检索结果-南通市图书馆

Hepatitis B virus reactivation with a rituximab-containing regimen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of hepatology 2015年第21期7卷 2344-2351页

作者： Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima Department of Hematology Hakodate Municipal Hospital Department of gastro-enterology Hakodate Municipal Hospital Department of Hematology Hokkaido University Graduate School of Medicine

Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives.

关键词： Rituximab Hepatitis B virus Reactivation Nucleosid

Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of hepatology 2015年第27期7卷 2757-2764页

作者： Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada Department of gastro-enterology and Medicine Faculty of Medicine Fukuoka University Department of gastroenterology and Metabolism Applied Life Sciences Graduate School of Biome-dical and Health SciencesHiroshima University Center of gastroenterology and hepatology Saiseikai Suita Hospital Department of gastroenterology and hepatology Sapporo Kousei Hospital Department of gastroenterology and hepatology Musashino Red-Cross Hospital Department of Medicine Shinshu University School of Medicine Department of gastroenterology and Hepa-tology Osaka University Graduate School of Medicine Department of gastroenterology and hepatology Kagoshima University Department of gastroenterology and Metabology Ehime University Graduate School of Medicine Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University the Center for Liver Disease Shin-Kokura Hospital Department of gastroenterology Yamagata University Department of gastroenterology Faculty of Medicine Oita University Department of hepatology Toranomon Hospital

AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance ***: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients.

关键词： Des-γ-carboxy prothrombin Hepatocellular carcinoma

Predictors of mortality and endoscopic intervention in patients with upper gastrointestinal bleeding in the intensive care unit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

gastroenterology Report 2020年第4期8卷 299-305,I0002页

作者： Vijaya L.Rao Nina Gupta Eric Swei Thomas Wagner Andrew Aronsohn KGautham Reddy Neil Sengupta section of gastroenterology Hepatology and NutritionDepartment of Internal MedicineUniversity of Chicago MedicineChicagoILUSA Department of Internal Medicine University of Chicago MedicineChicagoILUSA

Background:The outcomes of patients undergoing esophagogastroduodenoscopy(EGD)in the intensive care unit(ICU)for upper gastrointestinal bleeding(UGIB)are not well *** aims were to determine predictors of 30-day mortality and endoscopic intervention,and assess the utility of existing clinical-prediction tools for UGIB in this ***:Patients hospitalized in an ICU between 2008 and 2015 who underwent EGD were identified using a validated,machine-learning *** regression was used to determine factors associated with 30-day mortality and endoscopic *** under receiver-operating characteristics(AUROC)analysis was used to evaluate established UGIB scoring systems in predicting mortality and endoscopic intervention in patients who presented to the hospital with ***:A total of 606 patients underwent EGD for UGIB while admitted to an *** median age of the cohort was 62 years and 55.9%were *** analysis revealed that predictors associated with 30-day mortality included American Society of Anesthesiologists(ASA)class(odds ratio[OR]4.1,95%confidence interval[CI]2.2-7.9),Charlson score(OR 1.2,95%CI 1.0-1.3),and duration from hospital admission to EGD(OR 1.04,95%CI 1.01-1.07).Rockall,Glasgow-Blatchford,and AIMS65 scores were poorly predictive of endoscopic intervention(AUROC:0.521,0.514,and 0.540,respectively)and in-hospital mortality(AUROC:0.510,0.568,and 0.506,respectively).Conclusions:Predictors associated with 30-day mortality include ASA classification,Charlson score,and duration in the hospital prior to *** risk tools are poorly predictive of clinical outcomes,which highlights the need for a more accurate risk-stratification tool to predict the benefit of intervention within the ICU population.

关键词： upper gastrointestinal bleeding esophagogastroduodenoscopy intensive care unit

Intestinal amyloidosis:Two cases with different patterns of clinical and imaging presentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2010年第20期16卷 2566-2570页

作者： Pier Paolo Mainenti Sabrina Segreto Marcello Mancini Antonio Rispo Immacolata Cozzolino Stefania Masone Ciro Roberto Rinaldi Gerardo Nardone Marco Salvatore IBB CNR NaplesVia Pansini 580131NaplesItaly Department of Biomorphological and Functional Sciences Section of RadiologyUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly Department of gastro-enterology University of Naples"Federico II"Via Pansini 580131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples "Federico II"Via Pansini 580131NaplesItaly Department of General Surgery Geriatry and EndoscopyUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly Department of Biotechnology Haema-tology UnitUniversity of Naples"Federico II"Via Pansini 580131NaplesItaly

The involvement of the small bowel in systemic forms of amyloidosis may be diffuse or very rarely *** cases of focal amyloidomas of the duodenum and jejunum without extraintestinal manifestations have been *** focal amyloidomas consisted of extensive amyloid infiltration of the entire intestinal wall *** barium studies,ultrasound and computed tomography(CT)patterns of diffuse small bowel amyloidosis have been described:the signs are non-specific and may include small-bowel dilatation,symmetric bowel wall thickening,mesenteric infiltration,and mesenteric *** data are available about the positron emission tomography (PET)/CT and magnetic resonance imaging(MRI)patterns of intestinal *** report two cases of small bowel amyloidosis:the former characterized by focal deposition of amyloid proteins exclusively within blood vessel walls of the terminal ileum,the latter characterized by diffuse intestinal involvement observed on MRI and PET/CT studies.

关键词： Amyloidosis Small bowel Positron emission tomography/computed tomography Magnetic resonance imaging Computed tomography

Significant cohort of non-alcoholic fatty liver disease with portal vein thrombosis in transplant waiting list

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of hepatology 2016年第7期8卷 376-384页

作者： Metin Basaranoglu Sonia M Najjar Ali Ebag Demirbag Hakan Senturk Division of gastro-enterology Department of Internal Medicine Bezmialem Vakif University Faculty of Medicine Division of gastroenterology Türkiye- Yüksek Ihtisas Hospital Department of Physiology and Pharmacology Center for Diabetes and Endocrine Research (Ce DER) University of Toledo College of Medicine and Life Sciences Division of gastrointestinal Surgery Türkiye Yüksek Ihtisas Hospital

AIM: To characterize non-alcoholic fatty liver disease(NAFLD) presentation with esophageal varices. METHODS: We carried out a retrospective cohort study on 258 patients with esophageal varices at a single tertiary referral center. These patients underwent diagnosis of several liver diseases, including: NAFLDassociated cirrhosis, hepatitis B, hepatitis C, Wilson disease, autoimune liver diseases, and others. RESULTS: Of the 258 patients, 39% of patients exhibited esophageal varices due to NAFLD-associated cirrhosis. Of the 38(14.7%) patients developed hepatocellular carcinoma during follow-up, 52% were due to hepatitis B, 26% due to hepatitis C and 13.2% due to NAFLD. Of the 258 patients, 50.0% with NAFLD, 33.3% with hepatitis B, 26.3% with hepatitis C, and 58.3% with other diseases were alive at the end of the 5-year period with a significant difference according to the Kaplan-Meier log Rank test(P = 0.040). Portal vein thrombosis was detected in 47.5% of patients with NAFLD, in 29% of patients with hepatitis B, in 17% of patients with hepatitis C, and in 62% of patients with other related diseases(P < 0.0001). CONCLUSION: Our study showed a proportionally greater elevation in liver transplant candidacy in patients with NAFLD and portal vein thrombosis. Older patients were more prone to developing cirrhosis, hepatocellular carcinoma and a high mortality rate. However, younger patients exhibited more portal vein thrombosis and gastric varices.

关键词： Hepatocellular carcinoma Non-alcoholic fatty liver disease Portal vein thrombosis Esophageal varices

Identification of the distinguishing features of Crohn’s disease and ischemic colitis using computed tomographic enterography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

gastroenterology Report 2017年第3期5卷 219-225,I0002页

作者： Min Chen Erick M.Remer Xiuli Liu Rocio Lopez Bo Shen Department of gastroenterology/hepatology Cleveland Clinic FoundationClevelandOHUSA Department of gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina section of Abdominal Imaging Imaging InstituteCleveland Clinic FoundationClevelandOHUSA

Background and aims:The differential diagnosis between Crohn’s disease(CD)and ischemic colitis(ISC)is important as their clinical management is *** can easily be misdiagnosed as CD,especially in elderly *** distinctive radiographic features of the two disease entities have not been *** aim of this study is to assess the utility of computed tomographic enterography(CTE)in the differential diagnosis between CD and ***:Patients with confirmed CD and ISC were identified through an electronic medical record search of the Cleveland Clinic *** who had undergone CTE,with or without concurrent colonoscopy and histopathological specimens,were included in this *** images were blindly re-reviewed by an expert gastrointestinal *** sensitivities,specificities,accuracies and positive and negative predictive values for each of the CTE findings in differentiating CD from ISC were *** coefficients(j)were calculated tomeasure diagnosis agreement between CTE and the reference ***:A total of 34 eligible patients were included in this study with 17 having CD and 17 having *** differentiating CD from ISC,the presence ofmucosal hyperenhancement and absence of the“target sign”on CTE showed a sensitivity of 100% each for CD,while the two radiographic features yielded a low specificity of 35.3%and 76.5%,*** presence of stricture had a lower sensitivity of 64.7% for the detection of CD but had a high specificity of 100%.In distinguishing CD fromISC,the accuracy of presence ofmucosal hyperenhancement,stricture and absence of target sign were 67.7%,82.4% and 88.2%,*** combination of the presence ofmucosal hyperenhancement and the absence of the target sign achieved an accuracy of 100%for distinguishing CD from *** was a good correlation between CTE and the reference standard for distinguishing CD fromISC(k=0.882).Conclusions:CTE appeared to be clinically useful

关键词： computed tomographic enterography Crohn’s disease ischemic colitis differential diagnosis

Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2014年第10期6卷 840-845页

作者： Luigi Camera Rosa Severino Antongiulio Faggiano Stefania Masone Gelsomina Mansueto Simone Maurea Rosa Fonti Marco Salvatore Department of Advanced Biomedical Sciences Diagnostic Imaging Section University "Federico Ⅱ"80131 Naples Italy Institute of Biostructures and Bioimaging (C.N.R.) 80131 Naples Italy Department of Clinical Medicine and Surgery Endocrinology Section University "Federico Ⅱ"80131 Naples Italy Department of gastro-enterology Endocrinology and Surgery University "Federico Ⅱ"80131 Naples Italy Department of Advanced Biomedical Sciences Pathology Section University "Federico Ⅱ"80131 Naples Italy

Pancreatic vipoma is an extremely rare tumor accounting for less than 2% of endocrine pancreatic neoplasms with a reported incidence of 0.1-0.6 per million. While cross-sectional imaging findings are usually not specific, exact localization of the tumor by means of either computed tomography(CT) or magnetic resonance(MR) is pivotal for surgical planning. However, cross-sectional imaging findings are usually not specific and further characterization of the tumor may only be achieved bysomatostatin-receptor scintigraphy(SRS). We report the case of a 70 years old female with a two years history of watery diarrhoea who was found to have a solid, inhomogeneously enhancing lesion at the level of the pancreatic tail at Gadolinium-enhanced MR(Somatom Trio 3T, Siemens, Germany). The tumor had been prospectively overlooked at a contrast-enhanced multi-detector CT(Aquilion 64, Toshiba, Japan) performed after i.v. bolus injection of only 100 cc of iodinated non ionic contrast media because of a chronic renal failure(3.4 mg/mL) but it was subsequently confirmed by SRS. The patient first underwent a successful symptomatic treatment with somatostatin analogues and was then submitted to a distal pancreasectomy with splenectomy to remove a capsulated whitish tumor which turned out to be a well-differentiated vipoma at histological and immuno-histochemical analysis.

关键词： Pancreatic endocrine tumor Vasoactive intestinal peptide Multi-detector computed tomography Contrast induced nephropathy Magnetic resonance imaging Nephrogenic systemic fibrosis Somatostatin receptor scintigraphy

Pill or procedure?Patient preferences on beta-blockers as an alternative to endoscopic variceal screening during the COVID-19 pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

gastroenterology Report 2022年第1期10卷 632-634页

作者： Zheng Che Jeremy Louissaint Ihab Kassab Elliot B.Tapper Department of Internal Medicine University of MichiganAnn ArborMIUSA Division of gastroenterology and hepatology University of MichiganAnn ArborMIUSA gastroenterology section VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Introduction Certain patients at low risk of clinically significant esophageal varices by Baveno criteria can safely avoid screening esophagogastroduodenoscopy(EGD)[1,2].However,regardless of variceal status,the PREDESCI study suggests that earlier betablocker(BB)use in compensated disease with clinically significant portal hypertension by hepatic venous pressure gradient may result in benefit by delaying the time to decompensated cirrhosis[3,4].This carries significant ramifications for future clinical guidelines and decision-making for whom we decide to initiate BB.

关键词： esophageal hepatic screening

How to perform gastrointestinal ultrasound: anatomy and normal findings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2017年第38期23卷 6931-6941页

作者： Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich Translational gastroenterology Unit Oxford University Hospitals NHS Foundation Trust School of Medicine University of Adelaide Department of gastroenterology and hepatology Royal Adelaide Hospital Department of Ultrasound Zhongshan Hospital Fudan University Ambulanzzentrum gastroenterologie Klinikum Lüneburg Department of gastroenterology Stadtisches Klinikum Luneburg gGmbH gastrointestinal Unit Department of Biomedical and Clinical Sciences 'L.Sacco' University Hospital Department of gastroenterology and Hepato-logy The Alfred Hospital Monash University Piedmont Hospital Department of Emergency Medicine Fremantle Hospital and Health Service Emergency Department National Centre for Ultrasound in gastro- enterology Haukeland University Hospital Department of Clinical Medicine University of Bergen Department of gastroenterology Brandenburg Medical School Med. Klinik 2 Caritas-Krankenhaus Bad Mergentheim

gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth.

关键词： Ultrasound Intestinal Inflammatory bowel disease Guidelines Teaching