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Chinese medical Sciences Journal 2024年第2期39卷 140-143页

作者： Pu-An Cui Zhe-Xi Gong Zhong He school of humanities and Social Sciences Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China

Since the early 20th century,China has gradually established a clinical,educational,and research system centered around modern scientific medicine,which has now become the dominant force in China's medical and health system and services,with the construction and development of the Chinese Academy of medical Sciences and Peking Union medical College as the most prominent *** scientific medicine in the new era requires close cooperation across multiple disciplines and fields to build a high-quality and efficient medical and health service *** also involves combining the excellent traditional Chinese culture with Western medicine to explore a unique path of modern scientific medicine with Chinese characteristics.

关键词： modern scientific medicine cultural confidence multiple view

Public transport inclusion and active aging: A systematic review on elderly mobility

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 312-347页

作者： Na Zhang Qi Yang school of humanities Chang'an UniversityXi'an 710064China school of Transportation Engineering Chang'an UniversityXi'an 710064China school of Economics and Management Chang'an UniversityXi'an 710064China

Global aging has brought attention to addressing the elderly mobility dilemma,and a commitment to address inclusive transport in *** inclusion for older adults aims at establishing an age-friendly transport *** a direct policy goal and promoting active aging as an indirect social goal,to help older populations gain access to transport and social *** on the analysis of scientific knowledge mapping over the past 30 years,this study visualizes the hotspots and trends in elderly mobility *** a qualitative analysis of 138 papers,this paper reviews the theoretical foundations for transport inclusion and three themes of elderly mobility research,proposes a framework for public transport(PT)inclusion research as well as future research *** study suggests that transport inclusion can help enhance elderly health,social participation,and subjective *** can improve their travel opportunities for active aging in four ways:opportunity accessibility,physical accessibility,age-friendly informationalization,and cost *** research should pay attention to examining the mechanism of perceived transport inclusion on active aging,expanding the multilevel research space of the capability approach(CA),and exploring the subjectiveobjective integrated research model for PT *** research contributes to the overall knowledge of the theoretical and empirical researches on PT inclusion for the elderly and promotes the integrated application of interdisciplinary knowledge in the field.

关键词： Transportation engineering Elderly mobility Transport-related social exclusion Transport inclusion Active aging

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Bianjing Spectacle: Soundscapes of Bianjing and Identities in Song Dynasty Literature

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2024年第1期18卷 77-102页

作者： LI Gui school of humanities Shanghai Normal UniversityShanghai 200234China

By closely examining the literary works of the Song Dynasty,such as prose,poetry,rhyme-prose,lyrics,notes,and miscellaneous theses,this paper combines historical and literary evidence to rediscover the 13 types of soundscapes and their corresponding spaces in the Bianjing City,the capital of the Northern Song Dynasty,and it reveals the causes and historical-cultural significance of these *** on the key issues of soundscapes,this paper analyzes the sound spaces,identities,discourses,and literary achievements depicted in the writings about *** argues that the“Bianjing Spectacle”of vendors’cries described by the Southern Song people can be used as a summary of the soundscape characteristics of ***,it interprets the special silence,crying,and the absence of the sounds of production from an aesthetic *** rediscovering,analyzing,and interpreting the soundscapes of Bianjing,this paper reveals significant differences between the Tang and Song dynasties at the sound level and differentiates various“auditory communities.”It thereby demonstrates the portrayal of Bianjing in Song literature,addresses theoretical hot topics in literature and geography,and builds on Marx’s arguments to propose that a thorough understanding of history,the world,and ourselves requires an in depth study of the soundscapes in literature.

关键词： Song literature Bianjing in the Northern Song Dynasty soundscapes identities transformation during the Tang and Song dynasties

A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics:A Journal of Chinese Universities 2024年第3期 448-457页

作者： WU Peng ZHANG Yu-huai WANG Ling school of Sciences Hangzhou Dianzi University school of humanities and Management Zhejiang Chinese Medical University Public Foundational Courses Department Nanjing Vocational University of Industry Technology

Biologically, because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells, time delay and spatial heterogeneity should be considered. In this paper, we establish an HIV infection model with nonlocal dispersal and infection age. Moreover, applying the theory of Fourier transformation and von Foerster rule, we transform the model to an integrodifferential equation with nonlocal time delay and dispersal. The well-posedness, positivity, and boundedness of the solution for the model are studied.

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Search for an exotic vectorlike X-quark in same-sign dilepton final states at the future 3 TeV CLIC

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Chinese Physics C 2024年第7期48卷 67-74页

作者：张艳菊常金龙刘太刚 school of medical Engineering Xinxiang Medical UniversityXinxiang 453003China

Vectorlike quarks(VLQs)with masses at the TeV-scale have been predicted in many new physics scenarios beyond the Standard Model(SM).Based on a simplified(X,T)doublet model including the exotic vectorlike X quark(VLQ-X)with an electric charge 5/3,we study the production of the VLQ-X decaying into tW at the future Compact Linear Collider(CLIC)with■TeV including the initial state radiation and beamstrahlung *** focus on the final signals,including same-sign dileptons(electrons or muons),at least one b-tagged jet,and large missing transverse *** performing detailed signal-to-background analyses and detector simulations,we obtain the 2σexclusion capabilities and discovery reaches,respectively,on the mass of the VLQ-Xmx as well as the relevant parameters■for mx≥1500GeV and the coupling strengthg*formx≥1500 GeV)for some typical luminosities at the 3 TeV CLIC.

关键词： Vectorlike quarks CLIC same-sign dilepton

Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan Guo-Kai Liu school of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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Photocontrolled polymer adhesives facilitate the assembly of hydrogels for soft robotics

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Science China Chemistry 2024年第10期67卷 3184-3186页

作者： Diling Yang Hao Zhang Hongbo Zeng school of Materials and Environmental Engineering Hunan University of HumanitiesScience and Technology Department of Chemical and Materials Engineering University of Alberta

Both Sun Wukong in eastern mythology and Transformers in western science fiction animation have profoundly inspired the design of deformable materials and modern robots. The application scope of intelligent materials, also known as smart materials, which are capable of responding to external stimuli to achieve shape changes, structural reorganization,and functional reconfiguration, is wide-ranging, and it covers areas such as soft robotics and flexible electronics [1–3], 4D printing [4,5], biomedical equipment [6, 7], sensing devices [8], and energy harvesting systems [9].

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Analysis of Hot Topics Regarding Global Smart Elderly Care Research—1997-2021

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China CDC weekly 2024年第9期6卷 157-161页

作者： Hongman Wang Hong Chen Yuqi Wang school of Health humanities Peking UniversityBeijingChina Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?With the assistance of the internet,big data,cloud computing,and other technologies,the concept of smart elderly care has *** is added by this report?This study presents information on the countries or regions that have conducted research on smart elderly care,as well as identifies global hotspots and development trends in this field.

关键词： Smart internet smart

Impact of tourism on the vigilance behavior of the Cyprus rock agama(Laudakia cypriaca)

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Integrative Zoology 2024年第3期19卷 577-583页

作者： Artur GOLAWSKI Iris CHARALAMBIDOU Sylwia GOLAWSKA Faculty of Sciences Siedlce University of Natural Sciences and HumanitiesSiedlcePolandand Department of Life Sciences School of Life and Health SciencesUniversity of NicosiaNicosiaCyprus

Escape behavior is a common antipredator strategy among wild ***,we investigated the effect of four factors on the vigilance behavior of the endemic Cyprus rock agama(Laudakia cypriaca).Flight initiation distance(FID,the minimum distance to which an observer can approach a lizard before it flees)was measured in relation to the type of location(tourist *** area),the observer’s starting distance,air temperature,and substrate *** collected data for 39 agamas in tourist areas and 34 of these lizards in nontourist *** a whole,the mean starting distance was 10.5 m and the FID was 3.6 *** average substrate temperature was 34.0℃ and the average air temperature 29.6℃.Only the type of area affected the agamas’escape decisions with FID being 1.8 m shorter in tourist areas than in nontourist areas(2.7 m vs.4.5 m).This is probably due to the habituation of lizards to the presence of humans in the former *** study shows that tourism strongly affects the behavior of lizards,which may have consequences for the functioning of the *** can increase the safety of lizards by creating a human shield to deter *** the tourist season is over,lizards may become more vulnerable to predators.

关键词： anthropogenic disturbance flight initiation distance lizards tourism vigilance behavior

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA Zhe GENG Qing-hua LI Yu-lin REN Chun-guang David P.Molloy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma *** Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,*** reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was *** Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-*** addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin *** underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

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