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Anti-psoriasis molecular targets and active components discovery of Optimized Yinxieling Formula via affinity-purified strategy

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Chinese Journal of Natural medicines 2024年第2期22卷 127-136页

作者： WANG Wei LIU Lijuan YANG Zhuo LU Chuanjian TU Pengfei ZHAO Ruizhi ZENG Kewu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Dampness Syndrome of Chinese medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China

Psoriasis,a prevalent inherited skin condition,involves an inflammatory response as a key pathogenic *** Optimized Yinxieling Formula(OYF),rooted in traditional Chinese medicine,is extensively utilized in clinical settings to treat *** previous studies have demonstrated OYF’s significant anti-inflammatory effects in psoriasis,its potential molecular targets and active components remain *** study aimed to unveil the anti-psoriasis molecular targets and active components of *** findings indicated that OYF extract markedly reduced the production of several inflammatory mediators,including IL-23,nitric oxide,TNF-α,and IL-1β,in LPS-induced RAW264.7 *** synthesized OYF extract-crosslinked beads to isolate pharmacological targets from RAW264.7 lysates using an affinity purification strategy,known as Target *** enriched target proteins were subsequently identified via LC-MS/MS,followed by bioinformatics analysis to map the psoriasis-associated pathway-gene *** identified a total of 76 potential target proteins,which were highly associated with mRNA transcription *** particular,pathway-gene network analysis revealed that the IL-23 inflammatory pathway was involved in the anti-psoriasis effect of OYF *** further utilized a target protein-based affinity capture strategy,combined with LC-MS and SPR analysis,to globally screen OYF’s active components,focusing on the mRNA transcription regulator,fused in sarcoma(FUS).This process led to the identification of umbelliferone,vanillic acid,protocatechuic acid,gentisic acid,and echinacoside as key compounds targeting FUS to inhibit IL-23 ***,we formulated a compound cocktail(CpdC),which significantly reduced psoriasis area and severity index(PASI)scores and the expressions of IL-23 and Ki67 in an imiquimod(IMQ)-induced psoriasis mouse ***,our study elucidates the primary molecular targets and active components of OYF,offeri

关键词： Psoriasis Optimized Yinxieling Formula(OYF) FUS protein Molecular targets Affinity-purified strategy

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Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens

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fundamental Research 2024年第2期4卷 394-400页

作者： Huaxia Wang Qing Tian Ying Zhang Yibo Xi Lidan Hu Ke Yao Jingyuan Li Xiangjun Chen Eye Center of the Second Affiliated Hospital Zhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Institute of Translational medicine Zhejiang University School of Medicine268 Kaixuan RoadHangzhou 310020China. State Key Laboratory of Membrane Biology School of Life SciencesTsinghua UniversityBeijing 100084China The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityZheda Road 38Hangzhou 310027China

Protein misfolding and aggregation are crucial pathogenic factors for cataracts,which are the leading cause of visual impairment worldwide.α-crystallin,as a small molecular chaperone,is involved in preventing protein misfolding and maintaining lens *** chaperone activity of α-crystallin depends on its oligomeric *** previous work identified a natural compound,celastrol,which could regulate the oligomeric state of α*** this work,based on the UNcle and SEC analysis,we found that celastrol induced𝛼αB-crystallin to form large *** oligomer formation enhanced the chaperone activity of αB-crystallin and prevented aggregation of the cataract-causing mutant α*** interactions between𝛼αB-crystallin and celastrol were detected by the FRET(Fluorescence Resonance Energy Transfer)technique,and verified by molecular *** least 9 binding patterns were recognized,and some binding sites covered the groove structure of α***,αB-R120G,a cataract-causing mutation located at the groove structure,and celastrol can decrease the aggregates of α***,our results suggested celastrol not only promoted the formation of large αB-crystallin oligomers,which enhanced its chaperone activity,but also bound to the groove structure of its α-crystallin domain to maintain its structural *** might serve as a chemical and pharmacological chaperone for cataract treatment.

关键词： αB-crystallin Celastrol Interactions Oligomeric state Chaperone activity Structural stability

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Regenerative treatment of ophthalmic diseases with stem cells:Principles,progress,and challenges

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Advances in Ophthalmology Practice and Research 2024年第2期4卷 52-64页

作者： Yifei Niu Junfeng Ji Ke Yao Qiuli Fu Eye Center of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Zhejiang Provincial Key Lab of Ophthalmology HangzhouZhejiang ProvinceChina Center of Stem Cell and Regenerative medicine School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative medicine HangzhouChina

Background:Degenerate eye disorders,such as glaucoma,cataracts and age-related macular degeneration(AMD),are prevalent causes of blindness and visual impairment *** eye disorders,including limbal stem cell deficiency(LSCD),dry eye diseases(DED),and retinitis pigmentosa(RP),result in symptoms such as ocular discomfort and impaired visual function,significantly impacting quality of *** therapies are limited,primarily focus on delaying disease progression,while emerging stem cell therapy directly targets ocular tissues,aiming to restore ocular function by reconstructing ocular *** text:The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant,owing to the regenerative and malleable properties of stem cells and their functional ***,stem cell therapy for ophthalmopathy involves various cell types,such as embryonic stem cells(ESCs),induced pluripotent stem cells(iPSCs),mesenchymal stem cells(MSCs),and retinal progenitor cells(RPCs).In the current article,we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the *** therapies aim to address the loss of functional cells,restore damaged ocular tissue and or in a paracrine-mediated *** also provide an overview of the ocular disorders that stem cell therapy is targeting,as well as the difficulties and opportunities in this ***:Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflam-mation and provide neuroprotection,making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.

关键词： Stem cell Ocular diseases Induced pluripotent stem cells Mesenchymal stem cells Cataracts Glaucoma Diabetic retinopathy Retinal degenerative diseases

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Is Yang-Mills theory unitary in fractional spacetime dimensions?

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 59-64页

作者： Qingjun Jin Ke Ren Gang Yang Rui Yu Graduate school of China Academy of Engineering Physics Beijing 100193China school of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China school of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Hangzhou 310024China school of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China Beijing Computational Science Research Center Beijing 100193China

We present concrete evidence that Yang-Mills theory exhibits non-unitarity in non-integer spacetime *** violation of unitarity stems from evanescent operators that,while vanishing in four dimensions,are non-zero in general d *** demonstrate that these evanescent operators lead to the emergence of both negative-norm states and complex anomalous dimensions.

关键词： gauge field theories field theories in dimensions other than four renormalization

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Flurbiprofen microneedle patches for the management of acute postoperative pain

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Nano Research 2024年第8期17卷 7493-7503页

作者： Huaqing Chu Yanyan Zhang Yuan Yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western medicine on Prevention and Treatment of Cardio-Cerebral Diseases School of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208China school of Life Science Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are *** study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be *** crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic *** solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared *** demonstrated increasing mechanical strength with higher *** release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of *** vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 *** tests confirmed good ***/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关键词： microneedle postoperative pain flurbiprofen non-steroid anti-inflammatory drug cross-linked gelatin

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Advances in All-Solid-State Lithium-Sulfur Batteries for Commercialization

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Nano-Micro Letters 2024年第9期16卷 209-246页

作者： Birhanu Bayissa Gicha Lemma Teshome Tufa Njemuwa Nwaji Xiaojun Hu Jaebeom Lee Research Institute of Materials Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea Institute of fundamental Technological Research Polish Academy of Sciences02‑106 WarsawPoland school of Life Sciences Shanghai University200444 ShanghaiPeople’s Republic of China Department of Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea

Solid-state batteries are commonly acknowledged as the forthcoming evolution in energy storage *** development progress for these rechargeable batteries has notably accelerated their trajectory toward achieving commercial *** particular,all-solid-state lithium-sulfur batteries(ASSLSBs)that rely on lithium-sulfur reversible redox processes exhibit immense potential as an energy storage system,surpassing conventional lithium-ion *** can be attributed predominantly to their exceptional energy density,extended operational lifespan,and heightened safety *** these advantages,the adoption of ASSLSBs in the commercial sector has been *** expedite research and development in this particular area,this article provides a thorough review of the current state of *** delve into an in-depth analysis of the rationale behind transitioning to ASSLSBs,explore the fundamental scientific principles involved,and provide a comprehensive evaluation of the main challenges faced by *** suggest that future research in this field should prioritize plummeting the presence of inactive substances,adopting electrodes with optimum performance,minimizing interfacial resistance,and designing a scalable fabrication approach to facilitate the commercialization of ASSLSBs.

关键词： All-solid-state lithium-sulfur batteries Commercialization Enhancement strategies Solid-state electrolytes Sulfurbased cathodes

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Time-reversal asymmetries in Λ_(b)→Λ(→pπ^(−))ℓ^(+)ℓ^(−)

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Chinese Physics C 2024年第3期48卷 1-14页

作者：耿朝强刘佳韦魏正乙 school of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China University of Chinese Academy of Sciences Beijing 100190China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China

We study the decays ofΛb→Λ(→pπ^(−))ℓ^(+)ℓ^(−)withℓ=(e,μ,τ).We examine the full angular distributions with polarizedΛb,where the T-odd observables are *** discuss the possible effects of new physics(NP)and find that the T-odd observables are sensitive to them as they vanish in the standard *** attention is given to the interference of(pseudo)scalar operators with(axial)vector operators in polarized Λ_(b)→Λ(→pπ^(−))τ^(+)τ^(−),which are studied for the first *** effects are proportional to the lepton masses and therefore may evade the constraint from Λ_(b)→Λ(→pπ^(−))μ^(+)μ^(−) at the LHCb ***Λ_(b)→Λ(→pπ^(−))τ^(+)τ^(−) is uncontaminated by the charmonia resonance,it provides a clean background to probe *** addition,we show that the experimental central value of K10 in Λ_(b)→Λ(→pπ^(−))μ^(+)μ^(−) at the LHCb can be explained by the NP case,which couples to the right-handed quarks and *** polarization fraction of Λ_(b) at the LHCb is found to be consistent with zero regardless of the NP scenarios.

关键词： time reversal asymmetry angular distribution new physics T-odd correlation

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Impacts of gravitational-wave background from supermassive black hole binaries on the detection of compact binaries by LISA

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Chinese Physics C 2024年第6期48卷 198-203页

作者：黄帆毕研晨曹周键黄庆国 CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China school of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Applied Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China school of fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China

In the frequency band of the Laser Interferometer Space Antenna(LISA),extensive research has been conducted on the impact of foreground confusion noise generated by galactic binaries within the Milky Way ***,recent evidence of a stochastic signal,announced by the NANOGrav,EPTA,PPTA,CPTA,and InPTA,indicates that the stochastic gravitational-wave background(SGWB)generated by supermassive black hole binaries(SMBHBs)can contribute strong background noise within the LISA *** the presence of such strong noise,it is expected to have significant impacts on LISA's scientific *** this study,we investigate the impacts of the SGWB generated by SMBHBs on the detection of individual massive black hole binaries,verified galactic binaries,and extreme mass ratio inspirals in the context of *** find it essential to resolve and eliminate the excess noise from the SGWB to guarantee the success of LISA's missions.

关键词： gravitational-wave background supermassive black hole binaries LISA

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Classification research of TCM pulse conditions based on multi-label voice analysis

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 172-179页

作者： Haoran Shen Junjie Cao Lin Zhang Jing Li Jianghong Liu Zhiyuan Chu Shifeng Wang Yanjiang Qiao Key Laboratory of TCM-information Engineer of State Administration of TCM School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China school of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing102488China Sinosense Technology Co. LtdBeijing100141China

Objective To explore the feasibility of remotely obtaining complex information on traditional Chinese medicine(TCM)pulse conditions through voice *** We used multi-label pulse conditions as the entry point and modeled and analyzed TCM pulse diagnosis by combining voice analysis and machine *** features were extracted from voice recordings in the TCM pulse condition *** obtained features were combined with information from tongue and facial diagnoses.A multi-label pulse condition voice classification DNN model was built using 10-fold cross-validation,and the modeling methods were validated using publicly available *** The analysis showed that the proposed method achieved an accuracy of 92.59%on the public *** accuracies of the three single-label pulse manifestation models in the test set were 94.27%,96.35%,and 95.39%.The absolute accuracy of the multi-label model was 92.74%.Conclusion Voice data analysis may serve as a remote adjunct to the TCM diagnostic method for pulse condition assessment.

关键词： Pulse conditions TCM pulse diagnosis Voice analysis Multi-label classification Machine learning

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A post-modification strategy to precisely construct dual-atom sites for oxygen reduction electrocatalysis

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Journal of Energy Chemistry 2024年第3期90卷 511-517,I0012页

作者： Juan Wang Xinyan Liu Chang-Xin Zhao Yun-Wei Song Jia-Ning Liu Xi-Yao Li Chen-Xi Bi Xin Wan Jianglan Shui Hong-Jie Peng Bo-Quan Li Jia-Qi Huang school of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina school of Materials Science and Engineering Beihang UniversityBeijing 100191China

Dual-atom catalysts(DACs) afford promising potential for oxygen reduction electrocatalysis due to their high atomic efficiency and high intrinsic ***,precise construction of dual-atom sites remains a *** this work,a post-modification strategy is proposed to precisely fabricate DACs for oxygen reduction ***,a secondary metal precursor is introduced to the primary single-atom sites to introduce direct metal-metal interaction,which ensures the formation of desired atom pair structure during the subsequent pyrolysis process and allows for successful construction of *** as-prepared FeCo-NC DAC exhibits superior oxygen reduction electrocatalytic activity with a half-wave potential of 0,91 V *** hydrogen ***-air batteries equipped with the FeCo-NC DAC demonstrate higher peak power density than those with the Pt/C *** importantly,this post-modification strategy is demonstrated universal to achieve a variety of dual-atom *** work presents an effective synthesis methodology for precise construction of catalytic materials and propels their applications in energy-related devices.

关键词： Dual-atom catalysts Electrocatalysis Oxygen reduction reaction Post-modification Zinc–air batteries

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