizhan Xu See Leang Chin State Key Laboratory of high Field Laser Physics Shanghai Institute of Optics and Fine Mechanics and CAS Center for Excellence in Ultra-intense Laser ScienceChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Centre d’Optique Photonique et Laser(COPL)and Département de physiquede génie physique et d’optiqueUniversitéLavalQuébecQuébecCanada

Supercontinuum(SC)light source has advanced ultrafast laser spectroscopy in condensed matter science,biology,physics,and *** to the frequently used photonic crystal fibers and bulk materials,femtosecond laser filamentation in gases is damage-immune for supercontinuum generation.A bottleneck problem is the strong jitters from filament induced self-heating at khz repetition rate *** demonstrated stable khz supercontinuum generation directly in air with multiple mJ level pulse *** was achieved by applying an external dC electric field to the air plasma *** pointing jitters of the 1 khz air filament induced SC light were reduced by more than 2 *** stabilized high repetition rate laser filament offers the opportunity for stable intense SC generation and its applications in air.

关键词： intense repetition light

Eradication Treatment of helicobacter pylori Infection: Evaluation of Therapeutic Strategies in n’djamena

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Open Journal of Gastroenterology 2024年第2期14卷 59-67页

作者： Mayanna habkréo Ali Mahamat Moussa Tahir Mahamat Saleh djerabet Franckly Fany haby Mairé dehainssala Adama ngaré Mahamat Ali hachim service de Medecine Interne et Gastroenterologie Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad service de Medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad service de Médecine Hopital de l’Amitié Tchad-Chine N’Djamena Tchad

Background: helicobacter pylori (hp) infection is the most widespread bacterial infection in the world. The infection is generally acquired in childhood, but can persist into adulthood. Eradication therapy has undergone several modifications. The aim of this study was to evaluate the different therapeutic strategies used in the eradication of helicobacter pylori infection in the Centre hospitalier Universitaire La Reference nationale of n’djaména. Patients and Methods: This was a prospective, descriptive analytical study spread over one year, from September 2021 to September 2022. Patients at least 15 years of age presenting with dyspeptic symptoms, seen consecutively in a hepato-gastroenterology consultation and with a positive stool test for h. pylori infection, were included in the study. Equally, 1/3 of patients were treated with dual or triple therapy. The remaining third received quadritherapy. Results: A total of 268 patients were included in the study (mean age 38.40 ± 14.66 with extremes of 16 and 80 years). Males predominated in 58% of cases. Overall therapeutic efficacy was 88.9%. According to different therapeutic strategies, efficacy was 90.75% for dual therapy with PPI (Rabeprazole) and Amoxicillin. On the other hand, efficacy was 87% and 88.88% for PPI-based triple therapy and dual antibiotic therapy, and for PPI-based quadruple therapy and triple antibiotic therapy. Conclusion: h. pylori infection is a common disease in Chad. dual therapy with rabeprazole combined with a high dose of amoxicillin over a period of at least two weeks showed similar if not better efficacy than triple or quadruple therapy.

关键词： helicobacter pylori Therapeutic Strategies Eradication dyspepsia Chad