检索结果-南通市图书馆

Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy

引用

Nano Research 2024年第3期17卷 1710-1724页

作者： Yiwei Peng Yiliang Yang Zhenzhen Yang Datong Gao Jiajia Li Qi Sun Yitian Du Meng Lin Xianrong Qi Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery system School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Immunotherapy has great promise in improving malignant tumor ***,the efficacy of existing strategies is often limited by the immunosuppressive ***,we demonstrate an in situ bionic immunoactivator,PLT-Bec1/DTA-1,with possessed natural advantages of platelets for tumor recruitment and activation,on which DTA-1(CD357 monoclonal antibody)and Bec1 were tethered as combined immune ***-Bec1/DTA-1,as a self-triggered release repository,can deliver the pre-tethered Bec1 and DTA-1 deeply through the secretion of platelet microparticles(PMPs),thereby cooperate tacitly and exhibit superiority in immune activation of dendritic cells(DCs)and T cells via autophagy inducibility,coupled with glucocorticoid-induced tumor necrosis factor receptor(GITR)-triggered T_(Reg) suppression,remodeled the immunosuppressive network of tumor ***-Bec1/DTA-1 promoted antigen presentation and T cell proliferation,and alleviated the low activity state of bone marrow-derived dendritic cells(BMDCs)in tumor suppressive ***-Bec1/DTA-1 inhibited tumor recurrence(5-and 13-fold lower of control group in tumor volume)and CD8^(+)T/T_(Reg) ratio(6.3-and 8.8-fold *** group)in mouse tumor model after intravenous or subcutaneous ***,PLT-Bec1/DTA-1 prevented tumor colonization in lung through in situ immune activation,and was slightly superior to the combined of Bec1 and *** findings highlight the promise of delivering immunostimulatory payloads via bionic carriers,eliciting automatic in situ activation of effector immune cells in tumor microenvironment for tumor *** these results provide promising prospects into the application of immunoactivator in improving cancer synergistic immunotherapy to overcome the bottlenecks in clinic.

关键词： in situ bionic immunoactivator autophagy glucocorticoid-induced tumor necrosis factor receptor(GITR)agonist platelets and platelet microparticles cancer immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicted Critical State Based on Invariance of the Lyapunov Exponent in Dual Spaces

引用

Chinese Physics Letters 2024年第1期41卷 68-76页

作者：刘通夏旭 Department of Applied Physics School of ScienceNanjing University of Posts and TelecommunicationsNanjing 210003China Academy of Mathematics and system sciences Chinese Academy of SciencesBeijing 100190China

Critical states in disordered systems,fascinating and subtle eigenstates,have attracted a lot of research ***,the nature of critical states is difficult to describe quantitatively,and in general,it cannot predict a system that hosts the critical *** propose an explicit criterion whereby the Lyapunov exponent of the critical state should be 0 simultaneously in dual spaces,namely the Lyapunov exponent remains invariant under the Fourier *** this criterion,we can exactly predict a one-dimensional quasiperiodic model which is not of self-duality,but hosts a large number of critical ***,we perform numerical verification of the theoretical prediction and display the self-similarity of the critical *** to computational complexity,calculations are not performed for higher dimensional ***,since the description of extended and localized states by the Lyapunov exponent is universal and dimensionless,utilizing the Lyapunov exponent of dual spaces to describe critical states should also be ***,we conjecture that some kind of connection exists between the invariance of the Lyapunov exponent and conformal invariance,which can promote the research of critical phenomena.

关键词： state exponent critical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chronological Study of Coal-seam Water and its Implication on Gas Production in the South Qinshui Basin

引用

Acta Geologica Sinica(English Edition) 2024年第1期98卷 207-219页

作者： CHEN Biying FANG Lujia LANG Yunchao XU Sheng LIU Congqiang ZHANG Luyuan HOU Xiaolin Institute of Surface-Earth system Science School of Earth System ScienceTianjin UniversityTianjin 300072China Institute of Earth Environments Chinese Academy of SciencesXi’an 710061China

The knowledge of the residence time of formation water is fundamental to understanding the subsurface flow and hydrological *** better identify the origin and evolution of coal seam water and its impact on gas storage and production,this study collected coalbed methane co-produced water in the southeast Qinshui Basin and detected chemical and isotopic compositions,especially 36Cl and 129I *** calculated tracer ages of 129I(5.2–50.6 Ma)and 36Cl(0.13–0.76 Ma)are significantly younger than the age of coal-bearing formation(Pennsylvanian-Cisuralian),indicating freshwater recharge after coal *** model that utilises 129I/I and 36Cl/Cl ratios to constrain the timing of recharge and the proportion of recharge water reveals that over 60%of pre-anthropogenic meteoric water entered coal seams since 10 Ma and mixed with residue initial deposition water,corresponding to the basin inversion in *** spatial distribution of major ion concentrations reveals the primary recharge pathway for meteoric water from coal outcrops at the eastern margin to the basin *** study demonstrates the occurrence of higher gas production rates from wells that accept water recharge in recent times and suggests the possible potential of the non-stagnant zones for high gas production.

关键词： CBM co-produced water iodine-129 chlorine-36 water chemistry Qinshui Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

引用

Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan Yu Shang Jiang Hai-dong Yu Bi-yu Pang Xin Dong Yi-qian Wang school of Mathematical sciences Soochow UniversitySuzhou215006China Beijing Institute of Astronautical system Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction *** and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various *** this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well *** conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted *** in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet *** with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag *** obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further *** compare turbulent statistics of the scalloped riblet case with those of the triangular riblet *** mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the *** also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex *** Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be bene

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of phase preservation and interferometric offset test in sparse SAR imaging

引用

Science China(Information sciences) 2024年第2期67卷 219-231页

作者： Zhongqiu XU Bingchen ZHANG Guangzuo LI Xueli ZHAN Yanfei BAO Yirong WU Key Laboratory of Spatial Information Processing and Application system Technology Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences school of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of Sciences PLA Academy of Military sciences

Sparse synthetic aperture radar(SAR) imaging has emerged as a reliable microwave imaging scheme in the recent decade and excels in down-sampling reconstruction and full-sampling performance improvements such as noise, sidelobe, speckle, and ambiguity suppression. To utilize complex image products of sparse reconstruction for improvement in polarimetric, interferometric, and tomographic SAR imaging, it is necessary to evaluate the phase preservation of sparse SAR imaging. In this study, we first introduce the general alternating direction method of multipliers(ADMM) as the universal framework for sparse reconstruction algorithms and adopt chirp scaling algorithm(CSA)-based azimuth-range decouple operators to avoid expensive data storage and processing. Further, we theoretically analyze the phase preservation of the sparse reconstruction algorithm through a comparison with the reconstruction results of CSA. Finally,we conduct the interferometric offset test on the sparse reconstruction results of simulated and real Gaofen-3(GF-3) SAR data, demonstrating the phase-preserving ability of sparse methods.

关键词： sparse SAR imaging phase preservation interferometric offset test general ADMM azimuth-range decouple

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Adaptive observer-based integral event-triggered antivibration control of a full aircraft active landing gear system with irregular runway excitations

引用

Science China(Information sciences) 2024年第6期67卷 248-261页

作者： Wenxiao HU Chenglong DU Fanbiao LI Xinmin CHEN Chunhua YANG Weihua GUI school of Automation Central South University Research Center in system Engineering for Special Aircrafts Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences

This study addresses the antivibration issue of a full aircraft active landing gear system(LGS)under landing impact and runway excitations via a novel adaptive observer-based integral event-triggered control method. First, a full aircraft active LGS comprising a front gear and two synchronized main left and right gears with active suspensions is established, where the information exchange among them is not implemented directly. Second, two adaptive observers are designed separately for the front and main LGSs to identify the varying damping parameters and estimate the system states simultaneously. Third, estimated states are transmitted to a shared network through a novel integral event-triggered mechanism(I-ETM);thus, the front and main LGSs are interconnected, and a networked control scheme for the aircraft LGS is constructed. Additionally, the integrated active control law is designed with the aid of the transmitted states of the front and main LGSs, enhancing the robustness against the pitch vibration of the ***, the L2-stability of the hybrid system is guaranteed to depress the vertical vibration effect of the landing impact and irregular runway excitations, thus improving passenger safety and comfort. Moreover,a codesign method is provided to obtain feasible solutions to the gain matrices of the observers and controllers simultaneously. Simulation and comparison results are presented to illustrate the effectiveness and superiority of the proposed control scheme in antivibration and saving communication resources.

关键词： aircraft active landing gear antivibration control integral event-triggered mechanism adaptive observer ${\mathcal{L}}_2$-stability

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sequential Inverse Optimal Control of Discrete-Time systems

引用

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 608-621页

作者： Sheng Cao Zhiwei Luo Changqin Quan the Graduate school of system Informatics Kobe University Kobe 657-8501Japan

This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time *** proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian *** calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to *** remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC *** paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution *** effectiveness of the proposed method is demonstrated through simulation results.

关键词： Inverse optimal control promised calculation step sequential calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New black-to-white hole solutions with improved geometry and energy conditions

引用

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 30-43页

作者： Zhongwen Feng Yi Ling Xiaoning Wu Qingquan Jiang school of Physics and Astronomy China West Normal UniversityNanchong 637009China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China school of Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Mathematics Academy of Mathematics and System Science and Hua Loo-Keng Key Laboratory of MathematicsChinese Academy of SciencesBeijing 100190China school of Mathematical sciences University of Chinese Academy of SciencesBeijing 100190China

We construct new black-to-white hole solutions which connect the geometry of spacetime at some gluing surface inside the *** continuity of the metric can be guaranteed up to the arbitrary order which is controlled by the power factor *** sort of black-to-white holes is characterized by the sub-Planckian scalar curvature,independent of the mass of black-to-white *** importantly,we show that the energy condition is only violated within a small region near the gluing *** geodesics of particles within the region from black hole to white hole is also *** turns out that the matter falling into the black hole may pass through the center without singularity and come out from the white *** scenario provides novel ideas for understanding the information loss paradox in traditional black hole physics.

关键词： regular black hole energy condition singularity quantum gravity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2-Independent Domination in Trees

引用

Journal of the Operations Research Society of China 2024年第2期12卷 485-494页

作者： Gang Zhang Baoyindureng Wu College of Mathematics and system sciences Xinjiang UniversityUrumqi830046XinjiangChina

A subset D■V(G)in a graph G is a dominating set if every vertex in V(G)I D is adjacent to at least one vertex of S.A subset S■V(G)in a graph G is a 2-independent set if△(G[S])<*** 2-independence numberα2(G)is the order of a largest 2-independent set in ***,a subset D■V(G)in a graph G is a 2-independent dominating set if D is both dominating and *** 2-independent domination number i^(2)(G)is the order of a smallest 2-independent dominating set in *** this paper,we characterize all trees T of order n with i^(2)(T)=n/***,we prove that for any tree T of order n≥2,i^(2)(T)≤2/3α2(T),and this bound is sharp.

关键词： Domination-Independent domination 2-Independent domination:2-Independence.Trees

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Parallel system Based Quantitative Assessment and Self-evolution for Artificial Intelligence of Active Power Corrective Control

引用

CSEE Journal of Power and Energy systems 2024年第1期10卷 13-28页

作者： Tianyun Zhang Jun Zhang Feiyue Wang Peidong Xu Tianlu Gao Haoran Zhang Ruiqi Si school of Electrical Engineering and Automation Wuhan UniversityWuhan 430072HubeiChina State Key Laboratory for Management and Control of Complex system Institute of AutomationChinese Academy of SciencesBeijing 100190China

In artificial intelligence(AI)based-complex power system management and control technology,one of the urgent tasks is to evaluate AI intelligence and invent a way of autonomous intelligence ***,there is,currently,nearly no standard technical framework for objective and quantitative intelligence *** this article,based on a parallel system framework,a method is established to objectively and quantitatively assess the intelligence level of an AI agent for active power corrective control of modern power systems,by resorting to human intelligence evaluation *** this basis,this article puts forward an AI self-evolution method based on intelligence assessment through embedding a quantitative intelligence assessment method into automated reinforcement learning(AutoRL)systems.A parallel system based quantitative assessment and self-evolution(PLASE)system for power grid corrective control AI is thereby constructed,taking Bayesian Optimization as the measure of AI evolution to fulfill autonomous evolution of AI under guidance of their intelligence assessment *** results exemplified in the power grid corrective control AI agent show the PLASE system can reliably and quantitatively assess the intelligence level of the power grid corrective control agent,and it could promote evolution of the power grid corrective control agent under guidance of intelligence assessment results,effectively,as well as intuitively improving its intelligence level through selfevolution.

关键词： AI quantitative intelligence assessment and self-evolution automated reinforcement learning Bayesian optimization corrective control parallel system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：