检索结果-南通市图书馆

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu Tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Target-to-Background Separation for Spectral Unmixing in In-Vivo Fluorescence Imaging

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 600-611页

作者：赵勇胡程彭金良秦斌杰 school of biomedical Engineering Shanghai Jiaotong University

We present a novel fluorescence spectral unmixing based on target-to-background separation preprocessing, which effectively separates the multi-target fluorescence from all background autofluorescence(BF)without any hardware-based BF acquisition and tissue specific BF estimation. Specifically, we first enhance the intrinsic accumulation contrast in target-to-background fluorescence using h-dome transformation; then separate multi-target fluorescence areas from the background in sparse multispectral data utilizing kernel maximum autocorrelation factor analysis; we further use fast marching-based image inpainting method to patch up the removed target fluorescence areas and reconstruct the multispectral BF; with the BF matrix being subtracted from the original data, the multi-target fluorophores are easily unmixed from the subtracted data using multivariate curve resolution-alternating least squares method. In two preliminary in-vivo experiments, the proposed method demonstrated excellent performance to unmix multi-target fluorescences while other state-of-art unmixing methods failed to get desired results.

关键词： fluorescence imaging spectral unmixing autofluorescence removal target detection kernel maximum autocorrelation factor target-to-background separation

5’-Cap Selection Methods and Their Application in Full-Length cDNA Library Construction and Transcription Start Site Profiling

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 580-586页

作者：白玲王琪李红梅程酩张宁波李华 school of biomedical Engineering Shanghai Jiaotong University

With the accomplishment of the genome draft sequences, identification of functional elements in genome has become an urgent task. Full-length cDNAs provide an important resource for gene identification and their precise structural feature determination. It also provides a basis for genomic element definition. As many regulatory elements are around transcription start sites(TSSs), precise localization of TSSs in the genome becomes a critical step for identifying the associated core promoters. Massive parallel snapshot of TSSs at a particular time under a specific experimental condition makes it possible to globally analyze important regulatory elements around TSSs and further construct transcriptional regulatory networks. In this paper, we first reviewed two important full-length cDNA cloning techniques: cap-trapper technique and oligo-capping technique. Then,we introduced deepCAGE, a cap-trapper and deep sequencing-based TSS profiling technique, and its applications in the research of transcriptional regulation.

关键词： cap-trapper oligo-capping deepCAGE transcription start sites(TSSs) deep sequencing

Progress of Optically Encoded Microspheres for Multiplexed Assays

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 521-530页

作者：朱莹徐宏古宏晨 school of biomedical Engineering Shanghai Jiaotong University

New initiatives put forward by clinical diagnosis require the development of technologies for high throughput screening(HTS) of multiple analytes. Suspension arrays have great advantages over the planar arraybased multiplexing assays, and the encoded bead is the key for providing multiplexing capability. Among various encoding strategies, optically encoded microspheres have been widely used while the number of codes is still limited. This review discusses the progress of optical encoding strategy from mainly three aspects, namely organic dyes, quantum dots(QDs) and surface-enhanced Raman scattering(SERS) active substrates. Emphases are put up on describing how these optical encoded microbeads are manufactured and the merits and demerits of different encoding materials are compared.

关键词： multiplexing suspension arrays optically encoded microspheres fluorescent dyes quantum dots(QDs) surface-enhanced Raman scattering(SERS)

Skin Penetration of Inorganic and Metallic Nanoparticles

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第6期19卷 691-697页

作者：王莉萍王瑾晔 school of biomedical Engineering Shanghai Jiaotong University

Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles. These nanomaterials are already having an impact on health care. Nowadays we are using nanoproducts in various fields,and this leads to direct and indirect exposure in human. Skin is the largest organ of the body and functions as the first-line barrier between the external environment and the internal organs of the human body. Then people worry about the nanoparticle(NP) small enough to penetrate the skin. The potential of solid NPs to penetrate the stratum corneum and to diffuse into underlying structures raises a considerable health and safety issue for their topical use. We review the current state of knowledge on the potential risk to human health presented by skin penetration of NPs nanotechnologies, and explore the robustness of current research strategies and directions to ensure the development of "safe" and publicly accepted nano-based products and technologies.

关键词： nanomaterials skin penetration toxicity quantum dots TiO2 silver nanoparticles

Segmentation of Haustral Folds and Polyps on Haustral Folds in CT Colonography Using Complementary Geodesic Distance Transformation

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 513-520页

作者：徐嫣然赵俊 school of biomedical Engineering Shanghai Jiaotong University

Computer-aided detection(CAD) for CT colonography refers to a scheme that automatically detects polyps in CT images of colon. Current CAD schemes already have a relatively high sensitivity and a low false positive rate. However, misdiagnosis and missed diagnosis are still common to happen, mainly due to the existence of haustral folds(HFs). An innovative idea of segmenting semilunar HFs from the smooth colonic wall and then using different methods to detect polyps on HFs and those on the smooth colonic wall is proposed in this paper to reduce the false positives and false negatives caused by HFs. For the polyps on HFs, a novel segmentation method is specially developed based on complementary geodesic distance transformation(CGDT). The proposed method is tested on four different models and real CT data. The property of CGDT is proved and our method turns out to be effective for HF segmentation and polyp segmentation. The encouraging experimental results primarily show the feasibility of the proposed method and its potential to improve the detection performance of CAD schemes.

关键词： computer-aided detection (CAD) complementary geodesic distance transformation (CGDT) polyp haustral fold colonic wall

Generation of diverse neural cell types through direct conversion

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2016年第2期8卷 32-46页

作者： Gayle F Petersen Padraig M Strappe school of biomedical Sciences Charles Sturt University

A characteristic of neurological disorders is the loss of critical populations of cells that the body is unable to replace,thus there has been much interest in identifying methods of generating clinically relevant numbers of cells to replace those that have been damaged or *** process of neural direct conversion,in which cells of one lineage are converted into cells of a neural lineage without first inducing pluripotency,shows great potential,with evidence of the generation of a range of functional neural cell types both in vitro and in vivo,through viral and non-viral delivery of exogenous factors,as well as chemical induction *** neural cells have been proposed as an attractive alternative to neural cells derived from embryonic or induced pluripotent stem cells,with prospective roles in the investigation of neurological disorders,including neurodegenerative disease modelling,drug screening,and cellular replacement for regenerative medicine applications,however further investigations into improving the efficacy and safety of these methods need to be performed before neural direct conversion becomes a clinically viable *** this review,we describe the generation of diverse neural cell types via direct conversion of somatic cells,with comparison against stem cell-based approaches,as well as discussion of their potential research and clinical applications.

关键词： Adult stem cells Embryonic stem cells Generation of neural cells Induced pluripotent stem cells In vitro differentiation In vivo differentiation Clinical applications Direct conversion Induced neural cells

Computer-Aided Detection for CT Colonography

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 531-537页

作者：徐嫣然赵俊 school of biomedical Engineering Shanghai Jiaotong University

CT colonography （CTC） is a non-invasive screening technique for the detection of eolorectal polyps, as an alternative to optical colonoscopy in clinical practice. Computer-aided detection （CAD） for CTC refers to a scheme which automatically detects colorectal polyps and masses in CT images of the colon. It has the potential to increase radiologists＇ detection performance and greatly shorten the detection time. Over the years, technical developments have advanced CAD for CTC substantially. In this paper, key techniques used in CAD for polyp detection are reviewed. Illustrations about the performance of existing CAD schemes show their relatively high sensitivity and low false positive rate. However, these CAD schemes are still suffering from technical or clinical problems. Some existing challenges faced by CAD are also pointed out at the end of this paper.

关键词： computer-aided detection(CAD) colonography polyps false positive

Dual single-site catalyst promoter boosts catalytic performance

在线全文

学校读者我要写书评

暂无评论

National Science Review 2020年第12期7卷 1841-1842页

作者： Bin Liu school of Chemical and biomedical Engineering Nanyang Technological University

Single-atom catalysts(SACs) have received great research interest because of their maximum atom-utilization efficiency and unique catalytic properties[1–5].However,most of the reported SACs only focus on single-site active components,with rare reports studying catalyst promoters in their single-site forms [6–8].Because promoters are essential components in many industrial catalysts,

关键词：