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Influence of Age on the Clinical and Prognostic Features of Tetanus in Mali

International Journal of Clinical Medicine 2021年第3期12卷 77-86页

作者： Mikaï la Kaboré Issa Konaté Yacouba Cissoko Jean Paul Dembélé Mariam Soumaré Assetou Fofana Dramane Sogoba Oumar Magassouba Hermine Méli Abdoulaye Zaré Mohamed Aly Cissé Bintou Coulibaly Hama Hamidou Issa Fodé Kouyaté Japhet Dembélé Sounkalo Dao Infectious Diseases Department Point “G” University Teaching Hospital Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali serefo program University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali

Background: The regression of post-vaccination immunity with age exposes elderly subjects to certain infectious diseases, in particular tetanus. The aim was to compare the clinical and prognostic features of tetanus according to the age of patients. Methodology: Analytical study of the files of patients hospitalized for tetanus in the Infectious Diseases Department at Point “G” University Teaching Hospital from 2013 to 2019 with retrospective collection. According to age, three groups of patients were formed: group I (Results: In total, 202 cases of tetanus were recorded or 7.3% of admissions. The mean age was 41.9 ± 15.6 years (range, 6 and 85 years) with a sex ratio of 19.2. According to the age grouping, group II was predominant (79.2%) followed by group III (14.9%) with respective mean ages of 39.2 ± 10.6 and 67.3 ± 6.5 and sex ratio of 39 and 29. Workers (33.3%), farmers (25.8%), traders (19.7%) and drivers (7.1%) represented the most important occupations most at risk. Clinically, bad general condition (p Conclusion: Tetanus is more prevalent in men. Complications and mortality increase with age. It is important to include booster immunization of adults in existing national programs in order to reduce disease-related morbidity and mortality in this age group.

关键词： Tetanus Elderly Clinical Prognosis Mali

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Neuropsychic Disorders Unmasking the Coexistence of Fahr Syndrome and Neuromeningeal Cryptococcosis

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Case Reports in Clinical Medicine 2020年第11期9卷 329-334页

作者： Mikaila Kaboré Issa Konaté Yacouba Cissoko Souleymane P. Coulibaly Jean-Paul Dembélé Assetou Fofana Mariam Soumaré Hermine Méli Dramane Sogoba Oumar Magassouba Adama Sissoko Mohamed Aly Cissé Abdoulaye Zaré Bintou Coulibaly Fodé Kouyaté Moïse Nguemeni Sounkalo Dao Infectious Diseases Department Point “G” University Teaching Hospital Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Psychiatry Department Point “G” University Teaching Hospital Bamako Mali Neurology Department Point “G” University Teaching Hospital Bamako Mali serefo program University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali

Background: Fahr syndrome associates a set of neuropsychiatric manifestations with bilateral calcifications in the basal ganglia and phosphocalcic disorders. Neuromeningeal cryptococcosis can be present in its manifestations, neuropsychic disorders with or without meningeal signs. The objective was to describe a rare association between Fahr syndrome and neuromeningeal cryptococcosis which can be expressed by the same clinical symptomatology in the context of co-infection with the human immunodeficiency virus (HIV) and the hepatitis B virus (HBV). Presentation: A 37-year-old patient without pathological history, who presented behavioral disorders that led to a fight with those around her and a psychiatric consultation. Then, she was hospitalized in the infectious diseases Department upon discovery of her HIV status and viral hepatitis B. She was logorrheic with behavioral disturbances and subsequently presented with tonic-clonic convulsions. Laboratory tests and imaging have concomitantly discovered Fahr syndrome due to pseudohypoparathyroidism and neuromeningeal cryptococcosis. The correct management of these two pathologies enabled stabilization of the patient’s clinical condition with regular monitoring for HIV-HBV coinfection. Conclusion: Farh syndrome and neuromeningeal cryptococcosis are two different entities but sometimes similar symptoms and risk factors. Treatment of metabolic disorders combined with anticryptococcal therapy improved the prognosis.

关键词： Neuropsychic Disorders Neuromeningeal Cryptococcosis Fahr Syndrome Pseudohypoparathyroidism HIV

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Microbiological Assessment and Antimicrobials’ Use in an Infectious Diseases Department in Mali

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Advances in Microbiology 2021年第8期11卷 384-398页

作者： Mikaila Kaboré Issa Konaté Yacouba Cissoko Ibrehima Guindo Bintou Coulibaly Meli Hermine Aboubacar Alassane Oumar Mariam Soumaré Assetou Fofana Abdoulaye Zaré Mohamed Aly Cissé Dramane Sogoba Omar Magassouba Hama Hamidou Issa Fodé Kouyaté Sounkalo Dao Infectious Diseases Department Point “G” University Teaching Hospital Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Laboratory and Biomedical Research Department National Institute of Public Health Bamako Mali Faculty of Pharmacy University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Laboratory of Biomedical Analysis University Teaching Hospital of Kati Kati Mali serefo program University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali

The use of antimicrobials without microbiological proof is frequent and contributes to the emergence of resistance. The aim was to identify the organisms isolated during laboratory examinations and the type of antimicrobials consumed by patients hospitalized to Infectious Diseases’ Clinic. This is a cross-sectional and analytical study, carried out from January 1 to December 31, 2017 in the Infectious Diseases Department of Point “G” Teaching Hospital in Mali. All biological specimens from patients during the study period were analyzed. In total, 322 patients benefited from microbiological test, with a mean age of 40.9 ± 12.2 years (range 15 and 74 years) with a sex ratio of 0.93. Only 5.6% of patients were HIV negative. In all participants, a total of 658 microbiological specimen were taken, 224 (34.0%) identified at least one pathogen including bacteria in more than a half of the cases (58.5%). On the report of bacteriological analysis, the most frequently identified organisms were Mycobacterium tuberculosis (42.2%) mainly in sputum;Escherichia coli (24.2%) and Klebsiella pneumoniae (7.8%) commonly in urine and Gardnerella vaginalis (7.0%) exclusively in vaginal secretions. Candida albicans (5/8) and Cryptococcus neoformans (3/8) were the most common fungi while Plasmodium falciparum (96.4%) represented the parasite frequently found in blood. From a therapeutic standpoint, 1143 antimicrobials were prescribed to 322 admitted patients, i.e. 3.55 anti-infectives per patient. Antibiotics (excluding tuberculosis drugs), antiparasitics and antifungals represented respectively 46.2%;18.8% and 15.1% of anti-infectives. Antibiotic therapy was effective in 274 (85.1%) patients and among them, only 76 (27.7%) cases were based on microbiological evidence. Antibiotics are the most widely used antimicrobials in an infectious disease department. Empiric treatments are common but must be minimized by the search for microbiological evidence.

关键词： Antimicrobial Microbiology Infectious Diseases Mali

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