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STING signaling in islet macrophages impairs insulin secretion in obesity

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Science China(Life sciences) 2024年第2期67卷 345-359页

作者： Ze Hong Saihua Chen Jing Sun Dan Cheng Hanli Guo Jiahao Mei Xiang Zhang Munire Maimaiti Haiping Hao Peng Cao Haiyang Hu Chen Wang school of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of natural Medicines Department of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China school of Life sciences Westlake UniversityHangzhou 310012China

The innate immune regulator stimulator of interferon genes(STING)mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines,which promotes the progression of various inflammatory and autoimmune *** immune system plays a critical role in regulating obesity-induced islet dysfunction,whereas the potential effect of STING signaling is not fully ***,we demonstrate that STING is mainly expressed and activated in islet macrophages upon high-fat diet(HFD)***^(-/-)alleviates HFD-induced islet inflammation by inhibiting the expression of pro-inflammatory cytokines and the infiltration of ***,palmitic acid incubation promotes mitochondrial DNA leakage into the cytosol and subsequently activates STING pathway in ***,STING activation in macrophages impairs glucose-stimulated insulin secretion by mediating the engulfment ofβcell insulin secretory *** inhibiting STING activation enhances insulin secretion to control ***,our results reveal a regulatory mechanism in controlling the islet inflammation and insulin secretion in dietinduced obesity and suggest that selective blocking of the STING activation may be a promising strategy for treating type 2 diabetes.

关键词： STING obesity type 2 diabetes insulin macrophages islet

Exploring the influence of optical and thermal parameters on the effectiveness of parabolic trough collector receiver units

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Clean Energy 2024年第4期8卷 15-33页

作者： Khaled Mohamad Engineering and natural sciences Faculty SDU UniversityAlmatyKazakhstan

This study investigates the optimization of physical parameters in a parabolic trough collector receiver unit to improve its thermal and optical *** parameters include the transmissivity,reflectivity,absorptivity,emissivity and thermal conductivity of the outer cover and absorber *** study utilizes a novel experimental design and a simulation model that accounts for the infrared reflectivity inside the *** simulation results were validated by the experimental data,with a maximum deviation of 8%.The study analyses the effects of varying the physical parameters on the heat transfer fluid temperature,total plant efficiency,temperature profiles,temperature gradients and thermal *** study finds that increasing the reflectivity and decreasing the emissivity of the outer cover and the absorber pipe significantly enhance the performance,with maximum increases of 25.8%and 26.5%in total efficiency,*** study also finds that increasing the thermal conductivity of the absorber pipe reduces the temperature gradients and thermal stress,with maximum decreases of 42.2%and 29%,*** study provides valuable insights for optimizing the receiver design and operation in solar-thermal systems.

关键词： parabolic trough collector heat transfer fluid receiver unit outer cover absorber pipe

Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease

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Journal of Pharmaceutical Analysis 2024年第4期14卷 552-561页

作者： Panpan Chen Zihan Zhu Haoyuan Geng Xiaoqing Cui Yuhao Han Lei Wang Yaqi Zhang Heng Lu Xiao Wang Yun Zhang Chenglong Sun Key Laboratory for natural Active Pharmaceutical Constituents Research in Universities of Shandong Province School of Pharmaceutical SciencesQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Key Laboratory for Applied technology of Sophisticated Analytical Instruments of Shandong Province Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China school of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan250103China

Eclipta prostrata *** been used in traditional medicine and known for its liver-protective properties for ***(WEL)and demethylwedelolactone(DWEL)are the major coumarins found in *** ***,the comprehensive characterization of these two compounds on non-alcoholic fatty liver disease(NAFLD)still remains to be *** a well-established zebrafish model of thioacetamide(TAA)-induced liver injury,the present study sought to investigate the impacts and mechanisms of WEL and DWEL on NAFLD through integrative spatial metabolomics with liver-specific transcriptomics *** results showed that WEL and DWEL significantly improved liver function and reduced the accumulation of fat in the *** biodistributions and metabolism of these two compounds in whole-body zebrafish were successfully mapped,and the discriminatory endogenous metabolites reversely regulated by WEL and DWEL treatments were also *** on spatial metabolomics and transcriptomics,we identified that steroid biosynthesis and fatty acid metabolism are mainly involved in the hepatoprotective effects of WEL instead of *** study unveils the distinct mechanism of WEL and DWEL in ameliorating NAFLD,and presents a“multi-omics”platform of spatial metabolomics and liver-specific transcriptomics to develop highly effective compounds for further improved therapy.

关键词： Spatial metabolomics Transcriptomics Non-alcoholic fatty liver disease Wedelolactone Demethylwedelolactone

Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria Younes Ghady Loubnane Christopher Sleiman Sandra Rizk Department of natural sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

A Systematic Literature Review of Machine Learning and Deep Learning Approaches for Spectral Image Classification in Agricultural Applications Using Aerial Photography

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Computers, Materials & Continua 2024年第3期78卷 2967-3000页

作者： Usman Khan Muhammad Khalid Khan Muhammad Ayub Latif Muhammad Naveed Muhammad Mansoor Alam Salman A.Khan Mazliham Mohd Su’ud College of Computing and Information sciences Karachi Institute of Economics and TechnologyKarachi75190Pakistan Faculty of Computing and Informatics(FCI) Multimedia UniversityCyberjaya63100Malaysia Faculty of Computing Riphah International UniversityIslamabad46000Pakistan Faculty of Engineering and Information technology School of Computer ScienceUniversity of Technology SydneySydneyAustralia

Recently,there has been a notable surge of interest in scientific research regarding spectral *** potential of these images to revolutionize the digital photography industry,like aerial photography through Unmanned Aerial Vehicles(UAVs),has captured considerable *** encouraging aspect is their combination with machine learning and deep learning algorithms,which have demonstrated remarkable outcomes in image *** a result of this powerful amalgamation,the adoption of spectral images has experienced exponential growth across various domains,with agriculture being one of the prominent *** paper presents an extensive survey encompassing multispectral and hyperspectral images,focusing on their applications for classification challenges in diverse agricultural areas,including plants,grains,fruits,and *** meticulously examining primary studies,we delve into the specific agricultural domains where multispectral and hyperspectral images have found practical ***,our attention is directed towards utilizing machine learning techniques for effectively classifying hyperspectral images within the agricultural *** findings of our investigation reveal that deep learning and support vector machines have emerged as widely employed methods for hyperspectral image classification in ***,we also shed light on the various issues and limitations of working with spectral *** comprehensive analysis aims to provide valuable insights into the current state of spectral imaging in agriculture and its potential for future advancements.

关键词： Machine learning deep learning unmanned aerial vehicles multi-spectral images image recognition object detection hyperspectral images aerial photography

Energy Absorption by 3D-Printed Mesh Structures with a Negative Poisson’s Ratio

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 205-212页

作者： Wenyu Li Weiming Yang Mingze Li Xiang Zhang Ping Zhang Yucheng Zhao Peijian Chen Haishun Liu school of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou221116China school of Materials sciences and Physics China University of Mining and TechnologyXuzhou221116China

A negative Poisson's ratio(NPR)structure represents optimal impact-resistance with applications in various fields,including the crash box in vehicles,which absorbs impact kinetic *** crash box is designed to deform in response to impact,increasing local structural density,which enhances impact resistance *** studies have only focused on the NPR effect in the plane dimension at low-speed *** studies have considered high-speed impact loads on three-dimensional NPR *** have developed two types of AlSi10Mg alloy energy-absorbing structures with NPR using three-dimensional printing technology,and have compared our systems with a conventional hexagonal mesh *** testing involved split-Hopkinson pressure bar measurements,which showed good agreement with dynamic numerical *** subjected to an impact load,the NPR structure exhibited better impact resistance and energy absorption compared with the positive Poisson's ratio *** proposed dual-layer hexagonal structure ensures an NPR effect while exhibiting higher strength and improved stability relative to the conventional concave hexagon structure.

关键词： Negative Poisson’s ratio Energy absorption 3D printing Split-Hopkinson pressure bar Numerical simulation

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating Link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei LIN school of Mathematical sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

FROM WAVE FUNCTIONS TO TAU-FUNCTIONS FOR THE VOLTERRA LATTICE HIERARCHY

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Acta Mathematica Scientia 2024年第2期44卷 405-419页

作者：付昂李明金杨迪 school of Mathematical sciences University of Science and Technology of ChinaHefei230026China

For an arbitrary solution to the Volterra lattice hierarchy,the logarithmic derivatives of the tau-function of the solution can be computed by the matrix-resolvent *** this paper,we define a pair of wave functions of the solution and use them to give an expression of the matrix resolvent;based on this we obtain a new formula for the k-point functions for the Volterra lattice hierarchy in terms of wave *** an application,we give an explicit formula of k-point functions for the even GUE(Gaussian Unitary Ensemble)correlators.

关键词： volterra lattice hierarchy matrix-resolvent method wave functions even GUE correlators

ALTERNATING OPTIMIZATION METHOD FOR ISOGEOMETRIC TOPOLOGY OPTIMIZATION WITH STRESS CONSTRAINTS

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Journal of Computational Mathematics 2024年第1期42卷 134-155页

作者： Xiaoya Zhai school of Mathematical sciences University of Science and Technology of ChinaHefei 230071China

Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient computation, iterative oscillation, and convergence guarantee problems. At the same time, isogeometric analysis (IGA) is accepted by more and more researchers, and it has become one important tool in the field of topology optimization because of its high fidelity. In this paper, we focus on topology optimization with stress constraints based on isogeometric analysis to improve computation efficiency and stability. A new hybrid solver combining the alternating direction method of multipliers and the method of moving asymptotes (ADMM-MMA) is proposed to solve this problem. We first generate an initial feasible point by alternating direction method of multipliers (ADMM) in virtue of the rapid initial descent property. After that, we adopt the method of moving asymptotes (MMA) to get the final results. Several benchmark examples are used to verify the proposed method, and the results show its feasibility and effectiveness.

关键词： Isogeometric topology optimization Stress constraints The ADMM-MMA solver