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网络系统的端到端延时分析（英文）

Frontiers of Information technology & Electronic Engineering 2015年第9期16卷 732-743页

作者： Jie SHEN Wen-bo HE Xue LIU Zhi-bo WANG Zhi WANG Jian-guo YAO Department of Control Science and Engineering Zhejiang University school of Computer Science Mc Gill University school of Computer Wuhan University Su zhou Institute of Wuhan University school of software Shanghai Jiao Tong University

目的:面向大规模复杂网络,提出一种有效的端到端延时的分析方法,保障网络服务性能。创新点:基于频域分析方法提出一种新的网络延时分析方法,具有高效率的特点。方法:首先,将网络系统的延时从时域转换到频域,并用信号流图建模(图1)。然后... 详细信息

目的:面向大规模复杂网络,提出一种有效的端到端延时的分析方法,保障网络服务性能。创新点:基于频域分析方法提出一种新的网络延时分析方法,具有高效率的特点。方法:首先,将网络系统的延时从时域转换到频域,并用信号流图建模(图1)。然后,用克莱姆法则或者梅森增益公式计算信号流图模型的传递函数。接着,分析传递函数的脉冲响应和阶跃响应得到系统的端到端延时的概率密度函数和概率分布函数(图2)。最后,用该方法分析两个实际例子。包括:第一,用该方法得到网络中的瓶颈链路(图3、4);第二,用该方法分析网络通信协议(图6)。结论:针对大规模复杂网络,提出基于频域分析的网络延时分析方法,这种方法是有效的。

关键词：网络系统端到端延时分布

Advanced EMS and its trial operation in Shanghai power system

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Science China(Technological Sciences) 2008年第2期51卷 220-224页

作者： LU Qiang HE GuangYu MEI ShengWei SUN YingYun RUAN QianTu WANG Wei ZHANG WangJun YU XuFeng state key Lab of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Shanghai Power System Company Shanghai 200122China

To meet the demand of high stability,high quality,and low losses of power systems,the advanced energy management system (AEMS) is established and revealed in this bulletin,which has been put into trial operation in Shanghai power system for almost half a year. The AEMS is novel from all aspects covering idea,theory,method,software,and engineering. The essence of AEMS is exercising the hybrid automatic control theory and technology to realize multi-objective optimal closed-loop control of power systems. Based on an "event-driven" strategy,the AEMS transforms multi-objective optimal control problems into event identification and elimination by defining the unsatisfactory states of a power system as events. This bulletin concisely presents the theory and main advantages of AEMS,as well as its implementation in Shanghai power system.

关键词： hybrid automatic control multi-objective optimization AEMS event driven

Electrospun Nanofibers-Based Face Masks

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Advanced Fiber Materials 2020年第3期2卷 161-166页

作者： Mike Tebyetekerwa Zhen Xu Shengyuan Yang Seeram Ramakrishna Research school of Electrical Energy and Materials EngineeringCollege of Engineering and Computer ScienceThe Australian National UniversityCanberraACT 2601Australia Department of Chemical Engineering Imperial College LondonLondon SW72AZUK state key laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai“Belt&Road”International Joint Laboratory for Advanced Fiber and Low‑Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Centre for Nanofibers and Nanotechnology National University of SingaporeSingapore 117581Singapore

Textiles have proved to be very important materials to human beings since the time ***,fibers are the basic building units of these *** this perspective we substantiate the uniqueness and capability of nanofibers as active layers in face masks,to protect people against the novel coronavirus disease(COVID-19).This time-sensitive letter introduces the mechanisms based on which their active filters function,the uniqueness of electrospun nanofibers in face masks and do-it-yourself(DIY)steps to realize a fully functional face mask at home.

关键词： Electrospinning Nanofibers Face masks COVID-19 Textiles

Research of a novel biodegradable surgical staple made of high purity magnesium

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Bioactive Materials 2016年第2期1卷 122-126页

作者： Hongliu Wu Changli Zhao Jiahua Ni Shaoxiang Zhang Jingyi Liu Jun Yan Yigang Chen Xiaonong Zhang state key laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Suzhou Origin Medical technology Co.Ltd. Jiangsu 215513China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200233China Department of General Surgery Wuxi No.2 People's HospitalNanjing Medical UniversityWuxi214002China

Surgical staples made of pure titanium and titanium alloys are widely used in gastrointestinal *** the Ti staple cannot be absorbed in human body and produce artifacts on computed tomography(CT)and other imaging examination,and cause the risk of incorrect *** bioabsorbable staple made from polymers that can degrade in human body environment,is an *** the present study,biodegradable high purity magnesium staples were developed for gastric anastomosis.U-shape staples with two different interior angles,namely original 90and modified 100,were *** element analysis(FEA)showed that the residual stress concentrated on the arc part when the original staple was closed to B-shape,while it concentrated on the feet for the modified staple after *** in vitro tests indicated that the arc part of the original staple ruptured firstly after 7 days immersion,whereas the modified one kept intact,demonstrating residual stress greatly affected the corrosion behavior of the HP-Mg *** in vivo implantation showed good biocompatibility of the modified Mg staples,without inflammatory reaction 9 weeks *** Mg staples kept good closure to the Anastomosis,no leaking and bleeding were found,and the staples exhibited no fracture or severe corrosion cracks during the degradation.

关键词： Biodegradable staple High purity magnesium Finite element analysis Corrosion In vivo

Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2020年第1期41卷 3-19页

作者： Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng Yi-Xing Gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan state key laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China BGI-Shenzhen ShenzhenGuangdong 518083China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China key laboratory of High Altitude Medicine of People's Liberation Army Chongqing 400038China key laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationChongqing 400038China school of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006China Guangzhou Cellprotek Pharmaceutical Co.Ltd. GuangzhouGuangdong 510663China Institute of Medical Genetics School of MedicineCardiff UniversityCardiff CF144XNUK James D.Watson Institute of Genome Sciences HangzhouZhejiang 310058China Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China China National Genebank BGI-ShenzhenShenzhenGuangdong 518120China

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment.

关键词： Acute hypobaric hypoxia Cynomolgus monkeys Brain injury Neuroprotectant Gene regulatory networks

Algorithm to identify circulating tumor cell clusters using in vivo flow cytometer

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Journal of Innovative Optical Health Sciences 2018年第5期11卷 11-20页

作者： Kai Pang Dan Wei Pengfei Hai Zhangru Yang Xiaofu Weng Xunbin Wei state key laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Med-X Research Institute and school of Biomedical Engineering Shanghai Jiao Tong University 1954 Huashan Road Shanghai 200030P.R.China Department of Biomedical Engineering Washington University in St.Louis One Brookings Drive St.LouisMissouri 63130USA Radiation Oncology Center Fudan University Shanghai Cancer Center(FUSCC)Shanghai 200032 P.R.China

Recent studies in oncology have addressed the importance of detecting circulating tumor cell clusters because circulating tumor cell clusters might survive and metastasize more easily than single circulating tumor *** with larger peak widths detected by in vivo flow cytometer(IVFC)have been used to identify cell clusters in previous ***,the accuracy of this criterion might be greatly degraded by variance in blood°ow and the rolling behaviors of circulating tumor ***,we propose a criterion and algorithm to distinguish cell clusters from single *** this work,we first used area-based and volume-based models for single°uorescent *** each model,we analyzed the corresponding morphology of IVFC signals from cell *** to the Rayleigh criterion,the valley between two adjacent peak signals from two distinguishable cells should be lower than 73.5%of the peak values.A novel signal processing algorithm for IVFC was developed based on this *** results showed that cell clusters can be reliably identied using our proposed *** imaging was also performed to further support our *** enhanced accuracy,IVFC is a powerful tool to study circulating cell clusters.

关键词： In vivo flow cytometer circulating tumor cell cell clusters signal processing algorithm computer simulation Rayleigh criterion

An RSSl Gradient-based AP Localization Algorithm

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China Communications 2014年第2期11卷 100-108页

作者： ZHAO Fang LUO Haiyong GENG Hao SUN Qijin school of software Engineering B eijing University of Posts and Telecommunications B eijing 100876 China Institute of Computing technology CAS Beijing key laboratory of Mobile Computing and Pervasive Device Beijing 100190 China

Recent rapid rise of indoor location based services for smartphones has further increased the importance of precise localization of Wi-Fi Access Point(AP).However,most existing AP localization algorithms either exhibit high errors or need specialized hardware in practical *** this paper,we propose a novel RSSI gradient-based AP localization *** consists of the following three major steps:firstly,it uses the local received signal strength variations to estimate the direction(minus gradient) of AP,then employs a direction clustering method to identify and filter measurement outliers,and finally adopts triangulation method to localize AP with the selected gradient *** results demonstrate that the average localization error of our proposed algorithm is less than 2meters,far outperforming that of the weighted centroid approach.

关键词：定位算法梯度型 AP Wi-Fi接入点三角测量法精确定位智能手机定位服务

Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis

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Science China(Life Sciences) 2018年第8期61卷 947-953页

作者： Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang Mc Kusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Joy Orient Translational Medicine Research Center Co. Ltd The Research Center for Medical Genomics China Medical University Medical Genetics Institute Henan Provincial People's Hospital People's Hospital of Zhengzhou University People's Hospital of Henan University

Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency.

关键词：中国人口诊断效率家庭定序分子膜蛋白质非周期性基因

Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis

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Burns & Trauma 2022年第1期10卷 416-431页

作者： Yue Zhang Ying Wang Lin Zeng Yixiang Liu Huiling Sun Shanshan Li Siyu Wang Longjun Shu Naixin Liu Saige Yin Junsong Wang Dan Ni Yutong Wu Ying Yang Li He Buliang Meng Xinwang Yang Department of Anatomy and Histology&Embryology Faculty of Basic Medical ScienceKunming Medical UniversityKunming 650500YunnanChina key laboratory of Chemistry in Ethnic Medicinal Resources&key laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes State Ethnic Affairs Commission&Ministry of EducationSchool of Ethnomedicine and EthnopharmacyYunnan MinZu UniversityKunming 650504YunnanChina Endocrinology Department of Affiliated Hospital of Yunnan University Kunming 650021YunnanChina Institutional Center for Shared Technologies and Facilities of Kunming Institute of Zoology Chinese Academy of SciencesKunming 650223YunnanChina Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunming650500YunnanChina

Background:Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin ***(miRNAs)are also considered promising targets for the development of effective therapies against skin ***,further research in this field is *** study aims to identify and provide a new peptide drug candidate,as well as to explore the underlying miRNA mechanisms and possible miRNA drug target for skin wound ***:A combination of Edman degradation,mass spectrometry and cDNA cloning were adopted to determine the amino acid sequence of a peptide thatwas fractionated from the secretion of Odorrana andersonii frog skin using gel-filtration and reversed-phase high-performance liquid *** toxicity of the peptide was evaluated by Calcein-AM/propidium iodide(PI)double staining against human keratinocytes(HaCaT cells),hemolytic activity against mice blood cells and acute toxicity against *** stability of the peptide in plasma was also *** prohealing potency of the peptide was determined by MTS,scratch healing and a Transwell experiment against HaCaT cells,full-thickness injury wounds and scald wounds in the dorsal skin of *** transcriptome sequencing analysis,enzyme-linked immunosorbent assay,real-time polymerase chain reaction and western blotting were performed to explore the molecular ***:A novel peptide homodimer(named OA-GL17d)that contains a disulfide bond between the 16th cysteine residue of the peptide monomer and the sequence‘GLFKWHPRCGEEQSMWT’was *** showed that OA-GL17d exhibited no hemolytic activity or acute toxicity,but effectively promoted keratinocyte proliferation and migration and strongly stimulated the repair of full-thickness injury wounds and scald wounds in the dorsal skin of ***,OA-GL17d decreased the level of miR-663a to increase the level of trans

关键词： MicroRNA miR-663a Wound healing Peptide Amphibian Human keratinocytes OA-G17d Chronic wound Skin Transforming growth factor-β1 Smad