检索结果-南通市图书馆

Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

引用

Journal of Pharmaceutical Analysis 2024年第3期14卷 348-370页

作者： Binbin Zhao Dongfeng Wei Qinghua Long Qingjie Chen Fushun Wang Linlin Chen Zefei Li Tong Li Tao Ma Wei Liu Linshuang Wang Caishui Yang Xiaxia Zhang Ping Wang Zhanjun Zhang State Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing100875China Institute of Gerontology Hubei University of Chinese MedicineWuhan430065China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Medical school Hubei Minzu UniversityEnshiHubei445000China HuBei university of Science and Technology XianningHubei437100China Institute of Brain and Psychological Science Sichuan Normal UniversityChengdu610066China Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription Ministry of EducationHubei University of Chinese MedicineWuhan430065China Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing100700China school of Systems Science Beijing Normal UniversityBeijing100875China BABRI Centre Beijing Normal UniversityBeijing100875China

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial ***,the specific associations between these pathological changes remain *** this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro *** investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular *** results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD ***,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic *** cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular *** intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and ***,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial *** conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.

关键词： Alzheimer's disease Synaptic currents Mitophagy Mitochondrial fusion and fission Dengzhan Shengmai capsules

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Possibilities for the synthesis of superheavy element Z=121 in fusion reactions

引用

Nuclear Science and Techniques 2024年第6期35卷 90-100页

作者： Ming-Hao Zhang Yu-Hai Zhang Ying Zou Xiu-Xiu Yang Gen Zhang Feng-Shou Zhang The Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China school of Physical Science and Technology Guangxi UniversityNanning 530004China National Laboratory of Heavy Ion Accelerator of Lanzhou Center of Theoretical Nuclear PhysicsLanzhou 730000China

Based on the dinuclear system model,the calculated evaporation residue cross sections matched well with the current experimental *** synthesis of superheavy elements Z=121 was systematically studied through combinations of stable projectiles with Z=21-30 and targets with half-lives exceeding 50 *** influence of mass asymmetry and isotopic dependence on the projectile and target nuclei was investigated in *** reactions^(254)Es(^(46)Ti,3n)^(297)121 and^(252)Es(^(46)Ti,3n)^(295)121 were found to be experimentally feasible for synthesizing superheavy element Z=121,with maximal evaporation residue cross sections of 6.619 and 4.123 fb at 219.9 and 223.9 MeV,respectively.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Evaporation residue cross section

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Possibility of reaching the predicted center of the“island of stability”via the radioactive beam-induced fusion reactions

引用

Nuclear Science and Techniques 2024年第9期35卷 186-195页

作者： Ming-Hao Zhang Ying Zou Mei-Chen Wang Gen Zhang Qing-Lin Niu Feng-Shou Zhang The Key Laboratory of Beam Technology of Ministry of Education School of Physics and AstronomyBeijing Normal UniversityBeijing 100875China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China school of Physical Science and Technology Guangxi UniversityNanning 530004China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of LanzhouLanzhou 730000China

Based on the dinuclear system model,the synthesis of the predicted double-magic nuclei^(298)Fl and 304120 was investigated via neutron-rich radioactive beam-induced fusion *** reaction^(58)Ca+^(244)Pu is predicted to be favorable for producing^(298)Fl with a maximal ER cross section of 0.301 *** of the entrance channel effect reveal that the^(244)Pu target is more promising for synthesizing^(298)Fl than the neutron-rich targets^(248)Cm and^(249)Bk,because of the influence of the Coulomb *** the synthesis of 304120,the maximal ER cross section of 0.046 fb emerges in the reaction^(58)V+^(249)Bk,indicating the need for further advancements in both experimental facilities and reaction mechanisms.

关键词： Superheavy nuclei Dinuclear system model Fusion reaction Double-magic nucleus Radioactive beam

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear relationship between urban form and transport CO_(2)emissions:Evidence from Chinese cities based on machine learning

引用

Journal of Geographical sciences 2024年第8期34卷 1558-1588页

作者： LI Linna DENG Zilin HUANG Xiaoyan Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Northwest Land and Resources Research Center Global Regional and Urban Research InstituteShaanxi Normal UniversityXi'an 710119China

Reducing carbon emissions from the transport sector is essential for realizing the carbon neutrality goal in *** substantial studies on the influence of urban form on transport cO_(2)emissions,most of them have treated the effects as a linear process,and few have studied their nonlinear *** research focused on 274 Chinese cities in 2019 and applied the gradient-boosting decision tree(GBDT)model to investigate the nonlinear effects of four aspects of urban form,including compactness,complexity,scale,and fragmentation,on urban transport CO_(2)*** was found that urban form contributed 20.48%to per capita transport CO_(2)emissions(PTCEs),which is less than the contribution of socioeconomic development but more than that of transport *** contribution of urban form to total transport CO_(2)emissions(TCEs)was the lowest,at 14.3%.In particular,the effect of compactness on TCEs was negative within a threshold,while its effect on PTCEs showed an inverted U-shaped *** effect of complexity on PTCEs was positive,and its effect on TCEs was *** effect of scale on TCEs and PTCEs was positive within a threshold and negative beyond that *** effect of fragmentation on TCEs was also nonlinear,while its effect on PTCEs was positively *** results show the complex effects of the urban form on transport CO_(2)***,strategies for optimizing urban form and reducing urban transport carbon emissions are recommended for the future.

关键词： urban form transport CO,emissions nonlinear effect sustainable transport gradient-boosting decision treemodel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solutions of the(2+1)-dimensional Harry Dym Equation via Darboux Transformation Revisited

引用

Acta Mathematicae Applicatae Sinica 2024年

作者： Meng-yuan CUI Min XUE Meng-xia ZHANG Department of Mathematics China University of Mining and TechnologyBeijing school of mathematical sciences Capital Normal University

The link of (2+1)-dimensional Harry Dym equation with the modified Kadomtsev-Petviashvili equation by the reciprocal transformation is shown. With the help of Darboux transformation, exact solutions of the (2+1)-dimen...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Local field potentials,spiking activity,and receptive fields in human visual cortex

引用

Science China(Life sciences) 2024年第3期67卷 543-554页

作者： Lu Luo Xiongfei Wang Junshi Lu Guanpeng Chen Guoming Luan Wu Li Qian Wang Fang Fang school of Psychological and Cognitive sciences and beijing Key Laboratory of Behavior and Mental Health Peking UniversityBeijing 100871China school of Psychology Beijing Sport UniversityBeijing 100084China Department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China beijing Key Laboratory of Epilepsy Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing 100093China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Peking-Tsinghua Center for Life sciences Peking UniversityBeijing 100871China beijing Institute for Brain Disorders Beijing 100069China State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China

The concept of receptive field(RF) is central to sensory neuroscience. Neuronal RF properties have been substantially studied in animals,while those in humans remain nearly unexplored. Here, we measured neuronal RFs with intracranial local field potentials(LFPs) and spiking activity in human visual cortex(V1/V2/V3). We recorded LFPs via macro-contacts and discovered that RF sizes estimated from lowfrequency activity(LFA, 0.5–30 Hz) were larger than those estimated from low-gamma activity(LGA, 30–60 Hz) and high-gamma activity(HGA, 60–150 Hz). We then took a rare opportunity to record LFPs and spiking activity via microwires in V1 simultaneously. We found that RF sizes and temporal profiles measured from LGA and HGA closely matched those from spiking activity. In sum, this study reveals that spiking activity of neurons in human visual cortex could be well approximated by LGA and HGA in RF estimation and temporal profile measurement, implying the pivotal functions of LGA and HGA in early visual information processing.

关键词： human visual cortex receptive field intracranial EEG local field potential spiking activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Probing the Kinematic Signatures of Planet Formation in the Gas Disk of MWC 480

引用

Research in Astronomy and Astrophysics 2024年第6期24卷 110-118页

作者： Min Zhao Haochuan Yu Zhengxiang Li Department of Astronomy Beijing Normal UniversityBeijing 100875China Sub-department of Astrophysics Department of PhysicsUniversity of OxfordOxfordOX13RHUK

The disk around MWC 480 has shown multiple substructures in both dust and gas observations,possibly suggesting ongoing planet formation in *** this paper,we explore the gas kinematics of the MWC 480 disk by analyzing the archival Atacama Large Millimeter/submillimeter Array observations of^(12)CO(J=2-1),^(13)CO(J=2-1),and C^(18)O(J=2-1).By modeling the line-of-sight velocities,inferred from the Doppler shifts of the emission lines,we are able to decompose the three-dimensional(3D)velocity field of the disk into rotational,radial,and vertical *** analysis reveals the presence of large-scale gas flows in the(r,z)***,we identify potential meridional flows across various heights as traced by all three CO isotopologues in the 80–120 au region,possibly associated with ongoing planet formation activities in this ***,we find upward flows near 200 au for all three CO isotopologues,which may point to the presence of disk winds.

关键词： protoplanetary disks planet-disk interactions planet-star interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of adaptation measures in addressing heatwave exposure in China

引用

Advances in Climate Change Research 2024年第1期15卷 148-157页

作者： Qin-Mei HAN Qing-Chen CHAO Shao SUN Pei-Jun SHI National Climate Centre China Meteorological AdministrationBeijing 100081China State Key Laboratoryof Severe Weather Chinese Academy of Meteorological sciences Beijing 0o08lChina Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Heatwave exposure has increased dramatically because of climate warming and population growth,along with their interactive ***,effective adaptation measures can reduce these ***,the dynamic changes,regional inequality in adaptive capacity and their potential contributions to reducing exposure in the future remain *** study quantifies the impact of adaptive capacity and underscores regional variations in heatwave magnitudes,population exposure and adaptation levels in *** projected the future adaptive capacity using air-conditioner penetration,factoring in climate cooling requirements and individuals'purchasing *** population and gross domestic product(GDP)data from four Shared Socioeconomic Pathways(SSP1,SSP2,SSP3 and SSP5)and daily temperature data from four SSP-based emission scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5),we estimated heatwave duration,population exposure and avoided impacts through adaptation across China and its *** show a substantial increase in heatwave duration in Southwest and Southern China,especially under the SSP5-8.5 scenario,with a projection of 163.2±36.7 d during *** the SSP3|SSP3-7.0 scenario,total exposure reaches 156.4±76.8 billion person d per year,which is the highest among all scenarios and 23 times greater than that in 1986-2005 without *** considering adaptation measures,a noteworthy reduction in population exposure is observed,especially in the SSP3|SSP3-7.0 and SSP5JSSP5-8.5 scenarios,with reductions of(62.6±3.9)%and(65.8±5.1)%,respectively,compared with the scenario without adaptation during *** regional disparities in avoided impacts are also evident,with variations of up to 50%across different *** implementation of effective and environmentally friendly adaptation measures can notably address climate change,thereby alleviating the profound threats posed to human well-being.

关键词： Heatwaves Population exposure Adaptation Future projection China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Variability of urban fractional vegetation cover and its driving factors in 328 cities in China

引用

Science China Earth sciences 2024年第2期67卷 466-482页

作者： Fei FENG Xin YANG Baoquan JIA Xiaoting LI Xianwen LI Chengyang XU Kaicun WANG Research Centre of Urban Forestry Key Laboratory for Silviculture and Forest Ecosystem of State Forestry and Grassland AdministrationBeijing Forestry UniversityBeijing100083China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing100875China Research Institute of Forestry Chinese Academy of ForestryBeijing100091China school of Architecture Tsinghua UniversityBeijing100084China College of Urban and Environmental sciences Sino-French Institute for Earth System ScienceInstitute of Carbon NeutralityPeking UniversityBeijing100871China

Urban green space promotes the health of urban residents,enhances urban ecosystem biodiversity,mitigates environmental pollution,and attenuates urban heat island ***,urban vegetation cover is highly heterogeneous and difficult to *** this study,the variation of urban fractional vegetation cover(FVC)in 328 cities in China from 1990 to2022 was quantified based on Landsat satellite data at a 30-m *** was found that from 1990 to 2005,due to increases in building density and impervious surfaces in cities,the national mean urban vegetation cover decreased from 0.38 to ***2005,urban vegetation cover began to reverse,reaching 0.45 in *** increasing trend was most pronounced in newly built urban *** decrease in average urban vegetation cover before 2005 was mainly due to the expansion of low vegetation cover areas,while the increase in urban vegetation cover after 2005 manifested as the expansion of high vegetation cover *** reversal in the trend of urban vegetation cover change after 2004 is related to the gradual implementation of national policies requiring increased urban green space *** urban gross domestic product(GDP)showed the highest correlation with changes in urban vegetation *** large and medium-sized cities,the top three factors influencing vegetation cover were GDP,urban population,and ***,for cities in arid/semi-arid regions,changes in vegetation cover were more sensitive to climatic factors(such as precipitation).Although the urban vegetation cover in China has substantially increased in recent years,the urban green space in small-sized cities and in the old urban districts of large-sized cities still have room to improve.

关键词： Urban vegetation Urban vegetation cover Urbanization Remote sensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Short lifespan and ‘prime period’ of carbon sequestration call for multi-ages in dryland tree plantations

引用

Forest Ecosystems 2024年第5期11卷 670-676页

作者： Chongyang Xu Xiuchen Wu Yuhong Tian Liang Shi Yang Qi Jingjing Zhang Hongyan Liu College of Urban and Environmental sciences and MOE Laboratory for Earth Surface Processes Peking UniversityBeijing100871China College of Resources Science and Technology Beijing Normal UniversityBeijing100875China Institute of Geographic sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China College of JunCao Science and Ecology Fujian Agriculture and Forestry UniversityFuzhou350002China

Enhancing forest cover is important for effective climate change *** suggest that drylands are promising areas for expanding forests,but conflicts arise with increased forest area and water *** tree mortality in drylands raises concerns about carbon sequestration potential in tree *** Chinese dryland tree plantations as an example,we compared their growth with natural *** results suggested plantation trees grew 1.6–2.1 times faster in juvenile phases,significantly shortening time to maturity(13.5 vs.30 years)compared to natural forests,potentially stemming from simple plantation age *** from natural forests,74%of trees in plantations faced growth decline,indicating a short“prime period”for carbon sequestration and even a short ***,a negative relationship between evapotranspiration and tree growth was observed in tree plantations since maturity,leading to high sensitivities of trees to vapor pressure deficit and soil ***,this was not observed in natural *** address this,we suggest afforestation in drylands should consider complex age structures,ensuring a longer prime period for carbon sequestration and life expectancy in tree plantations.

关键词： Tree growth Drylands Tree plantations Carbon sequestration Lifespan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：