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人类环境杂志 1997年第8期26卷 497-502页

作者： Bronwen Croce Ronald M.Stagg Nicholas C.Everall David B.Groman Christopher G.Mitchell Roger Owen 张国梁 scottish office agriculture Severn Trent Water Ltd 大西洋兽医学院苏格兰农业环境与渔业部斯特灵大学

"鲑鱼变色综合症"是一种与大西洋鲑鱼(Salmo salar)的临床黄疸有关的非传染性溶血性贫血症,由多种化学污染物的综合影响而引起。这种病只发生于英国苏格兰阿伯丁郡唐河(River Don,Aberdeenshire)内洄游性成年大西洋鲑鱼种群中,本世纪80... 详细信息

"鲑鱼变色综合症"是一种与大西洋鲑鱼(Salmo salar)的临床黄疸有关的非传染性溶血性贫血症,由多种化学污染物的综合影响而引起。这种病只发生于英国苏格兰阿伯丁郡唐河(River Don,Aberdeenshire)内洄游性成年大西洋鲑鱼种群中,本世纪80年代初曾在那里达到流行病比率。人们认为造纸厂、供油工业区和机场的污流可能是该综合症的诱因。一些实验表明,当受到石油碳氢化合物(如柴油)和树脂酸的连续综合影响时,该综合症的症状能够再现。从1989年起,鲑鱼变色综合症在唐河的野生鲑鱼中再未出现,我们的研究表明这是由于唐河水质的直接改善。该病是多种污染物综合引起生物效应的很好的例证。而在单一污染物质影响下,这种作用并不明显。本文描述了确定病因的方法。

关键词：鲑鱼变色综合症生态毒理学污染毒理学病因

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Hepatitis E virus in patients with acute severe liver injury

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World Journal of Hepatology 2014年第6期6卷 426-434页

作者： Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie Department of Life Sciences Glasgow Caledonian UniversityGlasgowG4 0BAUnited Kingdom scottish Liver Transplant Unit Royal Infirmary of EdinburghEdinburghEH16 4SAUnited Kingdom Department of Pathology University of EdinburghEdinburghEH16 4SBUnited Kingdom Gastrointestinal Unit Royal Cornwall Hospitaland European Centre for the Environment and Human HealthUniversity of Exeter Medical SchoolTruroTR1 3HDUnited Kingdom Department of Life Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgowG40BAUnited Kingdom

AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant ***: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain ***: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient

关键词： Virology Infection Acute liver injury Hepatitis E virus

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促进步行的干预措施：系统性综述

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英国医学杂志中文版 2008年第1期11卷 16-25页

作者： David Ogilvie Charles E Foster Helen Rothnie Nick Cavill Val Hamilton Claire F Fitzsimons Nanette Mutrie 钱招昕(译) Medical ResearchCouncil Socialand Public HealthSciences Unit MRC fellow British Heart Foundation Health Promotion Research Group University of Oxford Oxford senior resarcher British Heart Foundation Health Promotion Research Group University of Oxford Oxford research associate Deparanent of Sport Culture and the Asts University of Strathclyde Glasgow research associate Deparanent of Sport Culture and the Asts University of Strathclyde Glasgow professor of exer5cise and sport psychology for the on behalf of the Scottish Physical Activity Research Collaboration(SPARColl) Deparanent of Sport Culture and the Asts University of Strathclyde SPARColl project coordinator Development and Alumni office University of Glasgow Glasgow research assistant 不详

目的评估在个体和群体中促进步行的干预措施的作用。设计系统性综述。数据来源通过搜索25个电子数据库、网站、文献目录和已有的系统性综述，以及通过联系专家，识别出已发表的和未发表的任一语言的报道。综述方法系统性搜索和评价关于... 详细信息

目的评估在个体和群体中促进步行的干预措施的作用。设计系统性综述。数据来源通过搜索25个电子数据库、网站、文献目录和已有的系统性综述，以及通过联系专家，识别出已发表的和未发表的任一语言的报道。综述方法系统性搜索和评价关于任何类型的干预对人们步行的影响的前后对照研究，对干预效果的大小、干预效果在不同社会组群中的分布以及干预对总的体育活动、健身、疾病危险因素、健康状况和体格的影响进行评价。结果研究包括19项随机试验和29项非随机研究。根据人们需求进行的干预乃以大部分久坐的人或者那些有运动动机的人为目标，不论干预的履行是在个体水平（简单建议，支持步程计、使用通讯设备）、家庭水平（个体化营销）或群体水平，都能够激励人们更多地步行，尽管许多此类方法的可持续性、可推广性和临床效果还不确定。应用于工作场所、学校、社区或者地区的干预措施的有效证据通常主要来源于单独的研究或者是亚组分析。结论在目标参与者中，最成功的干预要求要能够在短期内至少使步行量平均每周增加达30-60分钟。从提高人群健康的前景来看，目前许多的研究提供了有效果的证据而不是有效性的证据。然而，促进步行的干预能够大大提高那些最不习惯于运动的人的运动水平。

关键词：系统性综述干预措施个体水平疾病危险因素运动水平干预效果群体水平电子数据库

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How fertility preservation guidelines have progressed worldwide:Potential implications and inspiration

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Reproductive and Developmental Medicine 2022年第1期6卷 34-41页

作者： Min-Xin Chen Ying Zhang Qing-Qing Cai Shuo Zhang Ran Xu Hua Chen Yu Kang Yue Wu Ri-Cheng Chian Cong-Jian Xu President office Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China Fertility Preservation Center Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China Department of Genetics Shanghai JIAI Genetics and IVF InstituteShanghai 200011China Department of International Law China Foreign Affairs UniversityBeijing 100032China Department of Infertility Shanghai JIAI Genetics and IVF InstituteShanghai 200011China Clinical Research Center Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200090China Center for Reproductive Medicine Shanghai 10th People's Hospital of Tongji UniversityShanghai 200072China

To summarize fertility preservation (FP) guidelines and consensus provided by medical facilities worldwide. Five reference databases (PubMed/Embase, China BioMedical Literature Database, ClinicalKey, Wanfang Data, and China Knowledge Resource Integrated) and 7 guideline databases (Guideline International Network, National Collaborating Centre for Women’s and Children’s Health, National Guideline Clearinghouse, The National Institute for Health and Care Excellence, scottish Intercollegiate Guidelines Network, New Zealand Guideline Group, and Canadian Medical Association infobase) were searched. Official websites of societies were searched to find relevant guidelines and consensus, and guidelines and published systematic reviews and consensus were reviewed from inception through May 2021. A literature search was performed regarding guidance offered in professional facilities, and 304 records (including 4 in Chinese) of existing guidelines for full-text review were found. Moreover, 55 guidelines were identified after a manual search. The literature review demonstrated that FP guidance and options were unevenly distributed worldwide for women who wanted to post-pone pregnancy or had impaired fertility after gonadal toxicity. With promising cancer survival rates and diversified family decisions, more attention should be paid to the improvement and update of accessible guidelines and regulatory infrastructure to inform patients about the available options and empower them to make informed choices. Restrictions to such services can be gradually eased due to the efficacy and safety of certain FP techniques for the right candidates to initiate pregnancy conception.

关键词： Fertility preservation Cancer patient Aging Guidance

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