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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-chang Gan Xiao-Zhong Qiu Zhe-chen Gao Huan Wang Shi-Xuan chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec Mccarthy Johnson v.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial key laboratory of construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering research center of clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina key laboratory of resource Biology and Biotechnology in Western china Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(EcM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Fluorinated soft carbon as an ultra-high energy density potassium-ion battery cathode enabled by a ternary phase K_(x)Fc

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Journal of Energy chemistry 2023年第2期77卷 38-44,I0002页

作者： Pengyu chen Bojun Wang Zhenrui Wu Xiaobin Niu chuying Ouyang Hong Li Liping Wang school of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina school of Engineering The University of British ColumbiaKelowna V1V 1V7Canada c Innovation laboratory Contemporary Amperex Technology Ltd.(21C LAB)Ningde 352100FujianChina key laboratory for renewable Energy Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Fluorinated carbons(cFx)have been widely applied as lithium primary batteries due to their ultra-high energy *** will be a great promise if cFx can be *** this study,we rationally tune the c-F bond strength for the alkaline intercalated cFx via importing an electronegative weaker element K instead of *** forms a ternary phase K_(x)Fc instead of two phases(LiF+c)in lithium-ion ***,we choose a large layer distance and more defects cFx,namely fluorinated soft carbon,to accommodate ***,we enable cFx rechargeable as a potassium-ion battery *** detail fluorinated soft carbon cF_(1.01) presents a reversible specific capacity of 339 mA h g^(-1)(797 Wh kg^(-1))in the 2nd cycle and maintains 330 mA h g^(-1)(726 Wh kg^(-1))in the 15th *** study reveals the importance of tuning chemical bond stability using different alkaline ions to endow batteries with *** work provides good references for focusing on developing reversible electrode materials from popular primary cell configurations.

关键词： Fluorinated carbon High energy density battery Potassium-ion battery conversion reaction K-free cathode

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chromosome-level genome assembly of the glass catfish (Kryptopterus vitreolus) reveals molecular clues to its transparent phenotype

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动物学研究 2024年第5期 1027页

作者： chao Bian rui-Han Li Zhi-Qiang ruan Wei-Ting chen Yu Huang Li-Yue Liu Hong-Ling Zhou cheong-Meng chong Xi-Dong Mu Qiong Shi laboratory of Aquatic Genomics College of Life Sciences and Oceanography Shenzhen University key laboratory of Prevention and control for Aquatic Invasive Alien Species Ministry of Agriculture and Rural Affairs Guangdong Modern.Recreational Fisheries Engineering Technology Center Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Shenzhen key lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals BGI Academy of Marine SciencesBGI Marine cAS key laboratory of Mountain Ecological restoration and Bioresource Utilization & Ecological restoration and Biodiversity conservation key laboratory of sichuan province Chengdu Institute of Biology Chinese Academy of Sciences school of Life sciences Jiaying University china Zebrafish resource center National Aquatic Biological Resource Center State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Science Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences State key laboratory of Quality research in chinese Medicine Institute of Chinese Medical Sciences University of Macau center for Aquatic Genomics College of Life Sciences Neijiang Normal University

Glass catfish(Kryptopterus vitreolus) are notable in the aquarium trade for their highly transparent body *** transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body, although certain black and silver pigments remain in the face and head. To date, however, the molecular mechanisms underlying this transparent phenotype remain largely unknown. To explore the genetic basis of this transparency, we constructed a chromosome-level haplotypic genome assembly for the glass catfish,encompassing 32 chromosomes and 23 344 protein-coding genes, using PacBio and Hi-c sequencing technologies and standard assembly and annotation pipelines. Analysis revealed a premature stop codon in the putative albinismrelated tyrp1b gene, encoding tyrosinase-related protein 1,rendering it a nonfunctional pseudogene. Notably, a synteny comparison with over 30 other fish species identified the loss of the endothelin-3(edn3b) gene in the glass catfish genome. To investigate the role of edn3b, we generated edn3b-/-mutant zebrafish, which exhibited a remarkable reduction in black pigments in body surface stripes compared to wild-type zebrafish. These findings indicate that edn3b loss contributes to the transparent phenotype of the glass catfish. Our high-quality chromosome-scale genome assembly and identification of key genes provide important molecular insights into the transparent phenotype of glass catfish. These findings not only enhance our understanding of the molecular mechanisms underlying transparency in glass catfish, but also offer a valuable genetic resource for further research on pigmentation in various animal species.

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Analysis of an k-out-of-n:G system with redundant dependency and repair equipment procurement

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Journal of control and Decision 2021年第4期8卷 403-414页

作者： Wenqing Wu Kai Zuo Yinghui Tang Yuanyuan Zhang school of Science Southwest University of Science and TechnologyMianyangPeople’s Republic of China school of mathematical sciences Sichuan Normal UniversityChengduPeople’s Republic of China visual computing and virtual reality key laboratory of sichuan province Sichuan Normal UniversityChengduPeople’s Republic of China school of Mathematics Chengdu Normal UniversityChengdu 611130People’s Republic of China

This paper studies an k-out-of-n:G system with redundant dependency and repair equipment procurement lead time where the operating times and repair times of components follow exponential distributions and phase-type distributions,*** one component breaks down,it is repaired by a repair *** repair equipment may fail during the repair period and the following repair is not‘as good as new’.After a number of repairs,it is replaced by a new *** new spare repair equipment for replacement is only available by an order,and the procurement lead time for delivering follows a phase-type ***,in the multi-component system,the redundant dependency is taken into *** the matrix-analytical method,the system availability,the rate of occurrence of failures of the system,the expected number of broken components,the availability and the rate of occurrence of failures of the repair equipment are ***,numerical examples are given to show these theoretical results.

关键词： k-out-of-n:G system redundant dependency procurement lead time matrix-analytical method reliability measures

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Evidence for particle acceleration approaching Pev energies in the W51 complex

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Science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO collaboration Zhen cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.v.Bukevich Q.cao W.Y.cao Zhe cao J.chang J.F.chang A.M.chen E.S.chen H.X.chen Liang chen Lin chen Long chen M.J.chen M.L.chen Q.H.chen S.chen S.H.chen S.Z.chen T.L.chen Y.chen N.cheng Y.D.cheng M.Y.cui S.W.cui X.H.cui Y.D.cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang c.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao c.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou c.Hou X.Hou H.B.Hu Q.Hu S.c.Hu D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li c.M.Li cheng Li cong Li D.Li F.Li H.B.Li H.c.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.r.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu c.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.r.Mao Z.Min W.Mitthumsiri H.J.Mu Y.c.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.Y.Pei J.c.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.raza D.ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.c.Song Yu.v.Stenkin v.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata P.H.T.Tam Q.W.Tang r.Tang Z.B.Tang W.W.Tian c.Wang c.B.Wang G.W.Wang H.G.Wang H.H.Wang J.c.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.H.Wang r.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen c.Y.Wu H.r.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.r.Xiong Z.Xiong D.L.Xu r.F.Xu r.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan c.W.Yang c.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang r.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 key laboratory of Particle Astrophysics&Experimental Physics Division&computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of sciences Beijing 100049China TIANFU cosmic ray research center ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany school of Physical Science and Technology&school of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and Space Science Nanjing UniversityNanjing 210023China center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear research of russian Academy of sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of Science and Technology of china Hefei 230026China State key laboratory of Particle Detection and Electronics China key laboratory of Dark Matter and Space Astronomy&key laboratory of radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China research center for Astronomical computing Zhejiang LaboratoryHangzhou 311121China key laboratory for research in Galaxies and cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Physics and Astronomy Yunnan UniversityKunming 650091China key laboratory of cosmic rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(Zhuhai)&school of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APc UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(crs)accelerated by the shock of supernova remnant(SNr)W51c and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51c for crs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 Tev and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 Tev or a power-law break at~200 Tev in the cr proton spectrum,most likely providing the first evidence of SNrs serving as cr accelerators approaching the Pev ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme cr accelerators within the W51 complex and provide new insights into the origin of Galactic crs.

关键词： UHE c-ray cosmic rays SNr W51c Star clusters

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A photometric-spectroscopic study of the infrared-excess eclipsing binary v2364 cyg

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research in Astronomy and Astrophysics 2020年第12期20卷 307-316页

作者： Hui-Yu Yuan Lin-Qiao Jiang Hai-Feng Dai Shuang Wang Yuan-Gui Yang Information college&school of Physics and Electronic Information Huaibei Normal UniversityHuaibei 235000China Artificial Intelligence key laboratory of sichuan province Sichuan University of Science&EngineeringZigong 643000China

The eclipsing binary v2364 cyg is an A7 v-type contact binary with a period of 0.5921 *** present six spectra from LAMOST and Bvrc light curves(Lcs),which are simultaneously analyzed to obtain the absolute physical *** first light maxima are brighter than the second ones by up to 0.m038,0.m036 and 0.m024 for Bvrc bands,*** distorted Lcs are modeled by a cool spot on the less massive *** mass ratio and over-contact degree are q=0.319(±0.004) and f=28.4%(±1.0) % *** the mass-luminosity diagram,the primary component is a normal main-sequence star,while the secondary one is a subgiant *** the(O-c) curve,the orbital period secularly decreases at a rate dP/dt=-1.62(±0.03) × 10^-7 dyr^-1,which is mainly attributed to mass loss via stellar wind from the binary *** may result in the observed infrared excess in the W4 band.

关键词： stars:circumstellar matter stars:binaries:close stars:individual(v2364 cyg) mass loss infrared excess

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The first photometric investigation of the contact binary OQ cam

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research in Astronomy and Astrophysics 2020年第11期20卷 252-258页

作者： Ya-Ni Guo Kai Li Qi-Qi Xia Xing Gao Lin-Qiao Jiang Yuan Liu Shandong key laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and PhysicsInstitute of Space SciencesShandong UniversityWeihai 264209China Xinjiang Astronomical Observatory Urumqi 830011China Artificial Intelligence key laboratory of sichuan province Sichuan University of Science&EngineeringZigong 643000China Qilu Institute of Technology Jinan 250200China

The first charge-coupled device photometric light curves in B,v,rc,and Ic bands of the short-period contact binary star OQ cam are *** analyzing the light curves with the WilsonDevinney code,it is found that OQ cam is a W-type shallow contact binary star with a contact degree of f=20.2%.Based on the O-c analyzing,the orbit period displays a long term increasing with a rate of d P/dt=4.40×10^-7 d *** increasing in orbit period can be interpreted by mass transfer from the less massive component to the more massive *** the orbit period increases,OQ cam would evolve from the present shallow contact configuration to a non-contact *** it may be a potential candidate to confirm the thermal relaxation oscillation theory.

关键词： stars binaries close stars binaries eclipsing stars evolution stars individual(OQ cam)

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Hexyl substitution of pentathienoacene toward a significant improvement in charge transport

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chinese chemical Letters 2019年第4期30卷 903-905页

作者： Ping He Hantang Zhang chunhui Xu Yonggang Zhen Huanli Dong Wenping Hu chemical Synthesis and Pollution control key laboratory of sichuan province China West Normal University Beijing National laboratory for Molecular Science Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences college of chemistry and Material Science Shandong Agriculture University Tianjin key laboratory of Molecular Optoelectronic sciences Department of Chemistry School of Science Tianjin University and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

A novel semiconductor, dihexyl-substituted pentathienoacene(c6-PTA) is designed and synthesized in five steps with the total yield up to 25.2%. The introduction of hexyl chains endow the thin film semiconductor with about threefold increase in carrier mobility and one to three orders of magnitude improvement in current on/off ratio. Furthermore, single crystal FETs based on c6-PTA exhibited mobility up to 0.64 cm^2 v^(-1) s^(-1), which is over 50 times higher than the thin film counterpart. The results indicate clearly that c6-PTA is a promising organic semiconductor with high stability.

关键词： Organic field-effect transistors Organic semiconductors Thienoacene charge transport Stability

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1.7 kv normally-off p-GaN gate high-electron-mobility transistors on a semi-insulating Sic substrate

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Science china(Information sciences) 2023年第2期66卷 250-255页

作者： Shenglei ZHAO Jincheng ZHANG Yachao ZHANG Lansheng FENG Shuang LIU Xiufeng SONG Yixin YAO Jun LUO Zhihong LIU Shengrui XU Yue HAO key lab of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of Microelectronics Xidian University school of Mechano-Electronic Engineering Xidian University Testing center Sichuan Institute of Solid-State CircuitsChina Electronics Technology Group Corporation

A study of 1.7 kv normally-off p-GaN gate high-electron-mobility transistors(HEMTs) on Sic substrates is presented. The fabricated p-GaN HEMT with a gate-drain spacing LGD = 5 μm exhibited a threshold voltage of 1.10 v, a maximum drain current of 235 mA/mm, an ON/OFF ratio of 108, and a breakdown voltage of 440 v. Benefiting from the semi-insulating and high-critical-electric-field substrate, the p-GaN HEMT with LGD = 23 μm achieved the remarkably high breakdown voltage of 1740 v with substrate grounded. This breakdown voltage is very high compared with the reported values for p-GaN HEMTs on silicon substrates with substrate grounded. The vertical breakdown voltage for the p-GaN-on-Sic material exceeded 3 kv with substrate grounded. In addition, the maximum drain current at 500 K was 48% of that at 300 K with a negligible threshold voltage shift. These results indicate the substantial potential of p-GaN gate HEMTs on Sic substrates for high-voltage power applications.

关键词： p-GaN gate HEMTs high voltage Sic substrate

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Energy Transformation in Mammalian cell for Low Energy Ion Beam Impinging

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Plasma Science and Technology 2006年第6期8卷 751-754页

作者：丁克俭吴李君吴跃进余增亮 The key lab.of Ion-Beam Bioengineering Institute of Plasma PhysicsChinese Academy of SciencesHefei 230031China School of ScienceBeijing Jiaotong UniversityBeijing 100044China The key lab.of Ion-Beam Bioengineering Institute of Plasma PhysicsChinese Academy of SciencesHefei 230031China

This study investigates the stopping power of a mammalian cell for low energy ions. The energy equation of the incident ion has been conducted based on the elastic collision between the pairs of nuclei in order to establish the stopping powers of the mammalian cell for low energy ion implantation. Based on the biological structure of the mammalian cell and the measured thickness of the v79 cell, a physical structural model is proposed that the attached cell is approximately of a model of a constringent multi-membrane structure （c-2M model） in order to analyse the stopping power of the mammalian cell for low energy ions. With this model we have determined the mean line energy transfer, and roughly estimated the depth of ion implantation on the selected chinese hamster v79 cell for 30 kev N^＋ ions at a flux of 1 × 10^15 ion/cm^2, which is in agreement with those by using Monte carlo methods.

关键词： low energy ion sputtering stopping power c-2M model cell thickness

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