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Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy

Journal of Clinical and Translational Hepatology 2024年第4期12卷 406-415页

作者： Zahra Shafieizadeh Zohreh Shafieizadeh Maryam Davoudi Reza Afrisham Xiaolei Miao Department of Medical Laboratory sciences School of Allied Medical SciencesTehran University of Medical SciencesTehranIran school of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianningHubeiChina

Partial hepatectomy is a first-line treatment for hepatocellular *** 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver ***,residual microtumors may also exploit these pathways to reappear and *** targeting molecules that are differentially regulated between normal cells and malignancies,such as fibrinogen-like protein 1(FGL1),appears to be an effective *** potential functions of FGL1 in both regenerative and malignant cells are discussed within the ambit of this *** FGL1 is normally elevated in regenerative hepatocytes,it is normally downregulated in malignant *** does indeed upregulate FGL1 by increasing the release of transcription factors that promote FGL1,including HNF-1α and STAT3,and inflammatory effectors,such as TGF-β and ***,in turn,stimulates certain proliferative pathways,including EGFR/Src/*** alters the phase transition of highly differentiated hepatocytes from G0 to G1,thereby transforming susceptible cells into cancerous *** of the PI3K/Akt/mTOR pathway by FGL1 allele loss on chromosome 8,a tumor suppressor area,may also cause hepatocellular ***,FGL1 is specifically expressed in the liver via HNF-1α histone acetylase activity,which triggers lipid metabolic reprogramming in ***1 might also be involved in other carcinogenesis processes such as hypoxia,epithelial-mesenchymal transition,immunosuppression,and sorafenib-mediated drug *** study highlights a research gap in these disciplines and the necessity for additional research on FGL1 function in the described processes.

关键词： Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration Hepatectomy Lipogenesis Recurrence

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Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 269-278页

作者： Meshack Antwi-Adjei Ernest Obese Emmanuel Awintiig Adakudugu Benjamin Aboagye Daniel Anokwah Akua Afriyie Karikari Roberta Antwi-Adjei Elvis Ofori Ameyaw Department of Pharmacology School of Medical SciencesUniversity of Cape CoastCape CoastGhana Department of Pharmacotherapeutics and Pharmacy Practice School of Pharmacy and Pharmaceutical SciencesUniversity of Cape CoastCape CoastGhana Department of Forensic sciences School of Biological SciencesUniversity of Cape CoastCape CoastGhana Department of Pharmacognosy and Herbal Medicine School of Pharmacy and Pharmaceutical SciencesUniversity of Cape CoastCape CoastGhana Department of Biomedical sciences School of Allied Health SciencesCollege of Agriculture and Natural SciencesUniversity of Cape CoastCape CoastGhana

Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative ***:Rats were randomly divided into six groups:normal control,negative control,positive control(dexamethasone or sulfasalazine)as well as Persicaria lanigera(100-600 mg/kg)-treated *** effects of the extracts on body weight,antioxidant,and hematological parameters,as well as mast cell proliferation,were *** addition,a histological evaluation was ***:Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats(P<0.05).Additionally,the extract significantly increased body weight,improved hematological profile,reduced the disease activity index score and malondialdehyde level,as well as enhanced catalase and superoxide dismutase activities(P<0.05).Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages,as evidenced by decreased cell necrosis,edema,and inflammatory cell ***:Persicaria lanigera extract possesses antiproliferative,antioxidative,and anti-colitis ***,its underlying mechanisms of action need further investigation.

关键词： Colitis Persicaria lanigera Antioxidant Cotton pellets Mast cells Granuloma tissue formation

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SIRS epidemic modeling using fractional-ordered differential equations:Role of fear effect

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International Journal of Biomathematics 2024年第5期17卷 79-100页

作者： Shiv Mangal O.P.Misra Joydip Dhar school of Mathematics and allied sciences Jiwaji University GwaliorMadhya PradeshIndia Department of Mathematics Post Graduate College BinaMadhya PradeshIndia Department of Applied sciences Atal Bihari Vajpayee-Indian Institute of Information Technology and Management GwaliorMadhya PradeshIndia

In this paper,an SIRS epidemic model using Grunwald-Letnikov fractional-order derivative is formulated with the help of a nonlinear system of fractional differential equations to analyze the effects of fear in the population during the outbreak of deadly infectious *** criteria for the spread or extinction of the disease are derived and discussed on the basis of the basic reproduction *** condition for the existence of Hopf bifurcation is discussed considering fractional order as a bifurcation ***,using the Grunwald-Letnikov approximation,the simulation is carried out to confirm the validity of analytic results *** the real data of COVID-19 in India recorded during the second wave from 15 May 2021 to 15 December 2021,we estimate the model parameters and find that the fractional-order model gives the closer forecast of the disease than the classical *** the analytical results and numerical simulations presented in this study suggest different policies for controlling or eradicating many infectious diseases.

关键词： SIRS epidemic model fear effect Mittag-Leffler function Hopf bifurcation parameter estimation

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Therapeutic Benefits of Vernonia amygdalina in the Treatment of Inflammation and Its Associated Diseases

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 44-53页

作者： Du-Bois Asante Gideon Akuamoah Wiafe Korantema Mawuena Tsegah Nelson Kwabla Domey Department of Forensic sciences School of Biological SciencesCollege of Agriculture and Natural SciencesUniversity of Cape CoastPMBCape CoastGhana Department of Biomedical sciences School of Allied Health SciencesCollege Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana school of Medical sciences College Health and Allied SciencesUniversity of Cape CoastPMBCape CoastGhana

Background:In the presence of a stimulus that disrupts homeostasis,the body elicits a response known as *** inflammatory response is expected to restore the normal functioning of the body and initiate healing where ***,the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and *** traditional medical practice,Vernonia amygdalina is used to treat several ailments such as malaria,fever,diabetes,and inflammatory conditions such as those related to pain and ***:This review seeks to explore and discuss the therapeutic benefits of *** in the treatment of inflammation and its associated ***:We reviewed the scientific literature indexed in PubMed,ScienceDirect and Springer,and discussed the reported anti-inflammatory properties of *** and its curative activity in inflammation-associated ***:A total of 30 published articles were identified describing the therapeutic effect of *** in predominately experimental *** anti-inflammatory properties of *** have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the ***:Multiple studies have demonstrated that the aqueous and ethanolic extracts of *** can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells,reducing inflammation and its associated *** critically appraise the current evidence,and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.

关键词： Vernonia amygdalina Inflammation Cytokines Wound healing Analgesic Antipyretic

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Stresses in the Scapular Fossa Do Not Exceed the Yield Stress When Elevated up to 135 Degrees of Abduction after Reverse Shoulder Arthroplasty

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Journal of Biomedical Science and Engineering 2024年第2期17卷 35-40页

作者： Rina Sakai Tomonori Kenmoku Ryo Tazawa Kazuhiro Yoshida Tomomi Mizuhashi Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Department of Orthopedic surgery Kitasato University School of Medicine Sagamihara Japan Kitasato University Graduate school of Medical sciences Sagamihara Japan

Reverse shoulder arthroplasty (RSA) is an effective treatment for rotator cuff tears. Despite its advantages, complications occur at a high rate. Complications requiring revision include a high rate of base plate failure, 38% of which are due to instability. The primary stability the base plate ensures is a crucial factor and, thus, is the subject of much debate in clinical studies and biomechanical research. This study is aimed to provide data that will contribute to the base plate’s pri-mary stability and glenoid longevity by clarifying the stresses at the scapular fossa and base plate interface associated with elevation after RSA. A 3D finite element model was created from the DICOM data for the scapulohumeral joint and SMR shoulder system. For loading conditions, 30 N was applied for each posi-tion with abduction angles of 0, 45, 90, and 135 degrees. A three-dimensional fi-nite element analysis was performed using the static implicit method with LS-DYNA. The von Mises stresses in the scapular fossa were found not to exceed the yield stress on the bone even after elevation to an abduction angle of 135 de-grees after RSA. It is rough to uniformly compare the yield stress and the von Mises stress, but it was inferred that the possibility of fracture is low unless a large external force is applied. A maximum von Mises stress showed 0 degrees of abduction, suggesting that the lowered position is in a more severe condition than the elevated position. If better improvement is desired, it may be necessary to devise ways to reduce the stress on the upper screw. .

关键词： Reverse Shoulder Arthroplasty Finite Element Analysis Yield Stress Glenoid

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Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

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Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying Hou Su Fu Jie Luan Breast Plastic and Reconstructive surgery Center Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular contracture is a prevalent and severe complication that affects the post-operative outcomes of patients who receive silicone breast *** present,prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction following breast cancer ***,the mecha-nism(s)underlying breast capsular contracture remains *** study aimed to identify the biological features of breast capsular contracture and reveal the potential underlying mechanism using RNA *** tissues from 12 female patients(15 breast capsules)were divided into low capsular contracture(LCC)and high capsular contracture(HCC)groups based on the Baker ***,41 lipid metabolism-related genes were identified through enrichment analysis,and three of these genes were identified as candidate genes by SVM-RFE and LASSO *** then compared the proportions of the 22 types of im-mune cells between the LCC and HCC groups using a CIBERSORT analysis and explored the Cor-relation between the candidate hub features and immune ***,PRKAR2B was positively correlated with the differentially clustered immune cells,which were M1 macro-phages and follicular helper T cells(area under the ROC=0.786).In addition,the expression of PRKAR2B at the mRNA or protein level was lower in the HCC group than in the LCC *** molecular mechanisms were identified based on the expression levels in the high and low PRKAR2B *** findings indicate that PRKAR2B is a novel diagnostic biomarker for breast capsular contracture and might also influence the grade and progression of capsularcontracture.

关键词： Biomarker Breastcapsular contracture Immune infiltration Machinelearning algorithms PRKAR2B

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Characteristics and trends of pediatric firepit burns: insights for prevention and safety

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World Journal of Pediatric surgery 2024年第1期7卷 54-58页

作者： Maria Fazal Charbel Chidiac Raheel Ahmad Oussama Issa Erica Hodgman Alejandro V Garcia Johns Hopkins school of Medicine BaltimoreMarylandUSA Department of surgery Division of Pediatric SurgeryJohns Hopkins School of MedicineBaltimoreMarylandUSA Division of the Biological sciences University of ChicagoChicagoIllinoisUSA school of Medicine American University of BeirutBeirutLebanon

Introduction As fire pits grow in popularity,so do the associated burn *** study examines pediatric fire pit burns characteristics to raise awareness and promote safety *** We conducted a retrospective review of pediatric patients(surgery,7(8.4%)had at least one rehabilitation visit,and 65(77.4%)had follow-up clinic *** median length of stay was 2 days(IQR=1.0-3.5).The peak months for burns were from August through October(n=40,46.0%),with an increase observed from 10 cases in 2016to 20 cases in *** Given the significant proportion of firepit burns resulting from unsafe fire behaviors,it is crucial that caretakers are aware of proper firepit safety *** ofevidence Il.

关键词： burns admitted prevention

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Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek Kumar Anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar Department of allied Medical sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

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Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair

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Science China(Technological sciences) 2024年第7期67卷 2153-2163页

作者： LIU SiCong LI Lei JIANG ChanYuan WANG QianYu DENG ZhongShan Key Laboratory of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Cleft Lip and Palate Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China school of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Low-melting-point alloys have the advantages of good biocompatibility, plasticity, and near-bone mechanical strength, making them suitable as bone defect-filling materials for direct injection into defective bone sites. However, using low-melting-point alloys for orthopedic implants poses the challenge of causing thermal damage to the surrounding bone tissue during injection. In this study, a thermosensitive hydrogel is prepared and synergistically injected into the bone defect site with BiInSn. BiInSn solidifies and releases heat during injection, while the thermosensitive hydrogel absorbs heat and transforms into a gel state,encapsulating BiInSn. Therefore, the surrounding bone tissue is effectively protected from thermal damage. When BiInSn and the thermosensitive hydrogel were injected synergistically, in vitro thermal experiments revealed that the maximum temperature of the surrounding bone tissue reached 42℃. This temperature is below the 47℃ threshold, which causes permanent damage to bone tissues. In vivo experiments demonstrated that rats in the BiInSn-thermosensitive hydrogel group exhibited better recovery at the bone defect sites. These results suggest that the synergistic injection of Bi-based alloy and thermosensitive hydrogel is beneficial in reducing thermal damage to bone tissue, guiding bone tissue growth, and effectively facilitating the repair of bone defects.

关键词： bone defects thermosensitive hydrogel thermal damage to tissue bismuth-based alloy bone cement

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Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa

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Infectious Diseases of Poverty 2024年第1期13卷 93-94页

作者： Shuchao Wang Roland Suluku Mohamed B.Jalloh Ahmed F.Samba Baogui Jiang Yubiao Xie Doris Harding Mengyao Zhang Foday Sahr Mahmud E.Sesay James S.Squire Mohamed A.Vandi Moinina N.Kallon Shoufeng Zhang Rongliang Hu Yuee Zhao Zhiqiang Mi Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun China Department of Animal sciences School of Agriculture and Food Sciences Njala University Njala Sierra Leone Department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Ministry of Agriculture and Food sciences Freetown Sierra Leone Beijing Institute of Microbiology and Epidemiology Beijing China Ministry of Health and Sanitation Freetown Sierra Leone Beijing Institute of Biotechnology Beijing China

Background Anthrax,a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis,remains a major global public health concern,especially in countries with limited *** Leone,a West African country historically plagued by anthrax,has almost been out of report on this disease in recent *** this study,we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the *** The causative agent of the animal outbreak in Port Loko District,Sierra Leone,between March and May 2022 was identified using the nanopore sequencing technique.A nationwide active surveillance was implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-specific symptoms in *** cases were subsequently verified using quantitative polymerase chain ***-genome sequencing was accomplished by combining long-read and short-read sequencing *** phylogenetic analysis was performed based on the full-chromosome single nucleotide *** The outbreak in Port Loko District,Sierra Leone,led to the death of 233 animals between March 26th and May 16th,*** ruled out the initial suspicion of Anaplasma species and successfully identified *** as the causative agent of the *** a result of the government's prompt response,out of the 49 suspected human cases identifed during the one-year active surveillance,only 6 human cases tested positive,all within the frst month after the official declaration of the *** phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the ***.153 clade within the TransEuroAsian group of *** We successfully identifed a large-scale anthrax outbreak in Sierra *** causative isolate of ***,BaSL2022,phylogenetically bridged other lineages in ***.153 clade and neighboring genetic groups,***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus anthracis Sierra Leone Phylogeny Single nucleotide polymorphism

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