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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

GSN antibody pretreatment aggravates radiation-induced lung injury in mice

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Nuclear Science and Techniques 2014年第2期25卷 26-31页

作者：王洁袁小鹏顾成黄建峰俞家华刘芬菊 Department of Radiobiology School of Radiation Medicine and ProtectionMedical College of Soochow University school for radiological and interdisciplinary sciences Soochow University

Radiation-induced lung injury is one of the main dose limiting factors for thoracic radiation ***(GSN) is a widespread,multifunctional regulator of cellular structure and *** this work,the roles of GSN in radiation-induced lung injury in Balb/c mice were *** GSN levels in plasma reduced progressively in 72 hours after irradiation,and then increased *** contents in the bronchoalveolar lavage(BAL) fluid increased after thoracic irradiation,whereas mRNA levels of GSN in the lung tissue decreased significantly within 24 hours after irradiation and then increased *** were intravenously injected with 50 ug GSN antibody 0.5 hour before 20 Gy of thoracic *** antibody pretreatment increased lung inflammation,protein concentration in the BAL fluid and leukocytes infiltration in the irradiated *** activities of superoxidase dismutase(SOD) in the plasma and the BAL fluid in irradiated mice injected with GSN antibody were less than that of control groups,whereas the levels of malondialdehyde(MDA)*** results suggest that pretreatment of GSN antibody may aggravate radiation-induced pneumonitis.

关键词： GSN 肺损伤放射性预处理小鼠抗体 mRNA水平超氧化物歧化酶

Condition dependence of Zr electrochemical reactions and morphological evolution of Zr deposits in molten salt

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Science China Chemistry 2017年第2期60卷 264-274页

作者： Kui Liu Ya-Lan Liu Jing-Wen Pang Li-Yong Yuan Lin Wang Zhi-Fang Chai Wei-Qun Shi Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of Sciences school of radiological & interdisciplinary sciences Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow University

This work presents a comprehensive study for the electrochemical behaviors of zirconium in LiCl-KCl *** effects of stirring,temperature and Zr concentration on the electrode reactions,the ZrCl_4 sublimation from the melt,microcosmic morphologies of Zr deposits(ZrCl and Zr)obtained at different potential and temperature have been *** behaviors of Zr(Ⅳ),on a large concentration range from 0.13%to 2.28%in melt,show a multiple-step reaction involving Zr(Ⅳ),Zr(Ⅱ),ZrCl and Zr *** plays a crucial role on the changes of Zr(IV)reduction behavior on the solid *** Zr(Ⅳ)/ZrCl couple is more easily observed at lower temperature and gradually diminishes with the increase of *** Zr(Ⅳ)/Zr(Ⅱ)and Zr(Ⅱ)/Zr reactions are predominant on the W electrode at higher *** 673 K,a layered structure of insoluble ZrCl formed by potentiostatic electrolyses at 1.1 V was visualized by scanning electron microscopy-energy dispersive X-ray(SEM-EDS),while only Zr metal particles was observed at higher temperature than 773 *** evolution of the Zr-based structure and size corresponding to the ZrCl and Zr metal based on different potentiostatic electrolysis was *** average particle size of the Zr metalparticles increases with the increase of temperature.

关键词： zirconium electrochemistry influence factor LiCl-KCl pyroprocessing

Poly(amidoxime)-reduced graphene oxide composites as adsorbents for the enrichment of uranium from seawater

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Science China Chemistry 2014年第11期57卷 1449-1458页

作者： SHAO DaDong LI JiaXing WANG XiangKe school of Environment and Chemical Engineering North China Electric Power University school for radiological and interdisciplinary sciences Soochow University Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

The development of efficient materials for high extraction of uranium(UO22+) from seawater is critical for nuclear energy. Poly(amidoxime)-reduced graphene oxide(PAO/rGO) composites with excellent adsorption capability for UO22+ were synthesized by in situ polymerization of acrylonitrile monomers on GO surfaces, followed by amidoximation treatment with hydroxylamine. The adsorption capacities of PAO/rGO composites for UO22+ reached as high as 872 mg/g at pH 4.0. The excellent tolerance of these composites for high salinity and their regeneration-reuse properties can be applied in the nuclear-fuel industry by high extraction of trace UO22+ ions from seawater.

关键词： uranium amidoxime graphene acrylonitrile adsorption

Towards understanding the correlation between UO_2^(2+) extraction and substitute groups in 2,9-diamide-1,10-phenanthroline

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Science China Chemistry 2018年第10期61卷 1285-1292页

作者： Xinrui Zhang Liyong Yuan Zhifang Chai Weiqun Shi Laboratory of Nuclear Energy Chemistry Institute of High Energy Physics Chinese Academy of Sciences school for radiological and interdisciplinary sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University

2,9-Diamide-1,10-phenanthroline(DAPhen)ligands represent a new family of tetradentate extractants given their strong affinity to actinides and the CHON *** this family,N,N′-diethyl-N,N′-ditolyl-2,9-diamide-1,10-phenanthroline(Et-TolDAPhen),initially reported by us,exhibits excellent selectivity towards actinides(U,Th,Am,Pu)over lanthanides and thus can be potentially applied in the group actinide extraction(GANEX)process for the group separation of *** this article,by tailoring the lengths of alkyl chains,we synthesized other four DAPhen ligands with different substitute groups in the diamide moieties,and characterized the relationship between properties and substitute groups of DAPhen *** extraction results show that three of the ligands exhibit high performance in UO_2^(2+)extraction from an acidic solution and the extracted UO_2^(2+)can be easily stripped by only using ultrapure *** titration confirms that UO_2^(2+)combined with all the four ligands in 1:1 *** extended X-ray absorption finestructure(EXAFS)study shows that six donor atoms comprise the first equatorial shell of the UO_2^(2+)ions bonded by the DAPhen ligands,among which two nitrogen and two oxygen atoms are from the DAPhen ligand,while other two oxygen atoms are from one nitrate *** article promises to provide basic data for assessing the feasibility of this kind of DAPhen ligands applied in actinides separation from nuclear wastes.

关键词： 2,9-diamide-1,10-phenanthroline UO2^2+ extraction UV-Vis titration EXAFS

Solvent extraction of U(VI) by trioctylphosphine oxide using a room-temperature ionic liquid

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Science China Chemistry 2014年第11期57卷 1432-1438页

作者： YUAN LiYong SUN Man LIAO XiangHong ZHAO YuLiang CHAI ZhiFang SHI WeiQun Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety Institute of High Energy Physics Chinese Academy of Sciences school of radiological & interdisciplinary sciences Soochow University

The unique physical and chemical properties of room-temperature ionic liquids(RTILs) have recently received increasing attention as solvent alternatives for possible application in the field of nuclear industry, particularly in liquid-liquid separations of radioactive nuclides. We investigated solvent extraction of U(VI) from aqueous solutions into a commonly used ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide([C4mim][NTf2]) using trioctylphosphine oxide(TOPO) as an extractant. The effects of contact time, TOPO concentration, acidity, and nitrate ions on the U(VI) extraction are discussed in detail. The extraction mechanism was proposed based on slope analysis and UV-Vis measurement. The results clearly show that TOPO/[C4mim][NTf2] provides a highly efficient extraction of U(VI) from aqueous solution under near-neutral conditions. When the TOPO concentration was 10 mmol/L, the extraction of 1 mmol/L U(VI) was almost complete(> 97%). Both the extraction efficiency and distribution coefficient were much larger than in conventional organic solvents such as dichloromethane. Slope analysis confirmed that three TOPO molecules in [C4mim][NTf2] bound with one U(VI) ion and one nitrate ion was also involved in the complexation and formed the final extracted species of [UO2(NO3)(TOPO)3]+. Such a complex suggests that extraction occurs by a cation-exchange mode, which was subsequently evidenced by the fact that the concentration of C4mim+ in the aqueous phase increased linearly with the extraction percent of U(VI) recorded by UV-Vis measurement.

关键词： uranium solvent extraction ionic liquid trioctylphosphine oxide

Design criteria for tetradentate phenanthroline-derived heterocyclic ligands to separate Am(Ⅲ) from Eu(Ⅲ)

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Science China Chemistry 2014年第11期57卷 1439-1448页

作者： XIAO ChengLiang WU QunYan WANG CongZhi ZHAO YuLiang CHAI ZhiFang SHI WeiQun Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Key Laboratory For Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences school of radiological and interdisciplinary sciences Soochow University

To design novel phenanthroline-derived soft ligands for selectively separating minor actinides from lanthanides, four tetradentate phenanthroline-derived heterocyclic ligands(BTPhen, BPyPhen, BPzPhen, and BBizPhen) were constructed and their complexation behaviors with Am(ⅡI) and Eu(ⅡI) were systematically investigated by density functional theory(DFT) coupled with relativistic small-core pseudopotential. In all the 1:1-type species, the metal ion is in the center of the cavity and coordinates with two nitrogen atoms(N1 and N1′) of the phenanthroline skeleton and the other two nitrogen atoms(N2 and N2′) of the auxiliary groups. The bond lengths of Am–N are comparable to or even shorter than those of Eu–N bonds because the ionic radii of Am(ⅡI) are larger than those of Eu(ⅡI). Additionally, the negative ΔΔGAm/Eu value for the reaction of [M(H2O)4-(NO3)3] + L → ML(NO3)3 + 4H2 O indicates that the complexation reaction of Am(ⅡI) is more energetically favorable than that of Eu(ⅡI); this can be considered as an important design criterion to screen phenanthroline-derived ligands for MA(ⅡI) extraction. According to this criterion, the selectivity of tetradentate phenanthroline-derived ligands for separating Am(ⅡI) over Eu(ⅡI) follows the order of BTPhen > BBizPhen > BPyPhen > BPzPhen.

关键词： minor actinide lanthanide phenanthroline separation DFT

Flexible interdigitated layered framework with multiple accessible active sites for high-performance CH_(3)I capture

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Science China Chemistry 2024年第5期67卷 1569-1577页

作者： Bo Tai Baoyu Li Linwei He Zhonglin Ma Shujing Lin Mingxing Zhang Junchang Chen Fuqi Wu Long Chen Xing Dai Fuyin Ma Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The development of adsorbent materials for effective capture of radioactive iodomethane(CH_(3)I) from the off-gas of used nuclear fuel reprocessing, remains a significant and challenging line of research because currently state-of-art adsorbents still suffer from low binding affinity with CH_(3)I. Here, we proposed a brand-new adsorption topological structure by developing a 2D interdigitated layered framework, named SCU-20, featuring slide-like channel with multiple active sites for CH_(3)I capture. The responsive rotating-adaptive aperture of SCU-20 enables the optimal utilization of all active sites within the pore for highly selective recognition and capture of CH_(3)I. A record-breaking CH_(3)I uptake capacity of 1.84 g/g was achieved under static sorption conditions with saturated CH_(3)I vapor. Both experimental and theoretical findings demonstrated that the exceptional uptake of SCU-20 towards CH_(3)I can be attributed to the confined physical electrostatic adsorption of F sites, coupled with the chemical nitrogen methylation reaction with uncoordinated N atoms of pyrazine. Moreover, dynamic CH_(3)I uptake capacity potentially allows for the capture of CH_(3)I in simulated real-world off gas reprocessing conditions. This study highlights the potential of SCU-20 as a promising candidate for efficient capture of iodine species and contributes to the development of effective solutions for radioactive iodine remediation.

关键词： 2D interdigitated layered framework iodomethane dual-sites electrostatic interaction physisorption and chemisorption

A uranyl based coordination polymer showing response to low-dosage ionizing radiations down to 10^(−5) Gy

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Science China Chemistry 2020年第11期63卷 1608-1612页

作者： Jian Xie Yaxing Wang Wei Liu Chengyu Liang Yugang Zhang Lanhua Chen Daopeng Sheng Zhifang Chai Shuao Wang school for radiological and interdisciplinary sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow UniversitySuzhou 215123China school of Environment and Material Engineering Yantai UniversityYantai 264005China

Radiation detection material is a central component of nuclear technology finding applications in many critical *** a highly radiation-sensitive material that shows a facilely detectable response to ultra-low dosage of radiation is a long-term research target and remains to be a *** reported most optimal chemical radiation dosimeter can detect low-dosage X-andγ-ray radiations down to 10^(−4) *** document here a new photoresponsive coordination polymer showing upgraded radiation detection capabilities with the detection limit on the radiation dose one order of magnitude lower than the previous *** radiation induced photoluminescence quenching process was elucidated by multiple spectroscopic characterizations.

关键词： uranium photoluniinescence radiation detection dosimeter