检索结果-南通市图书馆

Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第3期13卷 393-401页

作者： Nicole J.Scott-Hewitt Christopher J.Folts Mark D.Noble Department of biomedical Genetics University of Rochester School of Medicine and Dentistry

This review addresses two puzzling findings related to mutations in galactocerebrosidase （GALC） that cause Krabbe disease （KD）, a severe lysosomal storage disorder characterized by extensive myelin damage in children with mutations in both GALC alleles. First, heterozygous carriers of KD-causing mutations, which include the biological parents of children with KD, exhibit increased risk for developing other diseases. Second, variants in the GALC locus increase the risk of developing multiple sclerosis （MS）, another disease characterized by extensive myelin damage. What explains these correlations？ In studies on cuprizone-induced myelin damage in heterozygous （GALC＋/–） mice carrying one copy of a mutation that causes KD-like disease, the extent of damage was similar in GALC＋/– and wild-type （WT） mice. In contrast, GALC＋/- mice had striking defects in repair of cuprizone-induced damage. We further found unexpected microglial defects in myelin debris clearance and in the ability to up-regulate the Trem2 microglial protein critical for debris uptake. These defects were rescued by exposure to a lysosomal re-acidifying drug discovered in our studies on KD, and which provides multiple clinically relevant benefits in the twitcher （GALC＋/–） mouse model of KD. Thus, heterozygous GALC mutations cause effects on biological function that may help to understand the increased disease risk in heterozygous carriers of such mutations and to understand why GALC variations increase the risk of MS. Our findings indicate that while some genetic risk factors may contribute to complex diseases by increasing the risk of tissue damage, others may do so by compromising tissue repair.

关键词： vulnerability locus multiple sclerosis Krabbe disease galactocerebrosidase microglia myelin repair lysosomal storage disorders heterozygous carriers Trem2 demyelination

Pancreatic carcinoma coexisting with chronic pancreatitis versus tumor-forming pancreatitis:Diagnostic utility of the time-signal intensity curve from dynamic contrast-enhanced MR imaging

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第6期13卷 858-865页

作者： Yoshitsugu Tajima Tamotsu Kuroki Ryuji Tsutsumi Ichiro Isomoto Masataka Uetani Takashi Kanematsu Department of Surgery Nagasaki University Graduate School of Biomedical Sciences Japan Department of Radiology and Radiation Biology Nagasaki University Graduate School of Biomedical Sciences Japan

AIM: To evaluate the ability of the time-signal intensity curve (TIC) of the pancreas obtained from dynamic contrast-enhanced magnetic resonance imaging (MRI) for differentiation of focal pancreatic masses, especially pancreatic carcinoma coexisting with chronic pancreatitis and tumor-forming pancreatitis. METHODS: Forty-eight consecutive patients who underwent surgery for a focal pancreatic mass, including pancreatic ductal carcinoma (n = 33), tumor-forming pancreatitis (n = 8), and islet cell tumor (n = 7), were reviewed. Five pancreatic carcinomas coexisted with longstanding chronic pancreatitis. The pancreatic TICs were obtained from the pancreatic mass and the pancreatic parenchyma both proximal and distal to the mass lesion in each patient, prior to surgery, and were classified into 4 types according to the time to a peak: 25 s and 1, 2, and 3 min after the bolus injection of contrast material, namely, type-Ⅰ, Ⅱ, Ⅲ, and Ⅳ, respectively, and were then compared to the corresponding histological pancreatic conditions. RESULTS: Pancreatic carcinomas demonstrated type-Ⅲ (n = 13) or Ⅳ (n = 20) TIC. Tumor-forming pancreatitis showed type-Ⅱ (n = 5) or Ⅲ (n = 3) TIC. All islet cell tumors revealed type-Ⅰ. The type-Ⅳ TIC was only recognized in pancreatic carcinoma, and the TIC of carcinoma always depicted the slowest rise to a peak among the 3 pancreatic TICs measured in each patient, even in patients with chronic ***: Pancreatic TIC from dynamic MRI provides reliable information for distinguishing pancreatic carcinoma from other pancreatic masses, and may enable us to avoid unnecessary pancreatic surgery and delays in making a correct diagnosis of pancreatic carcinoma, especially, in patients with longstanding chronic pancreatitis.

关键词： Pancreatic carcinoma Chronic pancreatitis Focal pancreatic mass Tumor-forming pancreatitis Differential diagnosis, Dynamic magnetic resonance imaging Time-signal intensity curve

Influence of GABAergic Pathway on Retinal Adaptation-Related Response Changes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 592-599页

作者：冯新阳肖雷龚海庆张溥明梁培基 school of biomedical Engineering Shanghai Jiaotong University

Retinal ganglion cells(RGCs) exhibit adaptive changes in response to sustained light stimulation,which include decrease in firing rate, tendency to shrink in receptive field(RF) size and reduction in synchronized activities. Gamma-aminobutyric acid-ergic(GABAergic) pathway is an important inhibitory pathway in *** the present study, the effects of GABAergic pathway on the contrast adaptation process of bullfrog RGCs were studied using multi-electrode recording technique. It was found that the application of bicuculline(BIC), a gamma-aminobutyric acid A(GABAA) receptor antagonist, caused a number of changes in the RGCs' response characteristics, including attenuation in adaptation-dependent firing rate decrease and the adaptation-dependent weakening in synchronized activities between adjacent neuron-pairs, whereas intensified the adaptation-dependent RF size shrinkage. These results suggest that GABAAreceptors are involved in the modulation of the firing activity and synchronized activities in contrast adaptation process of the RGCs, whereas the adaptation-related RF property changes involve more complicated mechanisms.

关键词： retinal ganglion cells contrast adaptation gamma-aminobutyric acid-ergic(GABAergic) pathway receptive field(RF) synchronized activity

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

A smart supramolecular phototherapeutics for specific cancer therapy

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第11期61卷 1353-1354页

作者： Kanyi Pu school of Chemical and biomedical Engineering Nanyang Technological University

Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness. For example, photodynamic therapeutics,often termed as photosensitizer (PS), can be administered to the patients with subsequent exposure to a specific light that leads to the death of the disease cells via oxidative ***, the efficacy of traditional PS has been limited by several issues including poor tumor specificity, fast renal clearance, and phototoxic side effect on normal tissues [1].

关键词：癌症治疗超分子可控制性治疗学光力学副作用时间

Facile and One-step Direct Synthesis of Poly(valine)as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第9期40卷 1016-1027页

作者： Ya-Bin Meng Jun Wu school of biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China

Synthetic poly(amino acid)s with good biodegradable and biocompatible properties have attracted increased attention as carriers in biomedical applications in recent years,their synthesis and purification procedures are usually complicated and some by-products would occur *** this,polypeptide with good biodegradable and biocompatible properties is prepared and optimized by one-step and direct synthesis strategy and poly(valine)(PVal)is selected here as a model polypeptide in this *** newly generated PVal can self-assemble into poly(valine)nanoparticles(PVal-NPs)with a high drug-loading capacity(>20 wt%)of doxorubicin(DOX)and shows strong cytotoxicity against 4T1 *** cellular internalization,the release of DOX could be accelerated by the endosomal acidic environment which leads to enhanced anticancer *** results in vivo show that DOX@PVal-NPs have a long blood circulation time,high cancer accumulation and penetration,and good therapeutic performance in 4T1 tumor-bearing mice without causing obvious adverse effect on main *** these combined advantages,these PVal-based nanoplatform would provide an effective drug delivery tool for clinical breast cancer therapy.

关键词： Poly(amino acid) Nanoparticle Drug carrier Doxorubicin Breast cancer

Some nonlinear parameters of PP intervals of pulse main peaks

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1256-1262页

作者： HAN Qing-peng WANG Ping school of biomedical Engineering and Instrument Science Zhejiang University Hangzhou 310027 China

The PP intervals of pulse main peaks from healthy and unhealthy people(arrhythmia) have different nonlinear char-acteristics. In this paper,the extraction of PP intervals of pulse main peaks is achieved by picking up P peaks of pulse wave with wavelet transform. Furthermore,several nonlinear parameters(correlative dimensions,maximum Lyapunov exponents,com-plexity and approximate entropy) of the PP intervals of pulse main peaks extracted from normal and unhealthy pulse signals are calculated,with the results showing that these nonlinear parameters calculated from the main wave interval signals are helpful for analyzing human's health state and diagnosing heart diseases.

关键词： PP intervals of pulse main peaks Phase space reconstruction Correlative dimension Lyapunov exponent Complexity Approximate entropy

Enhancement of the Neuronal Dynamic Range by Proper Intensities of Channel Noise

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2013年第7期30卷 43-46页

作者： WANG Lei ZHANG Pu-Ming LIANG Pei-Ji QIU Yi-Hong school of biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240

The capability of a biological neuron to discriminate the intensity of external stimulus is measured in its dynamic *** previous studies,a few factors have been reported to be able to enhance the dynamic range,e.g.,electrical coupling and active *** we numerically show that intrinsic channel noise within neurons has a subtle effect in neuronal dynamic range *** simulation results indicate that for relatively weak noise intensity,the dynamic range of the neuron is enhanced ***,as the noise intensity becomes stronger,the dynamic range of the neuron is *** investigation suggests that sodium channel noise and potassium channel noise play opposite roles in modulating the dynamic ***,the model results suggest a new function of channel noise,that is,a proper value of noise intensity could optimize the dynamic range of neurons.

关键词： channel noise intensity

Effects of Spike Frequency Adaptation on Synchronization Transitions in Electrically Coupled Neuronal Networks with Scale-Free Connectivity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2014年第7期31卷 32-35页

作者：汪雷张溥明梁培基邱意弘 school of biomedical Engineering Shanghai Jiao Tong University Shanghai 200240

Effects of spike frequency adaptation （SFA ） on the synchronous behavior of population neurons are investigated in electrically coupled networks with a scale-free property. By a computational approach, we corroborate that pairwise correlations between neurons would decrease if neurons exhibit the feature of SFA, which is similar to previous experimental observations. However, unlike the case of pairwise correlations, population activities of neurons show a rather complex variation mode： compared with those of non-adapted neurons, neurons in the networks having weak-degrees of SFA will impair population synchronizations; while neurons exhibiting strong- degrees of SFA will enhance population synchronizations. Moreover, a variation of coupling strength between neurons will not alter this phenomenon significantly, unless the coupling strength is too weak. Our results suggest that synchronous activity of electrically coupled population neurons is adaptation-dependent, and this adaptive feature may imply some coding strategies of neuronal populations.

关键词： Neurons