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Etiology of Pancytopenia in Tabriz Shahid Ghazi Hospital:A Cross-sectional Study in Iran

Proceedings of Anticancer Research 2024年第4期8卷 104-115页

作者： Hossein Azari Bostanabad Safa Mousavi Mohammad Hossein Hosseini Sadra Sarandili Ali Esfahani Babak Nejati Department of Hematology and Oncology Faculty of MedicineTabriz University of Medical SciencesTabrizIran Liqvan Health Center Tabriz University of Medical SciencesTabrizIran Hematology and Oncology Research Center Tabriz University of Medical SciencesTabrizIran Department of Health sciences Curtin Medical SchoolCurtin UniversityPerthWAAustralia

Objective:Pancytopenia is characterized by a reduction in all three types of blood cells:erythrocytes,leukocytes,and *** is caused by a wide range of diseases,leading to diagnostic *** causes can range from drug reactions to life-threatening diseases such as aplastic anemia and *** study aims to investigate the causes of pancytopenia,specifically focusing on age and gender differences among ***:This cross-sectional study includes patients of all ages diagnosed with pancytopenia,as indicated by a CBC/H1 showing a WBC count less than 4,000/μL,platelet count less than 150,000/μL,and hemoglobin levels below 12 g/dL in women and less than 13 g/dL in *** study only included patients with pancytopenia who underwent bone marrow examination and were not subjected to chemotherapy or radiation ***:A total of 133 patients with pancytopenia were included in the *** average age was 47.35±17.62 years old,with 66%of the participants being male and 34%being *** leukemia,specifically acute myeloid leukemia(AML)and acute lymphoid leukemia(ALL),was identified as the primary cause of pancytopenia,accounting for 31.5%of *** anemia was the second most common cause,accounting for 30%of cases,followed by aplastic anemia at 7.5%.Conclusion:Pancytopenia,a condition marked by the decrease in both erythrocytes and leukocytes as well as thrombocytes,can arise from a myriad of *** main findings of this study revealed that megaloblastic anemia,acute myeloid leukemia(AML),and acute lymphoid leukemia(ALL)were the most common ***,a considerable proportion of cases of pancytopenia can be attributed to acute ***,expeditious and accurate diagnosis is imperative and has the potential to save lives in such cases.

关键词： Pancytopenia Leukemia Anemia Bone marrow Blood cells

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Influence of meteorological factors on open biomass burning at a background site in Northeast China

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Journal of environmental sciences 2024年第4期138卷 1-9页

作者： Yulong Wang Linlin Liang Wanyun Xu Chang Liu Hongbing Cheng Yusi Liu Gen Zhang Xiaobin Xu Dajiang Yu Peng Wang Qingli Song Jiumeng Liu Yuan Cheng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesBeijing 100081China Longfengshan Regional Background Station China Meteorological AdministrationHeilongjiang 150200China Heilongjiang Climate Center Heilongjiang 150030China

Biomass burning(BB)is a very important emission source that significantly adversely impacts regional air *** produces a large number of primary organic aerosol(POA)and black carbon(BC).Besides,BB also provides many precursors for secondary organic aerosol(SOA)*** this work,the ratio of levoglucosan(LG)to organic carbon(OC)and the fire hotspots map was used to identify the open biomass burning(OBB)events,which occurred in two representative episodes,October 13 to November 30,2020,and April1 to April 30,*** ratio of organic aerosol(OA)to reconstructed PM_(2.5)concentration(PM_(2.5)^(*))increased with the increase of LG/*** LG/OC ratio is higher than 0.03,the highest OA/PM_(2.5)^(*)ratio can reach 80%,which means the contribution of OBB to OA is *** to the ratio of LG to K^(+),LG to mannosan(MN)and the regional characteristics of Longfengshan,it can be determined that the crop residuals are the main *** occurrence of OBB coincides with farmers’preferred choices,i.e.,burning biomass in“bright weather”.The“bright weather”refers to the meteorological conditions with high temperature,low humidity,and without *** factors indirectly affect regional biomass combustion pollution by influencing farmers’active choices.

关键词： Air pollution Biomass burning Meteorological factors Organic trace Agricultural fires

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Inhibition of Heterogeneous Nucleation in Water by Hydrogel Coating

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Research 2024年第2期2023卷 139-147页

作者： Siyang Li Panpan Zhu Yaoting Xue Lei Wangg Tuck-Whye Wong Xuxu Yang Haoei Zhou Tiefeng Li We Yang Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang UniversityHangzhou 310027China Center for X-Mechanics Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China school of Biomedical Engineering and Health sciences and Advanced Membrane Technology Research Centre Universiti Teknologi MalaysiaSkudai 81310Malaysia

Heterogeneous nucleation plays a critical role in the phase transition of water,which can cause damage in various ***,we report that heterogeneous nucleation can be inhibited by utilizing hydrogel coatings to isolate solid surfaces and ***,which contain over 90%water when fully swelled,exhibit a high degree of similarity to *** to this similarity,there is a great energy barrier for heterogeneous nucleation along the water-hydrogel ***,hydrogel coatings,which possess polymer networks,exhibit higher fracture energy and more robust adhesion to solid surfaces compared to *** high fracture and adhesion energy acts as a deterrent for fracture nucleation within the hydrogel or along the hydrogel-solid *** a hydrogel layer approximately 100μm thick,the boiling temperature of water under atmospheric pressure can be raised from 100 to 108℃.Notably,hydrogel coatings also result in remarkable reductions in cavitation pressure on multiple solid *** have demonstrated the efficacy of hydrogel coatings in preventing damages resulting from acceleration-induced *** coatings have the potential to alter the energy landscape of heterogeneous nucleation on the water-solid interface,making them an exciting avenue for innovation in heat transfer and fluidic systems.

关键词： fracture cavitation similarity

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东亚地区栓皮栎叶片表皮毛空间变异特征及其与气孔的协同关系

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Journal of Plant Ecology 2024年第3期17卷 153-161页

作者： Yanhua Zhu Ji Zheng Hongzhang Kang Nan Hui Shan Yin Zhicheng Chen Baoming Du Chunjiang Liu school of Agriculture and biology Shanghai Jiao Tong UniversityShanghai 200240China Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China school of Design Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Urban Forest Ecosystem Research Station State Forestry AdministrationShanghai 200240China Shanghai Yangtze River Delta Ecoenvironmental Change and Management Observation and Research Station Ministry of Science and TechnologyShanghai 200240China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎... 详细信息

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎(Quercus variabilis)为研究对象,分析了东亚地区44个种群叶片表皮毛密度,并评估了它们与气候因子和气孔等性状之间的相关性。同时,为了进一步检测环境变化下的表皮毛响应特征以及与气孔之间的协同关系,本研究利用其中15个种群开展了同质园试验。研究结果发现,栓皮栎叶片表皮毛密度平均值为459.78个mm^(−2),变异范围为325.79–552.38 mm^(−2)。表皮毛密度会随纬度增加而增加,随经度减少而减少,并且与温度和降水呈负相关。同时发现,无论是在野外还是在同质园,叶片表皮毛密度均与气孔密度呈正相关,并且两者均会随干旱强度的增加而增加。这些结果表明,面对环境变化叶片表皮毛密度具有高度的适应性变异,并且可与气孔协同适应这种变化。该研究结果对加深理解气候变化下植物适应策略以及叶片功能性状之间的协同互作具有重要意义。

关键词：叶片功能性状表皮毛气孔性状-性状关系性状-环境关系气候变化

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Factors hindering the degradation of pharmaceuticals from human urine in an iron-activated persulfate system

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Journal of environmental sciences 2024年第1期135卷 130-148页

作者： Yiruiwen Xie Dao Guan Yangfan Deng Yugo Sato Yu Luo Guanghao Chen Department of Civil and environmental Engineering Water Technology LabHong Kong Branch of Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science&TechnologyHong Kong 999077China

This study investigated the degradation of clofibric acid(CFA),bezafibrate(BZF),and sulfamethoxazole(SMX)in synthetic human urine using a novel mesoporous iron powderactivated persulfate system(mFe-PS system),and identified the factors limiting their degradation in synthetic human urine.A kinetic model was established to expose the radical production in various reaction conditions,and experiments were conducted to verify the modeling *** the phosphate-containing mFe-PS system,the 120 min removal efficiency of CFA decreased from 95.1%to 76.6%as the phosphate concentration increased from 0.32 to 6.45 mmol/L,but recovered to 90.5%when phosphate concentration increased to 16.10 mmol/***,the increased concentration of phosphate from 0.32 to 16.10mmol/L reduced the BZF degradation efficacy from 91.5%to 79.0%,whereas SMX removal improved from 37.3%to 62.9%.The m Fe-PS system containing(bi)carbonate,from 4.20 to166.70 mmol/L,reduced CFA and BZF removal efficiencies from 100%to 76.8%and 80.4%,respectively,and SMX from 83.5%to 56.7%within a 120-min reaction *** addition,alkaline conditions(pH≥8.0)inhibited CFA and BZF degradations,while nonacidic pH(pH≥7.0)remarkably inhibited SMX *** of the kinetic model indicated the formation of phosphate(H_(2)PO_(4)^(·)/HPO_(4)^(·-))and/or carbonate radicals(CO_(3)^(·-))could limit pharmaceutical *** transformation products(TPs)of the pharmaceuticals revealed more incompletely oxidized TPs occurred in the phosphate-and(bi)carbonate-containing m Fe-PS systems,and indicated that H_(2)PO_(4)^(·)/HPO_(4)^(·-)mainly degraded pharmaceuticals via a benzene ring-opening reaction while CO_(3)^(·-)preferentially oxidized pharmaceuticals via a hydroxylation reaction.

关键词： Pharmaceutical degradation Human urine Iron-activated persulfate system Phosphate radicals Carbonate radicals Transformation products

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Photoacoustic elastography based on laser-excited shear wave

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Journal of Innovative Optical Health sciences 2024年第3期17卷 56-72页

作者： Yang Liu Ruoyi Shi Gang Li Mingjian Sun school of Astronautics Harbin Institute of TechnologyHarbin 150000P.R.China school of Information Science and Engineering Harbin Institute of TechnologyWeihai 264200P.R.China

Elastography can be used as a diagnostic method for quantitative characterization of tissue hardness information and thus,differential changes in pathophysiological states of *** this study,we propose a new method for shear wave elastography(SWE)based on laser-excited shear wave,called photoacoustic shear wave elastography(PASWE),which combines photoacoustic(PA)technology with ultrafast ultrasound *** using a focused laser to excite shear waves and ultrafast ultrasonic imaging for detection,high-frequency excitation of shear waves and noncontact elastic imaging can be *** laser can stimulate the tissue with the light absorption characteristic to produce the thermal expansion,thus producing the shear *** frequency of shear wave induced by laser is higher and the frequency band is *** tracking the propagation of shear wave,Young’s modulus of tissue is reconstructed in the whole shear wave propagation region to further evaluate the elastic information of *** feasibility of the method is verified by *** with the experimental results of supersonic shear imaging(SSI),it is proved that the method can be used for quantitative elastic imaging of the *** addition,compared with the SSI method,this method can realize the noncontact excitation of the shear wave,and the frequency of the shear wave excited by the laser is higher than that of the acoustic radiation force(ARF),so the spatial resolution is *** to the traditional PA elastic imaging method,this method can obtain a larger imaging depth under the premise of ensuring the imaging resolution,and it has potential application value in the clinical diagnosis of diseases requiring noncontact quantitative elasticity.

关键词： Elastography shear wave photoacoustic Young's modulus

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Epigenetic regulators as the foundation for molecular classification of colorectal cancer

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Cancer biology & Medicine 2024年第7期21卷 547-552页

作者： Zhenyu Liu Xin Zhou Fuchou Tang school of Life sciences Biomedical Pioneering Innovation Center Department of General Surgery Third Hospital Peking University Beijing Advanced Innovation Center for Genomics (ICG) Ministry of Education Key Laboratory of Cell Proliferation and Differentiation Peking University Third Hospital Cancer Center Academy for Advanced Interdisciplinary Studies Peking University

Colorectal cancer （CRC） accounts for approximately 10% of newly diagnosed cancer cases and cancer-related deaths worldwide1. The identification of molecular subtypes of CRCs has significantly advanced treatment stra... 详细信息

关键词： ISLAND METHYLATOR PHENOTYPE MICROSATELLITE INSTABILITY BRAF MUTATION SUBTYPES COLON

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基因组结构变异研究的前瞻性及临床应用

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Science Bulletin 2024年第6期69卷 705-708页

作者：陈仲中 Richard H.Finnell 雷云平王红艳 Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Shanghai Children’s Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200062China Center for Precision environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHouston 77030USA Departments of Molecular and Human Genetics and Medicine Baylor College of MedicineOne Baylor PlazaHouston 77030USA Shanghai Key Laboratory of Metabolic Remodelling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Children’s Hospital of Fudan University Shanghai 201102China

The challenges and breakthroughs in human genetics can largely depend on the depth of exploring the missing heritability[1]and understanding of genetic variants,which enabled scientists to better elucidate the underlying causes of diseases and apply this knowledge in clinical *** genomes differ from one individual to another in the form of single nucleotide variants(SNVs),small insertions and deletions(indels)(<50 base pairs(bp)),and structural variants(SVs)[2].

关键词： diseases breakthrough insertion

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Projected impacts of climate change on the habitat of Xerophyta species in Africa

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Plant Diversity 2024年第1期46卷 91-100页

作者： Vincent Okelo Wanga Boniface KNgarega Millicent Akinyi Oulo Elijah Mbandi Mkala Veronicah Mutele Ngumbau Guy Eric Onjalalaina Wyclif Ochieng Odago Consolata Nanjala Clintone Onyango Ochieng Moses Kirega Gichua Robert Wahiti Gituru Guang-Wan Hu CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of sciences Beijing 100049China Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun 666303China Botany Department Jomo Kenyatta University of Agriculture and TechnologyNairobiKenya East African Herbarium National Museums of KenyaP.O.Box 451660-0100NairobiKenya

Climate change poses a serious long-term threat to *** effectively reduce biodiversity loss,conservationists need to have a thorough understanding of the preferred habitats of species and the variables that affect their ***,predicting the impact of climate change on speciesappropriate habitats may help mitigate the potential threats to biodiversity ***,a monocotyledonous genus of the family Velloziaceae is native to mainland Africa,Madagascar,and the Arabian *** key drivers of Xerophyta habitat distribution and preference are *** 308 species occurrence data and eight environmental variables,the MaxEnt model was used to determine the potential distribution of six Xerophyta species in Africa under past,current and future climate change *** results showed that the models had a good predictive ability(Area Under the Curve and True Skill Statistics values for all SDMs were more than 0.902),indicating high accuracy in forecasting the potential geographic distribution of Xerophyta *** main bioclimatic variables that impacted potential distributions of most Xerophyta species were mean temperature of the driest quarter(Bio9)and precipitation of the warmest quarter(Bio18).According to our models,tropical Africa has zones of moderate and high suitability for Xerophyta taxa,which is consistent with the majority of documented species *** habitat suitability of the existing range of the Xerophyta species varied based on the climate scenario,with most species experiencing a range loss greater than the range gain regardless of the climate *** projected spatiotemporal patterns of Xerophyta species help guide recommendations for conservation efforts.

关键词： Africa Climate change MaxEnt model Potential suitable distribution Velloziaceae Xerophyta

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Exploring the combination of biochar‐amended soil and automated irrigation technology for water regulation and preservation in green infrastructure

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Deep Underground Science and Engineering 2024年第1期3卷 39-52页

作者： Honghu Zhu Yuanxu Huang Haihong Song Jian Chen Songlei Han Tanwee Mazumder Ankit Garg school of Earth sciences and Engineering Nanjing UniversityNanjingChina Department of Civil and Smart Engineering Construction Guangdong Engineering Center for Structure Safety and Health MonitoringShantou UniversityShantouChina Shanghai Municipal Engineering Design Co. LtdShanghaiChina Indian Institute of Technology Madras ChennaiIndia

Biochar is a carbon sink material with the potential to improve water retention in various ***,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water contents in the covers to maintain vegetation growth in semiarid *** this study,biochar‐amended soil was combined with subsurface drip irrigation,and the water preservation characteristics of this treatment were investigated through a series of one‐dimensional soil column *** ascertain the best treatment method specific to semiarid climatic conditions,the test soil was amended with 0%,1%,3%,and 5%*** irrigation devices equipped with soil moisture sensors were used to control the subsurface water content with the aim of enhancing vegetation *** soil column test lasted 150 h,during which the volumetric water contents and soil suction data were *** experimental results reveal that the soil specimen amended with 3%biochar is the most water‐saving regardless of the time *** with a higher biochar content(e.g.,5%)consumes a more significant amount of water due to the enhancement of the water‐holding *** on the experimental results,it can be concluded that the appropriate ratio can be determined within 1%–3%,which can reduce not only the amount of irrigated/used water but also the time *** technology can be explored for water content regulation in green infrastructure and the development of barriers for protecting the environment around deep underground waste containment.

关键词： biochar drip irrigation underground water preservation water regulation

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