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Therapeutic Potential of the Medicinal Plant Tinospora cordifolia–Minireview

Phyton-International Journal of Experimental Botany 2022年第6期91卷 1129-1140页

作者： Lohanathan Bharathi Priya Balamuralikrishnan Balasubramanian Balamurugan Shanmugaraj Shanmugam Subbiah Rouh-Mei Hu Chih-Yang Huang Rathinasamy Baskaran Integrative Stem Cell Center China Medical University HospitalTaichung40432Taiwan Department of Food Science and biotechnology College of Life SciencesSejong UniversitySeoul05006South Korea Faculty of Pharmaceutical Sciences Chulalongkorn UniversityBangkok10100Thailand Department of Zoology School of Life SciencesBharathiar UniversityCoimbatore641046India Department of Bioinformatics and Medical Engineering Asia UniversityTaichung41354Taiwan Centre of General Education Buddhist Tzu Chi Medical FoundationTzu Chi University of Science and TechnologyHualien97004Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi University of Science and TechnologyHualien97004Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40432Taiwan Department of Medical Laboratory Science and biotechnology Asia UniversityTaichung41354Taiwan

For thousands of years,plant based herbal medicines have been utilized by millions of people all over the *** materials or products are used in different folk/traditional medical systems,such as the Chinese,African and Indian medical systems,like Siddha,Ayurveda,Unani,and *** cordifolia(TC)is a medicinal plant belonging to the family *** is a big deciduous,climbing shrub growing prevalently in the tropical part of Indian subcontinent regions such as India,Pakistan,Nepal,Bhutan,Bangladesh and Srilanka,and in Myanmar,and ***,Giloy,Shindilkodi,and Amritha are all the common names for this *** from different parts of this herbal plant have been used to treat many *** Ayurvedic medicine,extract from this plant is used for preparing“rasayanas”,which is known to cure diabetes,skin diseases,allergic conditions,jaundice,cardiovascular diseases,rheumatoid arthritis,poisoning,and microbial *** has a many bioactive phytochemicals that have been isolated from its aerial parts and *** bioactive principles have been reported from this plant which belong to various classes like alkaloids,aliphatic compounds,diterpenoid lactones,phenolics,flavonoids,glycosides,sesquiterpenoids,lignans,steroids and *** possesses medicinal properties such as antioxidant,antiallergic,antiinflammatory,antimicrobial,antiviral,antidote,antitumor,antileprotic,antispasmodic,and antidiabetic *** present review will provide a comprehensive therapeutic potential of ***.

关键词： Tinospora cordifolia medicinal plant alkaloid phytomedicine immunomodulatory

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Dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2005年第9期6卷 869-872页

作者：翁晓川周亮付垠燕祝胜美何慧梁吴健 Department of Anesthesiology First Affiliated Hospital School of Medicine Zhejiang UniversityHangzhou 310003 China Department of Anesthesiology Affiliated Women’s Hospital School of Medicine Zhejiang UniversityHangzhou 310006 China

Objective： To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation （OLT） in humans. Methods： Twenty male patients undergoing liver transplantation were randomly assigned to two comparable groups of 10 patients each to receive a continuous infusion of rocuronium or atracurium under intravenous balanced anesthesia. The response of adductor pollicis to train-of-four （TOF） stimulation of unlar nerve was monitored. The infusion rates of rocuronium and atracurium were adjusted to maintain Tl/Tc ratio of 2%-10%. The total dose of each drug given during each of the three phases of OLT was recorded. Results： Rocuronium requirement, which were （0.468±0.167）mg/（kg·h） during the paleohepatic phase, decreased significantly during the anhepatic phase to （0.303±0.134）mg/（kg·h） and returned to the initial values at the neohepatic period （（0.429±0.130） mg/（kg·h））; whereas atracuruim requirements remained unchanged during orthotopic liver transplantation. Conclusions： This study showed that the exclusion of the liver from the circulation results in the significantly reduced requirement of rocuronium while the requirement of atracurium was not changed, which suggests that the liver is of major importance in the clearance of rocuronium. A continuous infusion of atracurium with constant rate can provide stable neuromuscular blockade during the three stages of OLT.

关键词： Rocuronium Atracurium Orthotopic liver transplantation

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GM1 stabilizes expression of NMDA receptor subunit 1 in the ischemic hemisphere of MCAo/reperfusion rat

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2005年第4期6卷 254-258页

作者：刘建仁丁美萍魏尔清罗建红宋英黄鉴政葛求富胡华朱丽君 Department of Neurology Department of Pharmacology Department of Neurobiology School of Medicine Zhejiang University Hangzhou 310009 China Department of Neurosurgery Second Affiliated Hospital School of MedicineZhejiang University Hangzhou 310009 China

Objective: To determine the protective effect of monosialoganglionside (GM1) and evaluate the influence of GM1 on expression of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in Sprague-Dawley (SD) rats with focal cerebral ische- mia-reperfusion (I/R). Methods: Left middle cerebral artery (MCA) was occluded by an intraluminal suture for 1 h and the brain was reperfused for 72 h in SD rats when infarct volume was measured, GM1 (10 mg/kg) was given ip (intraperitoneally) at 5 min (group A), 1 h (group B) and 2 h (group C) after MCA occlusion (MCAo). Expression of NMDAR1 was detected by Western blot at various time after reperfusion (4 h, 6 h, 24 h, 48 h and 72 h) in ischemic hemispheres of the rats with or without GM1 admin- istered. Results: (1) Adjusted relative infarct volumes of groups A and B were significantly smaller than that of group C and the control group (P<0.01 and P<0.05, respectively). (2) Expression level of NMDAR1 was temporally high at 6 h after reperfusion, and dipped below the normal level at 72 h after reperfusion. GM1 at 5 min after MCAo significantly suppressed the expression of NMDAR1 at 6 h after reperfusion (P<0.05 vs the control). At 72 h after reperfusion, the NMDAR1 expression level of rats treated with GM1 administered (at 5 min or 2 h after MCAo) was significantly higher than that of the control (P<0.05). Conclusion: GM1 can time-dependently reduce infarct volume in rats with focal cerebral I/R partly through stabilizing the expression of NMDAR1.

关键词： G(M1) ganglioside Middle cerebral artery occlusion Reperfusion N-methyl-D-aspartate receptors Rats

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Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?

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World Journal of Pharmacology 2014年第4期3卷 39-55页

作者： Pamela J Weathers Melissa Towler Ahmed Hassanali Pierre Lutgen Patrick Ogwang Engeu Department of Biologyand biotechnology Worcester Polytechnic Institute Worcester MA 01609 United States school of Pure and Applied Sciences Kenyatta University IFBV-BELHERB PO Box 98 L-6908 Nieder-anven Luxembourg Natural Chemotherapeutics Research Institute Ministry of Health PO Box 4864 Kampala Uganda

Artemisinin from the plant Artemisia annua （A. annua） L., and used as artemisinin combination therapy （ACT）, is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat “fever”. More recently, investiga-tors have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic effcacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and effcacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes （mainly mono and sesqui）, favonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. an-nua may enhance bioavailability of artemisinin. Rodent pharmacokinetics showed longer T？ and Tmax and greater Cmax and AUC in Plasmodium chabaudi -infected mice treated with A. annua dried leaves than in healthy mice. Pharmacokinetics of deoxyartemisinin, a liver metabolite of artemisinin, was more inhibited in infected than in healthy mice. In healthy mice, artemisinin serum levels were 〉 40-fold greater in dried leaf fed mice than those fed with pure artemisinin. Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. ACTs are still unaffordable for many malaria patients, and cost estimates for A. annua dried leaf tablet production are orders of magnitude less than for ACT, despite improvements in the production capacity. Considering that for 〉 2000 years this plant was used in traditional Chinese medicine for treatment of fever with no apparent appearance of artemisinin drug resistance, the evidence argues for inclusion of affordable A. annua dried leaf tablets into the a

关键词： Malaria Infectious disease Artemisia annua Artemisinin Combination therapy Artemisinin combination therapy

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Integration of peripheral circadian clock and energy metabolism in metabolic tissues

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Journal of Molecular Cell Biology 2020年第7期12卷 481-485页

作者： Yanchen Zhang Wenxiang Zhang Chang Liu State Key Laboratory of Natural Medicines and school of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China

The mammalian circadian clock precisely controls various physiological processes,including energy metabolism,to help the body adapt to the diurnal light–dark cycles induced by the earth *** the clock and metabolism are tightly coupled and interacted,the molecular mechanism through which these two pathways are integrated remains largely *** the past 10 years,we have been focusing on this important scientific question and innovatively proposed three integration modes,including the‘parallel connection’mode orchestrated by nuclear factors.

关键词： energy precisely metabolism

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Case Report:A case study of imported pulmonary coccidioidomycosis

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2011年第4期12卷 298-302页

作者： Zheng-yang WANG Sheng-lan WEN Ke-jing YING Department of Respiratory Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Coccidioidomycosis is an endemic disease of the Western *** cases in non-endemic areas are mostly *** a history of exposure is critical for performing the diagnosis of coccidioidomycosis,especially for cases occurring in a non-endemic *** this study,a 71-year-old Chinese male presented to our hospital with chronic cough and malaise,and was found to have a mass in the middle lobe of right *** had been visiting Arizona,USA for four months before *** coccidioidomycosis was confirmed by the results of histopathological examination after *** microscopic features of Coccidioides are definitely diagnostic,but need be differentiated from other budding yeast infection or carcinoma histopathologically.

关键词： Coccidioidomycosis Imported disease Pulmonary fungal infection Endemic disease

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The use of bioactive peptides to modify materials for bone tissue repair

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Regenerative Biomaterials 2017年第3期4卷 191-206页

作者： Cunyang Wang Yan Liu Yubo Fan Xiaoming Li Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China school of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of Advanced Materials of Ministry of Education of China Tsinghua UniversityBeijing 100084China

It has been well recognized that the modification of biomaterials with appropriate bioactive peptides could further enhance their ***,it has been shown that peptide-modified bone repair materials could promote new bone formation more efficiently compared with conventional *** purpose of this article is to give a general review of recent studies on bioactive peptide-modified materials for bone tissue ***,the main peptides for inducing bone regeneration and commonly used methods to prepare peptide-modified bone repair materials are ***,current in vitro and in vivo research progress of peptide-modified composites used as potential bone repair materials are reviewed and *** speaking,the recent related studies have fully suggested that the modification of bone repair materials with osteogenicrelated peptides provide promising strategies for the development of bioactive materials and substrates for enhanced bone regeneration and the therapy of bone tissue ***,we have proposed some research trends in the conclusion and perspectives part.

关键词： bone repair material peptide osteogenic activity

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Study of androgen and atherosclerosis in old-age male

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2005年第9期6卷 931-935页

作者：杨云梅吕雪英黄卫东徐哲荣吴灵娇 Department of Very Important People First Affiliated Hospital School of Medicine Zhejiang UniversityHangzhou 310003 China Department of Emergency Sir Run Run Shaw Hospital School of Medicine Zhejiang UniversityHangzhou 310016 China Institute of Infectious Disease First Affiliated Hospital School of Medicine Zhejiang UniversityHangzhou 310003 China

Objective： To observe the difference of androgen and inflammatory cytokines level in atherosclerosis and analyse their relations. Method： Both carotid arteries and arteries of lower extremity were subjected to ultrasonic examination by Doppier＇s method. Those with much atheromatous plaque formation were ranged into case group, and those with normal result formed control group. Total, free testosterone and estradiol were assayed by radioimmunoassay. C reactive protein （CRP） was assayed by nepheloturbidity. Tumor necrosis factor-α（TNF-α）, lnterleukin-6 （IL-6）, lnterleukin-8 （IL-8）, lnterleukin-10 （IL-10）, Interleukin-18 （IL-18）, soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion molecule-1 （sVCAM-1） were assayed by ELISA. The mean difference between two groups and the correlation between free testosterone and cytokines were analysed. Results： Free testosterone was （6.337±3.371） pg/L in case group and （11.375±4.733）pg/L in control group, P〈0.01. No differences were found in total testosterone and estradiol. CRP was （27.294±10.238）mg/L in case group and （12.843±6.318） mg/L in control group, P〈0.01. IL-6 was （41.700±31.385）pg/L in case group and （25.396±20.772）pg/L in control group, P〈0.05. IL-8 was （89.249±58.357）pg/L in case group and （67.873±31.227）pg/L in control group, P〈0.05. sICAM-1 was （470.491±134.078）pg/L in case group and （368.487±97.183）pg/L in control group, P〈0.01. sVCAM-1 was （537.808±213.172）pg/L in case group and （457.275±157.273）pg/L in control group, P〈0.05. There were no differences in TNF-α, IL-10 and IL-18. Correlation analysis showed that FT （free testosterone） had negative correlation with CRP, IL-6 and sICAM-1. Among them FT had well correlation with CRP, correlation index was -0.678. Conclusion： Free testosterone was in negative correlation with atherosclerosis in old-age male. Free testosterone may have the role of anti-atherosclerosis, and this effect was not achieved by its transformation to estradiol. Low

关键词： Atherosclerosis Old-age male Androgen Free testosterone Inflammatory cytokine

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Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle

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Regenerative Biomaterials 2023年第1期10卷 261-270页

作者： Ellen Ngarande Emma Doubell Ousman Tamgue Manuel Mano Paul Human Mauro Giacca Neil Hamer Davies Cardiovascular Research Unit Department of SurgeryFaculty of Health SciencesUniversity of Cape TownObservatory 7925South Africa International Centre for Genetic Engineering and biotechnology(ICGEB) Cape Town ComponentObservatory 7925South Africa Institute of Infectious Diseases and Molecular Medicine(IDM) Department of PathologyDivision of Immunology and South African Medical Research Council(SAMRC)Immunology of Infectious DiseasesFaculty of Health SciencesUniversity of Cape TownObservatory 7925South Africa King’s College London British Heart Foundation Centre of Research ExcellenceSchool of Cardiovascular Medicine&SciencesWC2R 2LSLondonUK Present address:Department of Biochemistry Faculty of SciencesUniversity of DoualaDoualaCameroon

RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual *** hydrogels are one potentially simple and direct route towards overcoming these *** we report on the utility of a combination of a mildly modified form of the clinically utilised fibrin hydrogel with Invivofectamine^(■)3.0,a lipid nonviral transfection vector,for local and sustained *** of fibrin allowed for controlled release of small interfering RNA(siRNA)-lipopolyplexes for at least 10 days and greatly increased the stability of fibrin in vitro and in vivo.A 3D cell culture model and a release study showed transfection efficacy of siRNA-lipopolyplexes was retained for a minimum of 7 *** in conjunction with PEGylated-fibrinogen significantly increased retention of siRNA-lipopolyplexes in mouse skeletal muscle and enhanced knockdown of myostatin mRNA that correlated with muscle ***,the increased efficacy observed here for the combination of a lipid nanoparticle,the only type of nonviral vector approved for the clinic,with fibrin,might allow for more rapid translation of injectable hydrogel-based RNA interference.

关键词： RNA interference controlled release fibrin lipopolyplex

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Simple and Rapid Synthesis ofα-Fe_(2)O_(3)Nanowires Under Ambient Conditions

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Nano Research 2009年第5期2卷 373-379页

作者： Albert G.Nasibulin Simas Rackauskas Hua Jiang Ying Tian Prasantha Reddy Mudimela Sergey D.Shandakov Larisa.Nasibulina Jani Sainio Esko I.Kauppinen NanoMaterials Group Department of Applied Physics and Center for New MaterialsHelsinki University of TechnologyPuumiehenkuja 202150EspooFinland Laboratory of Carbon NanoMaterials Department of PhysicsKemerovo State UniversityKemerovo 650043Russia Laboratory of Physics Helsinki University of TechnologyOtakaari 1 M02150EspooFinland VTT biotechnology Biologinkuja 702044EspooFinland

We propose a simple method for the efficient and rapid synthesis of one-dimensional hematite(α-Fe_(2)O_(3))nanostructures based on electrical resistive heating of iron wire under ambient ***,1-5μm longα-Fe_(2)O_(3)nanowires were synthesized on a time scale of seconds at temperatures of around 700℃.The morphology,structure,and mechanism of formation of the nanowires were studied by scanning and transmission electron microscopies,energy dispersive X-ray spectroscopy,X-ray photoelectron spectroscopy,and Raman techniques.A nanowire growth mechanism based on diffusion of iron ions to the surface through grain boundaries and to the growing wire tip through stacking fault defects and due to surface diffusion is proposed.

关键词： Fe_(2)O_(3) hematite mechanism nanowire synthesis

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