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Demographic Characteristics and Environmental Risk Factors Exposure of Birth Defects in Pregnant Women: A Population-based Study

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Biomedical and Environmental sciences 2019年第1期32卷 51-57页

作者： LIN Hong LUO Mi Yang LUO Jia You ZENG Rong LI Ya Mei DU Qi Yun FANG Jun Qun Xiangya school of Public health Central South University Saw Swee Hock school of Public health National University of Singapore Xiangya Hospital of Central South University Hunan Provincial Maternal and Child health Care Hospital

Worldwide, the incidence of birth defects in low-income countries is 6.42%, while in middle-income and high-income countries it is 5.57% and 4.72%, respectively;approximately 303, 000 newborns die from birth defects each year. In China, the incidence of birth defects is about 5.6%, and around 8.14 million people have congenital disabilities, accounting for 9.6% of total disabled people[1]. Birth defect remains a major clinical and public health challenge because of its high fatality rate and protracted and severe sequela.

关键词： Birth defects demographics Environmental risk factors

Reconstitution of membrane contact by unilamellar vesicles

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Biophysics Reports 2023年第4期9卷 188-194页

作者： Shulin Li Min Zhang Liang Ge State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life sciences school of Life sciences Tsinghua University school of Pharmaceutical sciences Tsinghua University

Eukaryotic cells compartmentalize diverse biochemical functions within organelles defined by intracellular membranes. Recent focus has intensified on studying the interactions among organelles and the role of membrane contacts in maintaining cellular balance. While analyzing these contacts mainly involves fluorescence and electron microscopy, as well as biochemical cell fractionation, understanding their mechanisms and responses to genetic and environmental changes remains challenging. Here we describe an approach employing in vitro reconstitution of membrane contacts using unilamellar vesicles. This technique offers insights into contact mechanisms when combined with established methods like fluorescence imaging and mass spectrometry, potentially deepening our understanding of membrane contacts and organelle networks.

关键词： Membrane contacts Organelle interaction network Giant unilamellar vesicle (GUV) Liposome ER-Golgi intermediate compartment (ERGIC) ER-exit sites (ERES) COPII TMED9 SEC12 Autophagy Autophagosome

Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats

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World Journal of Gastroenterology 2004年第19期10卷 2814-2817页

作者： Hiroshi Ichikawa Norimasa Yoshida Tomohisa Takagi Naoya Tomatsuri Kazuhiro Katada Yutaka Isozaki Kazuhiko Uchiyama Yuji Naito Takeshi Okanoue Toshikazu Yoshikawa Department of Food sciences and Nutritional health Faculty of Human EnvironmentKyoto Prefectural University606-8522Japan Department of Molecular Gastroenterology and Hepatology Graduate School of Medical SciencesKyoto Prefectural University of Medicine606-8522Japan Department of Inflammation and Immunology Graduate School of Medical SciencesKyoto Prefectural University of Medicine606-8522Japan

AIM: To investigate the protective effect of lansoprazoleon ischemia and reperfusion (I/R)-induced rat intestinalmucosal injury in ***: Intestinal damage was induced by clampingboth the superior mesenteric artery and the celiac trunkfor 30 rain followed by reperfusion in male Sprague-Dawleyrats. lansoprazole was given to rats intraperitoneally 1 hbefore vascular ***: Both the intraluminal hemoglobin and proteinlevels, as indices of mucosal damage, significantlyincreased in I/R-groups comparion with those of sham-operation groups. These increases in intraluminal hemoglobinand protein levels were significantly inhibited by the treatmentwith lansoprazole at a dose of 1 mg/kg. Small intestineexposed to I/R resulted in mucosal inflammation that wascharacterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associatedmyeloperoxidase activity (MPO), and mucosal content of ratcytokine-induced neutrophil chemoattractant-1 (CINC-1).These increases in TBARS, MPO activities and CINC-1 contentin the intestinal mucosa after I/R were all inhibited bypretreatment with lansoprazole at a dose of 1 mg/***, the CINC-1 mRNA expression was increasedduring intestinal I/R, and this increase in mRNA expressionwas inhibited by treatment with ***: Lansoprazole inhibits lipid peroxidation andreduces development of intestinal mucosal inflammationinduced by I/R in rats, suggesting that lansoprazole mayhave a therapeutic potential for I/R injury.

关键词： Animals Gastrointestinal Agents Inflammation control Intestinal Mucosa Ischemia Lipid Peroxidation Male Omeprazole derivatives Rats Rats, Sprague-Dawley Reperfusion

High density gas state at water/graphite interface studied by molecular dynamics simulation

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Chinese Physics B 2008年第7期17卷 2646-2654页

作者：王春雷李朝霞李敬源修鹏胡钧方海平 Shanghai Institute of Applied Physics Chinese Academy of Sciences Graduate school of the Chinese Academy of sciences Department of Physics Zhejiang University school of Physics and Microelectronics Shandong University Bio-X Life sciences Research Center College of Life Science and TechnologyShanghai Jiaotong University

In this paper molecular dynamics simulations are performed to study the accumulation behaviour of N2 and H2 at water/graphite interface under ambient temperature and pressure. It finds that both N2 and H2 molecules can accumulate at the interface and form one of two states according to the ratio of gas molecules number to square of graphite surface from our simulation results： gas films （pancake-like） for a larger ratio and nanobubbles for a smaller ratio. In addition, we discuss the stabilities of nanobubbles at different environment temperatures. Surprisingly, it is found that the density of both kinds of gas states can be greatly increased, even comparable with that of the liquid N2 and liquid H2. The present results are expected to be helpful for the understanding of the stable existence of gas film （pancake-like） and nanobubbles.

关键词： nanobubbles and gas film hydrophobic interface molecular dynamics simulations high density

Using single-molecule approach to visualize the nucleosome assembly in yeast nucleoplasmic extracts

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Science Bulletin 2017年第6期62卷 399-404页

作者： Xiuqiang Chen Ershuang Zhao Yu V.Fu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of Sciences Savaid Medical school University of Chinese Academy of Sciences

In eukaryotic cells,the smallest subunit of chromatin is the nucleosome,which consists of a segment of DNA wound on histone protein cores. Despite many years of effort,the process of nucleosome assembly and disassembly is still not very clear. Here,we present a convenient method to investigate the process of nucleosome assembly at the single molecule level. We invented a novel system derived from the yeast nucleoplasmic extracts(YNPE),and demonstrated that the YNPE supports the nucleosome assembly under physiological condition. By combining the total internal reflection fluorescence microscopy with microfluidic flow-cell technique,the dynamic process of nucleosome assembly in YNPE was visualized at single-molecule level. Our system provides a novel in vitro single-molecule tool to investigate the dynamics of nucleosome assembly under physiological conditions.

关键词： Nucleosome assembly Single-molecule Yeast nucleoplasmic extracts Total internal reflection fluorescence Microfluidic flow-cell

Clinical significance of erectile dysfunction developing after acute coronary event： exception to the rule or confirmation of the artery size hypothesis？

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Asian Journal of Andrology 2015年第1期17卷 21-25,I0006页

作者： Piero Montorsi Paolo M Ravagnani Charalambos Vlachopoulos Department of Clinical sciences and Community health Cardiovascular Section University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Department of Cardiology Athens Medical School Greece.

Erectile dysfunction （ED） has been found to frequently precedes the onset of coronary artery disease （CAD）, representing an early marker of subclinical vascular disease, included CAD. Its recognition is, therefore, a ＂window opportunity＂ to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis （ASH） has been proposed as a putative mechanism to explain the relationship between ED and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels （i.e. the penile artery） being able to less well tolerate the same amount of plaque when compared with larger ones （i.e. the coronary artery）. If true, ED will develop before CAD. We present a case in which ED developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.

关键词： artery size hypothesis coronary artery disease erectile dysfunction

Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors

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Science China Chemistry 2014年第6期57卷 823-832页

作者： ZOU DingBiao QIU YaTao TU ZhengChao LIAO ChenZhong LUO JinFeng MENG QingQing YAO RiSheng LI Zheng JIANG Sheng Laboratory of Medicinal Chemistry Guangzhou Institute of Biomedicine and HealthChinese Academy of Sciences school of Medical Engineering Hefei University of Technology Department of Radiology the Methodist Hospital Research Institute

We designed a series of 2-methylpyrimidine derivatives as new BCR-ABL inhibitors using scaffold-hopping *** synthetic compounds exhibited significant inhibition against a broad spectrum of Bcr-Abl mutants including the gatekeeper T315I *** 7u showed very potent kinase inhibitory activities against Bcr-Abl WT,Bcr-Abl E255K,Bcr-Abl Q252H,Bcr-Abl G250E and Bcr-Abl T315I,with IC50 values of 0.13 nM,0.17 nM,0.24 nM,0.19 nM and 0.65μM,*** compound also displayed anti-proliferation activity against K562 cell line with an IC50 value of 1.1 nM,thus representing a new lead for further optimization.

关键词： chronic myeloid leukemia(CML) anticancer agents Bcr-Abl imatinib resistance

High-temperature failure mechanism and defect sensitivity of TC17 titanium alloy in high cycle fatigue

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Journal of Materials Science & Technology 2022年第27期122卷 128-140页

作者： Gen Li Chengqi Sun State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences school of Engineering Science University of Chinese Academy of Sciences

Crack initiation is an essential stage of fatigue process due to its direct effect on fatigue ***,for titanium alloys in high-temperature high cycle fatigue(HCF),the crack initiation mechanisms remain unclear and the understanding for the defect sensitivity is also *** this study,a series of fatigue tests and multi-scale microstructure characterizations were conducted to explore the high-temperature failure mechanism,and the coupled effect of temperature and defect on TC17 titanium alloy in *** was found that an oxygen-rich layer(ORL)was produced at specimen surface at elevated temperatures,and brittle fracture of ORL at surface played a critical role for surface crack initiation in ***,internal crack initiation with nanograins at high temperatures was a novel finding for the titanium *** on energy dispersive spectroscopy,electron backscatter diffraction and transmission electron microscope characterizations,the competition between surface and internal crack initiations at high temperatures was related to ORL at surface and dislocation resistance in inner *** fatigue strengths of smooth specimens decreased at elevated temperatures due to the lower dislocation *** the fatigue strengths of the specimens with defect were not very sensitive to the ***,a fatigue strength model considering the coupled effect of temperature and defect was proposed for TC17titanium alloy.

关键词： TC17 titanium alloy High temperature Defect High cycle fatigue Oxygen-rich layer Rough area

Enhanced removal of Cr(Ⅵ) by biochar with Fe as electron shuttles

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Journal of Environmental sciences 2019年第4期31卷 109-117页

作者： Jingwen Xu Yongguang Yin Zhiqiang Tan Bowen Wang Xiaoru Guo Xia Li Jingfu Liu school of Environmental sciences Liaoning University State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of sciences

Biochar is extensively used as an effective soil amendment for environmental *** addition to its strong contaminant sorption capability, biochar also plays an important role in chemical transformation of contaminant due to its inherent redox-active ***, the transformation efficiency of inorganic contaminants is generally very limited when the direct adsorption of contaminants on biochar is inefficient. The present study demonstrates the role of Fe ion as an electron shuttle to enhance Cr(Ⅵ) reduction by biochars. Batch experiments were conducted to examine the effects of Fe(Ⅲ) levels,pyrolysis temperature of biochar, initial solution pH, and biochar dosage on the efficiency of Cr(Ⅵ) removal. Results showed a significant enhancement in Cr(Ⅵ) reduction with an increase in Fe(Ⅲ) concentration and a decrease of initial pH. Biochar produced at higher pyrolysis temperatures(e.g., 700°C) favored Cr(Ⅵ) removal, especially in the presence of Fe(Ⅲ), while a higher biochar dosage proved unfavorable likely due to the agglomeration or precipitation of biochar. Speciation analysis of Fe and Cr elements on the surface of biochar and in the solution further confirmed the role of Fe ion as an electron shuttle between biochar and Cr(Ⅵ). The present findings provide a potential strategy for the advanced treatment of Cr(Ⅵ) at low concentrations as well as an insight into the environmental fate of Cr(Ⅵ) and other micro-pollutants in soil or aqueous compartments containing Fe and natural or engineered carbonaceous materials.

关键词： Biochar Electron shuttle Fe(Ⅲ) Reduction Cr(Ⅵ)