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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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science China Life sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications

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Journal of Materials science & Technology 2021年第4期63卷 35-53页

作者： Gopinathan Janarthanan Insup Noh Department of Chemical and biomolecular Engineering Seoul National University of Science and TechnologySeoul01811Republic of Korea Convergence Institute of biomedical Engineering and Biomaterials Seoul National University of Science and TechnologySeoul01811Republic of Korea

Recently,the metal ion cross-linked hydrogels have gained enormous interest because of its excellent properties like self-healing,fast recovery,biocompatibility and high mechanical properties combined with multi-stimuli *** this review article,we have summarized the recent trends in the development of metal ion cross-linked hydrogels for tissue engineering and biomedical applications.A number of metal ions and their contribution in the synthesis of various cross-linked hydrogels are discussed with respect to their crosslinking mechanisms,compositions,physio-chemical and biological properties.A special emphasis has been given to ferric(Fe^(3+))ion cross-linked hydrogels and their different combinations owing to their numerous researches reported in the recent past with exceptional *** application of these metal ion based hydrogels in biomedical applications including tissue engineering,sensing,wound healing,drug delivery and as tissue adhesive and tissue sealants are reviewed with specific ***,the application of these metal ion cross-linked hydrogels as inks in 3 D printing is explained in a separate ***,the possible toxic effects of the different metal ions and their effects have been *** directions and comprehensive applications of the hydrogels are highlighted.

关键词： properties. biomaterials exceptional

Tailor-made high elasticity and low-hysteresis hydrogels based on asymmetric H-bonding crosslinking for wearable applications

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science China Chemistry 2025年

作者： Xiaofang Shi Nan Shi Miaomiao Dang Chengyu Ji Yingjie Li Peiyi Wu Zhiguo Hu Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials School of Chemistry and Chemical Engineering Henan Normal University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology & Center for Advanced Low-dimension Materials Donghua University

The conventional method of fabricating hydrogels constantly confronts the conflict between elasticity and toughness, limiting their repetitive application. Achieving the desired elasticity through a simple and low-cost approach is a significant challenge for hydrogels, particularly through rational molecular design. Here, low-hysteresis and high-toughness hydrogels are developed from the design of a new feature monomer, N-acryloylethylsemicarbazide (NACE). Based on a concept of “asymmetric Hbonding design”, the unique double and triple H-bonding of NACE can result in a novel asymmetric crosslinking polymer with alternating strong and weak H-bonding regions. The NACE is copolymerized with acrylamide (AM) to regulate the mechanical properties of hydrogel via H-bonding density. The P(NACE-AM) ionic hydrogels are obtained simply and rapidly via one-step photopolymerization without a chemical cross-linking agent. The P(NACE-AM) hydrogels combine superb mechanical elasticity and toughness, and excellent ionic conductivity, showing great potential as durable ionic conductive devices for wearable utilization.

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Heterogeneous genetic architecture by gender for precision medicine of cardiovascular disease

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Journal of Geriatric Cardiology 2018年第5期15卷 325-327页

作者： Chaeyoung Lee school of Systems biomedical science Soongsil University Seoul Republic of Korea

It is well-known that gender differences exist in the onset, progression, and prognosis of cardiovascular diseases （CVDs）, and that risk factors such as high blood pressure and lipid profiles vary between men and women, Cur- rently, sex differences are stressed as important variables to take into account when examining the etiology of CVD. Genome-wide association studies of CVD have employed the sex as a covariate in their analytical models, but generally disregarded potential genetic heterogeneity （GHS） attributable to sex.

关键词： Cardiovascular disease Genetic heterogeneity Genome-wide association study Mixed model Sex difference

A Bipartite Network-based Method for Prediction of Long Non-coding RNA–protein Interactions

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Genomics, Proteomics & Bioinformatics 2016年第1期14卷 62-71页

作者： Mengqu Ge Ao Li Minghui Wang school of Information science and Technology University of Science and Technology of China Centers for biomedical Engineering University of Science and Technology of China

As one large class of non-coding RNAs （ncRNAs）, long ncRNAs （IneRNAs） have gained considerable attention in recent years. Mutations and dysfunction of lncRNAs have been implicated in human disorders. Many lncRNAs exert their effects through interactions with the corresponding RNA-binding proteins. Several computational approaches have been developed, but only few are able to perform the prediction of these interactions from a network-based point of view. Here, we introduce a computational method named lncRN^protein bipartite network inference （LPBNI）. LPBNI aims to identify potential lncRNA-interacting proteins, by making full use of the known IncRNA-protein interactions. Leave-one-out cross validation （LOOCV） test shows that LPBNI significantly outperforms other network-based methods, including random walk （RWR） and protein-based collaborative filtering （ProCF）. Furthermore, a case study was performed to demonstrate the performance of LPBNI using real data in predicting potential lncRNA-interacting proteins.

关键词： lncRNA Protein Interaction Bipartite network Propagation

Insight into the effect of thick graphite electrodes towards high-performance cylindrical Ni-rich NCA90 Li-ion batteries

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Journal of Energy Chemistry 2023年第12期87卷 322-333,I0009页

作者： Nattanon Joraleechanchai Thitiphum Sangsanit Kan Homlamai Purin Krapong Montree Sawangphruk Centre of Excellence for Energy Storage Technology(CEST) Department of Chemical and Biomolecular EngineeringSchool of Energy Science and EngineeringVidyasirimedhi Institute of Science and TechnologyRayong 21210Thailand

This study explored the complex effect of graphite tortuosity on the electrochemical performance of Ni-rich NCA90 Li-ion batteries(LIBs).Different levels of graphite anode tortuosity were analyzed,revealing that low-tortuosity electrodes had better graphite *** in-plane tortuosities of the graphite anode electrodes examined were 1.70,1.94,2.05,and 2.18,while their corresponding through-plane tortuosities were 4.74,6.94,8.19,and ***-operando X-ray diffraction and differential electrochemical mass spectrometry were employed to investigate the charge storage mechanism and gas *** study revealed that while graphite electrode tortuosity impacted the amount of Li present in the lithiated graphite phase due to diffusion constraints,it did not affect gas *** Li-ion utilization in low-tortuosity electrodes was higher than that in high-tortuosity electrodes because of solid-diffusion ***,the galvanostatic intermittent titration technique(GITT) was employed to investigate a lithium-ion diffusion *** results indicate that the lithium-ion diffusion coefficient exhibits a significant difference only during LiC_(6) phase *** also observed that the use of a lower tortuosity electrode leads to improved lithium-ion ***,graphite utilization is influenced by the porous electrode *** tests adhering to UN38.3 guidelines verified battery *** study demonstrated the practical application of optimized NCA90 LIB cells with diverse graphite electrode tortuosities in a high-performance Lamborghini GoKart,paving the way for further advancements in Ni-rich LIB technology.

关键词： Li-ion batteries Tortuosity Ni-rich NCA90 cathode On-line gas detection In-operando XRD

Metal–Organic Framework-Assisted Synthesis of Compact Fe_2O_3 Nanotubes in Co_3O_4 Host with Enhanced Lithium Storage Properties

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Nano-Micro Letters 2018年第3期10卷 70-78页

作者： Song Lin Zhang Bu Yuan Guan Hao Bin Wu Xiong Wen David Lou school of Chemical and biomedical Engineering Nanyang Technological University school of Materials science and Engineering Zhejiang University

Transition metal oxides are promising candidates for the high-capacity anode material in lithium-ion *** electrochemical performance of transition metal oxides can be improved by constructing suitable composite architectures. Herein, we demonstrate a metal–organic framework(MOF)-assisted strategy for the synthesis of a hierarchical hybrid nanostructure composed of Fe_2O_3 nanotubes assembled in Co_3O_4 host. Starting from MOF composite precursors(Fe-based MOF encapsulated in a Cobased host matrix), a complex structure of Co_3O_4 host and engulfed Fe_2O_3 nanotubes was prepared by a simple annealing treatment in air. By virtue of their structural and compositional features, these hierarchical composite particles reveal enhanced lithium storage properties when employed as anodes for lithium-ion batteries.

关键词： Metal–organic framework(MOF) Hierarchical structures Fe2O3 nanotubes Co3O4 Lithium-ion batteries(LIBs)

A Modified Monte Carlo Model of Speckle Tracking of Shear Wave Induced by Acoustic Radiation Force for Acousto-Optic Elasticity Imaging

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Chinese Physics Letters 2016年第11期33卷 54-57页

作者：李玉娇黄伟骏马风超王睿陆明珠万明习 Key Laboratory of biomedical Information Engineering of Ministry of Education Department of Biomedical EngineeringSchool of Life Science and TechnologyXi'an Jiaotong University

A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum （0.071）.

关键词： of on is for A Modified Monte Carlo Model of Speckle Tracking of Shear Wave Induced by Acoustic Radiation Force for Acousto-Optic Elasticity Imaging by in