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Bacteriological Profile of Infections Encountered in a Pneumology service in a moderate-Income Country [Pneumology department of CHU Cocody (Côte d’Ivoire)]

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Open Journal of Respiratory diseases 2024年第1期14卷 1-11页

作者： Brou Jean marcel Ahui Alitonde Eudoxie djegbeton Alima Kone marc-Olivier Koffi Kouame Clarisse Elogne mobio Nancy Hermine Benjamin Kouraogo Erick Akouatia Constante Virginie Brou-Gode Kigninlman Horo Boko Alexandre Kouassi Ngoran Koffi Pneumology service Teaching Hospital of Cocody Abidjan C&#244te d’Ivoire medical School of Abidjan University Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Pasteur Institute of Cô te d’Ivoire Abidjan C&#244te d’Ivoire

Introduction: Infections represent a real public health problem aggravating the morbidity and mortality of hospitalized patients. methods: This was a retrospective study with descriptive purposes over a period of 05 years, in the Pneumology department of the University Hospital of Cocody. Results: The average age in our population was 42 years. We observed a male predo- minance of 64.5%, with a sex ratio of 1.8. medical history was dominated by HIV infection (23.5%), followed by tuberculosis (15.6%). Concerning lifestyle, smoking was found in 38% of cases. Symptoms progressed chronically in 80% of cases. An infectious syndrome was found in 75% of cases. microbial culture was positive in 42% of cases. Pseudomonas aeruginosa and Klebsiella pneumoniae were encountered in 26.4% of cases each, followed by Echerichia coli in 10.4% of cases. Klebsiella pneumoniae in the first three years topped the list, but gradually. Pseudomonas aeruginosa maintained its leadership over the last three years. Pseudomonas aeruginosa isolates expressed a resistance rate of 9.8% to ceftazidime and 8.1% to imipenem;to aztreonam (36%), ticarcillin (33.3%) and levofloxacin. These strains were susceptible to fosfomycin (100%), mero- penem (96.6%) and amikacin (96%). For isolated strains of Entero- bacteria- ceae, resistance was observed about ticarcillin (83.3%) and amoxicillin clavula- nic acid (71.2%). Streptococcaceae showed resistance to tetracycline (69.2%) and erythromycin (50%). Over the years there has been an increase in re- sistance to amoxicillin-clavulanic acid ceftriaxone. The death rate was 14%. Conclusion: The bacterial profile of infections is dominated by germs respon- sible for nosocomial infection with significant mortality.

关键词： Bacterial Pleural Pneumonia Nosocomial Infection Sub-Saharan Africa Antibiotic Therapy

Situational Analysis of malaria Incidence Under Integrated malaria service in Hotspot Township-minbya Township,Rakhine State,myanmar,2017–2020

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China CdC weekly 2024年第17期6卷 374-377页

作者： Aung Than Oo Hong Chen ASEAN Centre for Biodiversity Ringgold standard institution D.M.Lantican AvenueUniversity of the Philippines Los Baños LagunaLos BañosPhilippines Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina

Introduction:malaria is a significant public health concern and tropical disease,particularly affecting myanmar within the Greater mekong *** annual parasite index(API)exceeds 1 per 10,000 population in the northern seven townships of Rakhine State,with minbya Township designated as a highburden area for malaria by the World Health Organization(WHO)myanmar and the National malaria Control Programme(NmCP).Since 2017,the malaria reduction intensification plan has been in place in this township to combat the high disease transmission *** study aims to assess the malaria epidemiology in minbya Township from 2017 to 2020 under the intensification plan for elimination,as well as to evaluate the effectiveness of the integrated strategy in reducing cases in hotspot ***:The study utilized a surveillance study design to collect secondary data from the malaria surveillance system(mSS)and the epidemiologic monitoring dashboard of minbya Township,maruk-U district,located in Rakhine ***:Since 2017,the malaria prevention and control(P&C)Program in minbya Township has successfully decreased malaria morbidity,eliminated malaria-related deaths,and bolstered malaria testing capabilities through the participation of village health volunteers(VHVs).Approximately 87%of malaria prevention and control services are executed by the township’s malaria elimination and disease control programs,with additional support from *** API dropped from 13 in 2017 to 2.5 in 2020,with Plasmodium vivax being the most prevalent malaria species,accounting for 55%of ***:The study suggests that early diagnosis and promotion of artemisinin-based combination treatment(ACT),along with strategic planning including expanding active case detection in rural health centers and implementing a communitybasedcommunitybased integrated healthcare approach,are effective and efficient strategies for malaria elimination.

关键词： malaria prevention epidemiology

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.martinez Philipe de Souto Barreto For the mAPT/dSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de Recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine mitochondria

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique minard-Colin Caroline Chopinet michael dussiot denise mAdams Tristan mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERm U1151 Institut Necker-Enfants MaladesParisFrance service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UmR 5220 Villeurbanne 69100France service de Radiologie mère-Enfant Hôpital NordSaint EtienneFrance service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERm U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA service de médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UmR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(mRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Case Retrieval Strategy of Turning Process Based on Grey Relational Analysis

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1663-1678页

作者： Jianfeng Zhao Yunliang Huo Ji Xiong Junbo Liu Zhixing Guo Qingxian Li School of mechanical Engineering Sichuan UniversityChengdu610065China Sichuan Engineering Technology Research Center of Intelligent design and service for Cutting Tools Yibin R&D Park of Sichuan UniversityYibin644000China department of R&d Pengxi Heye High-Tech Co.Ltd.Suining629000China

To solve the problem of long response time when users obtain suitable cutting parameters through the Internet based platform,a case-based reasoning framework is ***,a Hamming distance and Euclidean distance combined method is designed to measure the similarity of case features which have both numeric and category *** addition,AHP(Analytic Hierarchy Process)and entropy weight method are integrated to provide features weight,where both user preferences and comprehensive impact of the index have been *** relation analysis is used to obtain the similarity of a new problem and alternative ***,a platform is also developed on Visual Studio 2015,and a case study is demonstrated to verify the practicality and efficiency of the proposed *** method can obtain cutting parameters which is suitable without iterative *** with the traditional PSO(Particle swarm optimization algorithm)and GA(Genetic algorithm),it can obtain faster response *** method can provide ideas for selecting processing parameters in industrial *** guaranteeing the characteristic information is similar,this approach can select processing parameters which is the most appropriate for the production process and a lot of time can be saved.

关键词： CBR turning process grey relation AHP entropy weight

morbidity and mortality of Acute Renal Failure in COVId-19 Patients in Intensive Care According to Waves/Variant: Case of the Grand Hôpital de l’Est Francilien Site de meaux

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Open Journal of Internal medicine 2024年第1期14卷 16-29页

作者： Khazy Anga Ariel makembi Éric Amisi Éric delpierre Vivien Hong Tuan Ha Wilfrid mbombo Jean Claude mubenga dan Kankonde Chris Nsituavibidila Lionel diyamona Noelly mukuna Gracia Likinda Tharcisse mabiala martin mukenga médard Bula-Bula Berthe Barhayiga département d’Anesthésie Réanimation Université de Kinshasa Kinshasa République démocratique du Congo service de Réanimation Grand H&ocircpital de l’Est Francilien Meaux France département de médecine Interne Université de Kinshasa Kinshasa République démocratique du Congo service d’Anesthésie Réanimation Centre Hospitalier Monkole Kinshasa République démocratique du Congo department of Anaesthesia and Intensive Care H&ocircpital Général de Référence de Kinshasa Kinshasa République démocratique du Congo department of Anaesthesia and Intensive Care Université Protestante du Congo Kinshasa République démocratique du Congo

Introduction: The incidence of acute renal failure (ARF) varies between 20% and 40% of cases for COVId-19 patients admitted to the intensive care unit, with very high mortality, but heterogeneous according to the different epidemic waves, probably due to the genetic variant phenomenon of the virus. The aim of this study is to determine the morbidity and mortality of COVId-19 patients admitted with ARF to the intensive care unit of the Grand H?pital Est Francilien (GHEF) according to the waves and variants. methods: Cross-sectional observational study of COVId-19 patients with ARF admitted to the intensive care unit of the GHEF site in meaux covering the period from march 1st 2020 to december, 31st 2021. Per-hospitalisation and outcome data were collected and analysed with SPSS version 25.0 software using the Chi-square or Fischer’s exact test or Student’s t-test and logistic regression for p Results: A total of 86 patients were included. The mean age was higher (70 ± 8.5) in patients in the fourth wave than in the other waves (p = 0.015), with male predominance in all waves without significant difference. Co-morbidities: hypertension, diabetes, heart disease, dyslipidaemia and arrhythmia complete with fibrillation were present in all waves. The majority of patients were classified as KdIGO 1 for the different waves (1st: 61.9%, 2nd: 86.5%, 3rd: 80%, and 4th: 75%), with the same trend according to variant (alpha: 80%, beta: 75%, delta: 81.3%, omicron: 75%). mortality by the wave was: 1st: 28.5%, 2nd: 37.5%, 3rd: 23% and 4th: 11%) and by variant: alpha: 24.2%, beta: 44.8%, delta: 20.7%, omicron: 10.3%). Overall mortality was 33.7%. Case fatality was higher in the fourth wave. Hypertension, shock, failure to recover renal function, acute lung oedema, ventilator-associated lung disease and hyperkalaemia were factors associated with mortality (p Conclusion: Acute renal failure is common in COVId-19 patients admitted to the intensive care unit, and m

关键词： mortality COVId-19 morbidity Renal Failure Intensive Care Unit

Epdemiology and Treatment of Pseudarthrosis of Long Bones in the Servce d Orthopedics-Traumatology of the University Hospital of donka

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Open Journal of Orthopedics 2024年第3期14卷 133-138页

作者： Camara Nouhou mangué diallo mamadou moustapha moustapha Alhassane diallo Alpha mamadou Fela Sidimé Sory Camara Abdoulaye Kolié Germain Lamah Léopold service d’Orthopédie-Traumatologie Centre Hospitalier Universitaire de Donka Conakry Republic of Guinea

Introduction: Pseudarthrosis (PSA) of the diaphysis of long bones still remains a current problem, despite improvements in the treatment of these fractures. Our study aims to study the epidemiological and therapeutic aspects of PSA of the diaphysis of long bones. method: This retrospective work concerns 30 cases of non-union of the diaphysis of long bones treated in the orthopedic and trauma surgery department at donka National Hospital, during a period of 18 months from January 1, 2019 to June 30, 2020. Results: We recruited 30 patients, 80% of whom were male, with an average age of 39.9 years. Public road accidents (AVP) represented the main cause of fractures of the diaphysis of long bones 87%, they were open in 25 cases or 83%. The fractures were located in the middle 1/3 of the diaphysis of the long bones in 50% of cases. Treatment of initial fractures was traditional in 21 cases, orthopedic in 2 cases and surgical in 7 cases. It was aseptic nonunion in 28 cases (93%) and septic nonunion in 2 cases. They were hypertrophic in 7 cases, slightly hypertrophic in 5 cases, oligotrophic in 11 cases, atrophic in 6 cases and with bone defect in 1 case. The treatment was based on osteosynthesis including 16 cases of screwed “PV” plate: 7 cases of centromedullary “ECm” nailing, 2 cases of external fixator, 1 case of broaching and 4 cases of Plastering. The results according to ASAmI criteria on an anatomical level were excellent in 19 cases, good in 3 cases and poor in 3 cases, with a union rate of 76%. And 5 patients undergoing consolidation. Conclusion: Based on the literature data and the experience of our department, the true treatment of PSA requires correct management of the initial fracture without forgetting the interest in preventing AVP which appears to be an element essential, making it possible to reduce the incidence of fractures of the diaphysis.

关键词： Pseudarthrosis Aseptic-Septic-diaphysis Long Bones Screwed Plate Intramedullary Nailing Bone Graft Osteo-muscular decortication

Clinical and Bacteriological Profile of Infections in Sickle Cell Children in Two Referral Hospitals in Niamey, Niger

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Open Journal of Pediatrics 2024年第1期14卷 36-42页

作者： Kamaye moumouni Samaila Aboubacar Garba moumouni Georges Thomas Ibrahim mamoudou Abdou djafar mamane Halima Hamadou Ibrahim Hamani Issaka djibrilla Almoustapha Amadou Yacouba Abdourahamane marou Soumana Boubacar moussa Saley Sahada Bade malam Abdou Soumana Alido service de Pédiatrie A H&#244pital National de Niamey Niamey Niger Faculté des Sciences de la Santé Université Abdou Moumouni de Niamey Niamey Niger service de Pédiatrie H&#244pital national Amirou Boubacar Diallo Niamey Niger service d’Onco-Hématologie H&#244pital national de Niamey Niamey Niger service de Biologie médicale H&#244pital national Amirou Boubacar Diallo Niamey Niger

Introduction: Infections are significant causes of mortality in sickle cell children in resource-limited countries. This study aimed to determine the clinical profile and bacterial ecology of infections in children with sickle-cell disease in two referral hospitals in Niamey. Patients and methods: A retrospective descriptive study was conducted from January 2018 to July 2020 in two referral hospitals in Niamey. All children aged one (1) to 15 years with sickle cell disease admitted for suspected infection, including at least one bacterial culture, were studied. Bacteriological analysis was performed using the appropriate culture media, using BactAlert (Reference 4700003 BTA3d60 Biomérieux). Results: Over 36-months, 350 children with a mean age of 10.9 months were admitted. The sex ratio was 1.2. The SS electrophoretic profile was the most common (93.4%). Immunization status was up to date in 66% of patients. Fever was the common reason for consultation (55.1%). Infection was confirmed in 62 patients (17.7%). The primary diagnoses were bacterial gastroenteritis (24.2%) and urinary tract infection (19.4%). Blood cultures were isolated from Salmonella typhi (13.0%) and Escherichia coli (8.7%). Klebsiella spp (7.1%) and Escherichia coli (5.0%) were detected in cytobacteriological examination of urine. Salmonella typhi (23.5%) and Escherichia coli (5.9%) were isolated on coproculture. Conclusion: Bacterial ecology appears not different from that usually observed in sickle-cell children. Salmonella and Escherichia coli were predominant.

关键词： Sickle Cell disease Child Infection Niger

Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： Georges Jourdi Samuel Fleury Imane Boukhatem marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECd)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECd levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECd could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECd in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia