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Regulation of swelling-activated chloride channels in embryonic chick heart cells

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Cell Research 2003年第1期13卷 21-28页

作者： HUA WEI, VAN AI MEI, JIA TING SUN, HAN QING ZHOU, ZHI HONG ZHANGDepartment of Physiology and Biophysics, liren Laboratory, school of Life Sciences, Fudan University, Shanghai 200433, China Fishery College, Shanghai Fisheries University, Shanghai 200090, China 2Fishery College Shanghai Fisheries University Shanghai 200090 China 1Department of Physiology and Biophysics Liren Laboratory School of Life Sciences Fudan University Shanghai 200433 China 1Department of Physiology and Biophysics Liren Laboratory School of Life Sciences Fudan University Shanghai 200433 China 1Department of Physiology and Biophysics Liren Laboratory School of Life Sciences Fudan University Shanghai 200433 China 1Department of Physiology and Biophysics Liren Laboratory School of Life Sciences Fudan University Shanghai 200433 China

Swelling-activated Cl- currents, I(ci,swell), were measured during hyposmotic shock in white Leghorn embryonic chick heart cells using the whole-cell recording of patch-clamp technique. Genistein, an inhibitor of protein tyrosine kinase (PTK), suppressed I(ci,swell), Under isosmotic condition phorbol 12-myristate 13-acetate (PMA), an activator of PKC, elicited the Cl~ current similar to that in hyposmotic solution, whereas hyposmotic shock did not elicit I(ci,swell) in chelerythrine chloride(an inhibitor of PKC)-treated cells. Con-focal microscopy experiments using FITC-phalloidin as a fluorescent label of F-actin showed that the actin network was moved from cortical region of the cell to the center after hyposmotic shock as compared with the image under isosmotic condition. When the cells were treated with cytochalasin B (CB) or cytochalasin D (CD) under isosmotic condition the disruption of the F-actin integrity was observed, and I(ci,Sweii) was not elicited. With combination treatment of CB with PMA,

关键词： swelling activation myocardium chloride current F-actin phosphorylation.

Analysis of G-Queue with Pseudo-Fault and Multiple Working Vacations

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Journal of Systems Science & Complexity 2020年第4期33卷 1144-1162页

作者： MA Zhanyou CHEN Li WANG Pengcheng school of Science Yanshan UniversityQinhuangdao 066004China liren College Yanshan UniversityQinhuangdao 066004China school of Transportation Science and Engineering Beihang UniversityBeijing 100000China

This paper presents a new model of discrete time Geo/Geo/1 repairable queueing system with pseudo-fault, negative customers and multiple working vacations. The authors assume that system service may be interrupted by breakdown or pseudo-fault, this system may become disabled only when it is in a regular busy period, and negative customers adopt two types of typical killing strategies. In this paper, the authors know that the evolution of the system can be described by a two-dimensional Markov chain, and the two-dimensional Markov chain satisfies the condition of quasi birth and death chains. Based on the method of matrix-geometric solution, the authors obtain distributions for the stationary queue length in RCH and RCE strategy, respectively. Moreover, the reliability of the system is analyzed and the number of customers and waiting time of a customer in the system in steady state are obtained. The authors analyze the impact of two killing strategies on the system *** paper studies the individually and socially optimal behaviors of positive customers, and presents a pricing policy for positive customers, therefore, the authors obtain the socially optimal arrival *** numerical results are provided to show the change of performance measures.

关键词： system assume stationary

Influence of Non-smooth Surface on Tribological Properties of Glass Fiber-epoxy Resin Composite Sliding against Stainless Steel under Natural Seawater Lubrication

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Chinese Journal of Mechanical Engineering 2015年第6期28卷 1171-1176页

作者： WU Shaofeng GAO Dianrong LIANG Yingna CHEN Bo school of Mechanical Engineering Yanshan University Heibei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Yanshan University liren College Yanshan University

With the development of bionics, the bionic non-smooth surfaces are introduced to the field of tribology. Although non-smooth surface has been studied widely, the studies of non-smooth surface under the natural seawater lubrication are still very fewer, especially experimental research. The influences of smooth and non-smooth surface on the frictional properties of the glass fiber-epoxy resin composite（GF/EPR） coupled with stainless steel 316 L are investigated under natural seawater lubrication in this paper. The tested non-smooth surfaces include the surfaces with semi-spherical pits, the conical pits, the cone-cylinder combined pits, the cylindrical pits and through holes. The friction and wear tests are performed using a ring-on-disc test rig under 60 N load and 1000 r/min rotational speed. The tests results show that GF/EPR with bionic non-smooth surface has quite lower friction coefficient and better wear resistance than GF/EPR with smooth surface without pits. The average friction coefficient of GF/EPR with semi-spherical pits is 0.088, which shows the largest reduction is approximately 63.18% of GF/EPR with smooth surface. In addition, the wear debris on the worn surfaces of GF/EPR are observed by a confocal scanning laser microscope. It is shown that the primary wear mechanism is the abrasive wear. The research results provide some design parameters for non-smooth surface, and the experiment results can serve as a beneficial supplement to non-smooth surface study.

关键词： non-smooth surface friction coefficient wear resistance glass fiber-epoxy resin composite seawater lubrication stainless steel 316L

A general method for large-scale fabrication of Cu nanoislands/dragonfly wing SERS flexible substrates

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Chinese Physics B 2018年第1期27卷 564-569页

作者：王玉红王明利沈琳朱艳英孙鑫史国超许晓娜李瑞峰马万里 Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University liren College of Yanshan University Department of Mathematics NC State University

Noble metal nanorough surfaces that support strong surface-enhanced Raman scattering （SERS） is widely applied in the practical detection of organic molecules. A low-cost, large-area, and environment-friendly SERS-active substrate was acquired by sputtering inexpensive copper （Cu） on natural dragonfly wing （DW） with an easily controlled way of magnetron sputtering. By controlling the sputtering time of the fabrication of Cu on the DW, the performance of the SERS substrates was greatly improved. The SERS-active substrates, obtained at the optimal sputtering time （50 min）, showed a low detection limit （10-6M ） to 4-aminothiophenol （4-ATP）, a high average enhancement factor （EF, 1.98 x10^4）, excellent signal uniformity, and good reproducibility. In addition, the results of the 3D finite-difference time-domain （3D- FDTD） simulation illustrated that the SERS-active substrates provided high-density ＂hot spots＂, leading to a large SERS enhancement.

关键词： surface-enhanced Raman scattering dragonfly wing copper magnetron sputtering

Performance Analyses of Production Inventory Systems Considering Service Time and Product Returns of Online Shopping

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Journal of Systems Science & Complexity 2019年第3期32卷 888-906页

作者： QIN Yaling YUE Dequan school of Economics and Management Yanshan University Qinhuangdao 066004 China liren College Yanshan University Qinhuangdao 066004 China College of Science Yanshan University Qinhuangdao 066004 China

This paper considers a production inventory system with service time and product returns, dependent on the characteristics of online shopping beliaviors. The customers arrive according to a Poisson process, in which the arriving customer requires an item in the inventory, as well as a server service that the service time is exponentially distributed. Moreover, there is one production facility to produce items according to (s, S) policy, and the production time also follows an exponential (listribution. In the beginning, the stationary joint distribution is obtained in the product form for the queue length and the on-hand inventory level. Additionally, the resulting distribution is applied to derive some performance measures, which can be adopted to numerically calculate the optimal (s, S) policy. Finally, numerical analyses are processed to investigate the effects of some system parameters on the performance measures. The numerical results clearly indicate that the product return rate has a significantly monotonic effect on the optimal policy and optimal cost.

关键词： Online shopping production inventory return service time (s, S) policy

Mongolian Text Recognition Based on CRNN Algorithm

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Data Intelligence 2024年第3期6卷 869-890页

作者： YongHui Wei Naimannaran Chuluunbandi Badarch Tuyatsetseg Ayush Altangere school of Information and Communication Technology Mongolian University of Science and Technology(MUST)UlaanbaatarMongolia liren College Yanshan UniversityQinhuangdao066004HebeiChina

Optical Character Recognition(OCR)algorithm is a technology that converts text images from paper documents into a digital format using electronic devices such as scanners and digital *** process transforms the captured text images into editable and searchable versions using text recognition *** advancements in deep learning,Al models have increasingly become pivotal in applications requiring operation on mobile devices without network connectivity,including small underwater devices,high-altitude environments,and license plate recognition systems in front-end *** the maturity of general OCR models,there is a notable scarcity of OCR algorithms that are compatible with embedded single-chip *** models,capable of functioning autonomously at the front-end without network support,are particularly crucial for remote ***,virtually no models for single-chip systems currently support the recognition of the Mongolian *** study focuses on the development of an OCR system designed for single-chip microcomputers operating without network *** system is engineered to perform character recognition for Mongolian,English,and Chinese scripts,thereby expanding the utility of front-end single-chip ***,the research introduces a novel approach to the recognition of modern Mongolian characters,broadening the scope of OCR system in linguistically diverse contexts.

关键词： CRNN OCR Mongolian character recognition Text detection

Transcriptomic analysis reveals key lnc RNAs associated with ribosomal biogenesis and epidermis differentiation in head and neck squamous cell carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第9期19卷 674-688页

作者： Yu-zhu GUO Hui-hui SUN Xiang-ting WANG Mei-ting WANG school of Life Sciences University of Science and Technology of China College of liren Yanshan University

Objective： In this study, we aimed to expand current knowledge of head and neck squamous cell carcinoma （HNSCC）-associated long noncoding RNAs （IncRNAs）, and to discover potential IncRNA prognostic biomarkers for HNSCC based on next-generation RNA-seq. Methods： RNA-seq data of 546 samples from patients with HNSCC were downloaded from The Cancer Genome Atlas （TCGA）, including 43 paired samples of tumor tissue and adjacent normal tissue. An integrated analysis incorporating differential expression, weighted gene co-expression networks, functional enrichment, clinical parameters, and survival analysis was conducted to discover HNSCC-associated IncRNAs. The function of CYTOR was verified by cell-based experiments. To further identify IncRNAs with prognostic significance, a multivariate Cox proportional hazard regression analysis was performed. The identified IncRNAs were validated with an independent cohort using clinical feature relevance analysis and multivariate Cox regression analysis. Results： We identified nine HNSCC-relevant IncRNAs likely to play pivotal roles in HNSCC onset and development. By functional enrichment analysis, we revealed that CYTOR might participate in the multistep pathological processes of cancer, such as ribosome biogenesis and maintenance of genomic stability. CY-I-OR was identified to be positively correlated with lymph node metastasis, and significantly negatively correlated with overall survival （OS） and disease free survival （DFS） of HNSCC patients. Moreover, CYTOR inhibited cell apoptosis following treatment with the chemotherapeutic drug diamminedichloroplatinum （DDP）. HCG22, the most dramatically down-regulated IncRNA in tumor tissue, may function in epidermis differentiation. It was also significantly associated with several clinical features of patients with HNSCC, and positively correlated with patient survival. CYTOR and HCG22 maintained their prognostic values in- dependent of several clinical features in multivariate Cox hazards

关键词： Head and neck squamous cell carcinoma Long noncoding RNA (IncRNA) Weighted gene co-expressionnetwork analysis (WGCNA) Clinicopathological feature Multivariate Cox regression model

An M/M/1 Queueing-Inventory System with Geometric Batch Demands and Lost Sales

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Journal of Systems Science & Complexity 2018年第4期31卷 1024-1041页

作者： YUE Dequan ZHAO Guoxi QIN Yaling College of Science Yanshan University Qinhuangdao 066004 China school of Economics and Management Yanshan University Qinhuangdao 066004 China school of Mathe- matics and Information Science Xinxiang University Xinxiang 453000 China College of liren Yanshan University Qinhuangdao 066004 China

This paper studies an M/M/1 queueing-inventory system with batch demands. Customers arrive in the system according to a compound Poisson process, where the size of the batch demands for each arrival is a random variable that follows a geometric distribution. The inventory is replenished according to the standard （s, S） policy. The replenishment time follows an exponential distribution. Two models are considered. In the first model, if the on-hand inventory is less than the size of the batch demands of an arrived customer, the customer takes away all the items in the inventory, and a part of the customer＇s batch demands is lost. In the second model, if the on-hand inventory is less than the size of the batch demands of an arrived customer, the customer leaves without taking any item from the inventory, and all of the customer＇s batch demands are lost. For these two models, the authors derive the stationary conditions of the system. Then, the authors derive the stationary distributions of the product-form of the joint queue length and the on-hand inventory process. Besides this, the authors obtain some important performance measures and the average cost functions by using these stationary distributions. The results are illustrated by numerical examples.

关键词： Batch demands cost optimization lost sales product-form solution queuing-inventory system

Actuation Spaces Synthesis of Lower-Mobility Parallel Mechanisms Based on Screw Theory

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Chinese Journal of Mechanical Engineering 2021年第1期34卷 280-291页

作者： Shihua Li Yanxia Shan Jingjun Yu Yaxiong Ke Hebei Provincial Key Laboratory of Parallel Robot and Mechatronic Systems Yanshan UniversityQinhuangdao 066004China school of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China school of liren Yanshan UniversityQinhuangdao 066004China Robotics Institute Beihang UniversityBeijing 100191China

The lower-mobility parallel mechanism has been widely used in the engineering field due to its numerous excellent ***,little work has been devoted to the actuator selection and placement that best satisfy the system's functional requirements during concept *** this study,a unified approach for synthesizing the actuation spaces of both rigid and flexure parallel mechanisms has been presented,and all possible combinations of inputs could be obtained,laying a theoretical foundation for the subsequent optimization of *** to the linear independence of actuation space and constraint space of the lower-mobility parallel mechanism,a general expression of actuation spaces in the format of screw systems is deduced,a unified synthesis process for the lower-mobility parallel mechanism is derived,and the efficiency of the method is validated with two selective examples based on screw *** study presents a theoretical framework for the input selection problems of parallel mechanisms,aiming to help designers select and place actuators in a correct and even optimal way after the configuration design.

关键词： Lower-mobility parallel mechanism Screw theory Actuation space Actuator placement Input selection