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Rapid Health Technology Evaluation of Off-label Use of Magnesium Isoglycyrrhizinate Injection

Asian Journal of Social Pharmacy 2025年第1期20卷 80-87页

作者： Yao Lan Li Lin Tian Lijuan school of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To evaluate the preventive drug use of magnesium isoglycyrrhizinate injection beyond the instructions by rapid health technology,and to provide reference for its rational clinical *** The databases such as PubMed,Embase,the Cochrane Library,HowNet,Wanfang,VIP and HTA websites were *** researchers screened the literature to extract data according to the inclusion and exclusion *** necessary,a third researcher was *** included literature was analyzed and concluded through corresponding quality *** and Conclusion Four meta-analysis articles and five pharmacoeconomics articles were *** terms of effectiveness,compared with the blank group and the control group(diammonium glycyrrhizinate,glutathione,and polyene phosphatidylcholine),the preventive use of magnesium isoglycyrrhizinate injection had a lower incidence of drug-induced liver injury with a more significant reduction in the levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and total *** terms of safety,except for an economic study in which some patients had a transient increase in blood pressure during the use of magnesium isoglycyrrhizinate injection,other studies did not show the increasing risk of adverse reactions due to preventive *** terms of economy,the use of magnesium isoglycyrrhizinate injection for prevention of different diseases did not necessarily have economic advantages over the control group(blank group and reduced glutathione,polyene phosphatidylcholine injection,traditional Chinese medicine combined with magnesium isoglycyrrhizinate injection).In the prevention of drug induced liver injury,magnesium isoglycyrrhizinate injection used beyond the instructions has certain efficacy and safety,but it may not be the economic optimal for other different diseases.

关键词： magnesium isoglycyrrhizinate preventive medication rapid health technology assessment

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Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment

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Traditional Medicine Research 2025年第3期10卷 56-74页

作者： Li-Yan Yang Shi-Zeng Lei Wen-Jing Xu Yu-Xin Lai Ying-Ying Zhang Ying Wang Zhong-Lei Wang school of Physics and Physical engineering Qufu Normal UniversityQufu 273165China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Green Natural Products and pharmaceutical Intermediates in Colleges and Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China school of pharmaceutical Sciences Key Laboratory of Bioorganic PhosphorusChemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China

Tumors,due to their diversity and heterogeneity,pose a significant threat to human *** resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer *** resistance renders conventional drug therapies ineffective,presenting a substantial challenge to human health and medical *** natural products as potential sources for anti-cancer drugs could lead to the development of innovative and efficacious cancer *** article aims to investigate the health implications of natural products(such as paclitaxel,podophyllotoxin,homoharringtonine,camptothecin,and vinblastine)in the discovery of anti-cancer drugs while discussing the methods and progress made in researching novel anti-cancer drugs derived from natural *** paper discusses the diversity,intricate structures,and target affinity of natural products along with their structural modification techniques,combination therapies utilization possibilities with prodrugs or ***,considering the escalating multidrug resistance observed in tumors nowadays;certain natural products offer new insights and approaches for discovering effective anti-tumor drugs that are crucial for addressing global public health *** challenges faced by natural products during drug development including issues related to bioavailability toxicity concerns as well as limited resources are examined *** opportunities current issues along with future challenges are highlighted aiming at facilitating the clinical translation of original anti-cancer drugs using natural products.

关键词： tumors multidrug resistance natural products camptothecin future challenges

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Finger tracking for wearable VR glove using flexible rack mechanism

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虚拟现实与智能硬件(中英文) 2025年第01期7卷 1-25页

作者： Roshan THILAKARATHNA Maroay PHLERNJAI school of Manufacturing Systems and Mechanical engineering Sirindhorn International Institute of TechnologyThammasat University

Background With the increasing prominence of hand and finger motion tracking in virtual reality(VR) applications and rehabilitation studies, data gloves have emerged as a prevalent solution. In this study, we developed an innovative, lightweight, and detachable data glove tailored for finger motion tracking in VR environments. Methods The glove design incorporates a potentiometer coupled with a flexible rack and pinion gear system, facilitating precise and natural hand gestures for interaction with VR applications. Initially, we calibrated the potentiometer to align with the actual finger bending angle, and verified the accuracy of angle measurements recorded by the data glove. To verify the precision and reliability of our data glove, we conducted repeatability testing for flexion(grip test) and extension(flat test), with 250 measurements each, across five users. We employed the Gage Repeatability and Reproducibility to analyze and interpret the repeatable data. Furthermore, we integrated the gloves into a Steam VR home environment using the Open Glove auto-calibration tool. Conclusions The repeatability analysis revealed an aggregate error of 1.45 degrees in both the gripped and flat hand positions. This outcome was notably favorable when compared with the findings from assessments of nine alternative data gloves that employed similar protocols. In these experiments, users navigated and engaged with virtual objects, underlining the glove's exact tracking of finger motion. Furthermore, the proposed data glove exhibited a low response time of 17–34 ms and back-drive force of only 0.19 N. Additionally, according to a comfort evaluation using the Comfort Rating Scales, the proposed glove system is wearable, placing it at the WL1 level.

关键词： Finger tracking Virtual reality Data glove Hand gesture Rack and pinion

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu Tissue engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin school of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Narasaka reaction:Desilylative acylation of 1-alkenylsilanes with acid anhydrides

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Chinese Chemical Letters 2021年第9期32卷 2751-2755页

作者： Wei Xiao Jie Wu school of pharmaceutical and Materials engineering&institute for advanced studies Taizhou UniversityTaizhou 318000China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China school of Chemistry and Chemical engineering Henan Normal UniversityXinxiang 453007China

Recent advances in the desilylative acylation of 1-alkenylsilanes with acid anhydrides under transition metal catalysis are *** catalytic desilylative acylation of 1-alkenylsilanes provides an efficient route toα,β-unsaturated ketones by using rhodium or iridium as the ***,various one pot sequence reactions have been developed,which can synthesizeα,β-unsaturated ketones from simple starting materials in an economic ***,this approach is applied to the asymmetric synthesis of atropisomers possessing silanol groups with excellent enantioselectivity.

关键词： Acid anhydride 1-Alkenylsilane Desilylative acylation Transition metal catalysis α,β-Unsaturated ketone

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SO_(2)-Insertion induced enantioselective oxysulfonylation to access β-chiral sulfones with quaternary carbon stereocenters

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Science China Chemistry 2024年第3期67卷 908-913页

作者： Jun Zhang Xuefeng Wang Peiqi Wang Jiayuan Fang Shaoyu Li Jie Wu school of pharmaceutical and Chemical engineering&institute for advanced studies Taizhou UniversityShanghai 200438China Department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China school of Chemistry and Chemical engineering Henan Normal UniversityXinxiang 453007China

β-Chiral sulfones are structural motifs widely found in natural products and bioactive molecules, while also serving as important intermediates for the synthesis of valuable chiral scaffolds. In contrast to the rapid growth of sulfur dioxide insertion chemistry over the last decade, enantioselective catalytic variants for accessing β-chiral sulfones, especially those bearing a quaternary carbon stereocenter, remain rare. Herein, we report an enantioselective copper/bisoxazoline catalyzed oxysulfonylation of alkenes to yield isoxazolinyl-containing β-chiral sulfones bearing quaternary carbon stereocenters with moderate to excellent yields and up to 96:4 er. The advantage and irreplaceability of this sulfur dioxide insertion catalytic system have been demonstrated by achieving transformations clearly unavailable with the previously reported sulfonyl chloride system. Additionally,the recoverability of the new-developed bisoxazoline ligand L9 and its reusability without any erosion of the catalytic activity and enantioselectivity further demonstrate the usefulness of the protocol.

关键词： β-chiral sulfones sulfur dioxide insertion oxysulfonylation copper catalysis enantioselectivity

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Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling

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Chinese Journal of Natural Medicines 2025年第1期23卷 90-101页

作者： Yongxian Li Jinbo Yuan Wei Deng Haishan Li Yuewei Lin Jiamin Yang Kai Chen Heng Qiu Ziyi Wang Vincent Kuek Dongping Wang Zhen Zhang Bin Mai Yang Shao Pan Kang Qiuli Qin Jinglan Li Huizhi Guo Yanhuai Ma Danqing Guo Guoye Mo Yijing Fang Renxiang Tan Chenguang Zhan Teng Liu Guoning Gu Kai Yuan Yongchao Tang De Liang Liangliang Xu Jiake Xu Shuncong Zhang The First Clinical Academy Guangzhou University of Chinese Medicine The First Affiliated Hospital of Guangzhou University of Chinese Medicine Lingnan Medical Research Center of Guangzhou University of Chinese Medicine school of Biomedical Sciences University of Western Australia Curtin Medical school Curtin University Foshan Hospital of Traditional Chinese Medicine school of Public Health and Management Guangzhou University of Chinese Medicine The State Key Laboratory of pharmaceutical Biotechnology Institute of Functional Biomolecules Nanjing University

Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength, leading to increased fragility. Buqi-Tongluo(BQTL) decoction, a traditional Chinese medicine(TCM) prescription, has yet to be fully evaluated for its potential in treating bone diseases such as osteoporosis. To investigate the mechanism by which BQTL decoction inhibits osteoclast differentiation in vitro and validate these findings through in vivo *** employed MTS assays to assess the potential proliferative or toxic effects of BQTL on bone marrow macrophages(BMMs) at various concentrations. TRAc P experiments were conducted to examine BQTL's impact on osteoclast differentiation. RT-PCR and Western blot analyses were utilized to evaluate the relative expression levels of osteoclast-specific genes and proteins under BQTL stimulation. Finally, in vivo experiments were performed using an osteoporosis model to further validate the in vitro findings. This study revealed that BQTL suppressed receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis and osteoclast resorption activity in vitro in a dose-dependent manner without observable *** inhibitory effects of BQTL on osteoclast formation and function were attributed to the downregulation of NFATc1 and c-fos activity, primarily through attenuation of the MAPK, NF-κB, and Calcineurin signaling pathways. BQTL's inhibitory capacity was further examined in vivo using an ovariectomized(OVX) rat model, demonstrating a strong protective effect against bone loss. BQTL may serve as an effective therapeutic TCM for the treatment of postmenopausal osteoporosis and the alleviation of bone loss induced by estrogen deficiency and related conditions.

关键词： Buqi-Tongluo Estrogen deficiency MAPK NF-κB NFATc1 Osteoclast Osteoporosis

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Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety

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Nano Research 2025年第1期18卷 572-585页

作者： Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China school of Chemical engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

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Recent advances in the applications of[1.1.1]propellane in organic synthesis

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Chinese Chemical Letters 2020年第12期31卷 3065-3072页

作者： Fu-Sheng He Shimin Xie Yanfang Yao Jie Wu school of pharmaceutical and Materials engineering&institute for advanced studies Taizhou UniversityTaizhou 318000China College of Chemistry Xiangtan UniversityXiangtan 411105China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

As a highly strained small molecule,[1.1.1]propellane has been widely used in various synthetic transformations owing to the exceptional reactivity of the central bond between the two bridgehead *** strain-release approaches,the rapid development of strategies for the construction of bicyclo[1.1.1]pentane(BCP)and cyclobutane derivatives using[1.1.1]propellane as the starting material has been witnessed in the past few *** this review,we highlight the most recent advances in this ***,the reactivity of[1.1.1]p ropellane can be divided into three pathways,including radical,anionic and transition metal-catalyzed pathways under appropriate conditions.

关键词： [1.1.1]Propellane Bicyclo[1.1.1]pentane Cyclobutane Radical Transition metal catalysis Photocatalyst

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Recent progress on surface chemistryⅡ:Property and characterization

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Chinese Chemical Letters 2025年第1期36卷 8-57页

作者： Xin Li Zhen Xu Donglei Bu Jinming Cai Huamei Chen Qi Chen Ting Chen Fang Cheng Lifeng Chi Wenjie Dong Zhenchao Dong Shixuan Du Qitang Fan Xing Fan Qiang Fu Song Gao Jing Guo Weijun Guo Yang He Shimin Hou Ying Jiang Huihui Kong Baojun Li Dengyuan Li Jie Li Qing Li Ruoning Li Shuying Li Yuxuan Lin Mengxi Liu Peinian Liu Yanyan Liu Jingtao Lü Chuanxu Ma Haoyang Pan JinLiang Pan Minghu Pan Xiaohui Qiu Ziyong Shen Qiang Sun Shijing Tan Bing Wang Dong Wang Li Wang Lili Wang Tao Wang Xiang Wang Xingyue Wang Xueyan Wang Yansong Wang Yu Wang Kai Wu Wei Xu Na Xue Linghao Yan Fan Yang Zhiyong Yang Chi Zhang Xue Zhang Yang Zhang Yao Zhang Xiong Zhou Junfa Zhu Yajie Zhang Feixue Gao Yongfeng Wang Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China Spin-X institute School of MicroelectronicsSouth China University of TechnologyGuangzhou 511442China school of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006China Faculty of Materials Science and engineering Kunming University of Science and TechnologyKunming 650093China i-Lab CAS Key Laboratory of Nanophotonic Materials and DevicesSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Hefei National Research Center for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China institute of Physics&University of Chinese Academy of Sciences Beijing 100190China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry Beijing Normal UniversityBeijing 100875China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China school

Surface with well-defined components and structures possesses unique electronic,magnetic,optical and chemical *** a result,surface chemistry research plays a crucial role in various fields such as catalysis,energy,materials,quantum,and *** science mainly investigates the correspondence between surface property and *** probe microscopy(SPM)techniques are important tools to characterize surface properties because of the capability of atomic-scale imaging,spectroscopy and manipulation at the single-atom *** this review,we summarize recent advances in surface electronic,magnetic and optical properties characterized mainly by SPM-based *** focus on elucidating theπ-magnetism in graphene-based nanostructures,construction of spin qubits on surfaces,topology properties of surface organic structures,STM-based light emission,tip-enhanced Raman spectroscopy and integration of machine learning in SPM studies.

关键词： Surface chemistry Scanning probe microscopy π-Magnetism Spin qubits Tip-enhanced Raman spectroscopy

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