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Changes in muscle strength and risk of cardiovascular disease among middle-aged and older adults in China:Evidence from a prospective cohort study

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Chinese Medical Journal 2024年第11期137卷 1343-1350页

作者： Ze Yang Jiemin Wei Hongbo Liu Honglu Zhang Ruifang Liu Naijun Tang Xueli Yang Department of Occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin Medical UniversityTianjin 300070China Center for International Collaborative Research on Environment Nutrition and Public HealthTianjin 300070China

Background:Evidence indicates that low muscle strength is associated with an increased cardiovascular diseases(CVDs)***,the association between muscle strength changes based on repeated measurements and CVD incidence remains ***:The study used data from the China health and Retirement Longitudinal Study in 2011(Wave 1),2013(Wave 2),2015(Wave 3),and 2018(Wave 4).Low muscle strength was defined as handgrip strength<28 kg for men or<18 kg for women,or chair-rising time≥12 *** on changes in muscle strength from Waves 1 to 2,participants were categorized into four groups of Normal-Normal,Low-Normal,Normal-Low,and *** events,including heart disease and stroke,were recorded using a self-reported questionnaire during Waves 3 and 4 *** proportional hazards models were used to investigate the association between muscle strength changes and CVD incidence after multivariable *** ratios(HRs)and 95%confidence intervals(95%CIs)were estimated with the Normal-Normal group as the ***:A total of 1164 CVD cases were identified among 6608 *** to participants with sustained normal muscle strength,the CVD risks increased progressively across groups of the Low-Normal(HR=1.20,95%CI:1.01-1.43),the Normal-Low(HR=1.35,95%CI:1.14-1.60),and the Low-Low(HR=1.76,95%CI:1.49-2.07).Similar patterns were observed for the significant associations between muscle strength status and the incidence risks of heart disease and *** analyses showed that the significant associations between CVD and muscle strength changes were consistent across age,sex,and body mass index(BMI)***:The study found that muscle strength changes were associated with CVD *** suggests that continuous tracking of muscle status may be helpful in screening cardiovascular risk.

关键词： Muscle strength Cardiovascular disease Prospective cohort study Aging Body mass index Sarcopenia

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Effects of forsythin extract in Forsythia leaves on intestinal microbiota and short-chain fatty acids in rats fed a high-fat diet

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Food Science and Human Wellness 2024年第2期13卷 659-667页

作者： Lanlan Gui Shaokang Wang Jing Wang Wang Liao Zitong Chen Da Pan Hui Xia Guiju Sun Su Tian Department of nutrition and Food Hygiene School of Public HealthSoutheast UniversityNanjing 210009China Nanjing Municipal Center for Disease Control and Prevention Nanjing 210003China Department of nutrition and Food Hygiene School of Public HealthHebei Medical UniversityShijiazhuang 050017China

Forsythia suspensa,belonging to the deciduous shrubs of the Luteaceae family,a traditional Chinese medicine,has effects of alleviating swelling,clearing heat,detoxification and promoting blood *** leaves of *** contain multiple chemical components and have a long history of use in folk medicines and health *** purpose of this study was to explore the effects of forsythin extract from *** leaves on intestinal microbiota and short-chain fatty acid(SCFA)content in rats with obesity induced by a high-fat *** extract in *** leaves increased the abundance of the intestinal microbiota,ameliorated intestinal microbiota disorders and inhibited the increase in total SCFA content in the intestinal tract in rats with obesity induced by a high-fat *** results suggested that forsythin extract in *** leaves may slow the development of obesity induced by a high-fat diet;thus,its active components and efficacy are worthy of further study.

关键词： Forsythin High-fat diet Intestinal microbiota Short-chain fatty acid(SCFA)

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Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly

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Food Science and Human Wellness 2024年第1期13卷 191-197页

作者： Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo Institute of nutrition&health School of Public HealthQingdao UniversityQingdao 260071China Affiliated Hospital of Qingdao University Qingdao 260071China

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained *** present study aimed to investigate the associations between the two in the Chinese ***:A community-based health check-up program was conducted in Qingdao,*** was diagnosed by ultrasonography accompanied by epidemiological *** dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by nutrition Calculator *** cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD ***:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of *** increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.

关键词： Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis

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nutritional and lipid profile status of children with spinal muscular atrophy in China:A retrospective case-control study

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Chinese Medical Journal 2024年第10期137卷 1243-1245页

作者： Yijie Feng Jia Wei Mei Yao Jianing Jin Yiqin Cui Qi Long Fei Chen Yi Hong Dongming Zhou Jingjing Hu Xiao Chen Feng Gao Changzheng Yuan Shanshan Mao Department of Neurology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Infection Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of nutrition Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China school of public health Zhejiang University School of MedicineHangzhouZhejiang 310012China Children’s Hospital School of Public HealthZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China

To the Editor:5q spinal muscular atrophy(5qSMA)is an autosomal recessive neuromuscular disorder caused by the lack of the survival motor neuron(SMN)protein encoded by the SMN1 gene,located at 5q11.2-q13.3.[1]The incidence is 1/10,000-1/6000 live births,and the mutation carrier rate in China is 1/42.[1]Spinal muscular atrophy(SMA)is mainly divided into four subtypes:SMA type I,II,III,and IV,based on the motor milestones ever *** I-III occur in children,[1]which often result in progressive muscular atrophy and weakness as well as multi-system dysfunction,including nutritional and metabolic issues.[2]Children with SMA may have hidden nutritional and lipid imbalances,despite normal body appearance and anthropometric measurements,making it difcult to detect early and intervene.

关键词： atrophy muscular children

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Association of insomnia with diet quality and eating behavior

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中华医学杂志(英文版) 2024年第16期137卷 2002-2004页

作者： Jigeer Guliyeerke Huang Zhe Zou Jiaojiao Zhu Siwei Li Yaqi Chen Shuohua Yang Qishan Sun Liang Wu Shouling Gao Xiang Department of nutrition and Food Hygiene School of Public Health Institute of Nutrition Fudan University Shanghai China Department of Cardiology Kailuan General Hospital Tangshan Hebei China Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA Key Laboratory of public health Safety of the Ministry of Education Fudan University Shanghai China

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Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment:A Global Meta-Analysis,2000-2022

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China CDC weekly 2024年第25期6卷 589-596,I0001-I0012页

作者： Heng Jiang Xing Xing He Zhu Tuo Dong school of public health Harbin Medical UniversityHarbin CityHeilongjiang ProvinceChina school of public health Peking UniversityBeijingChina

Osteoarthritis(OA)treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid ***,the clinical use of opioids is controversial due to their adverse effects and addiction *** study,drawing on 24 randomized controlled trials(RCTs)with a total of 9,586 patients,thoroughly explored the various side effects associated with opioid use in OA *** results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use,potentially fostering the advancement of safer treatment *** reducing the risks of misuse and addiction,public health and safety can be enhanced.

关键词： potential. thoroughly insight

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Epidemiological Characteristics of Fracture Among Children Aged 6-17 Years-China,2019-2021

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China CDC weekly 2024年第32期6卷 799-803,I0001页

作者： Lu Cui Qian Gan Juan Xu Peipei Xu Titi Yang Wei Cao Hongliang Wang Haoyan Guo Ruihe Luo Jianfen Zhang Hui Pan Wenhua Zhao Zhenyu Yang Yuxiang Yan Qian Zhang Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijingChina National Institute for nutrition and health Chinese Center for Disease Control and PreventionBeijingChina Key Laboratory of public nutrition and health National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Fractures are a common and serious injury among *** many studies have utilized clinical data,there is a lack of large-scale community-based research in *** is added by this report?This cross-sectional study provides national and regionally representative data on the prevalence of fractures among Chinese children aged 6–17 years(6.93%),with higher rates observed in males than in females(8.13%vs.5.71%)and in rural areas compared to urban areas(7.22%vs.6.62%).The most common site of fracture was the upper limbs(4.24%,accounting for 63.0%of fractures).What are the implications for public health practice?The need to enhance awareness of fracture prevention is critical,particularly for children in rural areas and males in middle *** recommend that local authorities increase investments in educational programs and child safety ***,promoting balanced diets for children,training in proper exercise techniques,and reinforcing participation in outdoor sports are essential.

关键词： prevention utilized children

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Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

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Journal of Environmental Sciences 2024年第1期135卷 449-473页

作者： Jianwei Zhang Zhao Chen Dan Shan Yang Wu Yue Zhao Chen Li Yue Shu Xiaoyu Linghu Baiqi Wang Department of Occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Medical Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive Medicine Education(Tianjin Medical University) Tianjin 300070China

Particulate pollution is a global risk factor that seriously threatens human *** particles(FPs)and ultrafine particles(UFPs)have small particle diameters and large specific surface areas,which can easily adsorb metals,microorganisms and other *** and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells,tissues and *** the body,the particles can induce oxidative stress,inflammatory response and apoptosis,furthermore causing great adverse *** studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing ***,the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological *** epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of *** this review,the sources,compositions,and morphologies of FPs and UFPs are briefly introduced in the first *** effects and action mechanisms of exposure to FPs and UFPs on the heart,lungs,brain,liver,spleen,kidneys,pancreas,gastrointestinal tract,joints and reproductive system are systematically *** addition,challenges are further pointed out at the end of the *** work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health.

关键词： Fine particles Ultrafine particles Organs Adverse effect

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Associations between parental adherence to healthy lifestyles and cognitive performance in offspring:A prospective cohort study in China

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Chinese Medical Journal 2024年第6期137卷 683-693页

作者： Rongxia Lv Yuhui Huang Siyi Huang Shiyi Wu Siwen Wang Guangyu Hu Yanan Ma Peige Song Jorge E.Chavarro S.V.Subramanian Chunling Lu Zhihui Li Changzheng Yuan school of public health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Department of nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Institute of Medical Information/Center for health Policy and Management Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Biostatistics and Epidemiology School of Public HealthChina Medical UniversityShenyangLiaoning 110122China Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMA 02115USA Division of Global health Equity Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Global health and Social Medicine Harvard Medical SchoolBostonMA 02115USA Vanke school of public health Tsinghua UniversityBeijing 100084China Department of Global health and Population Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Background:Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early *** study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in ***:We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies.A healthy parental lifestyle score(ranged 0-5)was constructed based on the following five modifiable lifestyle factors:Smoking,drinking,exercise,sleep,and *** estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years(2012,2014,2016,and 2018).Results:Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence(multivariable-adjusted β=0.53,95%confidence interval[CI]:0.29-0.77)and overall crystallized intelligence(multivariable-adjusted β=0.35,95%CI:0.16-0.54)than those in the bottom tertile of parental healthy lifestyle *** results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic ***,maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance,with significant contribution observed for paternal never-smoking,weekly exercise,and diversified *** both parents and offspring adhered to a healthier lifestyle,we observed the highest level of the offspring’s overall crystallized ***:Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood,regardless of socioeconomic *** findings highlight the poten

关键词： Cohort study Parental healthy lifestyle Offspring Cognitive performance Intelligence Adolescence

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Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

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Food Science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang Department of nutrition and Food Hygiene School of public healthQingdao UniversityQingdao 266071China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic *** model ApoE^(-/-)mice were orally administered with *** F1-7 for 12 *** probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory *** widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after *** F1-7 *** analysis proved that ALC was associated with atherosclerotic inflammatory *** using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB ***,our results revealed that *** F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

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