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Promoting higher-valent pediatric combination vaccines in China: challenges and recommendations for action

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Infectious Diseases of Poverty 2024年第1期13卷 74-84页

作者： Jiuling Li Shu Chen dwin Asturias Shenglan Tang Fuqiang Cui global health Research Center Duke Kunshan UniversityKunshanJiangsuChina ARC Centre of Excellence in Population Ageing Research(CEPAR) Universityof New SouthWalesSydneyAustralia school of Risk and Actuarial Studies University of New South WalesSydneyAustralia Department of Pediatrics University of Colorado School of MedicineAuroraCOUSA Center for global health Colorado School of Public HealthAuroraCOUSA Department of Epidemiology Colorado School of Public HealthAuroraCOUSA Duke global health Institute Duke UniversityDurhamNCUSA Singhealth Duke-NUS global health Institute Duke-NUSSingaporeSingapore Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina Vaccine Research Center School of Public HealthPeking UniversityBeijingChina

Many countries have adopted higher-valent pediatric combination vaccines to simplify vaccination schedules and minimize health expenditures and social ***,China is conservative in the use of pediatric combina-tion *** reviewing and synthesizing quantitative and qualitative data,in this commentary we identify gaps and challenges to combination vaccine use and make recommendations for promoting use of higher-valent pediatric combination vaccines in *** are in four dimensions:(1)legislation and regulation,(2)immunization schedule design,(3)vaccine awareness and price,and(4)research and development *** optimize the use of combination vaccines to reduce vaccine-preventable disease burden,we make recommendations that address key challenges:(1)develop policies and regulations to strengthen enforcement of the Vaccine Administration Law and remove regulatory hurdles that hinder combination vaccine research and development,(2)establish an evi-dence-informed policy-making mechanism for combination vaccines,(3)resolve immunization schedule conflicts between monovalent and combination vaccines,and(4)implement effective interventions to increase vaccine awareness and reduce price.

关键词： Combination vaccine National immunization program Childhood immunization Vaccine-preventable disease

Associations between parental adherence to healthy lifestyles and cognitive performance in offspring:A prospective cohort study in China

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Chinese Medical Journal 2024年第6期137卷 683-693页

作者： Rongxia Lv Yuhui Huang Siyi Huang Shiyi Wu Siwen Wang Guangyu Hu Yanan Ma Peige Song Jorge E.Chavarro S.V.Subramanian Chunling Lu Zhihui Li Changzheng Yuan school of Public health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Institute of Medical Information/Center for health Policy and Management Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Biostatistics and Epidemiology School of Public HealthChina Medical UniversityShenyangLiaoning 110122China Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMA 02115USA Division of global health Equity Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of global health and Social Medicine Harvard Medical SchoolBostonMA 02115USA Vanke school of Public health Tsinghua UniversityBeijing 100084China Department of global health and Population Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Background:Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early *** study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in ***:We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies.A healthy parental lifestyle score(ranged 0-5)was constructed based on the following five modifiable lifestyle factors:Smoking,drinking,exercise,sleep,and *** estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years(2012,2014,2016,and 2018).Results:Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence(multivariable-adjusted β=0.53,95%confidence interval[CI]:0.29-0.77)and overall crystallized intelligence(multivariable-adjusted β=0.35,95%CI:0.16-0.54)than those in the bottom tertile of parental healthy lifestyle *** results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic ***,maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance,with significant contribution observed for paternal never-smoking,weekly exercise,and diversified *** both parents and offspring adhered to a healthier lifestyle,we observed the highest level of the offspring’s overall crystallized ***:Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood,regardless of socioeconomic *** findings highlight the poten

关键词： Cohort study Parental healthy lifestyle Offspring Cognitive performance Intelligence Adolescence

Predictors of global Disparities in COVID-19 Vaccination Coverage — 219 Countries and Territories, December 2020–July 2022

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China CDC weekly 2024年第15期6卷 318-323,I0006,I0007页

作者： Ying Zhang Shujie Zang Xu Zhang Zhiqiang Qu Xinyu Zhou Leesa Lin Zhiyuan Hou school of Public health and Global Health InstituteFudan UniversityShanghaiChina Department of Infectious Disease Epidemiology London School of Hygiene&Tropical MedicineLondonUnited Kingdom Laboratory of Data Discovery for health(D24H) Hong Kong Science ParkHong Kong Special Administrative RegionChina

What is already known about this topic?The significant disparities in global coronavirus disease 2019(COVID-19)vaccine coverage hamper the pace of epidemic *** is a need to better understand the factors contributing to disparities in COVID-19 vaccination rates across *** is added by this report?This report revealed significant associations between vaccination coverage and various country-level *** pandemic preparedness,higher levels of trust,and a lower proportion of young population aged 0–14 were strongly correlated with higher COVID-19 vaccination *** are the implications for public health practices?Our findings emphasize the need for enhanced pandemic preparedness and governance,coupled with building trust in government and healthcare *** also needs to address the hesitancy of vaccinating children and adolescents aged 0–14 as the vaccination campaign progresses.

关键词： vaccination vaccine COV

The Role of Childhood Circumstances in healthy Aging Inequalities Among Older Adults—China,2011–2020

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China CDC weekly 2024年第11期6卷 208-212,I0004-I0007页

作者： Peng Nie Xili Lin Lanlin Ding school of Economics and Finance Xi’an Jiaotong UniversityXi’an CityShaanxi ProvinceChina global health Institute Xi’an Jiaotong University Health Science CenterXi’an CityShaanxi ProvinceChina National school of Development Peking UniversityBeijingChina

What is already known about this topic?Addressing health disparities is a worldwide priority,with a well-established acknowledgment of the influence of childhood circumstances on these *** China,particularly among the elderly,health inequalities are a notable *** is added by this report?The inequality in healthy aging has increased from 2011 to 2020,both in general and concerning childhood ***,the impact of early-life healthcare access and parental health behaviors on healthy aging gaps has reduced among older adults in better health within the top segment of healthy *** are the implications for public health practice?Efforts towards reducing regional health disparities and improving healthcare access for children,along with promoting the health and well-being of parents,especially in economically disadvantaged households,are crucial policy considerations.

关键词： ledgment inequalities circumstances

A cross-sectional analysis of the effectiveness of a nutritional support programme for people with tuberculosis in Southern Madagascar using secondary data from a non-governmental organisation

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Infectious Diseases of Poverty 2024年第1期13卷 101-102页

作者： Mara Anna Franke Julius Valentin Emmrich Fierenantsoa Ranjaharinony Onja GbrilleRavololohanitra Harizaka Emmanuel Andriamasy Samuel Knauss Nadine Muller global Digital health Lab at Charité Center for global health Charité – Universitätsmedizin Berlin Berlin Germany London school of Hygiene and Tropical Medicine London UK Ärzte Für Madagaskar E.V. Leipzig Germany Heidelberg Institute of global health Heidelberg University Heidelberg Germany Berlin Institute of health at Charité - Universitätsmedizin Berlin Berlin Germany Doctors for Madagascar Antananarivo Madagascar Speciality Network: Infectious Diseases and Respiratory Medicine Charité - Universitätsmedizin Berlin Berlin Germany

Background There is a strong,bi-directional link between tuberculosis(TB)and undernutrition:TB often causes undernutrition,and undernourished people are more likely to contract TB and experience worse ***,several TB nutritional support programmes exist;however,evidence on their effectiveness is limited and *** study evaluates the effect of a nutritional support programme implemented for people with TB in the Atsimo-Andrefana region,Madagascar in *** this programme,undernourished people with TB[with a body mass index(BMI)of<18.5 kg/m]receive 0.6 L of vegetable oil and 6.0 kg of a soy-wheat blend per month throughout their TB *** We analysed secondary non-governmental organisation data collected between January and Novem-ber 2022 in the Atsimo-Andrefana region,Southern Madagascar,including information on an individual's medical conditions(e.g.,type of TB,treatment outcomes)and nutritional status measured prior to,during,and after comple-tion of treatment(e.g.,height,weight,mid-upper arm circumference).We conducted descriptive analyses of patient baseline characteristics and outcomes to assess the impact of the provided nutritional support on the BMI of people With *** A total of 1310 people with TB were included in the study[9.9%(130)children under the age of 5,32.1%(420)children between 5 and 18 years,58.0%(760)adults].55.4% of children under 5,28.1% of children between ages 5 and 18,and 81.3%of adults were undernourished at treatment initiation.42.3%(55/130)of children under 5 experi-enced severe acute malnutrition at treatment *** the average BMl of adults with TB receiving food support increased over time,from 17.1 kg/m^(2)(interquartile range:15.8-18.3,range:10.3-22.5)to 17.9 kg/m^(2)(interquartile range:16.6-19.1,range:11.9-24.1),most adults remained undernourished even after completing TB *** The current TB nutritional support programme falls short of sufficiently increasing the BM

关键词： Tuberculosis Sub-Saharan Africa Undernutrition Nutritional support

The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： Tongyu Zhang Yingxi Zhu Xiaochen Wang Danyang Chong Haiquan Wang Dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults—China,2017–2021

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China CDC weekly 2024年第23期6卷 537-541,I0001-I0007页

作者： Yidan Qiu Saisai Ji Chen Chen Jinhui Zhou Jun Wang Bing Wu Yuan Wei Fangyu Li Xulin Zheng Lanjing Xu Zheng Zhang Feng Zhao Guangdi Chen John SJi Yuebin Lyu Shilu Tong Xiaoming Shi Department of Big Data in health Science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for global health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina school of Public health China Medical UniversityShenyang CityLiaoning ProvinceChina Institute of Environmental health School of Public Healthand Bioelectromagnetics LaboratorySchool of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina Environmental Research Center Duke Kunshan UniversityKunshan CityJiangsu ProvinceChina Nicholas school of the Environment Duke UniversityDurhamNCUSA school of Public health Institute of Environment and Population HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina school of Public health and Social Work Queensland University of TechnologyBrisbaneAustralia

What is already known about this topic?Antimony(Sb)has been identified as a new neurotoxicant that impacts neurological functions in animal ***,its effects on the human population remain *** is added by this report?The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older *** dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible *** are the implications for public health practice?Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive *** intervention has the potential to significantly decrease the disease burden associated with cognitive impairment,ultimately contributing to social development.

关键词： Antimony development. exposure

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING Xue Xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li school of Public health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for global health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie Teo Jane Zi Ying Ee Chun En Yau Julian Thumboo Hiang Khoon Tan Qin Xiang Ng NUS Yong Loo Lin school of Medicine National University of SingaporeSingapore health Services Research Unit Singapore General HospitalSingapore Singhealth Duke-NUS Medicine Academic Clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS global health Institute Singapore Duke global health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee Hock school of Public health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** To evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,Cumulative Index for Nursing and Allied health Literature,PsycINFO and Cochrane Central Register of Controlled Trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and Laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers