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Atrial fibrillation and prediabetes:Interplay between left atrium and systemic diseases

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World Journal of Diabetes 2024年第11期15卷 2242-2244页

作者： Ming-Jui Hung Department of Internal medicine Section of Cardiovascular ImagingDivision of CardiologyChang Gung Memorial Hospital at KeelungChang Gung University College of MedicineKeelung 204201Taiwan

Atrial fibrillation(AF)is associated with multiple other comorbidities,*** is one of the multiple comorbidities observed in patients with AF,whereby these two disease entities share the same pathophysiological mechanisms,namely oxidative stress and *** prediabetes is reported to have a negative impact on major adverse cardiac or cerebrovascular events in hospitalized AF patients,information about the interactions between prediabetes and AF remains inconsistent.A more in-depth exploration of pathophysiology and more comprehensive prospective clinical studies of AF and diabetes would provide a thorough understanding of the timing of events and further treatment *** investigations are needed to clarify the interactions and causal relationships between AF and prediabetes.

关键词： Atrial fibrillation Endothelial dysfunction Inflammation Prediabetes Stroke

Disorders of cardiac rhythm in China

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Journal of Geriatric Cardiology 2024年第7期21卷 703-712页

作者： Sheng-Shou HU The Writing Committee of the Report on cardiovascular Health and Diseases in China

The Annual Report on cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in *** connection with the previous section,this seventh section of the report offers a comprehensive analysis of dis-orders of heart rhythm in *** 2021,China has achieved significant development and gratifying results in many aspects of the field of *** bundle branch pacing(LBBP),as an emerging pacing technique originating from China,has received widespread *** research results have emerged on its indications,surgical procedures,clinical evaluation,and com-parison with other pacing *** feasibility,effectiveness,and safety have been basically verified,but its long-term pro-gnosis still needs further confirmation from larger samples and longer follow-up time research *** pacemakers have begun to be used in a wider range of clinical applications,and related large sample cohort studies have been *** addi-tion,there are also noteworthy new achievements in the fields of pacemaker remote programming,anticoagulation and radiofre-quency catheter ablation(RFCA)therapy for atrial fibrillation,and implantable cardioverter defibrillator prevention of sudden cardiac *** terms of clinical practice,due to COVID-19 pandemic,the number of RFCA procedures and other device im-plantations in China has fluctuated,but it has gradually recovered since 2020.

关键词： cardiac prevention landscape

Adherence to Pharmacotherapy in Post-Menopausal Women with Hypertension or Metabolic Syndrome: Real World Experience

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International Journal of Clinical medicine 2024年第3期15卷 145-154页

作者： Maria Maiello Francesca Amati Vincenzo Ezio Santobuono Andrea Igoren Guaricci Cinzia Forleo Marco Matteo Ciccone Pasquale Palmiero Department of Cardiology ASL BR SSN3 Brindisi Italy cardiovascular Diseases section Interdisciplinary Department of Medicine (DIM) University of Bari “Aldo Moro” Bari Italy

Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several studies were conducted to test intervention strategies, results are uncertain. Aim: The aim of the study is to assess if a tailored combined intervention strategy improves medication adherence in a large population of post-menopausal women affected by hypertension or metabolic syndrome. Methods: We enrolled 6833 patients aged 50 to 69 years, 85.7% with hypertension, and 14.3% with metabolic syndrome. A network between patients, general practitioners, and cardiologists was established. Interventions included education, adequate information to patients, a simplified scheme of treatment, and periodic adherence assessment. These were either delivered as healthcare provider supports or using modern technology. Medication adherence was estimated by the proportion of days covered for all classes of drugs after the index date. Results: Non-adherent hypertensive women were 297 (5%), and those with metabolic syndrome were 73 (7.4%) (p Conclusions: The rate of non-adherence in both settings of postmenopausal women was 7.7%, much lower than that described in the literature. This rate was increased in patients with metabolic syndrome;probably it is related to the complexity of the therapeutic scheme or to a poor consciousness of the disease. Therefore, implementing a tailored combined intervention can improve significantly patients’ adherence to medical therapy.

关键词： Adherence cardiovascular Prevention Postmenopausal Women Hypertensive Metabolic Syndrome

Epidemiology and current management of cardiovascular disease in China

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Journal of Geriatric Cardiology 2024年第4期21卷 387-406页

作者： Sheng-Shou HU the Writing Committee of the Report on cardiovascular Health and Dis-eases in China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on cardiovascular Health and Diseases in China(2022) intricate landscape of cardiovascular health in China. This is the fourth section of the report with a specific focus on epidemiology and current management of cardiovascular disease(CVD) in China. This section of the report highlights the epidemiological trends of CVD in China. It reveal a concerning rise in prevalence, with approximately 330 million affected individuals, including significant numbers with stroke, coronary artery disease(CAD), heart failure, and other conditions. CVD stands as the primary cause of mortality among both urban and rural populations, accounting for nearly half of all deaths in 2020. Mortality rates are notably higher in rural areas compared to urban centers since 2009. While age-standardized mortality rates have decreased, the absolute number of CVD deaths has increased, primarily due to population aging. Ischemic heart disease, hemorrhagic and ischemic strokes are the leading causes of CVD-related deaths. Notably, the burden of atherosclerotic cardiovascular disease has risen substantially, with atherosclerotic cardiovascular disease-related deaths increasing from 1990 to 2016. The incidence of ischemic stroke and ischemic heart disease has shown similar increasing trends over the past three decades. CAD mortality, particularly acute myocardial infarction, has been on the rise, with higher mortality rates observed in rural areas since 2016. The prevalence of CAD has increased significantly, with over 11 million patients identified in 2013. Studies assessing hospital performance in managing acute coronary syndrome reveal gaps in adherence to guideline-recommended strategies, with disparities in care quality across hospitals. However, initiatives like the China Patient-centered Evaluative Assessment of Cardiac Events(PEACE)-Retrospective AMI Study and the Improving Care for cardiovascular Disease in China-Acute Coronary Syndrome(CCC-ACS) project aim to improve patien

关键词： epidemiology landscape deaths

The significance of long non-coding RNAs in the pathogenesis,diagnosis and treatment of inflammatory bowel disease

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Precision Clinical medicine 2024年第1期7卷 34-53页

作者： Fei Jiang Min Wu Rongpeng Li Jiangsu Province Engineering Research Center of cardiovascular Drugs Targeting Endothelial Cells School of Life SciencesJiangsu Normal UniversityXuzhou 221000China Department of Laboratory medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Drug Discovery section Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China Department of Neurology Medical College of WisconsinMilwaukeeWI 53226USA

Inflammatory bowel diseases(IBD)are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global *** the pathomechanism of IBD has been extensively investigated,several aspects of its pathogenesis remain *** non-coding RNAs(lncRNAs)are transcripts with more than 200 nucleotides in length that have potential protein-coding *** play important roles in biological processes such as epigenetic modification,transcriptional regulation and posttranscriptional *** this review,we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment,as well as their potential roles as immune regulators,diagnostic biomarkers and therapeutic targets or agents for IBD.

关键词： lncRNAs inflammatory bowel diseases intestinal barrier intestinal microenvironment immune regulator diagnostic biomarker therapeutic target

Influencing Factors on cardiovascular Health in China

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Journal of Geriatric Cardiology 2024年第1期21卷 4-33页

作者： Sheng-Shou HU 无 Fuwai Hospital Chinese Academy of Medical Sciences BeijingChina the Writing Committee of the Report on cardiovascular Health and Diseases in China

The Annual Report on cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in *** is the first section of the report,which dissects influential factors across diverse *** investigation identifies tobacco use as a paramount concern,portraying China as the global epicenter of tobacco *** smoking,exacerbated by second-hand smoke exposure,emerges as a critical and preventable risk factor,contributing to a surge in attributable deaths over the past three *** the realm of dietary nutrition,the study discerns an overall improvement,yet discerns worrisome deviations,notably an escalating fat intake surpassing recommended *** shifting dietary structure reveals diminished consumption of cereals and vegetables juxtaposed with an uptick in animal foods,while excessive intake of cooking oil and salt persists,straying substantially from endorsed *** exploration of physical activity patterns unfolds a nuanced *** trends are observed among students,with concerns arising from sedentary behaviors and inadequate adherence to recommended *** analysis spans a trajectory of declining physical activity in Chinese adults,coupled with an alarming surge in sedentary leisure time,ultimately linking these factors to heightened risks of cardiovascular diseases and increased *** examination of overweight and obesity trends uncovers a relentless upward trajectory,projecting substantial prevalence by *** prevalence rates underscore the imperative for targeted interventions to curtail this burgeoning health crisis,with the anticipated prevalence extending to nearly two-thirds of the adult *** factors,notably depression,constitute an integral facet of cardiovascular *** rates among patients with coronary artery disease and acute myocardial infarction underscore the intricate interplay between mental health and cardiovascular

关键词： Influencing smoke linking

Heart failure in China:epidemiology and current management

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Journal of Geriatric Cardiology 2024年第6期21卷 631-641页

作者： Sheng-Shou HU the Writing Committee of the Report on cardiovascular Health and Diseases in China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascularhealth in *** connection with the previous section,this sixth section of the report offers a comprehensive analysis of heart failure(HF)in *** is one of the most important cardiovascular disease in the 21st *** mortality is equivalent to that of *** is an important public health problem that seriously affects the health of Chinese *** recent years,with the deepeningof understanding,the change of treatment principles,the innovation of treatment methods and the update of treatment guidelines,the in-hospital mortality of HF patients has declined,and the long-term prognosis is also ***,there are stilldifferences in the management level of HF among different hospitals in *** to improve the standardized diagnosis andtreatment level of HF in China remains an important challenge.

关键词： epidemiology diagnosis treatment

Community-based prevention and treatment of cardiovascular diseases

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Journal of Geriatric Cardiology 2024年第3期21卷 315-322页

作者： Sheng-Shou HU The Writing Committee of the Report on cardiovascular Health and Diseases in China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The Annual Report on cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in *** is the third section of the report with a specific focus on community-based prevention and treatment of cardiovascular diseases(CVD).This section of the report underscores the importance of initiatives outlined in the"Healthy China 2030 Plan,"emphasizing the comprehensive prevention and control strategy for chronic diseases.A key aspect of this plan involves the establishment of national demonstration areas aimed at comprehensive prevention and control of chronic *** 2020,488 such areas had been set up across China,surpassing the initial target and covering a significant proportion of counties and *** report highlights the successful implementation of these strategies in Lishan district,Anshan city,where demonstration areas for comprehensive prevention and control of chronic diseases were launched in *** the course of seven years,the number of healthy units increased substantially,leading to improvements in managing risk factors for CVD among *** reductions in prevalence rates of overweight,obesity,smoking,passive smoking,and drinking were observed,along with the development of healthier behaviors among ***,Qiaokou district in Wuhan City,designated as a national demonstration area in 2014,implemented comprehensive public health promotion ***,special clinics for hypertension intervention were established,contributing to an increase in self-reported rates of hypertension,a slight decrease in prevalence,and a remarkable improvement in the control rate among treated ***,these efforts underscore the effectiveness of community-based approaches in driving positive health outcomes and advancing the comprehensive prevention and control of chronic diseases,particularly cardiovascular diseases,in China.

关键词： prevention district treatment

cardiovascular Risk Factors in China

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Journal of Geriatric Cardiology 2024年第2期21卷 153-199页

The Annual Report on cardiovascular Health and Diseases in China(2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China,with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia,have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in China,with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in

关键词： landscape adding spite