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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-López Iva Tic David Valle-García Marta Ribalta-Vilella Luis Labrador deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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Cholecystoenteric fistula with and without gallstone ileus: A case series

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 36-40页

作者： Mauricio Gonzalez-Urquijo Mario Rodarte-Shade Gerardo Lozano-Balderas Gerardo Gil-Galind Tecnologico de Monterrey Escuela de MedicinaCiencias de la SaludDr.Ignacio Morones Prieto O 3000Monterrey 64710México department of Surgery Hospital Metropolitano“Dr.Bernardo Sepúlveda”Secretaria de Salud de Nuevo LeónAdolfo López Mateos No.4600San Nicolás de los Garza 66400México

Background: A cholecystoenteric stula (CEF) is an uncommon complication of gallstone disease. The aim of this study was to present our experience of a series of patients with CEF, presenting with or without gallstone ileus, along with their surgical outcomes. Methods: From 2015 to 2018, 3245 consecutive patients underwent cholecystectomy for gallbladder disease at our institution, of which 15 were diagnosed with a CEF. All electronic medical records were retrospectively reviewed. Results: Fifteen patients presented with CEF. Ten patients presented cholecystoduodenal stula, four pa- tients cholecystocolonic, and one patient cholecystogastric counterparts. Twelve patients were female. The median patient age was 61 years (range 33 86 years). Five patients presented with gallstone ileus treated by laparotomy and enterolithotomy. In ten patients, a laparoscopic approach was attempted, but conversion to open surgery was necessary for eight of them. The median operative time was 140 min (range 60 240 min), and the median operative blood loss was 50 mL (range 10600mL). The procedure-related morbidity and mortality rates were 13.3% and 6.7%, respectively. Conclusions: There is no consensus on the best treatment modality for a CEF, as the treatment outcome is mostly dependent on the surgeon’s expertise and the patient’s condition. Not all CEFs are accompanied by gallstone ileus. For such case, the main purpose is to resolve the intestinal obstruction and, unless necessary, avoidance of the gallbladder area.

关键词： Cholecystoenteric stula Gallbladder disease Biliary-enteric stula Gallstone ileus Intestinal obstruction

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Frequency and severity of OSAHS in Mexican adolescents. The role of BMI and neck circumference

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Health 2013年第8期5卷 1-8页

作者： Armando Partida-Gaytán Arturo Berber Blanca Estela del Río-Navarro Reyes Haro-Valencia Chief of Sleep Breathing Disorders Clinic Universidad Nacional Autónoma de México Hospital General de México Secretaria de Salud Distrito Federal México departamento de Alergia e Inmunología Clínica Pediátrica Hospital Infantil de México Federico Gómez Instituto Nacional de Salud Secretaria de Salud Distrito Federal México

Background: Overweight and obesity are major public-health issues in Mexico. Sleep breathing disorders directly impact the health of affected subjects. The aim of this study was to describe the frequency and severity of obstructive sleep apnea/hypopnea syndrome (OSAHS) in Mexican adolescents grouped by weight status. Secondary objectives were to describe the influence of body mass index (BMI) and neck circumference (NC) as predictive factors of OSAH. Method: Somatometric, demographic data and full-night polysomnography were done. Linear and logistic regression models described the relationship between BMI and NC with OSAHS presence and severity. Receiver-Operating-Characteristics (ROC) curves showed different sensitivity and specificity performances of BMI and NC cutoff-values. Results: OSAHS frequency and severity were significantly greater in obese and extremely-obese adolescents (8% vs 22% vs 67%;p der the curve (AUC) of 0.83 for BMI defined cutoff-values, and of 0.80 for BMI percentile-for-age cutoff-values. The AUC of NC ROC curve was 0.8043. Conclusion: This is the largest study made on Latin-American population evaluating the frequency and severity of OSAHS with full-night polysomnography. We showed that obese and extremely-obese Mexican-adolescents are at highest risk for OSAHS. Increasing BMI and NC showed positive correlation with AHI. Different BMI cut-off values showed similar diagnostic performance. Extreme-obesity increases 8 times the risk association for OSAHS.

关键词： Obesity Obstructive Sleep Apnea Hyopopnea Syndrome (OSAHS) Obstructive Sleep Apnea Sleep Apnea Syndromes Polysomnography Body Mass Index (BMI) Neck Circumference Adolescents

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Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations

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Natural Products and Bioprospecting 2022年第1期12卷 107-120页

作者： Natividad Herrera Cano Sebastian A.Andujar Cristina Theoduloz Daniel A.Wunderlin Ana N.Santiago Guillermo Schmeda-Hirschmann Ricardo D.Enriz Gabriela E.Feresin Instituto de Biotecnología Facultad de IngenieríaUniversidad Nacional de San JuanCONICET-CCT San JuanAv.Libertador General San Martín1109(O)5400 San JuanArgentina Facultad de Química Bioquímica y Farmacia-IMIBIO-SL(CONICET)Universidad Nacional de San LuisChacabuco 9155700 San LuisArgentina Laboratorio de Cultivo Celular Facultad de Ciencias de la SaludUniversidad de TalcaCasilla 7473460000 TalcaChile ICYTAC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamentoQuímica OrgánicaCiudad UniversitariaBv.Juan Filloy s/n5000 CórdobaArgentina INFIQC CONICET and Universidad Nacional de CórdobaFacultad de Ciencias QuímicasDepartamento Química OrgánicaCiudad UniversitariaHaya de La Torre S/N5000 CórdobaArgentina Laboratorio de Química de Productos Naturales Instituto de Química de Recursos NaturalesUniversidad de TalcaCasilla 7473460000 TalcaChile

Triadimefon(TDM)and cyproconazole(CPZ)are two triazoles widely used as *** azoles were synthe-sised starting from commercial TDM and *** compounds were evaluated against phytopathogenic filamentous fungi,including Aspergillus fumigatus(AF),***(AN),***(AU),***(AJ),***(AT),Fusarium oxyspo-rum and Botrytis cinerea isolated from grapevine in the province of San Juan,*** of the synthesised compounds(1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one,1;2-(Biphenyl-4-yl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol,3;3-Cyclopropyl-2-(4’-fluorobiphenyl-4-yl)-1-(1H-1,2,4-triazol1-yl)butan-2-ol,4)presented remarkable in vitro fungicidal properties,with better effects than TDM and CPZ on some of the target *** was assessed using human lung fibroblasts *** 1,with IC50 values of 389.4μM,was less toxic towards MRC-5 human lung fibroblasts than commercial TDM(248.5μM)and CPZ(267.4μM).Docking analysis and molecular dynamics simulations suggest that the compounds present the same interaction in the binding pocket of the CYP51B enzyme and with the same amino acids as *** derivatives investigated could be considered broad-spectrum but with some selectivity towards imperfect fungi.

关键词： Azoles Antifungal cytotoxicity Conformational and electronic analysis

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TheI550Vpolymorphism in the renal human sodium/dicarboxylate cotransporter 1 (hNaDC-1) gene is associated with the risk for urolithiasis in adults from Southeastern, Mexico

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Open Journal of Genetics 2013年第2期3卷 59-66页

作者： Martha Medina-Escobedo Diana Franco-Bocanegra Salha Villanueva-Jorge Lizbeth González-Herrera departamento de Investigación en Enfermedades Renales Hospital General O’Horán Secretaria de Salud de Yucatán Mérida México Laboratorio de Genética Centro de Investigaciones Regionales Universidad Autónoma de Yucatán Mérida México

Urolithiasis (UL) is an endemic disease in Southeastern, Mexico. In order to evaluate the association of I550V polymorphism in the hNaDC-1 gene with risk for hypocitraturia and/or for UL;139 adults with UL and 132 adults without UL, were included under a case-control association study. Citrate levels in 24-h urine were quantified (citraturia). The polymorphism I550V-hNaDC-1 was determined by PCR-RFLP. Statistical analysis was performed using the STATA10.2 software. Comparison of genotype and allele frequencies between subjects with and without UL showed significant differences for genotype bb (OR = 2.34, CI: 1.19-4.59, p = 0.01) and for allele b (OR = 1.62, CI: 1.15-2.28, p = 0.005), suggesting an association with the risk for UL. Comparison of genotype and allele frequencies between subjects with hypocitraturia and subjects with normocitraturia, did not show any significant difference (p > 0.05), suggesting that this polymorphism is not associated with the risk of hypocitraturia. Interestingly, the risk for UL was increased due to an additive effect of hypocitraturia with the genotype bb (OR = 6.6, CI: 2.38-18.28, p = 0.0002) or with the allele b (OR: 4.2, CI = 2.52-6.97,

关键词： Hypocitraturia hNaDC-1 Urolithiasis Mexico Yucatan

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Knowledge and preventive measures practiced by junior high school students from Mexico City regarding influenza A (H1N1)

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Health 2012年第10期4卷 995-999页

作者： Veronica Cruz-Licea Fernando Gonzalez-Dominguez Laura Vargas-Parada Monica Hernandez-Riquelme Ana Flisser departamento de salud Publica Facultad de MedicinaUniversidad Nacional Autonoma de MexicoMexico CityMexico Direccion de Ensenanza Hospital General“Dr.Manuel Gea Gonzalez”Secretaria de SaludMexico CityMexico departamento de Biologia Facultad de CienciasUniversidad Nacional Autonoma de MexicoMexico CityMexico Direccion General de Innovacion y Fortalecimiento Academico Administracion Federal de Servicios Educativos en el Distrito FederalSecretaria de Educacion PublicaMexico CityMexico departamento de Microbiologia y Parasitologia Facultad de MedicinaUniversidad Nacional Autónoma de MexicoMexico CityMexico

Background: Influenza A (H1N1) is the most recent pandemic disease that has affected the human population. Objective: To evaluate knowledge and preventive measures related with this disease one year after the epidemic of Mexico- that took place in 2009. Material and methods: An epidemiologic survey regarding influenza A (H1N1) was conducted in June 2010 among 2541 students from the second grade of all public high schools in a borough in Mexico City. The questionnaire included items on the knowledge of the disease and practice of preventive measures. Results: Most students obtained the information from television, half of them from parents and only one fifth from teachers;72% of the participants had a favorable knowledge about the disease and the measures to avoid being infected. However, only 37% practiced such preventive measures. Conclusion: Knowledge has a positive influence on practices towards health. Parents and teachers have an important role in health education, thus efforts should be directed to involve them more intensely in health education.

关键词： Alcohol Gel Epidemiologic Survey Hand Washing Health Behavior Influenza A (H1N1) Outbreak Mexico City

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Molecular surveillance of dengue virus in Bahia State, Brazil

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American Journal of Molecular Biology 2012年第1期2卷 42-48页

作者： Paulo R.S.Melo Cistina Domingo Stênio Carvalho Santos Bruno Antonio Cerqueira Luis Jesuino Andrade Juliana Braga Nunes Isolina A.Ciuffo Antônio Tenório Ronald E.Blanton Mitermayer G.Reis Centro de Pesquisas Gonçalo Moniz Oswaldo Cruz FoundationRio de JaneiroBrazil Santa Cruz State University IlhéusBrazil Robert Koch-Institut(ZBS-1) BerlinGermany Laboratório Central do Estado da Bahia(LACEN) Secretaria de Saúde do Estado da Bahia(SESAB)SalvadorBrazil Instituto de salud Carlos Ⅲ MadridSpain Case Western Reserve University ClevelandUSA

dengue is an important emerging viruses, posing a threat to one-third of the global human population. In 2002, the introduction of deNV-3 in the state of Bahia produced massive epidemic (about 35,000 cases detected) and the first cases of dengue hemorrhagic fever. To understand the nature of the virus circulating at Bahia, E/NS1 sequence was determined for 31 deNV viruses isolated in Bahia during the 2006 and 2007 transmission season, from patients presenting with different degrees of severity. The carboxi-terminal region of the E gene (220 nt) of 31 viruses, isolated from dengue patients with clinical diagnosis of dengue infection were used to determine the genetic variability of dengue 2 (deNV-2) and dengue 3 (deNV-3). Sequence data were used in phylogenetic comparisons with global samples of deNV-2 and deNV-3. deNV-2 sample grouped in the South East Indian genotype, while deNV-3 samples were grouped within Indian genotype. This study is the first report on Bahia isolates during two transmission seasons. Our data confirms reports from other parts of Brazil and different countries showing the deNV-3 (geno-type III) strains circulating in the Americas are closely related, and cluster within the genotype that has been associated with DHF epidemics in different conti-nents.

关键词： dengue dengue Hemorrhagic Fever Molecular Surveillance deNV Genotypes E/NS1Junction

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Bridging the mental health treatment gap:effects of a collaborative care intervention(matrix support)in the detection and treatment of mental disorders in a Brazilian city

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Family Medicine and Community Health 2020年第4期8卷 2-13页

作者： Sonia Saraiva Max Bachmann Matheus Andrade Alberto Liria Leeds Institute of Health Sciences University of LeedsLeedsUK Norwich Medical School University of East AngliaNorwichUK secretaria Municipal de Saúde(Municipal Health department) FlorianópolisBrazil departamento de Especialidades Médicas Facultad de Medicina y Ciencias de la SaludUniversidad de AlcaláAlcaláde HenaresSpain

Objective To analyse temporal trends in diagnosis and treatment of mental disorders in primary care following implementation of a collaborative care intervention(matrix support).design Dynamic cohort design with retrospective time-series *** secondary data on medical visits to general practitioners of all study clinics were extracted from the municipal electronic records *** changes in the odds of mental disorders diagnoses and antidepressants prescriptions were estimated by multiple logistic regression at visit and patient-year levels with diagnoses or prescriptions as *** changes during two distinct stages of the intervention(stage 1 when it was restricted to mental health(2005-2009),and stage 2 when it was expanded to other areas(2010-2015))were compared by adding year-period interaction terms to each *** 49 primary care clinics in the city of Florianópolis,*** All adults attending primary care clinics of the study setting between 2005 and *** 3131983 visits representing 322100 patients were *** visit level,the odds of mental disorder diagnosis increased by 13%per year during stage 1(OR 1.13,95%CI 1.11 to 1.14,pdecreased by 5%thereafter(OR 0.95,95%CI 0.94 to 0.95,pdent mental disorder diagnoses decreased by 1%per year during stage 1(OR 0.99,95%CI 0.98 to 1.00,p=0.012)and decreased by 7%per year during stage 2(OR 0.93,95%CI 0.92 to 0.93,pdepressant prescriptions in patients with a mental disorder diagnosis increased by 7%per year during stage 1(OR 1.07,95%CI 1.05 to 1.20,pdent antidepressant prescriptions did not increase during stage 1(OR 1.00,95%CI 0.97 to 1.02,p=0.665)and increased by 3%during s

关键词： prescription diagnosis treatment

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Clinical,radiological and molecular diagnosis correlation in serum samples from patients with osteoarticular tuberculosis

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 581-585页

作者： Guadalupe Garcia-Elorriaga Olga Martinez-Elizondo Guillermo del Rey-Pineda Cesar Gonzalez-Bonilla Unidad de Investigacion Medica en Inmunologia e Infectologia Hospital de InfectologiaCentro Medico Nacional La Raza(CMNR).Instituto Mexicano del Seguro Social(IMSS)Mexico City.Mexico(Medical Research Unit in Immunology and Infectious DiseaseHospital for Infectious Disease"La Raza"National Medical Center(CMNR).Mexican Social Security Institute(IMSS)Mexico CityMexico) Hospital de Ortopedia "Dr.Victorio de la Fuente Narvaez" Instituto Mexicano del Seguro Social(IMSS)Mexico CityMexico(Orthopedics Hospital " Dr.Victorio de la Fuente Narvaez"Mexican Social Security Institute(IMSS)Mexico CityMexico) Banco Central de Sangre CMNRIMSSand Departamento de InfectologiaHospital Infantil de Mexico Federico Gomez.Secretaria de Salud(SSA)Mexico CityMexico(Central Blood BankCMNR.IMSS and Department of Infectious Disease "Federico Comez" Children's Hospital.Health Ministry (SSA)Mexico CityMexico)

Objective:To assess the role of polymerase chain reaction(PCR)in serum sauples,in the diagnosis of osteoarticular tuberculosis(OTB)in a setting where only clinical and imaging diagnoses determine the ***:A total of 44 consecutive serum specimens were collected from clinically suspected OTB patients,based on clinical and radiological[X-ray or magnetic resonance imagng/computecl tomography]*** were scrcened by in-house nested *** addition,a few specimens were examined by Gram stain,acid-fast bacilli stain,histand routine bacterial culture.A total of 39 specimens were collected from patients suffering from other bone diseases of nontuberculous origin and included as negative ***:of the 44 clinically suspected OTB patients,in-house nested PCR was positive in 40(91%)cases;PCR was negative in 38(97%)negative *** and specificity of our in—house nested PCR was 90.3%and 97.4%,*** PCR report was available within 48 *** was possible to standardize serum PCR technique and in positive cases,a good n was observed in terms of an adequate treatment ***:Nested PCR in serum samples is a rapid,highly sensitive and specific modality for OTB detection,PCR should be performed in addition to clinical evaluation,imaging studies,acidfast bacilli staining,culture and histopathology diagnosis,if possible.

关键词： Osteoarticular tuberculosis Molecular diagnosis Nested polymerase chain reaction Sensitivity Specificity

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Studying Some Brain and Ovarian Morphological Traits in Diaglena spatulata Female Frogs Thriving in Conserved and Perturbed Habitats:A Preliminary Report and Its Implications for Amphibian Survival and Continuity

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Advances in Bioscience and Biotechnology 2014年第9期5卷 740-747页

作者： Esperanza Melendez-Herrera Bryan Victor Phillips-Farfan Fany Edith Bucio-Pina Noemi Ramirez-Arres Gabriel Gutierrez-Ospina Ireri Suazo-Ortuno Javier Alvarado-Diaz Alma Lilia Fuentes-Farias Laboratorio de Ecofisiologia Animal Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMéxico Laboratorio de Nutricion Experimental Instituto Nacional de PediatriaSecretaria de SaludMexico Distrito FederalMexico Laboratorio de Biologia de Sistemas Departamento de Biologia Celular y FisiologiaInstituto de Investigaciones BiomedicasCoordinacion de Psicobiologia y NeurocienciasFacultad de PsicologiaUniversidad Nacional Autonoma de MexicoMexico Distrito FederalMexico Laboratorio de Ecologia Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico Laboratorio de Herpetologia Departamento de ZoologiaInstituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico

Amphibians are thought to be highly susceptible to perturbed environments. However, recent studies show that many of them are successful inhabitants of disturbed, fragmented habitats. The source of this resilience is yet unclear, but it may be the byproduct of having a robust phenotype and/or the result of phenotypic plasticity. We then assessed the contribution of each by evaluating cytological features of two brain nuclei that modulate reproductive behavior and of the ovary, using female specimens of the frog Diaglena spatulata prospering in conserved and disturbed areas of a tropical dry forest. Our results in the brain show that the medial amygdala, but not the preoptic area, had a reduced size in frogs collected in disturbed forests compared to specimens collected in conserved forests. Both brain nuclei displayed, however, neurons with a reduced size in frogs captured in disturbed forest patches. In contrast, ovarian cytological features were similar between groups. Our preliminary results lead us to propose that Diaglena spatulata female specimens might combine robust ovary and plastic brain’s phenotypic traits to confront disturbed environments. This, however, is still a working hypothetical framework that needs to be experimentally confirmed.

关键词： Amphibians Reproductive Traits Amygdala Medial Preoptic Area Ovary

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