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A Regi.nal Ocean Reanalysi. System for Coastal Waters of Chi.a and Adjacent Seas

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Advances i. Atmospheri. Sci.nces 2011年第3期28卷 682-690页

作者： Gui.un Han Wei.Li.Xuefeng Zhang Dong Li.Zhongji. He Xi.ong Wang Xi.rong Wu Ti.g Yu Ji.ui.Ma State Ocean Adm Natl Marine Data & Informat Serv Key Lab Marine Environm Informat Technol Tianjin 300171 Peoples R China

A regi.nal ocean reanalysi. system for the coastal waters of Chi.a and adjacent seas has been developed by the Nati.nal Mari.e Data and i.formati.n serv.ce（NMDi.）.i. produces a dataset package called CORA （Chi.a ocean reanalysi.）.The regi.nal ocean model used i. based on the Pri.ceton Ocean Model wi.h a generali.ed coordi.ate system（POMgcs）.The model i. paralleli.ed by NMDi. wi.h the addi.i.n of the wave breaki.g and ti.al mi.i.g processes i.to model *** assi.i.ati.n i. a sequenti.l three-di.ensi.nal vari.ti.nal（3D-Var） scheme i.plemented wi.hi. a multi.ri. *** i.clude satelli.e remote sensi.g sea surface temperature（SST）,alti.etry sea level anomaly（SLA）,and temperature/sali.i.y *** reanalysi. fi.lds of sea surface hei.ht,temperature,sali.i.y,and currents begi. wi.h January 1986 and are currently updated every year. Error stati.ti.s and error di.tri.uti.ns of temperature,sali.i.y and currents are presented as a pri.ary evaluati.n of the reanalysi. fi.lds usi.g sea level data from ti.al gauges,temperature profi.es,as well as the trajectori.s of Argo *** case studi.s offer the opportuni.y to veri.y the evoluti.n of certai. local *** evaluati.ns show that the reanalysi. data produced provi.e a good representati.n of the ocean processes and phenomena i. the coastal waters of Chi.a and adjacent seas.

关键词： ocean reanalysi. data coastal waters Chi.a adjacent seas sea temperature sali.i.y currents ocean ci.culati.n

分娩后大便失禁的危险因素:525例患者前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 60-61页

作者： Roman H. Robi.lard P.- Y. Payet E. 刘亦恒 serv. de Gynecologi. et Obstetri.ue Polyclinique- H.otel Dieu CHU de Clermont-Ferrand 63000 Clermont-Ferrand France

Objecti.e. To determi.e the prevalence of fecal i.conti.ence after chi.dbi.th and to i.enti.y the ri.k factors. Methods. Thi. was a prospecti.e observ.ti.nal study wi.h a consecuti.e i.clusi.n of 525 women who deli.ered over a three months peri.d. Women were questi.ned about thei. fecal conti.ence four days and si. weeks after deli.ery. Results. The i.ci.ence of fecal i.conti.ence four days and si. weeks after chi.dbi.th was respecti.ely 8.8% and 3.3% . The ri.k factors for fecal i.conti.ence at 4 days after chi.dbi.th were i.strumental deli.ery by forceps (adjusted odds rati. 8.64, 95% confi.ence i.terval 3.55- 21.0, p i.ted deli.ery at home (adjusted OR 8.06, 95% Ci.1.30- 50.0, p=0.025). i.dependent ri.k factors for the presence of fecal i.conti.ence 6 weeks later were: i.strumental forceps deli.ery (adjusted OR 10.8, 95% Ci.2.82- 41.3, p=0.001), unassi.ted deli.ery at home (adjusted OR 50.0, 95% Ci.3.09- 802, p=0.006), bi.pari.tal di.meter of the newborn >93mm (adjusted OR 4.56, 95% Ci.1.46- 14.1, p=0.009) and maternal age >30 years (adjusted OR 4.60, 95% Ci.1.11- 19.1, p=0.036). Conclusi.n. Fecal i.conti.ence i. common after chi.dbi.th and i.s prevalence i. predomi.antly associ.ted wi.h i.strumental deli.ery, unassi.ted deli.ery at home, bi.pari.tal di.meter of the newborn and maternal age.

关键词：大便失禁产钳助产排便控制前瞻性观察

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特发性下丘脑综合征:回顾性研究和文献回顾

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 36-37页

作者： Reynaud R. Lêger J. Polak M. 郭战宏 serv. de Pedi.t. Multi.i.ci. li.ai.e Hpital de la Timone 264 rue Saint-Pierre 13005 Marseille France

Hypothalami. obesi.y i. usually i.duced by tumoral or geneti. alterati.ns such as crani.pharyngi.ma or Prader-Wi.li.syndrome, respecti.ely. However, few case s have been reported wi.hout recogni.ed eti.logy, thi. syndrome i. also called i.i.pathi. hypothalami. syndrome. Objecti.es. -To i.prove defi.i.i.n a nd frequency of compli.ati.ns associ.ted wi.h thi. syndrome. Populati.n and Meth ods. -A retrospecti.e cohort study was performed i. French endocri.e paedi.tri. departments and was associ.ted wi.h a li.erature revi.w. Results. -We report f i.e cases of i.i.pathi. hypothalami. syndrome. Thi. syndrome i. correlated wi.h a hi.h mortali.y (one of our fi.e cases, 25%i. the li.erature) by neurovegetati.ve dysfuncti.n (breathi.g or thermal alterati.n). Obesi.y began before si. years old because of compulsi.e eati.g and resulted i. soci.l behavi.ur di.orders. Ab normal endocri.e secreti.ns were characteri.ed by early hyperprolacti.emi., perm anent but later somatotrope defi.i.ncy and 80%of thyreotrope defi.i.ncy. Pubert y abnormali.i.s i.cluded hypogonadotropi. hypogonadi.m as well as precoci.us (on e of our cases, three cases i.cludi.g li.erature) or normal puberty. Neurogeni. hypernatremi. and water and electrolyti. di.orders were also responsi.le of acut e neurologi.al alterati.ns. Conclusi.n. -Thi. largest study ever reported of i. i.pathi. hypothalami. syndrome emphasi.es the need of amulti.i.ci.li.ary coordi. ati.n to provi.e the best care of these pati.nts.

关键词：下丘脑综合征文献回顾普-威综合征下丘脑性肥胖行为障碍促生长激素内分泌科性腺功能低下促甲状腺素颅咽管瘤

脂质体阿霉素治疗复发性或晚期子宫平滑肌肉瘤的Ⅱ期临床试验研究:一项GOG研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 35-36页

作者： Sutton G. Blessi.g J. Hanjani.P. Kramer P. 李巍 Gynecologi. Oncology St. Vincent Hospitals Hlth. Serv. Oncology Center 8301 Harcourt Road Indianapolis IN 46260 United States

Objecti.e. Thi. i. a phase i. group- wi.e study of li.osomal doxorubi.i. chemotherapy i. pati.nts wi.h advanced or recurrent uteri.e lei.myosarcomas. The ai. was to evaluate cli.i.al response and toxi.i.y. Methods. Pati.nts wi.h hi.tologi.ally confi.med persi.tent or recurrent lei.myosarcomas of the uterus wi.h documented di.ease progressi.n after appropri.te local therapy were i.vi.ed to parti.i.ate i. thi. study. Bi.i.ensi.nally measurable di.ease, GOG performance status of 0, 1, or 2 (Karnofsky 80- 100) was requi.ed; all pati.nts must have fai.ed local therapeuti. measures and be consi.ered i.curable. Other eli.i.i.i.y cri.eri. i.cluded adequate hepati., renal, and hematologi. functi.n. Pati.nts were i.eli.i.le i. they had recei.ed previ.us chemotherapy or had other noncutaneous mali.nanci.s. Pati.nts recei.ed li.osomal doxorubi.i. 50 mg/m2 i. over 1 h. Courses were repeated every 4 weeks unti. di.ease progressi.n or adverse si.e effects supervened. Results. Thi.ty- fi.e pati.nts were entered i.to thi. study between May 2000 and June 2001. Three pati.nts were determi.ed i.eli.i.le because of wrong pathologi.al cell type or i.adequate pathology i.formati.n and one was i.evaluable for lack of data. Medi.n age was 52 years (range 36- 78 years). GOG performance status was 2 i. 1 i.stance, 1 i. 15 cases, and 0 i. 15 others. Eleven pati.nts (35.5% ) had recei.ed radi.therapy. A medi.n of 2.0 courses was gi.en (range 1- 8). Fi.e pati.nts (16.1% )- experi.nced grade 3 or 4 neutropeni., and seven (22.6% ) had grade 3 or 4 anemi.. Two pati.nts developed grade 3 and one pati.nt developed grade 4 cardi.vascular adverse events, not necessari.y drug related. There were seven cases of grade 3 or 4 gastroi.testi.al toxi.i.y and two pati.nts developed grade 3 dermatologi. toxi.i.y. One complete (3.2% ) and four parti.l (12.9% ) responses were reported. Ten pati.nts (32.3% ) had stable di.ease, 15 (48.4% ) had i.creasi.g di.ease, and response could not be assessed i. 1 (3.2% ). Co

关键词：子宫平滑肌肉瘤 GOG Ⅱ期临床试验皮肤恶性肿瘤组织病理学病理诊断妇科肿瘤学毒性反应化疗史耐受试验

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郎格罕细胞组织细胞增多症合并垂体柄横断

世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 38-39页

作者： Saad F. Chadli.Chai.b M. Harzallah L. 郭战宏 serv. d'End ocri.ol.-Di.bét. CHU Farhat Hached avenue Ibn El Jazzar 4000 Sousse Tunisia

Cli.i.al mani.estati.ns of hypothalami.-pi.ui.ary Langerhans’cell hi.ti.cyto si. are commonly, di.betes i.si.i.us and someti.es growth hormone defi.i.ncy. Th ei. morphologi. characteri.ti.s on magneti. resonance i.agi.g are absence of posteri.r pi.ui.ary hyperi.tensi.y and thi.keni.g of the pi.ui.ary stalk. Pi.ui.ary stalk transecti.n i. characteri.ed on magneti. resonance i.agi. g by the absence of pi.ui.ary stalk vi.i.i.i.y, hypoplasi. of the anteri.r hypop hysi. and ectopi. posteri.r pi.ui.ary hyperi.tense si.nal. Thi. syndrome has bee n shown to be associ.ted wi.h ei.her i.olated growth hormone defi.i.ncy or multi.ple anteri.r pi.ui.ary hormone defi.i.ncy, but normal posteri.r pi.ui.ary functi.on. Case *** report our experi.nce wi.h a si.-year-old boy who had been treated for three years for a multi.ystem Langerhans’cell hi.ti.cytosi. wi.h di.abetes i.si.i.us and who was admi.ted because of short stature. Endocri.ologi.al exami.ati.ns demonstrated a profound growth hormone defi.i.ncy and a parti.l ce ntral hypocorti.i.m. Magneti. resonance i.agi.g showed pi.ui.ary stalk transecti.on and a mi.li.e anomaly of the brai. (Arnold Chi.ri.type i.malformati.n). Concl usi.n. Although, some events of hi. peri.atal hi.tory lead to the hypothesi. of a malformati.e ori.i., the progressi.n of Langerhans’cell hi.ti.cytosi. affecte d ti.sues to fi.rosi., suggest that thi. di.ease i. the cause of the pati.nt’s hypothalamohypophyseal lesi.ns.

关键词：郎格组织细胞增多症垂体柄生长激素缺乏垂体前叶激素发育不全内分泌学检查纤维变性脑中线磁共振成像

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真性红细胞增多症对妊娠的影响

世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 61-62页

作者： Bei.lat T. Macro M. Dreyfus M. 刘亦恒 serv. Gy necol.- Obstet./Med. Repro. CHU avenue Cl' emenceau 14033 Caen Cedex France

Polycythemi. vera i. a rare chroni. myeloproli.erati.e di.ease. i.s excepti.nal associ.ti.n wi.h pregnancy can lead to severe compli.ati.ns. Anti.hromboti. treatment could prevent such adverse outcome. A pati.nt wi.h two previ.us pregnanci.s compli.ated by preeclampsi., was treated by hydroxyurea for polycythemi. vera. She started a new unexpected gestati.n wi.hout thi. myelosuppressi.e treatment and the pregnancy was conducted uneventfully wi.h low molecular wei.ht hepari. and low dose aspi.i.. Thromboti. compli.ati.ns requi.ed the rei.troducti.n of hydroxyurea. Di.gnosi. of polycythemi. vera duri.g pregnancy i. a very di.fi.ult task due to physi.logi. changes occurri.g duri.g gestati.n. Adverse outcome i.cludi.g severe vascular compli.ati.ns can be a precli.i.al phase of the di.ease. An adequate therapy could prevent these compli.ati.ns.

关键词：骨髓增生性疾病羟基脲预防性治疗低分子量肝素临床前期先兆子痫抑制治疗血栓形成意外妊娠

克罗恩病发病患者队列中肉芽肿的发生率和意义

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 26-27页

作者： Heresbach D. Alexandre J.L. Branger B. 陈云茹 serv. Malad. de l'Apparei. Di.esti. Hpital Pontchaillou Rue Henri Le Guilloux 35033- Rennes Cedex France Prof.

Background and ai.s: Epi.heli.i. granulomas i. one of the best hi.tologi.al c ri.eri.n for di.ti.gui.hi.g Crohn’ s di.ease (CD) from other i.flammatory bowel di.eases. Few data are avai.able on the ti.e of occurrence of epi.heli.i. granu lomas, and the value of epi.heli.i. granulomas i. predi.ti.g outcome has been de termi.ed only i. cohorts of prevalent CD cases. Our objecti.e was to evaluate ep i.heli.i. granuloma occurrence i. i.ci.ent CD cases and to exami.e the associ.ti.ns between epi.heli.i. granulomas and outc ome. Pati.nts and methods: We revi.wed the hi.tologi.al reports of endoscopi. an d surgi.al speci.ens i. a cohort of 188 consecuti.e i.ci.ent CD cases seen i. 19 94 and 1995, and recorded the occurrence of epi.heli.i. granulomas, i.olated gi. nt cells, and mi.rogranulomas. Kaplan- Mei.r curves were plotted for ti.e from CD di.gnosi. to i.munosuppressi.e treatment or surgery, and associ.ti.ns between epi.heli.i. granulomas and outcome were evaluated i. a multi.ari.te analysi.. F ollow up was at least fi.e years. Results: Granulomas were found i. 69 (37% ) p ati.nts, i.cludi.g 46 (25% ) at presentati.n. Medi.n ti.e from CD di.gnosi. to epi.heli.i. granuloma detecti.n was 0.16 (0- 63)months overall, and 9.59 (0.1- 63) months i. 23 pati.nts who became epi.heli.i. granuloma posi.i.e duri.g foll ow up. i.olated gi.nt cells were found i. 6% of pati.nts and mi.rogranulomas i.n 12% . Epi.heli.i. granuloma detecti.n i.creased wi.h the number of endoscopi. sampli.g procedures; sampli.g si.e had no i.fluence. By multi.ari.te analysi., epi.heli.i. granulomas were associ.ted wi.h surgi.al resecti.n but not i.munosup pressi.e therapy. Conclusi.ns: Epi.heli.i. granulomas may separate CD i.to two p athologi.al subsets and may i.di.ate aggressi.e di.ease.

关键词：克罗恩病炎症性肠病内镜检查预测价值免疫抑制治疗侵袭性多变量分析取样位置

颈动脉血管成形及支架安放术后的弥散/灌注加权MRi

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 24-25页

作者： Gauvri. J. Y. Delmai.e C. Henon H. 陈云春 serv. de Neuroradi.logi. andEA 2691 H.opital Roger Salen gro Rue Emile Laine 59037 Lille Cedex France Dr.

Background and purpose: Caroti. angi.plasty and stenti.g, a so far non vali.a ted procedure, may be an alternati.e to surgery i. pati.nts wi.h a hi.h surgi.al ri.k. However, i. carri.s also a ri.k of cerebral emboli. events. The purpose o f thi. study was to evaluate ti.sue si.nal abnormali.i.s i. the brai. before and after caroti. angi.plasty and stenti.g by means of di.fu si.n (DWi. and perfu si.n (PWi. wei.hted magneti. resonance i.agi.g (MRi.. Methods: We performed cere bral MRi.before and after caroti. angi.plasty i. 22 consecuti.e pati.nts, wi.h 2 3 treated hi.h grade caroti. stenoses. The lesi.ns were located at the ori.i. o f the i.ternal caroti. artery (i.A) i. 20 pati.nts, and at the ori.i. of the com mon caroti. artery (CCA) i. 2. MRi.was performed the day before, and repeated wi.thi. 24 hours after the procedure, and exami.ed by two neuroradi.logi.ts. Result s: All stent i.plantati.ns were successful but 4 pati.nts developed an acute neu rologi.al defi.i. wi.hi. 24 hours after caroti. angi.plasty. On PWi. Ti.e To Pea k (TTP) values i.si.ateral to the caroti. stenosi. were i.creased before the pro cedure i. 15 pati.nts, and had remai.ed normal i. 6 and were not assessable i. 1 . After the procedure, TTP values were normal i. 12 pati.nts, i.creased i. 8 and not assessable i. 2. On DWi. new i.si.ateral lesi.ns were detected i. 2 pati.nt s: 1 wi.h an acute neurologi.al defi.i. and 1 symptom free. Conclusi.n: Perfusi. n defi.i.s may be present i. severe caroti. stenosi. and be i.proved wi.hi. 24 h ours by caroti. angi.plasty and stenti.g. Asymptomati. i.farcts may occur.

关键词：血管成形 MRi 起始段颈内动脉无症状性脑梗死脑栓塞神经功能损害灌注不足神经放射学达峰值时间

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 60-60页

作者： Delval A. Stojkovi. T. DeS`eze J. 赵正卿 serv. de Neurol. Gen./Pathol. i. H.opital Salengro 59037 Lille Cedex France

i.troducti.n. Polyneuropathi.s associ.ted wi.h i.M monoclonal gammopathy were recently recogni.ed. Anti.odi.s can react wi.h glycoprotei.s such as myeli. asso ci.ted glycoprotei. (MAG), or gangli.si.es contai.i.g one si.losyl epi.ope such as GM1 or several si.losyl epi.opes (polysi.lyted gangli.si.es) i.cludi.g GD2, G D3, GT1b, GT1a, GQ1b. Methods. We report on three pati.nts presenti.g oculomotor dysfuncti.n, chroni. sensi.i.e ataxi. polyneuropathy, hi.h sedi.entati.n rate, i.M monoclonal paraprotei. of unknown si.ni.i.ati.n and anti.i.i.losyl i.M anti. odi.s and for two of them cold aggluti.i.s. Such features have been previ.usly d escri.ed under the acronym “CANOMAD”(chroni. ataxi. neuropathy wi.h ophthalmop legi., M protei., aggluti.ati.n and di.i.losyl anti.odi.s). Results. One of the pati.nts presents extra membranous glomerulopathy and severe motor di.abi.i.y as soci.ted wi.h thi. syndrome. The pathophysi.logy of the glomerulopathy seems to be li.ked wi.h the polyneuropathy. Pati.nts were treated ei.her by i.travenous i.mmunoglobuli., corti.osteroi.s or cyclophosphami.. Response to treatment di.fers i. the three cases and there i. currently no consensus. Conclusi.n. Our study d emonstrates that spectrum of polyneuropathy associ.ted wi.h monoclonal polyneuro pathy may be larger than ori.i.ally descri.ed.

关键词： di.i.losylated 多发性神经病单克隆蛋白冷凝集反应抗原决定簇神经节苷脂眼球运动障碍共济失调眼肌麻痹肾小球病