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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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Classification and Identification of indica P/TGMS Lines in China

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Rice science 2019年第3期26卷 195-198页

作者： ZHANG Mengchen WANG Shan YAN Jianfang SUN Shuiyong XU Xin XU Qun YUAN Xiaoping WEI Xinghua YANG Yaolong State Key Laboratory of Rice Biology China National Rice Research Institute seeds administration center of zhejiang province

Despite extensive studies on cultivated rice, the population structure and genetic diversity of the indica photoperiod-and thermo-sensitive genic male sterility(P/TGMS) lines in China remains unclear. Using 48 simple sequence repeat(SSR) markers, we genotyped a panel of 208 indica P/TGMS lines and confirmed three subgroups, named indica-I, indica-II and indica-III, in indica P/TGMS lines. Further diversity analysis indicated indica-II had the highest genetic diversity. The genetic differentiation between indica-II and indica-III was demonstrated as the largest among the three subgroups. Moreover, indica/japonica component identification was detected that five P/TGMS lines possess indica components less than 0.900. These results improve our knowledge on the genetic background for P/TGMS lines in China and will be beneficial for hybrid rice breeding programs.

关键词： Classification Identification Despite

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Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics

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World Journal of Psychiatry 2025年第1期15卷 7-11页

作者： Yan Zhang Hao-Yu Xing Juan Yan administration Office Lishui Second People’s HospitalLishui 323060Zhejiang ProvinceChina Department of Medical Engineering The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina Quality Control Office The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina

In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics *** recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this *** the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for ***,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.

关键词： Bibliometrics Schizophrenia Near-infrared spectroscopy Diagnostic technique Data analysis

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Severe mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature review

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World Journal of Clinical Cases 2019年第20期7卷 3329-3334页

作者： Qi-En He Min Xia Guang-Hui Ying Xue-Lin He Jiang-Hua Chen Yi Yang Kidney Disease center the First Affiliated HospitalCollege of MedicineZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang Provincethe Third Grade Laboratory Under the National StateAdministration of Traditional Chinese MedicineHangzhou 310000Zhejiang ProvinceChina Department of Nephrology Beilun People's HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Antiviral drugs are widely used in populations with viral infection caused by immunologic *** these drugs are mainly metabolized by the kidneys,patients with renal failure undergoing renal replacement therapy are prone to drug adverse effects and *** neurotoxicity caused by antiviral drugs is a rare but life-threatening *** SUMMARY This study reported one male patient on peritoneal dialysis who suffered from severe mental disorders after receiving an overdose of acyclovir and valacyclovir for the treatment of herpes *** literature review suggested that hemodialysis is better than peritoneal dialysis to clear acyclovir from the *** patient died after his consciousness deteriorated despite peritoneal dialysis and continuous blood *** This case emphasizes cautiousness when using anti-retroviral drugs in patients with *** is optimal method to remove the drugs.

关键词： Chronic renal failure Peritoneal dialysis Acyclovir Valacyclovir Neurotoxicity Herpes zoster Case report

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Research status on immunotherapy trials of gastric cancer

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World Journal of Clinical Cases 2021年第21期9卷 5782-5793页

作者： Chao Liang Heng-Miao Wu Wei-Ming Yu Wei Chen Department of General Surgery Ningbo Medical Center Lihuili HospitalNingbo 315040Zhejiang ProvinceChina Ningbo Medical center Lihuili Hospital Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Cancer Institute of Integrated Traditional Chinese and Western Medicine Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina

The breakthrough of immune checkpoint inhibitor(ICI)therapy has created extensive opportunities for cancer ***,the block of programmed death-1/programmed death ligand 1(PD-L1)axis using ICIs has become a new therapeutic strategy to treat advanced gastric cancer(GC).However,in the past decade,single-arm and randomized trials for single-drug ICI therapy showed that the therapeutic effect was not satisfactory,including clinical trials for advanced ***,after selecting suitable predictive biomarkers and developing a combination of anti-angiogenic targeted drugs and other chemotherapeutic drugs,the objective response rate and progression-free survival of patients with gastric cancer were improved *** United States Food and Drug administration has approved treatment with pembrolizumab for patients with advanced GC with PD-L1 expression or microsatellite instabilityhigh/mismatch repair *** this review,the updated data from the latest trial results of combination immunotherapy for GC are *** on the outcome of combination therapy,we discuss its possible molecular mechanism and summarize effective predictive *** also discuss possible problems stemming from results of other clinical trials of ICI treatment and propose other directions for ICI therapy.

关键词： Gastric cancer Immunotherapy Clinical trial Immune checkpoint inhibitor Neoadjuvant therapy

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Acute ischemic Stroke combined with Stanford type A aortic dissection:A case report and literature review

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World Journal of Clinical Cases 2022年第22期10卷 8009-8017页

作者： Zhi-Yang He Lin-Peng Yao Xiao-Ke Wang Nai-Yun Chen Jun-Jie Zhao Qian Zhou Xiao-Feng Yang Department of Emergency and Trauma center The International Medical CenterThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Radiology The First Affiliated HospitalZhejiang University school of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Acute aortic dissection(AAD)is a high mortality disease that can lead to acute ischemic strokes(AIS).Some of the patients with AAD combined with AIS initially present with neurological symptoms,which can easily lead to missed or delayed AAD *** is attributed to the lack of physician awareness or the urgency of patient *** administration of thrombolytic therapy(IVT)for AAD is associated with poor prognostic *** report a patient with AIS combined with AAD who developed a massive cerebral infarction after receiving IVT for a missed AAD *** SUMMARY A 49-year-old man was admitted to a local hospital with an acute onset of leftsided limb weakness accompanied by slurred *** patient had a history of hypertension that was not regularly treated with *** examination revealed incomplete mixed aphasia and left limb *** computed tomography(CT)scan showed bilateral basal ganglia and lateral ventricular paraventricular infarct *** patient was diagnosed with AIS and was administered with *** IVT,patient’s muscle strength and consciousness *** the local hospital,he was referred to our hospital for further *** head and neck CT angiography(CTA)scans were *** showed multiple cerebral infarctions,and aortic dissection in the ascending aorta,innominate artery,as well as in the right common carotid ***,the CTA of thoracoabdominal aorta was performed,which revealed a Stanford type A aortic dissection and aortic dissection extending from the aortic root to the left external iliac *** was located in the lesser curvature of the aortic *** complicated with AIS was considered,and the patient was immediately subjected to cardiovascular surgery for *** next day,the patient underwent aortic arch and ascending aortic replacement and aortic *** Clinical manifestations for AAD combined wi

关键词： Acute aortic dissection Acute ischemic stroke Intravenous thrombolysis Ultrasound evaluation Case report

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miRNA-26b suppresses the TGF-β2-induced progression of HLE-B3 cells via the PI3K/Akt pathway

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1350-1358页

作者： En Shi Xiang-Nan Ye Liu-Yi Xie Department of Ophthalmology Ningbo Eye HospitalNingbo 315040Zhejiang ProvinceChina Department of Ophthalmology Ningbo Medical Center Lihuili HospitalNingbo 315041Zhejiang ProvinceChina Department of Ophthalmology Beilun District Peopled HospitalNingbo 315826Zhejiang ProvinceChina

AIM:To study the effect of mi R-26 b on lens epithelial cells induced by transforming growth factor beta(TGF-β)2 and the underlying signaling ***:Human lens epithelial cell line B-3(HLE-B3)was incubated with TGF-β2(5 ng/m L)and then transfected with mi R-26 b *** expression of mi R-26 b was determined using quantitative reverse transcriptase polymerase chain reaction(q RT-PCR),while 5’-bromodeoxyuridine(Brd U)and wound-healing assays were used to measure the growth and migration of HLE-B3 cells,*** expression of epithelialmesenchymal transition(EMT)markers and the activity of the phosphatidylinositol 3-kinase(PI3 K)/Akt pathway were measured by Western blotting assay and immunofluorescence *** microscopy was also used to observe cellular ***:The expression levels of mi R-26 b were significantly reduced in human posterior capsular opacification-attached lens tissue and TGF-β2-stimulated HLE-B3 *** the presence of TGF-β2,the growth,migration,and EMT of HLE-B3 cells were distinctly enhanced;these effects were attenuated by the administration of mi R-26 b ***,the overexpression of mi R-26 b significantly reduced upregulation of the PI3 K/Akt pathway when stimulated by TGF-β2 in HLE-B3 ***,the addition of an activator(740 Y-P)led to the upregulation of the PI3 K/Akt pathway and abolished the protective effect of mi R-26 b on the HLE-B3 cells that was mediated by TGF-β***:The mi R-26 b suppresses TGF-β2-induced growth,migration,and EMT in HLE-B3 cells by regulating the PI3 K/Akt signaling pathway.

关键词： posterior capsule opacification miRNA-26b proliferation migration epithelial-mesenchymal transition

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Vitamin D 1,25-Dihydroxyvitamin D_(3) reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization

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World Journal of Gastrointestinal Oncology 2024年第12期16卷 4685-4699页

作者： Wen-Jing Luo Xian-Wen Dong Hua Ye Qiao-Su Zhao Qiu-Bo Zhang Wen-Ying Guo Hui-Wei Liu Feng Xu Department of Gastroenterology Ningbo Medical Center Lihuili HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD),which is a significant liver condition associated with metabolic syndrome,is the leading cause of liver diseases globally and its prevalence is on the rise in most *** protective impact of vitamin D on NAFLD and its specific mechanism remains *** To examine the role of vitamin D in NAFLD and how vitamin D affects the polarization of hepatic macrophages in NAFLD through the vitamin D receptor(VDR)-peroxisome proliferator activated receptor(PPAR)γ*** Wild-type C57BL/6 mice were provided with a high-fat diet to trigger NAFLD model and administered 1,25-dihydroxy-vitamin D[1,25(OH)_(2)D_(3)]supplementation.1,25(OH)_(2)D_(3) was given to RAW264.7 macrophages that had been treated with lipid,and a co-culture with AML12 hepatocytes was set *** accumulation,lipid metabolism enzymes,M1/M2 phenotype markers,proinflammatory cytokines and VDR-PPARγpathway were *** Supplementation with 1,25(OH)_(2)D_(3) relieved hepatic steatosis and decreased the proinflammatory M1 polarization of hepatic macrophages in *** of 1,25(OH)_(2)D_(3) suppressed the proinflammatory M1 polarization of macrophages induced by fatty acids,thereby directly relieving lipid accumulation and metabolism in *** VDR-PPARγpathway had a notable impact on reversing lipid-induced proinflammatory M1 polarization of macrophages regulated by the administration of 1,25(OH)_(2)D_(3).CONCLUSION Supplementation with 1,25(OH)_(2)D_(3) improved hepatic steatosis and lipid metabolism in NAFLD,linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages,partially by regulating the VDRPPARγ*** involvement of 1,25(OH)_(2)D_(3) in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes.

关键词： Non-alcoholic fatty liver disease Hepatocytes Macrophages Polarization Vitamin D receptor Peroxisome proliferator activated receptorγ

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Application of a Neural Network to Store and Compute the Optical Properties of Non-Spherical Particles

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Advances in Atmospheric Sciences 2022年第12期39卷 2024-2039页

作者： Jinhe YU Lei BI Wei HAN Xiaoye ZHANG Key Laboratory of Geoscience Big Data and Deep Resource of zhejiang province School of Earth SciencesZhejiang UniversityHangzhou 310027China center for Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China Numerical Weather Prediction center China Meteorological AdministrationBeijing 100081China Key Laboratory of Atmospheric Chemistry of China Meteorological administration Institute of Atmospheric CompositionChinese Academy of Meteorological SciencesBeijing 100081China

Radiative transfer simulations and remote sensing studies fundamentally require accurate and efficient computation of the optical properties of non-spherical *** paper proposes a deep learning(DL)scheme in conjunction with an optical property database to achieve this *** neural network(DNN)architectures were obtained from a dataset of the optical properties of super-spheroids with extensive shape parameters,size parameters,and refractive *** dataset was computed through the invariant imbedding T-matrix *** separate DNN architectures were created to compute the extinction efficiency factor,single-scattering albedo,asymmetry factor,and phase *** criterion for designing these neural networks was the achievement of the highest prediction accuracy with minimal DNN *** numerical results demonstrate that the determination coefficients are greater than 0.999 between the prediction values from the neural networks and the truth values from the database,which indicates that the DNN can reproduce the optical properties in the dataset with high *** addition,the DNN model can robustly predict the optical properties of particles with high accuracy for shape parameters or refractive indices that are unavailable in the ***,the ratio of the database size(~127 GB)to that of the DNN parameters(~20 MB)is approximately 6810,implying that the DNN model can be treated as a highly compressed database that can be used as an alternative to the original database for real-time computing of the optical properties of non-spherical particles in radiative transfer and atmospheric models.

关键词： non-spherical particles light scattering super-spheroid model deep learning neural network

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Profiling of gene fusion involving targetable genes in Chinese gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1528-1539页

作者： Zhen-Hua Liu Bo-Wen Zhu Min Shi Yu-Rong Qu Xun-Jun He Hong-Ling Yuan Jie Ma Wei Li Dan-Dan Zhao Zheng-Chuang Liu Bao-Ming Wang Chun-Yang Wang Hou-Quan Tao Tong-Hui Ma Department of Medical Oncology Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Medical center Genetron Health(Beijing)TechnologyCo.Ltd.Beijing 102200China Department of Genetics and Genomic Medicine Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Key Laboratory of Gastroenterology of zhejiang province Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People's HospitalHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology of zhejiang province Zhejiang Provincial People’s HospitalHangzhou 310000Zhejiang ProvinceChina Department of Translational Medicine Genetron Health(Beijing)TechnologyCo.Ltd.Beijing 102200China

BACKGROUND Approximately half of all new cases of gastric cancer(GC)and related deaths occur in *** than 80%of patients with GC are diagnosed at an advanced stage,which results in poor *** HER2-directed therapy and immune checkpoint inhibitors have been somewhat successful,new drugs are still needed for the treatment of ***,several gene fusion-targeted drugs have been approved by the United States Food and Drug administration for solid tumors,including GC,such as larotrectinib for NTRK fusion-positive cancers and zenocutuzumab for NRG1 fusion-positive ***,gene fusions involving targetable genes have not been well characterized in Chinese patients with *** To identify the profile of fusions involving targetable genes in Chinese patients with GC using clinical specimens and determine the distribution of patients with gene fusion variants among the molecular subtypes of *** We retrospectively analyzed gene fusion events in tumor tissue samples from 954 Chinese patients with *** characteristics were obtained from their medical *** alterations,such as single nucleotide variants,indels,amplifications,and gene fusions,were identified using a targeted sequencing panel containing 825 *** were validated by fluorescence in situ hybridization(FISH)using break-apart *** microsatellite instability(MSI)status was evaluated using MSIsensor from the targeted sequencing panel *** mutational burden(TMB)was calculated using the total number of nonsynonymous mutations divided by the total genomic targeted ***-square analysis was used to determine the enrichment of gene fusions associated with the molecular subtypes of *** We found that 1.68%(16/954)of patients harbored 20 fusion events involving targetable *** fusions(n=5)were the most common,followed by FGFR2,BRAF,MET,FGFR3,RET,ALK,EGFR,NTRK2,and NRG1 *** of the RARA fusions,EML4-ALK(E6:E20)and EGFRSEPT

关键词： Gene fusion Targetable genes Gastric cancer Chinese population ERBB2 amplification

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