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Trimetallic Au@PdPb nanowires for oxygen reduction reaction

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Nano Research 2020年第10期13卷 2691-2696页

作者： Xian Jiang Yuexin Xiong Ruopeng Zhao Jiancheng Zhou Jong-Min Lee Yawen Tang school of Chemistry and chemical engineering Southeast University Nanjing 11189China schoo of chemical and biomedical engineering Nanyang Technological University Singapore 637459Singapore jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

The development of highly efficient and stable Pd-based catalysts is crucial to improve their sluggish oxygen reduction reaction(ORR)kinetics in acid *** improve ORR activity and utilization efficiency of Pd,an ideal catalyst should have ORR-favorable chemical environment,optimized geometric structure,and long periods of *** this work,we first synthesize a novel trimetallic Au@PdPb core–shell catalyst consisting of PdPb alloy nano-layers grown on the surface of ultrathin Au nanowires(NWs)by a two-step water-bath *** Au@PdPb NWs have the merits of anisotropic one-dimensional nanostructure,high utilization efficiency of Pd atoms and doping of Pb *** of the structural and multiple compositional advantages,Au@PdPb NWs exhibit remarkably enhanced ORR activity with a high haIf-wave potential(0.827 V),much better than those of commercial Pd black(0.788 V)and bimetallic Au@Pd NWs(0.803 V).Moreover,Au@PdPb NWs display better electrocatalytic stability for the ORR than those of Pd black and Au@Pd *** study demonstrates the validity of our approach for deriving highly ORR-active Pd-based catalysts by modifying their structure and composition.

关键词： trimetallic Au@PdPb nanowires core–shell structure optimized electronic structure electrocatalyst oxygen reduction reaction

Lipid-polymer hybrid nanoparticles with rhamnolipid-triggered release capabilities as anti-biofilm drug delivery vehicles

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Particuology 2012年第3期10卷 327-333页

作者： Wean Sin Cheow Kunn Hadinoto school of chemical and biomedical engineering Nanyang Technological University

In lung biofilm infection therapies, the use of lipid-polymer hybrid nanoparticles to encapsulate drugs has emerged as a promising alternative to using liposomes because they have superior physicochemical stability and still possess the biofilm affinity and sputum-penetrating ability ofliposomes. To be deemed equally efficacious as liposomes against bacterial biofilms, however, the capability of hybrid nanoparticles to target-release encapsulated drugs at biofilm colonies must be demonstrated. This communication details our investigations into the trigger-release characteristics of hybrid nanoparticles in response to encountering rhamnolipids, which are ubiquitously present in biofilm colonies of Pseudomonas aeruginosa, a major respiratory pathogen. Poly（lactic-co-glycolic acid） and phospbatidylcholine were used as the poly- mer nanoparticle core and lipid coat, respectively. These investigations were performed using compounds from various biopharmaceutical classification systems （BCS） that differ in their lipid-membrane permeabilities. The release of BCS Class II1 compounds, which have poor lipid-membrane permeabilities, was successfully triggered by rhamnolipids at a concentration approximately equal to their clinically observed value, and this release was attributed to the disruption of lipid coats by rhamnolipid micelles. Not unexpectedly, BCS Class I compounds, which have high lipid-membrane permeabilities, were released freely whether or not rhamnolipids were present. The rate of the triggered release can be controlled by incor- porating an additional lipid layer on the hybrid nanoparticles via the electrostatically driven adsorption of lipid vesicles.

关键词： Hybrid nanoparticlesLiposomesBiofilmPseudomonas aeruginosaTriggered releaseRhamnolipidCalcein

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

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Nano-Micro Letters 2018年第1期10卷 85-94页

作者： Malathi Mathiyazhakan Christian Wiraja Chenjie Xu school of chemical and biomedical engineering Nanyang Technological University

The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications.

关键词： Photo-responsive liposome Controlled release Drug delivery Gold nanoparticles

Optimization of specific cell-peptide interactions at the bio-material interface via regulation of nonspecific biofouling interactions

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Science China Chemistry 2020年第2期63卷 143-144页

作者： John L.Brash Department of chemical engineering School of Biomedical EngineeringMcMaster University

Materials that interact with biological systems in a wellcontrolled,predictable manner are highly sought after for numerous biomedical and biotechnological *** example,it is essential that devices such as stents or heart valves in the blood stream of patients do not cause thrombosis or infection,or that biosensors do not lose their function due to adverse interactions with the bio environment.A general approach to the design of biointerfaces that addresses this need has been pursued over a number of years[1].It has two elements:(1)prevention of non-specific interfacial interactions,and(2)promotion of specific biointeractions required for the intended functioning of the *** practice this means preventing all interactions except for the desired one(s).With respect to the first point it should be appreciated that biological species such as proteins and cells have a natural affinity for the interfacial ***,the realization of a surface that eliminates the adsorption/adhesion of these species is extremely *** of PEO/PEG,other hydrophilic polymers(PVP,PHEMA),and zwitterionic polymers[2]to the surface is the most common strategy to achieve“bio-resistance”.Regarding the second point,the surface must be designed so that it interacts selectively and exclusively with the component(s)(proteins,cells)that will give the desired *** this purpose,“ligands”that bind these specific components are incorporated into the surface[3].

关键词： desired interfacial realization

Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model

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Particuology 2010年第1期8卷 51-59页

作者： Meer Saiful Hassan Raymond Lau school of chemical and biomedical engineering (SCBE) Nanyang Technological University (NTU)

Pollen-shape （spiked sphere） hydroxyapatite （HA） particles for drug carrier application are studied. The particle shape and size effect on flow characteristics and deposition are assessed. The pollen-shape HA particles are synthesized to have comparable size as typical carrier particles with mean diameter of 30-50 μm and effective density less than 0.3 g/cm^3. The flow behaviors of HA and commonly used lactose （LA） carrier particles are characterized by the Carr＇s compressibility index （CI）. The HA particles have lower CI than the LA particles for the same size range. The flow fields of HA and LA carrier particles are measured in an idealized inhalation path model using particle image velocimetry （PLY） technique. The particle streamlines indicate that a large portion of particles may deposit at the bending section due to inertial impaction and gravitational deposition. The flow field result shows that HA particles give smaller separation regions than the LA particles for the same size range. The pollen-shape HA particles are found to be able to follow the gas flow in the model and minimize undesired deposition. Deposition result confirms the bending section to have the most deposition. Deposition is found to be a function of particle properties. An empirical correlation is derived for the deposition efficiency of the pollen-shape particles as a function of particles Stokes number.

关键词： Aerosol Fluid mechanics Multiphase flow Particle Powder technology Pulmonary drug delivery

Using magnetic nanoparticles to manipulate biological objects

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Chinese Physics B 2013年第9期22卷 29-39页

作者：刘毅高宇徐臣杰 Division of Bioengineering School of Chemical and Biomedical EngineeringNanyang Technological University

The use of magnetic nanoparticles （MNPs） for the manipulation of biological objects, including proteins, genes, cellular organelles, bacteria, cells, and organs, are reviewed. MNPs are popular candidates for controlling and probing biological objects with a magnetic force. In the past decade, progress in the synthesis and surface engineering of MNPs has further enhanced this popularity.

关键词： magnetic nanoparticles manipulation biological objects

Effect of holding time on microstructure of Mg-9Al-1Si alloy during semisolid isothermal heat treatment

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Transactions of Nonferrous Metals Society of China 2010年第B07期20卷 430-434页

作者：马国睿李新林李庆芬 Center for biomedical Materials and engineering College of Materials Science and Chemical EngineeringHarbin Engineering University

The effects of isothermal holding time on the semisolid microstructure of Mg-9Al-1Si(mass fraction,%)alloy were *** research results indicate that the Mg-9Al-1Si alloy with non-dendritic microstructure can be produced by the semi-solid isothermal heat *** holding time varying from 5 to 30 min,the volume fraction of liquid is gradually enlarged from 29.3%to 38.6%,the morphology ofα-Mg grains changes from initial dendritic shape to spherical types and their average sizes increases from 41.1 to 56.1μ*** addition,during the isothermal heat treatment,the eutectic Mg2Si phase changes from the initial Chinese script shape to granule and/or polygon shape in Mg-9Al-1Si *** modification of Mg2Si phase is possibly attributed to a shift of the eutectic composition of the liquid in semi-solid slurries,towards lower silicon contents with increasing Al content due to a redistribution of Al during isothermal heat treatment.

关键词： Semi-solid isothermal heat treatment Mg2Si phase modification

Mechanically controlled FRET to achieve high-contrast fluorescence switching

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Science China Chemistry 2018年第12期61卷 1587-1593页

作者： Shenzhong Mo Lina Tan Bing Fang Zhen Wu Zhiqiang Su Yantu Zhang Meizhen Yin State Key Laboratory of chemical Resource engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology College of Chemistry & chemical engineering Yan'an University

Organic luminescent materials with the ability to reversibly switch the luminescence when subjected to external stimuli have attracted considerable interest in recent years. However, luminescent materials with mechanochromic and photochromic dualresponsive properties are rarely reported. Hererin, we designed and synthesized a molecule P1 with dipeptide as a spacer to link rhodamine B and spiropyran moieties. P1 exhibited efficient photochromic properties both in solution and solid state. Highcontrast independent fluorescence switch was also realized under the stimulus of external force. Moreover, two-step ring opening reaction and subsequent fluorescence resonance energy transfer process between the donor-acceptor pairs within one single molecule achieved successive color switch by mechanical control. Therefore, this behavior of P1 made it a promising candidate for high-contrast and sensitive optical recording and mechanical sensing system.

关键词： spiropyran rhodamine B photochromism mechanochromism fluorescence resonance energy transfer

Dual single-site catalyst promoter boosts catalytic performance

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National Science Review 2020年第12期7卷 1841-1842页

作者： Bin Liu school of chemical and biomedical engineering Nanyang Technological University

Single-atom catalysts(SACs) have received great research interest because of their maximum atom-utilization efficiency and unique catalytic properties[1–5].However,most of the reported SACs only focus on single-site active components,with rare reports studying catalyst promoters in their single-site forms [6–8].Because promoters are essential components in many industrial catalysts,

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