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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

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Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao Lai Saad Arif Cong Feng Guangjun Liao Chuntao Wang school of Automation Guangdong University and TechnologyGuangzhou510006China school of Immigration administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China school of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA school of Medicine and public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang Wenying Zheng Wei Gu school of Software Nanjing University of Information Science and TechnologyNanjing210044China school of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of public Big Data Guizhou UniversityGuiyang550025China school of Computer Science and Technology(school of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China school of Computer Science(school of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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Spatiotemporal characteristics and influencing factors of vegetation water use efficiency on the Tibetan Plateau in 2001–2020

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Journal of Geographical Sciences 2025年第1期35卷 39-64页

作者： HE Chenyang WANG Yanjiao YAN Feng LU Qi school of Ecological and Environmental Science East China Normal University Institute of Ecological Conservation and Restoration Chinese Academy of Forestry National Climate Center China Meteorological Administration

Water use efficiency （WUE）,as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ***,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain *** study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–*** indicated an annual mean WUE of 0.8088 gC/mm·m2across the plateau,with a spatial gradient reflecting decrease from the southeast toward the *** manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,***,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of *** factors accounted for 70.79%of the variability in *** leaf area index and temperature served as the major driving forces of WUE variation.

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Channel pruning on frequency response

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Science China(Information Sciences) 2025年第1期68卷 159-170页

作者： Hang LIN Yifan PENG Lin BIE Chenggang YAN Xibin ZHAO Yue GAO school of Software Tsinghua University school of Automation Hangzhou Dianzi University

Network pruning has a significant role in reducing network parameters and accelerating the inference time of the network. Some existing methods prune the network based on the frequency of the data, and finally obtain a sub-network with high accuracy. However, according to our experimental analysis, different frequencies of information in the data contribute differently to the accuracy of the model, and using this information directly for pruning without making a selection will lead to incorrect results. We believe that pruning should retain the convolutional kernels in the network that process important information, while those kernels that process unimportant information should be removed. In this paper, we first investigate the meaning of each frequency band information in the spectrum and their contribution to the prediction accuracy of the network,and according to these results, we propose a new pruning method based on frequency response(PFR). Our PFR finds and removes the convolutional kernels in the network that specialize in processing unimportant information, resulting in a compact neural network model. PFR obtains significant experimental results on different datasets, for example, a 56.0% raduction of float points operations(FLOPs) on Res Net-50 and only 0.37% of Top-1 accuracy degradation on the Image Net dataset.

关键词： deep learning model compression filter pruning channel pruning frequency response

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina school of public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Iterative Factors Favoring Collaboration for Interorganizational Resilience:The Case of the Greater Montréal Transportation Infrastructure

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International Journal of Disaster Risk Science 2015年第1期6卷 75-86页

作者： Marie-Christine Therrien Stéphane Beauregard Anais Valiquette-L'Heureux National school of public administration(ENAP) University of Montréal

Between members of a network, interorganizational resilience is favored by effective collaboration and coordination during a crisis. The quality of that collaboration depends on various iterative factors present between these organizations before the occurrence of a *** find that these factors are iterative since collaboration factors follow a mutually reinforcing cycle: collaboration within a crisis management network is conditioned by a general agreement, which is in turn conditioned by the extent to which the institutions coordinate themselves prior to crisis. We evaluated the factors that promote collaboration between public and private organizations that manage the Greater Montréal transportation *** factors are based on adaptive management processes such as mutual agreements, common organizational culture, knowledge and financial resources, levers of power,regulations, and pressure. Crisis management coordination represents the ability to build and assess the effectiveness of common response plans to risks to which they are exposed. We show how these processes vary depending on the links between private and public organizations.

关键词： Adaptive management Collaborative management Interorganizational resilience Montréal Transportation infrastructure

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The Community Renewal of Shantytown Transformation in Old Industrial Cities:Evidence from Tiexi Worker Village in Shenyang,China

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Chinese Geographical Science 2020年第6期30卷 1022-1038页

作者： DONG Lijing WANG Yongchao LIN Jiayi ZHU Ermeng school of public administration Liaoning UniversityShenyang 110136China

There are many problems,such as poverty,unemployment,poor infrastructure and how to improve the ecological environment,in the shantytowns of old industrial *** are the most centralized areas with different contradictions,referred to as the‘problem areas’of urban sustainable *** shantytown transformation of old industrial cities is a typical process of unit community disintegration,which is reflected not only in the reconstruction of physical space but also in the community renewal of social spatial integration and culture *** on qualitative research,questionnaires and in-depth interviews,taking Tiexi Worker Village in Shenyang as a research case,this paper attempts to analyse the characteristics and driving forces of the community renewal of shantytown transformation in old industrial *** found that the physical space of Tiexi Worker Village has changed considerably,which is embodied in its land use structure,living environment and community service facilities,reflecting the development of community function from simple industrial function to comprehensive *** residents in this community have experienced a transformation from a period of homogeneity to one of *** social network of the community has been *** stratification,social differentiation and higher fluidity have *** renewal is mainly affected by macro factors such as policy regulation,economic driving,condition constraints,and micro factors such as residents’choice of living space and willingness to renew their *** transformation policy of the old industrial zone and the development policy of the new urban area are the fundamental and deep-seated reasons for the renewal of Tiexi Worker Village,which determine the direction of the renewal and development of the *** paid use of land and the development of the real estate industry are the direct stimulating factors for the renewal of Tiexi

关键词： old industrial city shantytown community renewal mechanism Tiexi Worker Village

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Cross-Cultural Adaptation and Validation of the 10-Item Conjoint Community Resiliency Assessment Measurement in a Community-Based Sample in Southwest China

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International Journal of Disaster Risk Science 2019年第4期10卷 439-448页

作者： Ke Cui Ziqiang Han school of public administration Sichuan UniversityChengdu 610065China Institute of Contemporary Socialism/school of Political Science and public administration Shandong UniversityQingdao 266237China

Community resilience has received growing attention in disaster risk management policies and practices,especially in ***,few applicable instruments are available as a baseline for profiling and estimating a community’s resiliency in the face of *** purpose of this study is to cross-culturally adapt and validate the original version of the 10-Item Conjoint Community Resiliency Assessment Measurement(CCRAM-10)in *** study further investigates if and to what extent community members translate their participation in disaster risk reduction(DRR)activities into perceived community resilience.A Chinese version of CCRAM-10 was generated and applied to 369 participants from a rural and an urban community in southwest China affected by the 2008 Wenchuan *** consistency reliability and confirmatory factor analyses were performed to test the assessment instrument’s *** Communities Advancing Resilience Toolkit Assessment Survey was used to establish the convergent validity for the Chinese version of *** linear regression models were used to explore the correlations between respondents’participation in activities and their perception of community resilience,while controlling for basic socio-demographic *** results demonstrated good internal consistency reliability(Cronbach’s alpha=0.85)and satisfactory convergent validity for the Chinese version of the *** validity was also confirmed(χ~2/df=2.161;CFI=0.977;GFI=0.971;NFI=0.958;RMSEA=0.056;SRMR=0.030).The regression analysis results indicated that respondents’participation in DRR activities was positively correlated with their perception of community *** study contributes to the wider collection of disaster studies by providing a tested tool for assessing community resilience in the context of *** workers and practice researchers may be interested in applying CCRAM-10 to evaluate the effect of specific DRR pro

关键词： Assessment survey CCRAM-10 China Community resilience Disaster risk management

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