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Golgi-localized MORN1 promotes lipid droplet abundance and enhances tolerance to multiple stresses in Arabidopsis

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Journal of Integrative Plant Biology 2023年第8期65卷 1890-1903页

作者： Zhan Li Yue Gao Jiapei Yan Shuai Wang Shu Wang Yuanyuan Liu Shaokui Wang Jian Hua Guangdong Provincial Key Laboratory of Plant molecular Breeding State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesSouth China Agricultural UniversityGuangzhou 510640China School of Integrative Plant Science Plant Biology SectionCornell UniversityIthacaNY 14853USA

Lipid droplet(LD)in vegetative tissues has recently been implicated in environmental responses in plants,but its regulation and its function in stress tolerance are not well ***,we identified a Membrane Occupation and Recognition Nexus 1(MORN1)gene as a contributor to natural variations of stress tolerance through genome-wide association study in Arabidopsis *** of its loss-of-function mutant and natural variants revealed that the MORN1 gene is a positive regulator of plant growth,disease resistance,cold tolerance,and heat *** MORN1 protein is associated with the Golgi and is also partly associated with *** truncations that disrupt these associations abolished the biological function of the MORN1 ***,the MORN1 gene is a positive regulator of LD abundance,and its role in LD number regulation and stress tolerance is highly ***,this study identifies MORN1 as a positive regulator of LD abundance and a contributor to natural variations of stress *** implicates a potential involvement of Golgi in LD biogenesis and strongly suggests a contribution of LD to diverse processes of plant growth and stress responses.

关键词： cold Golgi heat immunity lipid droplet MORN1 natural variation stress tolerance

Changes in Growth,Photosynthetic Pigments,Cell Viability,Lipid Peroxidation and Antioxidant Defense System in Two Varieties of Chickpea(Cicer arietinum L.)Subjected to Salinity Stress

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 149-168页

作者： Zeenat Mushtaq Shahla Faizan Basit Gulzar Humira Mushtaq Sayyada Bushra Alisha Hussain Khalid Rehman Hakeem Environmental Physiology Laboratory Department of BotanyAligarh Muslim UniversityAligarh202002India Cellular Differentiation and molecular Genetics section Department of BotanyJamia HamdardNew Delhi110062India Research and Training Centre for Pollinators Pollinizers and Pollination Management SectionDivision of EntomologySKUAST KashmirSrinagar190025India Department of Biological Sciences Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia

Salinity is one of the most severe abiotic stresses for crop *** present study investigates the salinityinduced modulation in growth indicators,morphology and movement of stomata,photosynthetic pigments,activity of carbonic anhydrase as well as nitrate reductase,and antioxidant systems in two varieties of chickpea(Pusa-BG5023,and Pusa-BGD72).On 20^(th) day of sowing,plants were treated with varying levels of NaCl(0,50,100,150 and 200 mM)followed by sampling on 45 days of *** observations on both the varieties reveal that salt stress leads to a significant decline in growth,dry biomass,leaf area,photosynthetic pigments,protein content,stomatal behavior,cell viability,activity of nitrate reductase and carbonic anhydrase with the rise in the concentration of ***,quantitatively these changes were less in Pusa-BG5023 as compared to ***,salinity-induced oxidative stress enhanced malondialdehyde content,superoxide radicals,foliar proline content,and the enzymatic activities of superoxide dismutase,catalase,and *** variety Pusa-BGD72 was found more sensitive than Pusa-BG5023 to salt *** of different graded concentrations(50,100,150 and 200 mM)of sodium chloride,50 mM was least toxic,and 200 mM was most *** differential behavior of these two varieties measured in terms of stomatal behavior,cell viability,photosynthetic pigments,and antioxidant defense system can be used as prospective indicators for selection of chickpea plants for salt tolerance and sensitivity.

关键词： Salt stress ion homeostasis antioxidant defense cell viability chickpea

Contact pattern,current immune barrier,and pathogen virulence determines the optimal strategy of further vaccination

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Infectious Disease Modelling 2023年第1期8卷 192-202页

作者： Xiaohao Guo Ziyan Liu Shiting Yang Zeyu Zhao Yichao Guo Guzainuer Abudurusuli Shanlu Zhao Ge Zeng Shixiong Hu Kaiwei Luo Tianmu Chen State Key Laboratory of molecular Vaccinology and molecular Diagnostics School of Public HealthXiamen UniversityXiamen City361102Fujian ProvincePeople's Republic of China Hunan Provincial Center for Disease Control and Prevention 405 Furong Middle Road Section OneKaifu DistrictChangsha City410001Hunan ProvincePeople's Republic of China

Background:The current outbreak of novel coronavirus disease 2019 has caused a seriousdisease burden *** are an important factor to sustain the *** with a relatively high-vaccination worldwide,the decay of vaccine efficacy andthe arising of new variants lead us to the challenge of maintaining a sufficient immunebarrier to protect the ***:A case-contact tracking data in Hunan,China,is used to estimate the contactpattern of cases for scenarios including school,workspace,etc,rather than ordinary susceptible *** on the estimated vaccine coverage and efficacy,a multi-groupvaccinated-exposed-presymptomatic-symptomatic-asymptomatic-removed model(VEFIAR)with 8 age groups,with each partitioned into 4 vaccination status groups *** optimal dose-wise vaccinating strategy is optimized based on the currentlyestimated immunity barrier of coverage and efficacy,using the greedy algorithm thatminimizes the cumulative cases,population size of hospitalization and fatality respectivelyin a certain future *** of Delta and Omicron variants are used respectivelyin the ***:The estimated contact matrices of cases showed a concentration on middle ages,and has compatible magnitudes compared to estimations from contact surveys in *** VEFIAR model is numerically *** optimal controled vaccination strategy requires immediate vaccination on the un-vaccinated high-contact population of age30e39 to reduce the cumulative cases,and is stable with different basic reproductionnumbers(R_(0)).As for minimizing hospitalization and fatality,the optimized strategy requires vaccination on the un-vaccinated of both aged 30e39 of high contact frequencyand the vulnerable ***:The objective of reducing transmission requires vaccination in age groups ofthe highest contact frequency,with more priority for un-vaccinated than un-fully or *** objective of reducing total ho

关键词： Vaccine Allocation strategy SARS-CoV-2 Optimal control Immune barrier Contact pattern Greedy algorithm

Continued circulation of a single genotype of dengue virus serotype 2 in the Philippines

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 30-33页

作者： Joy Ann G Petronio Ricky B Vinarao Kristine Marie G Flores Raul V Destura Institute of molecular Biology and Biotechnology National Institutes of Health-University of the PhilippinesManila section of molecular Diagnostics The Medical CityPhilippines

Objective:To obtain descriptive information of behavioral pattern in Chinese school-aged children with cleft lip and ***:A total of 93 cleft lip and palate patients between the age of 6-11 year-old and treated at West China Stomatology Hospital were *** another100 unaffected controls,matched for age and gender,were recruited randomly from a common primary school in *** review of medical records was used to obtain psychosocial *** were compared with published norms and controls to evaluate the risk of problems,separately for three diagnostic ***:The patients group had lower scores of social and academic competencies,especially those with facial deformity or speech *** difference was found in the aspect of activity *** patients showed elevations in behavior *** the type of behavior problems varied in different ***:Chinese school-aged children with cleft lip and palate are at raised risk for social and academic *** pattern of behavior problems displays differently depending on gender of the patient.

关键词： Cleft lip and palate CBCL Psychosocial adjustment Behavior problems

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia Laboratory of molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

Bacteriolytic therapy of experimental pancreatic carcinoma

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World Journal of Gastroenterology 2010年第28期16卷 3546-3552页

作者： Claudia Maletzki Michael Gock Ulrike Klier Ernst Klar Michael Linnebacher Department of General VascularThoracic and Transplantation SurgerySection of Molecular Oncology and ImmunotherapyUniversity of Rostock18057 RostockGermany

AIM:To investigate the effectiveness of Clostridium novyi(***)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic,immunocompetent Panc02/C57Bl/6 model. METHODS:***-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different *** immune responses in peripheral blood and spleen were examined by flow ***,cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. RESULTS:Application of spores identified,that(1) small tumors(450 mm3)responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n=6);and(3)an optimal treatment window exists for tumors of approximately 250 mm 3 (n=21).In this latter group,all tumor-bearing animals had complete tu-mor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed(tumor volume at day 28:197.8±87.3 mm 3 vs 500.1±50.9 mm3,P<0.05). These effects were accompanied by systemic activation of immune response mechanisms predominantly mediated by the innate arm of the immune system. CONCLUSION:The observed complete tumor regression is encouraging and shows that immunotherapy with ***-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes.

关键词： Bacteriolytic immunotherapy Clostridium novyi-NT Immune response Pancreatic carcinoma

Role of exercise in the brain:focus on oligodendrocytes and remyelination

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Neural Regeneration Research 2023年第12期18卷 2645-2646页

作者： Grazia Maugeri Velia D'Agata Giuseppe Musumeci section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly Research Center on Motor Activities(CRAM) University of CataniaCataniaItaly Department of Biology Sbarro Institute for Cancer Research and Molecular MedicineCollege of Science and TechnologyTemple UniversityPhiladelphiaPAUSA

The phrase“Mens sana in corpore sano”taken from Juvenal's Satires(127 a.C.)represents one of the best-known and most used sentences of all time,whose meaning in the modern age refers to the importance of physical activity for mental health and *** literature demonstrated the positive role of exercise in counteracting several diseases,such as diabetes,cardiovascular diseases,neurodegenerative diseases,cancers and age-related disorders including muscle atrophy,the reduction of aerobic capacity,bone and cartilage loss.

关键词： meaning such exercise

Current status of radiation therapy for prostate cancer

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Nuclear Science and Techniques 2007年第2期18卷 65-72页

作者： FU Shen SUNYi LU Yaohong section of molecular Radiobiology RadioDepartment of Radiation Oncology the Sixth People＇s Hospital of Shanghai Jiaotong University Shanghai 200233 China

Radiotherapy for the treatment of prostate cancer has been extensively explored in the past. Along with the comprehensive understanding of the biology of prostate cancer and rapid advances in terms of technology, the out- come of treatment for the patients with prostate cancer has improved. The authors review radiotherapy as the primary treatment for the disease, with particular emphasis on the technological advances from both the radiobiological and radiophysics aspects. Nonconventional fractionated irradiation like hyper- or hypo-fractionation has been imple- mented in the clinic, the final results still need to be confirmed in the future. Technological advances like IMRT, IGRT, in the last two decades have significantly improved the delivery of external radiotherapy to the prostate. This has re- sulted in an overall increase in the total dose that can be safely delivered to the prostate, which has led to modest im- provements in the biochemical outcome. However, establishing the standard therapy for prostate cancer remains con- troversial. It is hoped that the next decades will bring continued advances in the development of biologicals that will further improve current clinical outcomes.

关键词：前列腺癌放射治疗现状分形 IMRT IGRT

Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： Antonella Antonelli Carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography