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Safest Route Detection via Danger Index Calculation and K-Means Clustering

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Computers, Materials & Continua 2021年第11期69卷 2761-2777页

作者： Isha Puthige Kartikay Bansal Chahat Bindra Mahekk Kapur Dilbag Singh Vipul Kumar Mishra Apeksha Aggarwal Jinhee Lee Byeong-Gwon Kang Yunyoung Nam Reham R.Mostafa school of Engineering and applied sciences Bennett UniversityGreater NoidaIndia Department of ICT Convergence Soonchunhyang UniversityAsanKorea Department of Information Systems Faculty of Computers and Information SciencesMansoura UniversityMansouraEgypt

The study aims to formulate a solution for identifying the safest route between any two inputted Geographical *** the New York City dataset,which provides us with location tagged crime statistics;we are implementing different clustering algorithms and analysed the results comparatively to discover the best-suited *** results unveil the fact that the K-Means algorithm best suits for our needs and delivered the best ***,a comparative analysis has been performed among various clustering techniques to obtain best *** compared all the achieved results and using the conclusions we have developed a user-friendly application to provide safe route to *** successful implementation would hopefully aid us to curb the ever-increasing crime rates;as it aims to provide the user with a beforehand knowledge of the route they are about to take.A warning that the path is marked high on danger index would convey the basic hint for the user to decide which path to ***,addressing a social problem which needs to be eradicated from our modern era.

关键词： Agglomerative clustering crime rate danger index DBSCAN

Utilization of Nanomaterials as Anode Modifiers for Improving Microbial Fuel Cells Performance

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Journal of Renewable Materials 2020年第12期8卷 1581-1605页

作者： Nishit Savla Raksha Anand Soumya Pandit Ram Prasad Amity Institute of Biotechnology Amity UniversityMumbaiIndia Department of Life sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida201306India Department of Botany Mahatma Gandhi Central UniversityBihar845401India

Microbial fuel cells(MFCs)are an attractive innovation at the nexus of energy and water security for the *** utilizes electrochemically active microorganisms to oxidize biodegradable substrates and generate bioelectricity in a single *** material of the anode plays a vital role in increasing the MFC’s power *** anode in MFC can be upgraded using nanomaterials providing benefits of exceptional physicochemical *** nanomaterials in anode gives a high surface area,improved electron transfer promotes electroactive *** power output in terms of Direct current(DC)can be obtained as the consequence of improved microbe-electrode ***,several limitations like complex synthesis and degeneration of property do exist in the development of nanomaterial-based *** present review discusses different renewable nanomaterial applied in the anode to recover bioelectricity in *** nanomaterials have emerged in the past decade as promising materials for anode con*** materials have also demonstrated the capacity to become potential anode materials of *** of a few transition metal oxides have been explored for efficient extracellular electron transport(EET)from microbes to the anode.

关键词： Microbial fuel cell(MFC) anodic modifications capacitance carbon nanotubes graphene porous carbons metallic nanomaterials power density coulombic efficiency

Effects of stenoses on non-Newtonian flow of blood in blood vessels

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International Journal of Biomathematics 2015年第1期8卷 123-135页

作者： Om Prakash O. D. Makinde S. P. Singh Nidhi Jain Devendra Kumar school of basic and applied sciences galgotias university greater noida Uttar Pradesh India Faculty of Military Science Stellenbosch University Private Bag X2 Saldanha 7395 South Africa Department of Mathematics DEI Dayalbagh Agra Uttar Pradesh India Department of Mathematics Sachdeva Institute of Technology Farah Mathura Uttar Pradesh India

In this paper, a mathematical model for steady blood flow through blood vessels with uniform cross-section in stenoses arteries has been proposed. Blood is assumed to be non- Newtonian, incompressible and homogeneous fluid. Blood in human artery is represented as Bingham plastic fluid. Expressions for flow rate, wall shear stress, and resistance to flow against stenoses size have been obtained. Obtained results indicate that stenoses size decreases the flow rate and increases the wall shear stress as well as resistance to flow.

关键词： Stenoses wall shear stress resistance to flow flow rate non-Newtonian fluid

Elimination of lymphatic filariasis:Where do we stand so far?

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Asian Pacific Journal of Tropical Medicine 2023年第9期16卷 385-399页

作者： Aashna Sinha Sudhashekhar Kumar Deen Dayal Vaishali Yadav Atreyi Pramanik Kundan Kumar Chaubey Sanjay Kumar Division of Research and Innovation School of Applied and Life SciencesUttaranchal UniversityArcadia GrantP.O.ChandanwariPremnagarDehradunUttarakhand-248007India Department of Physiology School of Medical Science and ResearchSharda UniversityGreater NoidaUP-201310India Department of Biotechnology GLA UniversityMathuraUP-281406India Department of Microbiology Central University of Haryana123031India school of basic and applied sciences Sanskriti UniversityMathuraUttar Pradesh-281401India Biological and Bio-computational Lab Department of Life ScienceSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUP-201310India

Lymphatic filariasis(LF),an asymptomatic,acute,and chronic condition in human beings,is the second most common vector-borne disease after *** to the World Health Organization,there are 120 million LF cases detected in 81 tropical and subtropical countries,and one billion people are at ***,the Global Program to Eliminate Lymphatic Filariasis was launched in 2000,with the primary objective of stopping LF transmission among all at-risk groups using mass drug administration(MDA),managing morbidities,and preventing LF-related impairments using a minimum treatment ***,other programs such as epidemiological assessment including National Filaria Control Program and World Health Organization recommended routine and pre-MDA microfilaremia surveys also implemented to stop the LF *** routine filaria surveys were also carried out in around 2000-4000 individuals/month throughout the year whereas pre-MDA surveys were also conducted every year in approximately 4000 individuals in four fixed and four random ***,the Transmission Assessment Survey was also conducted to check the risk of LF among primary school ***,potential diagnostic methods,systematic surveillance regimes,the Direct Network Report system,and regular trainings and awareness may be also effective in preventing the recurrence of ***,this review emphasizes the potential advocacy tools and various strategies as well as procedures for monitoring,which could be impactful in eliminating LF.

关键词： Lymphatic filariasis Treatment Challenges Prospect Elimination

ATS:A Novel Time-Sharing CPU Scheduling Algorithm Based on Features Similarities

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Computers, Materials & Continua 2022年第3期70卷 6271-6288页

作者： Samih M.Mostafa Sahar Ahmed Idris Manjit Kaur Faculty of Computers and Information South Valley UniversityQena83523Egypt College of Industrial Engineering King Khalid UniversityAbhaSaudi Arabia school of Engineering and applied sciences Bennett UniversityGreater NoidaIndia

Minimizing time cost in time-shared operating systems is considered basic and essential task,and it is the most significant goal for the researchers who interested in CPU scheduling *** time,turnaround time,and number of context switches are themost time cost criteria used to compare between CPU scheduling *** scheduling algorithms are divided into non-preemptive and ***(RR)algorithm is the most famous as it is the basis for all the algorithms used in *** this paper,the authors proposed a novel CPU scheduling algorithm based on *** proposed algorithm is called Adjustable Time Slice(ATS).It reduces the time cost by taking the advantage of the low overhead of RR *** addition,ATS favors short processes allowing them to run longer time than given to long *** specific characteristics of each process are;its CPU execution time,weight,time slice,and number of context *** clusters the processes in groups depending on these *** traditionalRRassigns fixed time slice for each *** the other hand,dynamic variants of RR assign time slice for each process differs from other *** essential difference between ATS and the other methods is that it gives a set of processes a specific time based on their similarities within the same *** authors compared between ATS with five popular scheduling algorithms on nine datasets of *** datasets used in the comparison vary in their *** evaluation was measured in term of time cost and the experiments showed that the proposed algorithm reduces the time cost.

关键词： Clustering CPU scheduling round robin average turnaround time average waiting time

Computational study of some potential inhibitors of COVID-19:A DFT analysis

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Quantitative Biology 2022年第4期10卷 341-350页

作者： Prabhat Ranjan Kumar Gaurav Tanmoy Chakraborty Department of Mechatronics Engineering Manipal University JaipurDehmi Kalan 303007India Department of Chemistry and Biochemistry School of Basic Sciences and ResearchSharda UniversityGreater Noida 201310India

Background:There is an urgent demand of drug or therapy to control the *** July 22,2021 the worldwide total number of cases reported is more than 192 million and the total number of deaths reported is more than 4.12 *** countries have given emergency permission for use of repurposed drugs for the treatment of COVID-19 *** report presents a computational analysis on repurposing drugs—tenofovir,bepotastine,epirubicin,epoprostenol,tirazavirin,aprepitant and valrubicin,which can be potential inhibitors of the ***:Density functional theory(DFT)technique is applied for computation of these repurposed *** geometry optimization,functional B3LYP/6-311G(d,p)is selected within DFT ***:DFT based descriptors—highest occupied molecular orbital(HOMO)-lowest unoccupied molecular orbital(LUMO)gap,molecular hardness,softness,electronegativity,electrophilicity index,nucleophilicity index and dipole moment of these species are *** and Raman activities are also analysed and *** result shows that the HOMO-LUMO gap of these species varies from 1.061 eV to 5.327 *** aprepitant with a HOMOLUMO gap of 1.419 eV shows the maximum intensity of IR(786.176 km mol‒1)and Raman spectra(15036.702 a.u.).Conclusion:Some potential inhibitors of COVID-19 are studied by using DFT *** study shows that epirubicin is the most reactive compound whereas tenofovir is found to be the most *** analysis and clinical trials of these compounds will provide more insight.

关键词： COVID-19 repurposing drug density functional theory HOMO-LUMO epirubicin aprepitant

Genome tuning through HLA and KIR gene clusters impact susceptibility to dengue

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Infectious Medicine

Infectious Medicine 2023年第3期2卷 167-177页

作者： Neha Sharma Gaurav Sharma Uma Kanga Devinder Toor Department of Biosciences School of Basic and Applied SciencesGalgotias UniversityGreater Noida 203201India Department of Translational and Regenerative Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Transplant Immunology and Immunogenetics All India Institute of Medical SciencesNew Delhi 110029India Amity university Uttar Pradesh Amity Institute of Virology and ImmunologyAmity UniversityNoida 201301India

Dengue is amongst the most prevalent viral diseases which globally affects millions of individuals annually and renders billions at risk,particularly in tropical and sub-tropical *** estimated 100-400 mil-lion infections each year and reported 4.2 million active cases in 2019 *** infection is caused by arthropod-transmitted dengue virus which is known to have 5 serotypes(DENV1-5).Most of the cases show mild clinical symptoms;though others may develop severe forms viz;dengue hemorrhagic fever and dengue shock *** limited literature suggests the population-specific genetic influence on susceptibility and the clinical course of dengue;the genetic propensity of dengue is largely unknown in most *** this context,the human leukocyte antigen(HLA)system represents the most polymorphic region of the human genome and is crucial for the initiation of an appropriate immune *** most of the genome-wide association studies,the HLA complex is the most significantly linked genetic region with susceptibility or protection towards vari-ous infectious and noninfectious *** immunoglobulin-like receptors represent another highly variable system present on the surface of natural killer(NK)cells which regulate the activity of NK cells through inter-actions with their cognate HLA *** is conceivable that the interaction of HLA-Killer immunoglobulin-like receptors systems influences the host susceptibility towards dengue infection as well the disease *** we attempt to review these parameters in dengue infection and disease *** detailed investigations are warranted towards the identification of novel susceptibility markers and targeted therapeutic interventions.

关键词： DENV Human leukocyte antigen Killer immunoglobulin receptor Pathogenesis and genetic susceptibility

Synthesis, Characterization and Remedial Action of Biogenic Silver Nanoparticles and Chitosan-Silver Nanoparticles against Bacterial Pathogens

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Journal of Renewable Materials 2022年第12期10卷 3093-3105页

作者： Piyush Kumar Gupta D.Karthik Kumar M.Thaveena Soumya Pandit Somya Sinha R.Ranjithkumar Walaa F.Alsanie Vijay Kumar Thakur Department of Life sciences School of Basic Sciences and ResearchSharda UniversityGreater Noida201310Uttar PradeshIndia Viyen Biotech LLP CoimbatoreTamil Nadu641031India Department of Biotechnology Kongunadu Arts and Science CollegeCoimbatoreTamil Nadu641029India Department of Biotechnology Graphic Era Deemed to be UniversityDehradunUttarakhand248002India Department of Clinical Laboratories sciences The Faculty of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biorefining and Advanced Materials Research Center SRUCEdinburghEH93JGUK Department of Mechanical Engineering School of EngineeringShiv Nadar UniversityNoidaGreater Noida201314India school of Engineering University of Petroleum&Energy Studies(UPES)DehradunUttarakhand248007India

Custard apple is a dry land *** leaves exhibit different pharmacological *** the present study,both silver(Ag)nanoparticles and chitosan-coated Ag(Chi-Ag)nanoparticles were fabricated using the aqueous leaf extract of the custard apple *** preliminary phytochemical analysis,various types of phytocompounds were found in the aqueous leaf extract of the same ***,both nanoparticles were physiochemically *** analysis exhibited the fingerprint vibrational peaks of active bioactive compounds in plant extract,Ag nanoparticles,and Chi-Ag ***/Visible spectral analysis revealed the highest absorbance peak at 419 nm,indicating the presence of Ag *** analysis presented the face-centered cubic(FCC)structure of both prepared ***,the average crystalline size of both Ag nanoparticles and Chi-Ag nanoparticles was calculated to be 23 and 74 nm,*** analysis showed the spherical and cubical shapes of Ag nanoparticles and Chi-Ag nanoparticles,*** analysis indicated a peak around 3.29 keV,conforming to the binding energies of Ag *** biogenic nanomaterial also showed strong antibacterial activity against all tested bacterial pathogens.

关键词： Custard apple chitosan Ag nanoparticles Chi-Ag nanoparticles antibacterial

PPARγLBD and its ligand specificity reveal a selection of potential partial agonist:Molecular dynamics based T2D drug discovery initiative

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BIOCELL 2021年第4期45卷 953-961页

作者： BIDYUT MALLICK ASHISH RANJAN SHARMA MANOJIT BHATTACHARYA SANG-SOO LEE CHIRANJIB CHAKRABORTY Department of applied Science Galgotias College of Engineering and TechnologyKnowledge Park-IIGreater Noida201306India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityVyasa ViharBalasore756020India Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityKolkata700126India

PPARγis a peroxisome proliferator-activated receptor(PPAR)family protein and is a target for type 2 diabetes(T2D).In this paper,we have performed a molecular docking analysis between ligand molecules(CID9816265,CID11608015,CID20251380,CID20251343,CID20556263,CID624491,CID42609928,and CID86287562)and PPARγto determine the ligand *** also helps to understand the ligand-binding domain(LBD)activity of PPARγduring the binding of the ***,a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ*** ligand specificity informed us about the potentiality of selecting a partial *** study also shows the binding conformation of Ceramicine B having hydrogen bonding affinity with a tricyclic polar head and stabilized theβ-sheet *** the other hand,the tricyclic polar head of nimbolide also formed hydrogen bonding(Ser342),but it shows a lesser degree of stabilization in theβ-sheet *** shows the binding conformation of partial agonist(PPARγ)in the Pocket-II of PPARγLBD,which has a significant role in stabilizing theβ-sheet *** might help to regulate ERK/Cdk5 mediated phosphorylation of *** study helps us understand the valid pose of a set of ligands confirmation and target protein conformation using docking and molecular dynamics *** in silico study will also help to initiate a drug discovery process of T2D.

关键词： PPARγ Partial agonist Molecular simulation T2D Drug discovery