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Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation

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World Journal of Gastroenterology 2022年第22期28卷 2509-2522页

作者： Florian Mourey Amélie Decherf Jean-François Jeanne Mathieu Clément-Ziza Marie-Lise Grisoni François Machuron Sophie Legrain-Raspaud Arnaud Bourreille Pierre Desreumaux research and Applications Department Gnosis by LesaffreLesaffre GroupMarcq-en-Baroeul 59700France Data Science and Bioinformatics Laboratory Research and Development DepartmentLesaffre InternationalLesaffre GroupMarcq-en-Baroeul 59700France Institut des Maladies de l'Appareil Digestif Centre Hospitalier Universitaire de NantesNantes 44093France Institute for Translational research in Inflammation Centre Hospitalier Universitaire de LilleLille 59000France

BACKGROUND Probiotics are a promising solution for managing irritable bowel syndrome(IBS).Saccharomyces cerevisiae(***)I-3856 has already demonstrated beneficial effects in IBS subjects,particularly in IBS with predominant constipation(IBS-C).AIM To confirm the efficacy of *** I-3856 in the management of gastrointestinal symptoms in *** A randomized,double-blind,placebo-controlled clinical study was performed in a total of 456 *** a run-in period,subjects were randomly assigned to the group receiving *** I-3856(8×109 CFU daily)or the placebo for 8 wk,and they performed daily self-evaluations of gastrointestinal *** primary objective was to assess the effect of the probiotic on abdominal *** secondary objectives were the evaluation of other gastrointestinal symptoms,bowel movement frequency and consistency,and quality of life(QOL).RESULTS A significantly higher proportion of abdominal pain responders was reported in the Probiotic group(45.1%vs 33.9%,P=0.017).A nonsignificant difference in the area under the curve for abdominal pain over the second month of supplementation was observed in subjects receiving probiotic vs placebo[P=0.073,95%CI:-0.59(-1.23;0.05)].No statistically significant differences were reported in the evolution of bowel movement frequency and stool consistency between the *** 8 wk of supplementation,the overall QOL score was significantly higher in the Probiotic group than in the Placebo group[P=0.047,95%CI:3.86(0.52;7.20)].Furthermore,exploratory analyses showed statistically significant and clinically relevant improvements in QOL scores in abdominal pain responders vs *** The results of this clinical study confirmed the abdominal pain alleviation properties of *** I-3856 in *** pain relief was associated with improved *** identifier:NCT03150212.

关键词： Probiotic Yeast Saccharomyces cerevisiae Irritable bowel syndrome Abdominal pain Quality of life

Photocatalytic application of magnesium spinel ferrite in wastewater remediation:A review

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Journal of Magnesium and Alloys 2024年第2期12卷 490-505页

作者： Rohit Jasrotia Nikhil Jaswal Jyoti Prakash Chan Choon Kit Jagpreet Singh Abhishek Kandwal School of Physics and Materials Science Shoolini UniversityBajholSolanH.P.India Himalayan centre of Excellence in Nanotechnology Shoolini UniversityBajholH.P.India INTI international University Putra NilaiNegeri SembilanMalaysia Department of Chemistry University Centre for Research&Development Chandigarh UniversityMohali140413PunjabIndia Shenzhen Institute of Advanced Technology Chinese Academy of SciencesChina

This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these *** analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the *** to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being *** in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater *** concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.

关键词： Magnesium ferrite Wastewater Dyes Antibiotics Photocatalytic degradation

Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties

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Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 707-713页

作者： Ezenyi Ifeoma Chinwude Kulkarni Roshan Joshi Swati Salawu Oluwakanyinsola Adeola Emeje Martins Department of Pharmacology and Toxicology National Institute for Pharmaceutical Research and Development Organic Chemistry Division National Chemical Laboratory centre for Nanomedkine and Biophysical Drug Delivery Department of Pharmaceutical Technology and Raw Material DevelopmentNational Institute for Pharmaceutical Research and Development

Objective:To evaluate the antiplasmodial properties of fractions of chloroform portion of Phyllanthus niruri(***) methanol extract and identify a suitable chemical marker present ***:Chloroform portion of *** methanol extract was separated from silica gel using gradient systems of hexane,ethylacetate and *** fractions were screened for antiplasmodial activity against Plasmodium falciparum HB3 and *** with IC_(50)<10μg/*** parasites were further screened for peripheral analgesic activity,while cytotoxicity was evaluated using THP-1 ***:Fractions 12-14 were very active(IC_(50)<10 μg/mL) against Plasmodium falciparum and showed no significant *** 12 and 13 exhibited significant(P<0.01) reduction in acetic acid-induced writhing in mice,decreasing the number of writhes by 66.67% and 65.22% respectively and comparable with 100 mg/kg aspirin(65.22%).From fraction 12,a compound was isolated and identified as sitosteryl-6-β-D-glucoside-6'-palmitate by ~1H,^(13)C nuclear magnetic resonance and mass ***:Our findings illustrate antiplasmodial column fractions of *** with analgesic activity and identify sitosteryl glucoside pahmitate as a chemical marker of activity.

关键词： Malaria Medicinal plant Plasmodium falciparum

Heat-tolerant maize for rainfed hot,dry environments in the lowland tropics:From breeding to improved seed delivery

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The Crop Journal 2023年第4期11卷 986-1000页

作者： Pervez H.Zaidi Madhumal Thayil Vinayan Sudha K.Nair Prakash H.Kuchanur Ramesh Kumar Shyam Bir Singh Mahendra Prasad Tripathi Ayyanagouda Patil Salahuddin Ahmed Aamir Hussain Atul Prabhakar Kulkarni Passang Wangmo Mitchell R.Tuinstra Boddupalli M.Prasanna international Maize and Wheat Improvement Center(CIMMYT) Hyderabad 502324India University of Agricultural Sciences Raichur 584104KarnatakaIndia ICAR-Indian Institute of Maize research Ludhiana 141001BiharIndia National Maize research Program RampurChitwan 44200Nepal Bangladesh Wheat and Maize research Institute Dinajpur-5201Bangladesh Maize and Millet research Institute YusafwalaSahiwal 57000Pakistan Agriculture research and development centre Wengkhar 43001Bhutan Institute of Plant Sciences Purdue UniversityWest LafayetteIN 47906USA international Maize and Wheat Improvement Center(CIMMYT) NairobiKenya

Climate change-induced heat stress combines two challenges:high day-and nighttime temperatures,and physiological water deficit due to demand-side drought caused by increase in vapor-pressure *** is one of the major factors in low productivity of maize in rainfed stress-prone environments in South Asia,affecting a large population of smallholder farmers who depend on maize for their sustenance and *** international Maize and Wheat Improvement Center(CIMMYT)maize program in Asia,in partnership with public-sector maize research institutes and private-sector seed companies in South Asian countries,is implementing an intensive initiative for developing and deploying heat-tolerant maize that combines high yield potential with resilience to heat and drought *** the integration of novel breeding tools and methods,including genomics-assisted breeding,doubled haploidy,fieldbased precision phenotyping,and trait-based selection,new maize germplasm with increased tolerance to heat stress is being developed for the South Asian *** a decade of concerted effort has resulted in the successful development and release of 20 high-yielding heat-tolerant maize hybrids in CIMMYT genetic *** public–private partnerships,eight hybrids are presently being deployed on over 50,000 ha in South Asian countries,including Bangladesh,Bhutan,India,Nepal,and Pakistan.

关键词： Climate change Drought Heat stress Lowland tropics Maize Vapor pressure deficit

Endosperm ontogeny through the lens of epigenetics

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Molecular Plant 2023年第2期16卷 295-297页

作者： Kajol B.M.Singh Jitendra K.Thakur National Institute of Plant Genome research New Delhi 110067India international centre for Genetic Engineering and Biotechnology New Delhi 110067India

Endosperm tissue is crucial to seed *** and dicots have evolved different fates for their endosperm:it is usually consumed in dicots during seed development,while monocot seeds retain the endosperm until ***,Wu et al.(2022)addressed the role of divergent epigenetic regulation over the functionally conserved IKU2 gene contributing to silenced or persistent endosperm proliferation and have provided insights into divergent seed ontogeny patterns in ***,we highlight the novel findings from this study and their potential significance.

关键词： maturity finding insight

Groundwater recharge rates and surface runoff response to land use and land cover changes in semi-arid environments

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Ecological Processes 2016年第1期5卷 195-215页

作者： S.O.Owuor K.Butterbach-Bahl A.C.Guzha M.C.Rufino D.E.Pelster E.Diaz-Pines L.Breuer Institute of Meteorology and Climate research Atmospheric Environmental Research(IMK-IFU)Karlsruhe Institute of Technology(KIT)Kreuzeckbahnstr.1982467 Garmisch-PartenkirchenGermany international Livestock research Institute(ILRI) Old Naivasha Rd.P.O.Box 30709-00100NairobiKenya United States Forest Service c/o CIFORWorld Agroforestry CentreUnited Nations Avenue GigiriP.O.Box 30677-00100NairobiKenya Center for international Forestry research(CIFOR) C/o World Agroforestry CentreUnited Nations Avenue GigiriP.O.Box 30677-00100NairobiKenya Institute for Landscape Ecology and Resources Management(ILR) Research Centre for BioSystemsLand Use and Nutrition(iFZ)Justus Liebig University GiessenHeinrich-Buff-Ring 2635392 GiessenGermany centre for international development and Environmental research(ZEU) Justus Liebig University GiessenGiessenGermany

The effects of land use and land cover(LULC)on groundwater recharge and surface runoff and how these are affected by LULC changes are of interest for sustainable water resources ***,there is limited quantitative evidence on how changes to LULC in semi-arid tropical and subtropical regions affect the subsurface components of the hydrologic cycle,particularly groundwater *** water resource management in these regions requires conclusive evidence and understanding of the effects of LULC changes on groundwater recharge and surface *** reviewed a total of 27 studies(2 modeling and 25 experimental),which reported on pre-and post land use change groundwater recharge or surface runoff magnitude,and thus allowed to quantify the response of groundwater recharge rates and runoff to *** between initial and subsequent LULC indicate that forests have lower groundwater recharge rates and runoff than the other investigated land uses in semi-arid tropical/subtropical *** of bare land induces a decrease in groundwater recharge from 42% of precipitation to between 6 and 12% depending on the final *** forests are cleared for rangelands,groundwater recharge increases by 7.8±12.6%,while conversion to cropland or grassland results in increases of 3.4±2.5 and 4.4±3.3%,*** of bare land to cropland results in surface runoff reductions of between 5.2 and 7.3%.The conversion of forest vegetation to managed LULC shows an increase in surface runoff from 1 to 14.1% depending on the final *** runoff was reduced from 2.5 to 1.1% when grassland is converted to forest *** there is general consistency in the results from the selected case studies,we conclude that there are few experimental studies that have been conducted in tropical and subtropical semi-arid regions,despite that many people rely heavily on groundwater for their ***,there is an urgent need to increase th

关键词： Groundwater recharge rate Infiltration Surface runoff Semi-arid Land use change Land cover change

A reductionist approach to dissecting grain weight and yield in wheat

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Journal of Integrative Plant Biology 2019年第3期61卷 337-358页

作者： Jemima Brinton Cristobal Uauy John Innes centre Norwich Research Park

Grain yield is a highly polygenic trait that is influenced by the environment and integrates events throughout the life cycle of a plant. In wheat, the major grain yield components often present compensatory effects among them, which alongside the polyploid nature of wheat,makes their genetic and physiological study challenging. We propose a reductionist and systematic approach as an initial step to understand the gene networks regulating each individual yield component. Here, we focus on grain weight and discuss the importance of examining individual subcomponents, not only to help in their genetic dissection, but also to inform our mechanistic understanding of how they interrelate. This knowledge should allow the development of novel combinations, across homoeologs and between complementary modes of action, thereby advancing towards a more integrated strategy for yield improvement. We argue that this will break barriers in terms of phenotypic variation,enhance our understanding of the physiology of yield, and potentially deliver improved on-farm yield.

关键词： Grain yield a highly polygenic integrates

Effect of ambient pressures on laser-induced breakdown spectroscopy signals

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Frontiers of physics 2024年第4期19卷 243-256页

作者： Kaifan Zhang Weiran Song Zongyu Hou Zhe Wang State Key Laboratory of Power System Operation and Control Tsinghua-Rio Tinto Joint Research Centre for ResourcesEnergy and Sustainable DevelopmentInternational Joint Laboratory on Low Carbon Clean Energy InnovationInstitute for Carbon NeutralityDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Shanxi research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

Laser-induced breakdown spectroscopy(LIBS)is regarded as the future superstar for analytical chemistry and widely applied in various *** the quality of LIBS signal is fundamental to achieving accurate quantification and large-scale commercialization of *** propose control methods that improve LIBS signal quality,it is essential to have a comprehensive understanding of the influence of key parameters,such as ambient gas pressure,temperature,and sample temperature on LIBS *** date,extensive research has been carried ***,different researchers often yield significantly different experimental results for LIBS,preventing the formation of consistent *** greatly prevents the understanding of influencing laws of key parameters and the improvement of LIBS quantitative *** ambient gas pressure as an example,this paper compares the effects of ambient gas pressure under different optimization conditions,reveals the influence of spatiotemporal window caused by inherent characteristics of LIBS signal sources,i.e.,intense temporal changes and spatial non-uniformity of laser-induced plasmas,on the impact patterns of key *** the perspective of plasma spatiotemporal evolution,the paper elucidates the influence patterns of ambient gas pressure on LIBS signals,clarifying seemingly contradictory research results in the literature.

关键词： laser-induced breakdown spectroscopy spatiotemporal window pressure condition signal uncertainty plasma modulation

Chilli anthracnose disease caused by Colletotrichum species

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 764-778页

作者： Po Po THAN Haryudian PRIHASTUTI Sitthisack PHOULIVONG Paul W.J.TAYLOR Kevin D.HYDE international Fungal research and development centre the Research Institute of Resources InsectChinese Academy of ForestryKunming 650224ChinaBioMarkaSchool of Agriculture and Food SystemsUniversity of MelbourneVictoria 3010Australia Fungal research Group School of ScienceMae Fah Luang UniversityTasudChiang Rai 57100ThailandDepartment of BiotechnologyFaculty of AgricultureBrawijaya UniversityMalang 65145Indonesia Fungal research Group School of ScienceMae Fah Luang UniversityTasudChiang Rai 57100ThailandMushroom Research Centre128 Moo 3 T. Pa PaeA. Mae TaengChiang Mai 50150Thailand6Department of Plant ScienceFaculty of AgricultureNational University of LaosVientianeLao PDR BioMarka School of Agriculture and Food SystemsUniversity of MelbourneVictoria 3010Australia international Fungal research and development centre the Research Institute of Resources InsectChinese Academy of ForestryKunming 650224ChinaFungal Research GroupSchool of ScienceMae Fah Luang UniversityTasudChiang Rai 57100Thailand

Anthracnose disease is one of the major economic constraints to chilli production worldwide, especially in tropical and subtropical regions. Accurate taxonomic information is necessary for effective disease control management. In the Colletotrichum patho-system, different Colletotrichum species can be associated with anthracnose of the same host. Little information is known concerning the interactions of the species associated with the chilli anthracnose although several Colletotrichum species have been reported as causal agents of chilli anthracnose disease worldwide. The ambiguous taxonomic status of Colletotrichum species has resulted in inaccurate identification which may cause practical problems in plant breeding and disease management. Although the management and control of anthracnose disease are still being extensively researched, commercial cultivars of Capsicum annuum that are resistant to the pathogens that cause chilli anthracnose have not yet been developed. This paper reviews the causal agents of chilli anthracnose, the disease cycle, conventional methods in identification of the pathogen and molecular approaches that have been used for the identification of Colletotrichum species. Pathogenetic variation and population structure of the causal agents of chilli anthracnose along with the current taxonomic status of Colletotrichum species are discussed. Future developments leading to the disease management strategies are suggested.

关键词： Capsicum annuum Disease management Identification Taxonomy Pathogenicity