检索结果-南通市图书馆

Progress in approved drugs from natural product resources

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of natural Medicines 2024年第3期22卷 195-211页

作者： LUO Zhongwen YIN Fucheng WANG Xiaobing KONG Lingyi State Key Laboratory of natural Medicines and Jiangsu Key Laboratory of Bioactive natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impactson the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs orindirectly through modifications of NPs. This review presents an overview of NP drugs recently approved in China, the United States,and other countries, spanning various disease categories, including cancers, cardiovascular and cerebrovascular diseases, centralnervous system disorders, and infectious diseases. The article provides a succinct introduction to the origin, activity, development process, approval details, and mechanism of action of these NP drugs.

关键词： New drugs natural products Structural modification

Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2039-2056页

作者： Pei Yu Yubao Han Lulu Meng Yanyuan Tian Zhiwei Jin Jun Luo Chao Han Wenjun Xu Lingyi Kong Chao Zhang State Key Laboratory of natural Medicines Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Osteosarcoma,a prevalent primary malignant bone tumor,often presents with lung metastases,severely impacting patient survival *** vesicles,particularly exosomes,play a pivotal role in the formation and progression of osteosarcoma-related pulmonary ***,the communication between primary osteosarcoma and exosome-mediated pulmonary lesions remains obscure,with the potential impact of pulmonary metastatic foci on osteosarcoma progression largely *** study unveils an innovative mechanism by which exosomes originating from osteosarcoma pulmonary metastatic sites transport the miR-194/215 cluster to the primary tumor *** transportation enhances lung metastatic capability by downregulating myristoylated alanine-rich C-kinase substrate(MARCKS)*** this phenomenon,in this study we employ cationic bovine serum albumin(CBSA)to form nanoparticles(CBSA-anta-194/215)via electrostatic interaction with antagomir-miR-194/*** nanoparticles are loaded into nucleic acid-depleted exosomal membrane vesicles(anta-194/215@Exo)targeting osteosarcoma lung metastatic *** with bioengineered exosome mimetics(anta-194/215@Exo)not only impedes osteosarcoma progression but also significantly prolongs the lifespan of tumor-bearing *** findings suggest that pulmonary metastatic foci-derived exosomes initiate primary osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS,making the miR-194/215 cluster a promising therapeutic target for inhibiting the progression of patients with osteosarcoma lung metastases.

关键词： Lung–bone transmission miR-194/215 cluster Exosome Lung metastasis Epithelial–mesenchymal transition Vasculogenic mimicry Bioengineered exosome mimetics Osteosarcoma

Effects of Different Concentrations of Sulfate Ions on Carbonate Crude Oil Desorption:Experimental Analysis and Molecular Simulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第8期20卷 1731-1741页

作者： Nannan Liu Hengchen Qi Hui Xu Yanfeng He school of Petroleum and natural Gas Engineering Changzhou UniversityChangzhou213164China

Low salinity water containing sulfate ions can significantly alter the surface wettability of carbonate ***,the impact of sulfate concentration on the desorption of oil film on the surface of carbonate rock is still *** study examines the variations in the wettability of the surface of carbonate rocks in solutions containing varying amounts of sodium sulfate and pure *** problem is addressed in the framework of molecular dynamics simulation(Material Studio software)and *** experiment’s findings demonstrate that sodium sulfate can increase the rate at which oil moisture is turned into water *** final contact angle is smaller than that of pure *** results of the simulations show that many water molecules travel down the water channel under the influence of several powerful forces,including the electrostatic force,the van der Waals force and hydrogen bond,crowding out the oil molecules on the calcite’s surface and causing the oil film to *** relative concentration curve of water and oil molecules indicates that the separation rate of the oil film on the surface of calcite increases with the number of sulfate ions.

关键词： Carbonate rocks wettability sulfate ions concentration molecular simulation desorption

Centennial Analysis of Human Activity Intensity and Associated Historical Events in Heilongjiang River Sino-Russo Watershed

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2024年第2期34卷 280-293页

作者： SONG Chaoxue LI Xiaoling HE Hongshi Michael SUNDE school of Geographical Sciences Northeast Normal UniversityChangchun 130024China school of natural Resources University of MissouriColumbia 65211USA

Human activities in a transborder watershed are complex under the influence of domestic policies,international relations,and global *** the forces driving human activity change is important for the development of transborder *** this study,we used global historical land cover data,the hemeroby index model,and synthesized major historical events to analyze how human activity intensity changed in the Heilongjiang River(Amur River in Russia)watershed(HLRW).The results showed that there was a strong spatial heterogeneity in the variation of human activity intensity in the HLRW over the past century(1900-2016).On the Chinese side,the human activity intensity change shifted from the plain areas for agricultural reclamation to the mountainous areas for timber *** the Russian side,human activity intensity changes mostly concentrated along the Trans-Siberian Railway and the Baikal-Amur *** variation of human activity intensity tended to respond to regional events while regionalized variation tends to reflect national policy change or broad international *** similarities and differences between China and Russia in policies and positions in international events resulted in synchronous and asynchronous changes in human activity ***,policy shifts were often confined by the natural features of the *** results reveal the historical origins and fundamental connotations of watershed development and contribute to formulating regional management policies that coordinate population,eco-nomic,social,and environmental activities.

关键词： human activity intensity changes hemeroby index centennial scale Heilongjiang River(Amur River in Russia)watershed China Russia

Phenylhydrazone anions excitation for the photochemical carbonylation of aryl iodides with aldehydes

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第4期35卷 346-351页

作者： Lei Shen Yang Zhang Linlin Zhang Chuanwang Liu Zhixian Ma Kangjiang Liang Chengfeng Xia Key Laboratory of Medicinal Chemistry for natural Resource Ministry of EducationYunnan Provincial Center for Research&Development of Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Spectroscopic investigations discovered that the in-situ generated phenylhydrazone anion was significantly bathochromically shifted to visible light region for photoactivation under irradiation. The photoexcited phenylhydrazone anion was potential to reduce aryl iodides via single electron transfer process for the subsequent radical chain reaction. A redox-neutral photochemical carbonylation of aryl iodides was developed on basis of the special spectroscopic features of phenylhydrazone anion. This protocol provided a convenient and efficient synthetic tool for accessing carbonylation products under redox neutral conditions without the need of transition-metals.

关键词： Organic anion Hydrazone Carbonylation Visible light Single electron transfer

Exploration of chromene-based BioAIEgens

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 47-48页

作者： Fritz E.Kühn Department of Chemistry&Catalysis Research Center School of Natural Sciences Technical University of Munich

Photoemission efficiency is usually higher in solution than in solid *** compounds however, display a reverse behavior. Such a behavior is called aggregation-induced emission(AIE).

关键词：

Participatory Risk Governance for Seoul, South Korea's Flood Risk Management

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2024年第3期15卷 317-331页

作者： Bokjin Ro Gregg Garfin school of Geography Development and Environment The University of Arizona Interdisciplinary Program for Disaster Crisis and Risk Management Sungkyunkwan University school of natural Resources and the Environment The University of Arizona

Risk governance is a widely used framework in natural and societal risk management research. Risks from natural hazards in urban areas call for the establishment of rigorous and participatory urban risk governance. In this study, we examined participatory risk governance(PRG) of flood risk management(FRM) in Seoul, South Korea. We conducted key informant interviews and implemented a survey with citizens, to explore perceptions of flood risks and risk management, and to examine prospects for improving PRG in Seoul. We found a gap between the perceptions of key informants and *** informants believed that citizens' low awareness of flood risks hinders PRG. Yet our research found that citizens' risk awareness was not low, and risk awareness may not be the main barrier to participation in PRG. Instead, we found that citizens lacked knowledge of FRM actions, and they assigned government bodies a high level of responsibility for FRM,compared to the level of responsibility that citizens assigned to themselves. Moreover, the actors involved in FRM tended not to trust each other, which implies a lack of mutual understanding. To increase the eff ectiveness of PRG, we suggest a polycentric governance structure anchored by a leading actor group, and active promotion of the participation of actors at multiple levels of governance. Communication between government and citizen participants, designed to foster improved understanding and recognition of one another's roles and contributions to FRM, will enhance trust and improve the implementation of PRG in Seoul.

关键词： Citizen participation Flood risk management Participatory risk governance Risk awareness South Korea Urban flood risk

Experimental Study on the Variation of Optical Imaging Characteristics with Zenith Angle due to Internal Solitary Waves in Sunglint

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2024年第4期23卷 943-952页

作者： LIU Tengfei SUN Lina CHANG Zhe ZHANG Meng LIANG Keda MENG Junmin WANG Jing school of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Internal solitary waves(ISWs)change the roughness of the sea surface,thus producing dark and bright bands in optical ***,reasons for changes in imaging characteristics with the solar zenith angle remain *** this paper,the optical imaging pattern of ISWs in sunglint under different zenith angles of the light source is investigated by collecting optical images of ISWs through physical *** experiment involves setting 10 zenith angles of the light source,which are divided into area a the optical images of ISWs in the three areas show dark-bright mode,single bright band,and bright-dark mode,which are consistent with those observed by optical remote *** addition,this study analyzed the percentage of the dark and bright areas of the bands and the change in the relative gray difference and found changes in both areas under different zenith angles of the light *** MODIS and ASAR images display a similar brightness-darkness distance of the same ***,the relationship between the brightness-darkness distance and the characteristic half-width of ISWs is determined in accordance with the eKdV theory and the imaging mechanism of ISWs of the SAR ***,the relationship between them in the experiment is almost consistent with the theoretical result.

关键词： internal solitary waves optical imaging characteristic laboratory simulation zenith angle sunglint

Experimental study on the variation of optical remote sensing imaging characteristics of internal solitary waves with wind speed

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第2期42卷 408-420页

作者： Zhe CHANG Lina SUN Tengfei LIU Meng ZHANG Keda LIANG Junmin MENG Jing WANG school of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Optical remote sensing has been widely used to study internal solitary waves(ISWs).Wind speed has an important effect on ISW imaging of optical remote *** light and dark bands of ISWs cannot be observed by optical remote sensing when the wind is too *** relationship between the characteristics of ISWs bands in optical remote sensing images and the wind speed is still *** influence of wind speeds on the characteristics of the ISWs bands is investigated based on the physical simulation experiments with the wind speeds of 1.6,3.1,3.5,3.8,and 3.9 m/*** experimental results show that when the wind speed is 3.9 m/s,the ISWs bands cannot be observed in optical remote sensing images with the stratification of h_(1)∶h_(2)=7∶58,ρ_(1)∶ρ_(2)=1∶*** the wind speeds are 3.1,3.5,and 3.8 m/s,which is lower than 3.9 m/s,the ISWs bands can be obtained in the simulated optical remote sensing *** location of the band’s dark and light extremum and the band’s peak-to-peak spacing are almost not affected by wind ***-significant wind speeds can cause a greater gray difference of the light-dark *** provided a scientific basis for further understanding of ISW optical remote sensing imaging.

关键词： internal solitary wave(ISW) optical remote sensing wind speed characteristics of ISWs bands