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CRISPR-detector:fast and accurate detection,visualization,and annotation of genome-wide mutations induced by genome editing events

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Journal of Genetics and Genomics 2023年第8期50卷 563-572页

作者： Lei Huang Dan Wang Haodong Chen Jinnan Hu Xuechen Dai Chuan Liu Anduo Li Xuechun Shen Chen Qi Haixi Sun Dengwei Zhang Tong Chen Yuan Jiang College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI-Shenzhen ShenzhenGuangdong 518083China BNU-HKBU United International College ZhuhaiGuangdong 519087China sentieon inc San JoseCA 94042USA School of Biology and Biological Engineering South China University of TechnologyGuangzhouGuangdong 510006China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

The leading-edge CRISPR/CRISPR-associated technology is revolutionizing biotechnologies through genome *** track on/off-target events with emerging new editing techniques,improved bioinformatic tools are *** tools suffer from limitations in speed and scalability,especially with whole-genome sequencing(WGS)data *** address these limitations,we have developed a comprehensive tool called CRISPR-detector,a web-based and locally deployable pipeline for genome editing sequence *** core analysis module of CRISPR-detector is based on the sentieon TNscope pipeline,with additional novel annotation and visualization modules designed to fit CRISPR ***-analysis of the treated and control samples is performed to remove existing background variants prior to genome ***-detector offers optimized scalability,enabling WGS data analysis beyond Browser Extensible Data file-defined regions,with improved accuracy due to haplotype-based variant calling to handle sequencing *** addition,the tool also provides integrated structural variation calling and includes functional and clinical annotations of editing-induced mutations appreciated by *** advantages facilitate rapid and efficient detection of mutations induced by genome editing events,especially for datasets generated from *** web-based version of CRISPR-detector is available at https://***/crispr-detector,and the locally deployable version is available at https://***/hlcas/CRISPR-detector.

关键词： Genome editing On/off-target Genetic background removal Structural variation

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Corrigendum to“CRISPR-detector:fast and accurate detection,visualization,and annotation of genome-wide mutations induced by genome editing events”[Journal of Genetics and Genomics(2023)563-572]

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Journal of Genetics and Genomics 2023年第10期50卷 813-813页

This corrigendum clarifies information in the article“CRISPR-detector:fast and accurate detection,visualization,and annotation of genomewide mutations induced by genome editing events”by Huang et al.(2023).In the figure legend of Fig.S1,the sentence“CRISPR-detector failed to report insertions larger than 72 bp while CRISPResso2 failed to report insertions larger than 53 bp.”should be corrected into“CRISPR-detector failed to report deletions larger than 71 bp while CRISPResso2 failed to report deletions larger than 53 bp.”

关键词： al. Cor insertion

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