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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the second People’s hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at tianjin second People’s hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Role of macrophage polarization in diabetic foot ulcer healing:A bibliometric study

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World Journal of Diabetes 2025年第1期16卷 169-186页

作者： You-Wen Zhang Lei Sun Yan-Nan Wang Shi-Yu Zhan Department of Peripheral Vascular Disease Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Surgery The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001Shandong ProvinceChina Department of Surgery Longkou Traditional Chinese Medicine HospitalYantai 265701Shandong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic *** polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU ***,the complex mechanism,the difficulty in clinical translation,and the large heterogeneity present significant ***,this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU *** To examine the relevant literature on macrophage polarization in DFU *** A bibliometric analysis was conducted using the Web of Science *** literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software(VOSviewer and CiteSpace)and bibliometric online *** obtained literature was then subjected to visualization and analysis of different countries/regions,institutions,journals,authors,and keywords to reveal the research’s major trends and *** The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023,especially in the latter *** researchers were the most prolific in this field,with 217 publications,while American researchers had been engaged in this field for a longer *** Tan of Nanjing Drum Tower hospital and Qian Ding of Nanjing university were the first to publish in this *** Jiao Tong university was the institution with the most publications(27).The keywords“bone marrow”,“adjustment,replacement,response,tissue repair”,and“activation,repair,differentiation”appeared more *** study of macrophage polarization in DFU healing focused on the regulatory mechanism,gene expression,and other *** This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polar

关键词： Diabetic foot Wound healing Macrophage polarization Bibliometric analysis Research cooperation Research trend

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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traditional medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative chinese and Western medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi Lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Effect of herb-partitioned moxibustion for primary dysmenorrhea:a randomized clinical trial

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Journal of traditional chinese medicine 2019年第2期39卷 237-245页

作者： Liu Yinghua Sun Jing Shi Ling Yan Ying Wang Xin Department of Obstetrics and Gynecology Affiliated Hospital Liaoning University of Traditional Chinese Medicine Department of Gynecology Second Affiliated Hospital Liaoning University of Traditional Chinese Medicine Department of Gynecology First Affiliated Hospital Tianjin University of Traditional Chinese Medicine

OBJECTIVE: To observe the effect of herb-partitioned moxibustion(HPM) for primary ***: Six hundred and forty patients were randomized assigned(1∶1) to HPM group and control group. Duration of treatment was 3 months with 3 month follow-up. The primary outcome was pain relief measured by visual analogue scale(VAS). The second outcomes were Cox Menstrual Symptom Scale(CMSS), menstrual pain duration and frequency of analgesics usage. The exploratory outcome included quality of life,RESULTS: After the 3-month treatment and follow-ups, the pain intensity measured by VAS was significantly reduced in both groups compared with baseline(P < 0.05), and it was significantly decreased in HPM group than that of control group(P < 0.001). The higher proportion of participants in the HPM group had a decrease of at least 50% in VAS at the end of treatment, as compared with the control group(P < 0.001). At the 3 rd and 6 th month, the menstrual pain duration, CMSS score and frequency of analgesics usage in HPM group were significantly lower than those of control group(P < 0.05). After 3 month treatment and follow-ups,the scores of physical, psychological, social and environmental domains were significantly increased than baseline in both groups(P < 0.05),and the sores of physical, psychological and environmental domains were significantly higher in HPM group than those of control group(P < 0.05).CONCLUSION: Herb-partitioned moxibustion reduced menstrual pain and improved quality of life,these were sustained for up to 3 months after treatment. Further research is needed to understand long term effect and the mechanism of the intervention.

关键词： Dysmenorrhea Moxibustion Visual analog scale Quality of life Randomized clinical trial

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Effects of Qizhukangxian granules on idiopathic pulmonary fibrosis:a randomized,double blind,placebo-controlled and multicenter clinical pilot trial

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Journal of traditional chinese medicine 2020年第4期40卷 674-682页

作者： Guo Sijia Song Yalin Feng Jihong Liu Shuang Li Yuechuan Liu Min Wei Luqing Zhang Xian Xie Hui Sun Zengtao Department of Respiratory medicine the Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China Department of Neurology the Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China Department of hospital Management Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Respiratory medicine Tianjin Chest HospitalTianjin 300300China Department of Respiratory medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Respiratory medicine the Affiliated Hospital of Tianjin Armed Police Medical CollegeTianjin 300162China Department of Respiratory medicine Tianjin Beichen Traditional Chinese Medicine HospitalTianjin 300400China Department of Respiratory medicine Tianjin Dongli Traditional Chinese Medicine HospitalTianjin 300300China

OBJECTIVE:To evaluate the effects of Qizhukangxian granules(QG)on idiopathic pulmonary fibrosis(IPF).METHODS:This is a randomized,double blind,placebo-controlled and multicenter clinical pilot *** medical centers in tianjin,China,participated in the study.A total of 120 IPF patients were enrolled and randomized into two groups,with 60 patients in each *** treatment group was treated with QG,while the control group received a Qizhukangxian *** pharmacological treatment lasted for 48 weeks from the enrollment *** indexes of patients were recorded on the admission day and at the end of the 24th and 48th *** were analyzed to study the effects of QG;forced vital capacity,change in forced vital capacity and maximal 6-min walk test(6MWT)distance were the primary *** endpoints were percentage of patients with episodes of acute exacerbation of IPF,pulmonary function,changes in pulse oxygen saturation during the 6MWT,dyspnea score,***'s respiratory questionnaire score,arterial blood gas analyses and the total traditional chinese medicine symptom pattern ***:After 24 weeks of treatment,QG showed greater efficacy than the placebo in certain parameters,including the dyspnea score,traditional chinese medicine symptom pattern score and some indicators in the ***'s respiratory questionnaire *** of the indexes obtained from all patients at the end of the 48th week showed that the therapeutic effects in the treatment group were significantly better than those in the control group because remarkable differences were observed in most of the primary and secondary endpoints between the two groups,except for the maximal distance of the 6MWT and arterial blood gas *** adverse reaction was observed in either group during the 48-week trial treatment ***:QG could effectively treat IPF patients by ameliorating pulmonary function,improving the quality of life and lowering the percentage of acu

关键词： Idiopathic pulmonary fibrosis Vital capacity Walk test Randomized controlled trial Qizhukangxian granules

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Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway in perimenopausal rats

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Journal of traditional chinese medicine 2019年第6期39卷 861-866页

作者： Zhang Fan Cao Junyan Zhang Xin Wang Jing Yi Xu the second affiliated hospital of Guiyang university of traditional chinese medicine

OBJECTIVE:To investigate the efficacy of self-made Gengnian decoction on expressions of phosphatidylinositol 3-kinase(PI3 K),protein kinase B(Akt)and mammalian target of rapamycin(m TOR)in ovarian tissues of perimenopausal *** were identified with symptom pattern of kidney-Yang deficiency in terms of traditional chinese ***:Female Sprague-Dawley rats aged10-12 months were *** cycle was observed by vaginal smears of keratinocytes to screen the perimenopausal model *** chosen rats were randomly divided into five groups,including perimenopausal model of kidney-Yang deficiency group(24 rats),self-made Gengnian decoction of high-dose group(24 rats),self-made Gengnian decoction of middle-dose group(24 rats),self-made Gengnian decoction of low dose group(24 rats)and tibolone control group(24 rats).In addition,rats aged 4-6 months were selected as young control *** perimenopausal model rats of kidney-Yang deficiency were prepared by alternative intramuscular injection of hydrocortisone 5 mg·kg^-1·d^-1The successfully prepared models in self-made Gengnian decoction of high-dose,middle-dose and low-dose groups and tibolone control group were given self-made Gengnian decoction 26.4,13.2 and 6.6 mg·kg^-1·d^-1,and tibolone tablets solvent 0.22 mg·kg^-1·d^-1,respectively,through intragastric *** group and young control group were given the same dose of normal saline,1 time a day for 15 consecutive days.24 h after the last administration,blood and ovarian tissues were collected after anesthesia with 20%ethyl *** follicles of different levels in ovarian tissue were observed and counted by histopathological hematoxylin-eosin *** linked immunosorbent assay was applied to test insulin-like growth factor-1(IGF-1)level in the serum of experimental *** expression levels of PI3 K,phosphorylated-Akt(p-Akt)and phosphorylated-m TOR(p-m TOR)m RNA in ovarian tissue were detected by quantitative real-time po

关键词： Premenopause Insulin-like growth factor-1 Phosphatidylinositol 3-kinase Protein-serine-threonine kinases TOR serine-threonine kinases Gengnian decoction

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Time-effect relationship of acupuncture on histopathology, ultrastructure, and neuroethology in the acute phase of cerebral hemorrhage

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Neural Regeneration Research 2019年第1期14卷 107-113页

作者： Zuo-Wei Li Xiao-Nan Zheng Ping Li Shandong university of traditional chinese medicine Department of Acupuncture Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine tianjin Third Central hospital

Many clinical studies have addressed the treatment of acute cerebral hemorrhage using acupuncture. However, few studies have examined the relationship between time of acupuncture and curative effect on cerebral hemorrhage. By observing the effect of acupuncture on changes in histopathology, ultrastructure, and neuroethology in a cerebral hemorrhage model of rats, we have directly examined the time-effect relationship of acupuncture. The rat model of cerebral hemorrhage was produced by slowly injecting autologous blood to the right caudate nucleus. The experimental groups were: 3-, 9-, 24-, and 48-hour model groups; and 3-, 9-, 24-, and 48-hour acupuncture groups. The sham-operation group was used for comparison. Acupuncture was performed at the Neiguan(PC6) and Renzhong(DU26) acupoints, twice a day, 6 hours apart, for 5 consecutive days. Brain tissue changes were observed by light microscopy and transmission electron microscopy. Neuroethology was assessed using Bederson and Longa scores. Our results show that compared with the sham-operation and model groups, Bederson and Longa scores were lower in each acupuncture group, with visibly improved histopathology and brain tissue ultrastructure. Further, the results were better in the 3-and 9-hour acupuncture groups than the 24-and 48-hour acupuncture groups. Our findings show that acupuncture treatment can relieve pathological and ultrastructural deterioration and neurological impairment caused by the acute phase of cerebral hemorrhage, and may protect brain tissue during this period. In addition, earlier acupuncture intervention following cerebral hemorrhage(by 3 or 9 hours) is associated with a better treatment outcome.

关键词： nerve regeneration acupuncture acute phase cerebral hemorrhage time-effect ultrastructure function histopathology neuroethology brain injury neural regeneration

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Effects of anterior sciatic nerve acupuncture on lower limb paralysis after cerebral infarction:study protocol for a randomized controlled trial

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Journal of traditional chinese medicine 2024年第1期44卷 205-211页

作者： LI Menghan WANG Yu RAN Dawei YANG Xinming DENG Shizhe SHI Lei MENG Zhihong Department of Acupuncture First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for chinese medicine Acupuncture and Moxibustion Tianjin 300193China Graduate department Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Massage and Rehabilitation Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

Stroke is the main cause of disability in the middle and old ***,especially lower limb paralysis,often leads to the loss of self-care ability and a series of secondary *** main method to improve hemiplegic limb movement is exercise therapy,but there are still many patients with disabilities after rehabilitation *** one of the non-pharmacological therapies for stroke,acupuncture has been recognized to improve motor function in ***,we propose a new method,anterior sciatic nerve acupuncture,which can stimulate both the femoral nerve and the sciatic *** designed this study to determine the effect of this method on lower limb motor *** participants recruited with hemiplegia after cerebral infarction will be randomly assigned to the test group or control group in a 1:1 *** control group will receive Xingnao Kaiqiao acupuncture,and the test group will receive anterior sciatic nerve acupuncture on this *** participants will get acupuncture treatment once a day,6 times a week for 2 *** primary outcome is Fugl-Meyer Assessment of Lower Extremity and the secondary outcomes are Modified Ashworth Scale and Modified Barthel *** will be collected before treatment,1week after treatment,and 2 weeks after treatment,and then statistical analysis will be *** study can preliminarily verify the effect of anterior sciatic nerve acupuncture on improving lower limb motor function in patients with cerebral infarction,which may provide an alternative approach for clinical treatment of hemiplegia.

关键词： anterior sciatic nerve acupuncture paralysis cerebral infarction Xingnao Kaiqiao clinical protocols

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Wake-Promoting Effect of Bloodletting Puncture at Hand Twelve Jing-Well Points in Acute Stroke Patients:A Multi-center Randomized Controlled Trial

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chinese Journal of Integrative medicine 2021年第8期27卷 570-577页

作者： YU Nan-nan XU Zhi-fang GAO Yang ZHOU Zhi-liang ZHAO Xue ZHOU Dan WANG Zhen-guo CHEN Ze-lin PAN Xing-fang GUO Yi Department of traditional chinese medicine Xijing Hospitalthe Air Force Medical UniversityXi’an710032China Acupuncture Research Center Tianjin University of traditional Chinese MedicineTianjin301617China Acu-moxibustion and Tuina Department Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Acupuncture and Moxibustion the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300193China Department of Acupuncture and Moxibustion the Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin300150China The Third Department of Encephalopathy Xi’an Encephalopathy Hospital of Traditional Chinese MedicineXi’an710032China Department of traditional chinese medicine Tianjin University of Traditional Chinese MedicineTianjin301617China

Objective To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points(HTWPs)in acute stroke patients with conscious *** In this multi-center and randomized controlled trial,360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting(180 cases)and control(180 cases)groups using a block *** in both groups received routine Western medicine,and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional *** primary outcome measure was Glasgow Coma Scale(GCS)score and the secondary outcomes included blood pressure,respiratory rate and pulse *** variables were evaluated at baseline(before bloodletting),0(after bloodletting immediately),15,30,50 and 80 min post *** At 80 min post bloodletting,the proportion of patients with improved consciousness in the bloodletting group was greater than the control group(Psecondary outcomes between two groups(P>0.05).Conclusion The bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients,highlighting a first-aid intervention for acute stroke.

关键词： acute stroke bloodletting Jing-Well point conscious disturbance randomized controlled trial

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