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Aggregate 2024年第1期5卷 436-450页

作者： Lianxue Zhang Jianxiang Huang Damiano Buratto Panli Han Zaixing Yang Ruhong Zhou Institute of Quantitative Biology Shanghai Institute for Advanced StudyCollege of Life SciencesZhejiang UniversityHangzhouChina state key laboratory of radiation medicine and protection School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina Cancer Center Zhejiang UniversityHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The efficacy of nanoparticle(NP)-based drug delivery technology is hampered by aberrant tumor stromal microenvironments(TSMs)that hinder NP ***,the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical ***,we propose a potential solution using a dihydralazine(HDZ)-loaded nanoparticle drug delivery system containing a pH-responsive,cyclic RGD peptide-modified prodrug based on doxorubicin(cRGD-Dex-DOX).With a combined experimental and theoretical approach,we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor *** can notably downregulate the expression levels of hypoxia-inducible factor 1α(HIF1α),α-smooth muscle actin,and fibronectin through the dilation of tumor blood *** changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors,suggesting that such a system may offer an effective“multifunctional therapy”through both improving the chemotherapeutic effect and enhancing the immune response to *** vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens,with the lowest side effects as well.

关键词： antitumor dihydralazine drug delivery system tumor stromal microenvironment vasculature

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RXRα agonist bexarotene attenuates radiation-induced skin injury by relieving oxidative stress

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radiation medicine and protection 2022年第2期3卷 56-63页

作者： Sheng Jiang Weichao Cai Jianhui Chen Wenling Tu Yulan Liu Lixin Gong Yahui Feng Wei Mo Tao Yan Shuyu Zhang Daojiang Yu The Second Affiliated Hospital of Chengdu Medical College China National Nuclear Corporation No.416 HospitalChengdu 610051China Department of Plastic Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China West China Second University Hospital West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China state key lab of radiation medicine and protection School of Radiation Medicine and ProtectionMedical College of Soochow UniversitySuzhou 215123China NHC key laboratory of Nuclear Technology Medical Transformation(Mianyang Central Hospital) Mianyang 621099China

Objective: To investigate the protective effect of bexarotene in radiation-induced skin injury and elucidate underlying ***: Irradiated cellular and animal models were established using an X-ray linear accelerator. Cell viabilityand apoptosis were evaluated by CCK8 and flow cytometry. In vivo protective effect of bexarotene was measuredin irradiated SD rats. The antioxidant capacity of bexarotene was validated by DCF-DA method. The signalingpathways involved in bexarotene-mediated skin repair were enriched by RNA ***: Bexarotene could significantly restore the proliferation and inhibit the apoptosis of WS1 cells with radiation damage (P radiation-induced skin injury (P radiation exposure. Furthermore, a transcriptome analysis indicated that bexarotene-mediated recovery of radiation damage involves redox signaling, immune regulation, lipid metabolism and ***: Bexarotene is a promising therapeutic agent in the treatment of radiation-induced skin injury.

关键词： radiation Skin injury Oxidative stress RXRα Bexarotene

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Prevention and treatment for radiation-induced skin injury during radiotherapy

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radiation medicine and protection 2020年第2期1卷 60-68页

作者： Yimin Wang Wenling Tu Yiting Tanga Shuyu Zhang school of radiation medicine and protection and state key lab of radiation medicine and radioprotection Soochow UniversitySuzhou215123China The Second Affiliated Hospital of Chengdu Medical College China National Nuclear Corporation 416 HospitalChengdu610051China West China school of Basic Medical Sciences&Forensic medicine Sichuan UniversityChengdu610041China

The skin tissue has the largest area in the human body and functions as both a barrier and a *** such,it tends to be the first tissue to be *** in medical technology provide prospects as well as side effects,for example,radiation therapy for *** increasing cancer morbidity and radiation widely applied for cancer therapy,radiation-induced skin injury(RSI)has become a serious *** recent decades,research efforts have focused on the mechanisms underlying *** review summarizes the mainstream opinions on these mechanisms,including the pathological,molecular biological,and cytobiological *** reactive oxygen species(ROS),cytokines and involved signaling pathways are *** relevant aspects include radiation-induced skin fibrosis(RSF)and radiation-related skin cell ***,we review strategies for the prevention and treatment in clinical and pre-clinical studies to support the treatment of RSI during *** prevention strategies include dose control,pre-irradiation instructions,and RSI assessments,while the main treatments include physical therapy,external-use dressings or creams,biological therapy and surgical reconstruction.

关键词： Ionizing radiation Radiotherapy radiation-induced skin injury(RSI) radiation-induced skin fibrosis(RSF) radiation-related skin cell senescence

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Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection

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Science Bulletin 2018年第14期63卷 925-934页

作者： Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang Tianjin key laboratory of Molecular Nuclear medicine Institute of Radiation MedicineChinese Academy of Medical Sciences and Peking Union Medical College Institute of Analytical Chemistry College of Chemistry and Molecular EngineeringPeking University Department of Physics and Tianjin key laboratory of Low Dimensional Materials Physics and Preparing Technology School of SciencesTianjin University state key laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center

Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation.

关键词：放射疗法抗氧化剂催化作用保护种类反应辐射防护簇

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