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Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases

Military Medical Research 2018年第3期5卷 263-278页

作者： Md.Saddam Hussain Vishwas Tripathi school of biotechnology Gautam Buddha University

Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases. In this review, we shed light on all reported mechanisms whereby cigarette smoke and a hypoxic environment can induce inflammatory and autoimmune diseases and discuss how hypoxic conditions influence the cigarette smoke-induced threat of inflammatory and autoimmune disease development. Cigarette smoke and hypoxia both lead to increased oxidative stress and production of reactive oxygen species and other free radicals, which have various effects including the generation of autoreactive pro-inflammatory T cells and autoantibodies, reductions in T regulatory(Treg) cell activity, and enhanced expression of pro-inflammatory mediators [e.g., interleukin-6(IL-6), interleukin-4(IL-4) and interleukin-8(IL-8)]. Accordingly, smoking and hypoxic environments may synergistically act as potent environmental risk factors for inflammatory and autoimmune diseases. To our knowledge, no studies have reported the direct association of cigarette smoke and hypoxic environments with the risk of developing inflammatory and autoimmune diseases. Future studies exploring the risk of autoimmune disease development in smokers at high altitudes, particularly military personnel and mountaineers who are not acclimatized to high-altitude regions, are required to obtain a better understanding of disease risk as well as its management.

关键词： Inflammatory and autoimmune diseases Cigarette smoke Hypobaric hypoxia Oxidative stress Epigenetic modifications Pro-inflammatory mediators Autoantibody

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Performance analysis of an improved dynamic power management model in wireless sensor node

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Digital Communications and Networks 2017年第1期3卷 19-29页

作者： Anuradha Pughat Vidushi Sharma school of Information and Communication Technology Gautam Buddha University Greater Noida India

The energy consumption in the wireless sensor networks is a very critical issue which attracts immediate attention for the sake of the growing demand of the billion dollar market in future. The Dynamic Power Management （DPM） technique is a way of controlling and saving the energy usage in a sensor node. Previously, researchers have proposed lifetime improving stochastic models for wireless sensor networks and limited work has been done focusing on the wireless sensor node. This paper proposes an analyser based Semi-Markov model for DPM in the event-driven sensor node. The power consumption comparison with previously proposed models without this analyser shows the analyser significant contributes to lifetime improvement. The improved model is more power efficient, presents how the DPM model observes the input event arrival and power states of the sensor node components, and then dynamically manages the power consumption of the overall system. Further, to observe the effect of event arrival, missed events, waiting time, processor utilization on the power consumption and lifetime, the proposed DPM system with the single server queuing model is developed.

关键词： Dynamic power managementStochastic modelLifetime improvementEvent drivenPower consumptionWireless sensor nodeAnalyser basedEvent arrivalSimulation modelPower analysis

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Visualizing the Transport of Porcine Reproductive and Respiratory Syndrome Virus in Live Cells by Quantum Dots-Based Single Virus Tracking

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Virologica Sinica 2020年第4期35卷 407-416页

作者： Zhenpu Liang Pengjuan Li Caiping Wang Deepali Singh Xiaoxia Zhang College of Life Sciences Key Laboratory of Enzyme Engineering of Agricultural Microbiology(Ministry of Agriculture)Henan Agricultural UniversityZhengzhou 450000China school of biotechnology Gautam Buddha UniversityGreater Noida 201312India

Quantum dots(QDs)-based single particle analysis technique enables real-time tracking of the viral infection in live cells with great sensitivity over a long period of *** porcine reproductive and respiratory syndrome virus(PRRSV)is a small virus with the virion size of 40–60 nm which causes great economic losses to the swine industry worldwide.A clear understanding of the viral infection mechanism is essential for the development of effective antiviral *** this study,we labeled the PRRSV with QDs using the streptavidin–biotin labeling system and monitored the viral infection process in live *** results indicated that the labeling method had negligible effect on viral *** also observed that prior to the entry,PRRSV vibrated on the plasma membrane,and entered the cells via endosome mediated cell entry *** moved in a slow–fast–slow oscillatory movement pattern and finally accumulated in a perinuclear region of the *** results also showed that once inside the cell,PRRSV moved along the microtubule,microfilament and vimentin cytoskeletal *** the transport process,virus particles also made contacts with non-muscle myosin heavy chainⅡ-A(NMHCⅡ-A),visualized as small spheres in *** study can facilitate the application of QDs in virus infection imaging,especially the smaller-sized viruses and provide some novel and important insights into PRRSV infection mechanism.

关键词： Single virus tracking Quantum dots(QDs) Biotinylation Porcine reproductive and respiratory syndrome virus(PRRSV) Transport

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Natural compounds as potential inhibitors of SARS-CoV-2 main protease: An insilico study

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 155-163页

作者： Amaresh Mishra Yamini Pathak Anuj Kumar Surabhi Kirti Mishra Vishwas Tripathi school of biotechnology Gautam Buddha UniversityGreater Noida-201310India Bioinformatics Laboratory Uttarakhand Council for BiotechnologyBiotech BhawanPantnagarU.S.NagarUttarakhand-263145India Advanced Centre for Computational and Applied biotechnology Uttarakhand Council for BiotechnologyDehradun-248007India school of biotechnology Jawaharlal Nehru UniversityNew DelhiIndia

Objective:To explore natural compounds as potential inhibitors against main protease(Mpro)of ***:In the current study,systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and *** natural compounds were further validated using a combination of molecular dynamic(MD)simulations and molecular mechanic Poisson-Boltzmann surface area(MM/PBSA)free energy c alculation ***:Out of twenty natural compounds,four natural metabolites namely,amentoflavone,guggulsterone,puerarin,and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking *** MD simulations,all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro ***:Guggulsterone is a potential inhibitor of COVID-19 main protease *** in vitro and pre-clinical studies are needed.

关键词： SARS-CoV-2 COVID-19 Amentoflavone Guggulsterone Puerarin Piperine

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Oxidative Stress Responsive <i>SERK1</i>Gene Directs the Progression of Somatic Embryogenesis in Cotton (<i>Gossypium hirsutum</i>L. cv. Coker 310)

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American Journal of Plant Sciences 2014年第1期5卷 80-102页

作者： Dhananjay K. Pandey Bhupendra Chaudhary school of biotechnology Gautam Buddha University Greater Noida India

Somatic embryogenesis (SE) is a prominent mode of regeneration in plants. The acquisition of SE is predominantly invoked by the oxidative stress which plays an important role in signal transduction and cellular redox. Since balanced generation of oxidants is important to cellular differentiation, modulation in cell redox could be responsive to genotypic refinement for SE. To study the dynamics of cellular redox during SE, we conducted comparative expression analyses of cotton (Gossypium hirsutum), using two independently purified near-isogenic lines for the trait of SE. We interrogated expression changes in cell-signaling factor Somatic Embryogenesis Receptor Kinase (SERK) and activity of antioxidant Glutathione in different developmental stages including cotyledonary leaf, calli from different stages of regeneration of fully-regenerating (FR) and non-regenerating (NR) lines of Coker310 cultivar. At evolutionary scale, the cotton SERKs showed high sequence similarity in receptor kinase domain with diverse systems. Exclusively, SERK1 responsible for potential signaling processes during SE revealed significant expression up-regulation in the embryogenic calli of FR line. Similarly, activity of antioxidant glutathione was substantially up-regulated in embryogenic calli of FR line in comparison to its counterpart form. In contrast, calli from early-stages of regeneration of both FR and NR lines had no significant influences on the regulation of SERK and glutathione levels prior to the acquisition of embryogenesis. These results highlight that in vitro purification of FR line in cotton for enhanced regeneration potential (through SE) resulted in signaling and metabolic transformations of the manner in which cellular redox levels have become modulated.

关键词： Cotton Somatic Embryogenesis SERK Antioxidant

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A Botanist’s Cognitive View on Plant Growth: Cross-Talk between Developmental and Sensitivity Networks

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American Journal of Plant Sciences 2016年第15期7卷 2307-2322页

作者： Dhananjay K. Pandey Bhupendra Chaudhary school of biotechnology Gautam Buddha University Greater Noida India

An alteration in plant phenotypes assisted by their responses to the environmental stimuli (=tropism) has been fundamental to understand the “plant sensitivity ” that plays a crucial role in plants’ adaptive success. Plants succeed through the deployment of moderators controlling polar auxin-transport determining organ bending. Stimulus-specific effectors can be synthesized by the outer peripheral cells at the bending sites where they target highly conserved cellular processes and potentially persuade the plant sensitivity at large. Remarkably, the peripheral cells require different time-intervals to achieve the threshold expression-levels of stimulus-specific molecular responders. After stimulus perception, tropic curvatures (especially at growing root-apices) are duly coordinated via integrated chemical and electrical signalling which is the key to cellular communications. Thus, the acquired phenotypic alterations are the perplexed outcome of plant’s developmental pace, complemented by the sensitivity. A novel aspect of this study is to advance our understanding of plant developmental-programming and the extent of plant-sensitivity, determining the plant growth and their future applications.

关键词： Tropism Anisotropy Plant Development Polar Auxin Transport Phototropic Response Gravitropic Response

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Prospects for 3D bioprinting of organoids

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Bio-Design and Manufacturing 2021年第3期4卷 627-640页

作者： Preety Rawal Dinesh M.Tripathi Seeram Ramakrishna Savneet Kaur Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences(ILBS)D1Vasant KunjNew Delhi 110070India school of biotechnology Gautam Buddha UniversityGreater NoidaIndia Department of Mechanical Engineering National University of SingaporeSingaporeSingapore

Three-dimensional(3D)organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative ***,lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies.3D bioprinting of organoids has recently emerged to address some of these *** this review,we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and *** also summarize the use of several vascularization strategies for the bioprinted organoids,that are critical for a complex tissue *** fully realize the translational applications of organoids in disease modeling and regenerative medicine,these areas in 3D bioprinting need to be appropriately harnessed and channelized.

关键词： Three-dimensional bioprinting Bioink Organoid Microfluidics Extracellular matrix(ECM) Biomaterial

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Role of Plant Somatic Embryogenesis Receptor Kinases (SERKs) in Cell-to-Embryo Transitional Activity: Key at Novel Assorted Structural Subunits

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American Journal of Plant Sciences 2014年第21期5卷 3177-3193页

作者： Dhananjay Kumar Pandey Bhupendra Chaudhary school of biotechnology Gautam Buddha University Greater Noida India

Somatic Embryogenesis Receptor Kinase (SERK) family of receptor kinases is functionally diverse, involved in cell-to-embryo transition and controlling a number of other fundamental aspects of plant development. The morphological transformation of somatic to embryonic cells has drawn scientific attention utmost due to remarkable genetic-switch system evolved across species. Receptor kinases having direct role in somatic embryogenesis (SE) and involved in other functions are designated as “SERK” and “SERK-like” genes, respectively. We aim for phylogenetic reconstruction to reveal major SERK groups across plant species (angiosperm to gymnosperm) for their functional diversification. Data indicate that the development of SERK proteins occurred prior to the divergence of monocots and eudicots. Also, the SERK orthology is not directly proportional to their functions. Structure prediction results identified novel transmembrane topologies, short linear motifs and O-glycosylation sites exclusively in SERK proteins than SERK-like proteins. Comparative temporal expression analyses of SERK and SERK-like genes provided significant accordance with their physiological function. The identification of intrinsic disordered regions (IDRs) exclusively in SERK proteins was assumed to perceive external stress-induced signals that may lead to rapid protein folding. In a result it switches-on the precise cellular signals essential for the acquisition of SE. Moreover, the regulatory sequences of SERK genes are evolved with unique cellular fate deciding AP2-like ethylene responsive transcription factor AINTEGUMENTA binding sites for their spatial expression in SE. Based on these analyses we suggest future avenues of research that may be imperative for elucidating the importance of SERK gene evolution in SE.

关键词： Somatic Embryogenesis Cell-Signalling SERK Evolution

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To Bloom or Not to Bloom： Role of MicroRNAs in Plant Flowering

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Molecular Plant 2015年第3期8卷 359-377页

作者： Sachin Teotia Provincial State Key Laboratory of Wheat and Maize Crop Science Henan Agricultural University Zhengzhou 450002 China school of biotechnology Gautam Buddha University Greater Noida U.P. 201312 India Department of Biological Sciences and biotechnology Research Center (BRC) Michigan Technological University Houghton MI 49931 USA

During the course of their life cycles, plants undergo various morphological and physiological changes un- derlying juvenile-to-adult and adult-to-flowering phase transitions. To flower or not to flower is a key step of plasticity of a plant toward the start of its new life cycle. In addition to the previously revealed intrinsic genetic programs, exogenous cues, and endogenous cues, a class of small non-coding RNAs, microRNAs （miRNAs）, plays a key role in plants making the decision to flower by integrating into the known flowering pathways. This review highlights the age-dependent flowering pathway with a focus on a number of timing miRNAs in determining such a key process. The contributions of other miRNAs which exist mainly outside the age pathway are also discussed. Approaches to study the flowering-determining miRNAs, their inter- actions, and applications are presented.

关键词： flowering time phase transition miRNA miR156 miR172 SPL AP2-like

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Bacterial Surface Layer Proteins: From Moonlighting to Biomimetics: A New Horizonto Lead

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Advances in Bioscience and biotechnology 2018年第8期9卷 352-372页

作者： Nimisha Gaur Ankit Sharma Barkha Singhal school of biotechnology gautam buddha university Greater Noida (U.P.) India

The landmark discovery of moonlighting proteins embarks the significant progress in understanding the biological complexity and their closed-circuit analysis. The growing continuum in the variety of moonlighting functions paved the way for further elucidation of structural-functional aspects of protein evolution and design of proteins with novel functions. Currently, the moonlighting functions in various adhesive properties of surface layer proteins, an essential component of cell surface architecture of archaea and all phylogenetic groups of eubacteria become more prominently recognized. The remarkable credentials of surface layer proteins to self-assemble into supramolecular structures at nano-scale dimension have been exploited for the production of smart biomaterials in the form of biomimetics has been thrust area of research. The finely tuned topological features in terms of shape, size, geometry and surface chemistry of surface layer proteins are crucial for the production of biomimetics. The current developments of biomimetic lipid bilayers and composite membranes find applicability in understanding the functional dynamism of evolutionary relationship of bacterial cell envelopes and vaccine development, drug development and drug delivery. Though the development of biomimetics embraces fascination but faces with technological challenges. The plethora of literature has been available for the moonlighting aspects and nano-technological applications separately but none of the review describes towards the rhythmic transition from moonlighting functions of surface layer proteins of bacteria to biomimetics development and applications. Therefore, this review describes certain basic aspects of moonlighting functions and their mechanism of action, surface layer proteins and their moonlighting functions of commensal bacteria and their transition towards biomimetics. The recent developments of biomimetics based on surface layer proteins have been summarized and also pos

关键词： Moonlighting Biomimetic Surface Layer Proteins Self-Assembly Nano-biotechnology

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