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Preparation and characterization of doxorubicin functionalized tiopronin-capped gold nanorods for cancer therapy

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Chinese Science Bulletin 2013年第33期58卷 4072-4076页

作者： HUO ShuaiDong JIN ShuBin ZHENG KaiYuan HE ShengTai WANG DongLiang LIANG XingJie CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology school of Materials Science and Engineering Tianjin Polytechnic University

Gold nanomaterials are immerging candidates in medical diagnosis and *** them,gold nanorods(Au NRs)are widely used for cancer *** as a novel thiol drug was used to stabilize Au NRs in this ***(DOX),a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis,was linked to Au NRs through electrostatic reaction with tiopronin,to obtain Au-TIOP-DOX *** NRs are also regarded as hyperthermia agents for photothermal cancer *** delivery system(Au-TIOP-DOX NRs)was designed for passively targeting tumor cells in cancer *** importantly,the carboxyl groups of tiopronin can be modified with some biological molecules(DNA/RNA,peptides,or drugs)to make Au NRs as a novel drug-delivery system for cancer treatment.

关键词：癌症治疗硫普罗宁纳米棒黄金阿霉素功能化自然保护区化疗药物

Probe the 2s_(1/2) and 1d_(3/2) state level inversion with electron-nucleus scattering

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Chinese Physics C 2014年第2期38卷 15-23页

作者：王再军任中洲董铁矿 school of Science Tianjin University of Technology and Education Department of Physics Nanjing University Center of Theoretical Nuclear Physics National Laboratory of Heavy-Ion Accelerator Purple Mountain Observatory Chinese Academy of Sciences

The neutron-rich even-even nuclei^26–40Mg,^28–46Si,^30–48S, and ^32–56Ar are calculated with the RMF model and the phase-shift electron scattering method. Results show that level inversion of the 2s1/2 and 1d3/2 proton states may occur for the magnesium, silicon, sulphur, and argon isotopes with more neutrons away from the stability line. Calculations show that the variation of the central charge densities for30–48S, and32–56Ar are very sensitive to the 2s1/2 and 1d3/2 proton state level inversion, and the level inversion can lead to a large measurable central charge depletion to the charge density distributions for the neutron-rich isotopes. Calculations also show that the charge density diferences between the isotopes with and without central charge depletion can reveal not only the level inversion of the 2s1/2 and 1d3/2 proton states but also the behavior of the proton wave functions of both states. The results can provide references for the possible study of the nuclear level inversion and nuclear bubble phenomenon with electron scattering of short-lived nuclei at RIKEN or/and GSI in the future. In addition, direct nuclear reaction 44S（n, d）43P or44S（3H, α）43P might also be a possible way to study the 2s1/2 and 1d3/2 proton state level inversion.

关键词： s-d level inversion electron-nucleus scattering RMF model phase-shift analysis

Synthesis and opto-electrical properties of Cu2NiSnS4 nanoparticles using a facile solid-phase process at low temperature

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Optoelectronics Letters 2020年第6期16卷 401-404页

作者： LI Shi-na MA Rui-xin NIU Jian-wen tianjin Research Institute for Water Transport Engineering Ministry of TransportTianjin 300000China school of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Cu_2NiSnS_4 nanoparticles were prepared for the first time using a facile solid-phase process at a temperature of 180 °C. The crystalline structure, morphology and optical properties of the Cu_2NiSnS_4 nanoparticles were characterized by means of X-ray diffraction(XRD), field emission scanning electron microscopy(FESEM), transmission electron microscope(TEM) and ultraviolet-visible(UV-vis) spectrophotometer. The band gap and conversion efficiency of Cu_2NiSnS_4 nanoparticles were studied at various temperature. The results showed that the Cu_2NiSnS_4 nanoparticles exhibited an optimum band gap of 1.58 e V and a conversion efficiency of 0.64% at 180 °C, indicating that it maybe be useful in low-cost thin film solar cells.

关键词： Synthesis and opto-electrical properties of Cu_2NiSnS_4 nanoparticles using a facile solid-phase process at low temperature

Hysteretic Neural Network and Its Application in the Prediction of the Wind Speed Series

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Hysteretic Neural Network and Its Application in the Predict...

Electrocatalytic reduction of NO to NH_(3) in ionic liquids by P-doped TiO_(2) nanotubes

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作者： Wang Hongfei Xiu Chunbo Li Yanqing Cheng Yi Chen Yimei school of Electrical Engineering and Automation Tianjin polytechnic University Key Laboratory of Advanced Electrical Engineering and Energy technology Tianjin polytechnic University school of Mathematics and Physics University of Science and Technology Beijing

ISBN: (纸本)9781479937066

In order to improve the information processing capabilities of the traditional neural network, and improve the forecast accuracy of the wind speed series, a new hysteretic neural network based on the hysteretic neurons is proposed. The hysteretic neuron is constructed by adding a hysteretic operator into the activation function. The hysteretic characteristic can make the response of the neuron is related to not only the current input information but also the history input information. In this way, the amount of information used in the prediction process is increased, and the prediction ability of the neural network can be improved. In order to avoid the information redundancy or loss, the structure and the training samples are determined according to the autocorrelation function and the partial autocorrelation function of the wind speed series. Simulation results show that the hysteretic neural network can complete the prediction of the wind speed series, and the prediction performance is superior to that of the same type neural network.

关键词： Wind Speed Series Hysteretic Neural Network Prediction Training Samples

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Frontiers of Chemical Science and Engineering 2023年第6期17卷 726-734页

作者： Shangcong Zhang Qian Liu Xinyue Tang Zhiming Zhou Tieyan Fan Yingmin You Qingcheng Zhang Shusheng Zhang Jun Luo Xijun Liu College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035China Low Voltage Apparatus technology Research Centre of Zhejiang Wenzhou UniversityWenzhou 325035China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China College of Chemistry Zhengzhou UniversityZhengzhou 450000China tianjin Key Lab for Photoelectric Materials&Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Compesite Structures School of ResourceEnvironments and MaterialsGuangxi UniversityNanning 530004China

Designing advanced and cost-effective electrocatalytic system for nitric oxide(NO)reduction reaction(NORR)is vital for sustainable NH_(3) production and NO removal,yet it is a challenging ***,it is shown that phosphorus(P)-doped titania(TiO_(2))nanotubes can be adopted as highly efficient catalyst for *** catalyst demonstrates impressive performance in ionic liquid(IL)-based electrolyte with a remarkable high Faradaic efficiency of 89%and NH3 yield rate of 425μg·h^(−1)·mg_(cat).^(−1),being close to the best-reported ***,the obtained performance metrics are significantly larger than those for N_(2) reduction *** also shows good durability with negligible activity decay even after 10 *** simulations reveal that the introduction of P dopants tunes the electronic structure of Ti active sites,thereby enhancing the NO adsorption and facilitating the desorption of ^(*)NH_(3).Moreover,the utilization of IL further suppresses the competitive hydrogen evolution *** study highlights the advantage of the catalyst−electrolyte engineering strategy for producing NH_(3) at a high efficiency and rate.

关键词： nitric oxide reduction reaction electrcatalysis ammonia production phosphorus-doped titania

Germanium nanopyramid arrays showing near-100% absorption in the visible regime

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Nano Research 2015年第7期8卷 2216-2222页

作者： Qi Han Yongqi Fu Lei Jin Jingjing Zhao Zongwei Xu Fengzhou Fang Jingsong Gao Weixing Yu school of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 China Key Laboratory of Precision Measuring technology & Instruments Centre of Micro-Nano Manufacturing Technology Tianjin University Tianjin 300072 China Institute of Micro & Nano Optics College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China

Solar energy is regarded as one of the most plentiful sources of renewable energy. An extraordinary light-harvesting property of a germanium periodic nanopyramid array is reported in this Letter. Both our theoretical and experimental results demonstrate that the nanopyramid array can achieve perfect broadband absorption from 500- to 800-nm wavelength. Especially in the visible regime, the experimentally measured absorption can even reach 100%. Further analyses reveal that the intrinsic antireflection effect and slow-light waveguide mode play an important role in the ultra-high absorption, which is helpful for the research and development of photovoltaic devices.

关键词： nanopyramid array,absorption coefficient,antireflection coatings,slow-light mode

Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

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Journal of Materials Science & technology 2021年第4期63卷 228-235页

作者： Yuxuan Mao Peng Li Jiewei Yin Yanjie Bai Huan Zhou Xiao Lin Huilin Yang Lei Yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou215000China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215000China school of Public Health Soochow UniversitySuzhou215000China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringHebei University of TechnologyTianjin300000China school of Mechanical Engineering Jiangsu University of TechnologyChangzhou213000China

Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue ***,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still *** this purpose,a series of ionically crosslinked starch hydrogels were developed *** viscoelastic properties and tissue adhesiveness of the starch hydrogels were *** is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue *** the starch gels,there was one exhibiting a unique and stable"Gel Point"viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and *** GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial *** wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury *** blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the *** above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.

关键词： sealing viscoelastic hydrogel

The Preparation of 2-Chloro-5-chloromethylpyridine in an Airlift Loop Reactor

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Chinese Journal of Chemical Engineering 2003年第5期11卷 608-610页

作者：闻建平王长林乔萍 school of Chemical Engineering and technology Tianjin University Tianjin 300072 China

A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5-chloro-methylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction conditions including TR, na/ns, cp, Qg and dD/dR were optimized. The average molar yield and purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under the optimum operating conditions. Finally, the efficiency for the preparation of 2-chloro-5-chloromethylpyridine with ALR and stirred tank reactor (STR) respectively was compared.

关键词： 2-chloro-5-chloromethylpyridine 2-chloro-5-methylpyridine direct chlorination airlift loop reactor

Targeting Tumor-Associated Macrophages by Anti-tumor Chinese Materia Medica

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Chinese Journal of Integrative Medicine 2017年第10期23卷 723-732页

作者： PU Wei-ling SUN Li-kang GAO Xiu-mei Curzio Rüegg Muriel Cuendet Micheal O.Hottiger ZHOU Kun MIAO Lin ZHANG Yun-sha Margaret Gebauer Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin (300193) China tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin (300193) China school of Integrative Medicine Tianjin University of Traditional Chinese Medicine Tianjin (300193) China Pathology Unit Department of Medicine FacUlty of Sciences University of Fribourg Fribourg Switzerland school of Pharmaceutical Sciences University of Geneva University of Lausanne Geneve Switzerland Department of Molecular Mechanisms of Disease University of Zurich-lrchel Zurich Switzerland Chingcura Center for Traditional Chinese Medicine. Zurich. Switzerland

Tumor-associated macrophages（TAMs） play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica（CMM） is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine（CM） and its practice, some prescriptions of CM regulate the body＇s internal environment possibly including the remodeling the tumor microenvironment（TME）. Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasisand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM＇s dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy.

关键词： tumor-associated macrophages tumor microenvironment Chinese materia medica Chinese medicine anti-tumor therapy