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Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

Eye and Vision 2024年第3期10卷 1-12页

作者： Meifang Yan Junjian Li Li Yan Xue Li Jie-Guang Chen school of ophthalmology and optometry and Eye Hospital Wenzhou Medical UniversityState Key Laboratory of OptometryOphthalmology and Vision Scienceand Zhejiang Provincial Key Laboratory of Optometry and Ophthalmology270 Xueyuan RoadWenzhouZhejiang325027People’s Republic of China Joint Shantou International Eye Center(JSIEC)of Shantou University and the Chinese University of Hong Kong ShantouGuangdong515000People’s Republic of China

Background The exudative form of age-related macular degeneration(AMD)is characterized by abnormal blood vessel growth,which is stimulated by vascular endothelial growth factor(VEGF)released from retinal pigment epithelium(RPE).The angiogenic behaviors of vascular endothelial cells in vitro depend on forkhead box protein P1(Foxp1),a transcription repressor widely expressed in human and murine tissues during *** this study,we aimed to determine whether loss of Foxp1 affects laser-induced choroidal neovascularization(CNV)in *** Eye-selective deletion of Foxp1 was obtained by crossing Foxp1flox/flox with Six3-Cre *** photocoagulation was delivered to six-to eight-week-old mice to induce *** expression of Foxp1 and Cre was determined by immunofluorescence in cryostat sections of the *** fluorescein angiography(FFA),optical coherence tomography(OCT),and B4 isolectin staining were applied to analyze the leakage,bulge height,and area of CNV lesions,***-choroid tissues were isolated for the determination of VEGF and pigment epithelium derived factor(PEDF)by Western *** Foxp1 was expressed in retinal ganglion cells,RPE,and the choroidal endothelial *** photocoagulation increased the number of Foxp1+-endothelial cells and induced ***3-Cre reduced Foxp1 expression in RPE but not the endothelium,leading to a lower level of VEGF in the ***1 knockout inhibited pathological angiogenesis and vascular leakage of the laser-induced CNV *** Foxp1 regulates the expression of VEGF in the RPE,and inhibition of Foxp1 could potentially be a novel strategy for the prevention and therapy of neovascularization related to AMD.

关键词： Foxp1 Choroidal neovascularization Angiogenesis Laser photocoagulation Age-related macular degeneration

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Postoperative pneumocranium after endoscopic transnasal optic canal decompression

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International Journal of ophthalmology(English edition) 2024年第5期17卷 973-975页

作者： Sheng-Jian Lu Bo Yu Wen-Can Wu The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Dear Editor,We present the first time,a case of a patient developed cerebrospinal fluid(CSF)leak and pneumocranium following optic canal decompression(OCD).INTRODUCTION Indirect traumatic optic neuropathy(ITON)impairs visual functions and quality of *** transnasal optic canal decompression(ETOCD)is one of the standard treatment strategies for the *** the ETOCD,the optic nerve sheath are usually incised for sufficient decompression of optic nerve after removal of optic canal,which is associated with complications like CSF leakage,ophthalmic artery injury,and optic nerve injury[1].Generally,the mild CSF leak is common and can heal spontaneously using conventional treatment,the severe CSF leak requires surgical repair[2].

关键词： decompression nasal traumatic

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Author correction to‘Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics’[Acta Pharm Sin B 12(2022)4458–4471]

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2359-2360页

作者： Qiang Niu Yu Liu Yujing Zheng Ziwei Tang Yuna Qian Ruogu Qi Jianliang Shen Ping Zhao school of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China State Key Laboratory of ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China school of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China

The authors regret that there is an error in Fig.6 in the article due to the mistake of copying and pasting in the process of assemblingﬁgures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

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Repeatability and reproducibility of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpfug-Placido topographer

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Eye and Vision 2024年第1期10卷 1-9页

作者： Rui Ning Rongrong Gao David PPiñero Jun Zhang Qingyi Gao Yili Jin Yiran Wang Chenxiao Wang Jinhai Huang Eye Hospital and school of ophthalmology and optometry Wenzhou Medical UniversityWenzhouZhejiangChina Eye Institute and Department of ophthalmology Eye and ENT HospitalFudan UniversityShanghaiChina Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicanteSpain NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of ophthalmology and optometry ShanghaiChina

Background:To evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction(SMILE)using the Sirius Scheimpfug-Placido topographer(CSO,Italy).Methods:Seventy-fve eyes from 75 postoperative subjects were included in this prospective *** consecutive corneal aberrometric measurements were obtained with the Scheimpfug-Placido topographer by two experienced operators to assess intra-and inter-observer *** within-subject standard deviation(Sw),test-retest repeatability(TRT)and the intraclass correlation coefcient(ICC)were ***:For intraobserver repeatability of anterior and total corneal aberrations,all ICCs were more than 0.922,except for trefoil(0.722 to 0.768).The ICCs of total root mean square(RMS),coma Z(3,±1),and spherical aberration Z(4,0)were over 0.810 while higher-order RMS,trefoil Z(3,±3),and astigmatism II Z(4,±2)were below 0.634 for posterior corneal surface *** Sw values for all types of aberrations were equal to or below 0.07μ*** interobserver reproducibility,all TRT values were no more than 0.12μm,0.05μm,and 0.11μm for anterior,posterior,and total corneal aberrations,*** ICC values ranged from 0.875 to 0.989,from 0.686 to 0.976 and over 0.834 for anterior,posterior,and total corneal aberrations,***:The repeatability of measurements of anterior and total corneal aberrations with the Sirius system in corneas after SMILE surgery was high,except for *** was some variability in posterior corneal aberrometric *** reproducibility of corneal aberrometric measurements was observed between measurements of both examiners,except for trefoil,with poor to moderate reproducibility.

关键词： Sirius Higher-order aberrations Repeatability Reproducibility Small incision lenticule extraction

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A deep learning based fine-grained classification algorithm for grading of visual impairment in cataract patients

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Optoelectronics Letters 2024年第1期20卷 48-57页

作者： JIANG Jiewei ZHANG Yi XIE He YANG Jingshi GONG Jiamin LI Zhongwen school of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China school of ophthalmology and optometry and Eye Hospital Wenzhou Medical UniversityWenzhou 325000China Ningbo Eye Hospital Wenzhou Medical UniversityNingbo 315000China

Recent advancements in artificial intelligence(AI)have shown promising potential for the automated screening and grading of ***,the different types of visual impairment caused by cataracts exhibit similar phenotypes,posing significant challenges for accurately assessing the severity of visual *** address this issue,we propose a dense convolution combined with attention mechanism and multi-level classifier(DAMC_Net)for visual impairment ***,the double-attention mechanism is utilized to enable the DAMC_Net to focus on lesions-related ***,a hierarchical multi-level classifier is constructed to enhance the recognition ability in distinguishing the severities of visual impairment,while maintaining a better screening rate for normal *** addition,a cost-sensitive method is applied to address the problem of higher false-negative rate caused by the imbalanced *** results demonstrated that the DAMC_Net outperformed ResNet50 and dense convolutional network 121(DenseNet121)models,with sensitivity improvements of 6.0%and 3.4%on the category of mild visual impairment caused by cataracts(MVICC),and 2.1%and 4.3%on the category of moderate to severe visual impairment caused by cataracts(MSVICC),*** comparable performance on two external test datasets was achieved,further verifying the effectiveness and generalizability of the DAMC_Net.

关键词： visual classifier algorithm

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Controlling the dynamic behavior of decentralized cluster through centralized approaches

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Chinese Physics B 2024年第6期33卷 46-54页

作者：袁大明王培龙王鹏马星宇汪楚云王璟陈怀城王高叶方富 school of ophthalmology and optometry Eye HospitalSchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325035China Postgraduate Training Base Alliance Wenzhou Medical UniversityWenzhou 325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325011China school of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

How to control the dynamic behavior of large-scale artificial active matter is a critical concern in experimental research on soft matter, particularly regarding the emergence of collective behaviors and the formation of group patterns. Centralized systems excel in precise control over individual behavior within a group, ensuring high accuracy and controllability in task execution. Nevertheless, their sensitivity to group size may limit their adaptability to diverse tasks. In contrast, decentralized systems empower individuals with autonomous decision-making, enhancing adaptability and system robustness. Yet, this flexibility comes at the cost of reduced accuracy and efficiency in task execution. In this work, we present a unique method for regulating the centralized dynamic behavior of self-organizing clusters based on environmental interactions. Within this environment-coupled robot system, each robot possesses similar dynamic characteristics, and their internal programs are entirely identical. However, their behaviors can be guided by the centralized control of the environment, facilitating the accomplishment of diverse cluster tasks. This approach aims to balance the accuracy and flexibility of centralized control with the robustness and task adaptability of decentralized control. The proactive regulation of dynamic behavioral characteristics in active matter groups, demonstrated in this work through environmental interactions, holds the potential to introduce a novel technological approach and provide experimental references for studying the dynamic behavior control of large-scale artificial active matter systems.

关键词： self-organizing system centralized control dynamics regulation

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Two different autorefractors for vision screening in children and adolescents

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International Journal of ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun Dan-Dan Jiang Shu-Shu Zuo Yan-Hui Wang Chun-Hua Zhang Yan-Yan Chen school of optometry and ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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Author correction to“Cascade two-stage tumor re-oxygenation and immune re-sensitization mediated by self-assembled albumin-sorafenib nanoparticles for enhanced photodynamic immunotherapy”[Acta Pharm Sin B(2022)4204-4223]

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Acta Pharmaceutica Sinica B 2024年第2期14卷 900-903页

作者： Zaigang Zhou Jiashe Chen Yu Liu Chunjuan Zheng Wenjuan Luo Lele Chen Shen Zhou Zhiming Li Jianliang Shen State Key Laboratory of ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China Department of the First Affiliated Hospital of Wenzhou Medical University Wenzhou325000China school&Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang325000China

The authors regret that there are errors in the article Fig.8A and Fig.S22A due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,these are obvious *** authors have now modified as *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data *** authors apologize for any inconvenience caused to the journal and readers.

关键词： journal correction conclusion

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The Research on the Paths of Popular Science Education about Myopia Prevention and Control among College Students in the Context of Shifting the Focus Forward

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Open Journal of Applied Sciences 2024年第2期14卷 371-378页

作者： Shengpo Zeng Yang’ai Gu school of ophthalmology & optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou China

Currently, the number of myopic people in China has reached as high as 600 million, and it shows a trend of “early onset, high incidence, and a high degree of severity”. The issue of myopia among children and adolescents has attracted widespread attention from all sectors of society. Comprehensive myopia prevention and control efforts have been launched nationwide. Popular science education, vision screening, and improving visual environments are effective measures for preventing myopia. However, among the target audience for comprehensive myopia prevention and control, the preschool children group has been neglected, and the work of myopia prevention and control for this group has been significantly weakened and marginalized. Due to insufficient awareness of prevention and control, the hyperopia reserve in the preschool children group is being continuously depleted, leading to the early onset of myopia. In light of this situation, the focus of myopia prevention and control needs to shift forward, and it is worth exploring and pondering how college students with a background in optometry can develop entertaining and engaging popular science education materials and methods.

关键词： Myopia Prevention and Control Popular Science Education Hyperopia Reserve Eye Health Preschool Children Group

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Patient satisfaction and follow-up adherence to glaucoma case management clinic in China

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International Journal of ophthalmology(English edition) 2024年第1期17卷 73-81页

作者： Hao Lin Hu-Jie Lu Wen-Zhe Zhou Shu-Shu Zuo Yan-Yan Chen Shao-Dan Zhang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina school of ophthalmology and optometry Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient ***:In this cross-sectional study,a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic *** data was obtained from the case management ***-up adherence was defined as completing each follow-up within±30d of the scheduled time set by ophthalmologists during the study ***:Average satisfaction scored 78.65±7,with an average of 4.39±0.58 across the seven *** negatively correlated with satisfaction(P=0.008),whilst patients with follow-up duration of 2 or more years reported higher satisfaction(P=0.045).Multivariate logistics regression analysis revealed that longer follow-up durations were associated with lower follow-up adherence(OR=0.97,95%CI,0.95-1.00,P=0.044).Additionally,patients with suspected glaucoma(OR=2.72,95%CI,1.03-7.20,P=0.044)and those with an annual income over 100000 Chinese yuan demonstrated higher adherence(OR=5.57,95%CI,1.00-30.89,P=0.049).CONCLUSION:The case management model proves effective for glaucoma patients,with positive adherence *** implementation of this model can be optimized in the future based on the identified factors and extended to glaucoma patients in more hospitals.

关键词： glaucoma patient satisfaction follow-up adherence case management

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