检索结果-南通市图书馆

Differential diagnosis and management of immune checkpoint inhibitor-induced colitis: A comprehensive review

World Journal of Experimental Medicine 2021年第6期11卷 79-92页

作者： Hua Li Zhi-Yan Fu Mustafa Erdem Arslan Daniel Cho Hwajeong Lee Department of pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States schenectady pathology associates Ellis HospitalSchenectadyNY 12308United States

Immune checkpoint inhibitors(ICIs)are a new class of cancer pharmacotherapy consisting of antibodies that block inhibitory immune regulators such as cytotoxic T lymphocyte antigen 4,programmed cell death 1 and programmed death-ligand *** blockade by ICIs reactivates a tumor-specific T cell ***-related adverse events can occur in various organs including skin,liver,and gastrointestinal *** to severe colitis is the most common side effect with some experiencing rapid progression to more serious complications including bowel perforation and even *** diagnosis and management of ICI-induced colitis is crucial for optimal ***,its clinical,endoscopic and histopathologic presentations are non-specific and overlap with those of colitis caused by other etiologies,such as infection,medication,graftversus-host disease and inflammatory bowel ***,a definitive diagnosis can only be rendered after these other possible etiologies are *** an extensive clinical,laboratory and radiologic workup is required,making it challenging to arrive at a prompt *** patients experience full resolution of symptoms with corticosteroids and/or *** ICI-induced colitis that is treatment-refractory,small scale studies offer alternative strategies,such as vedolizumab and fecal microbiota *** this review,we focus on the clinical features,differential diagnosis,and management of ICIinduced colitis with special attention to emerging treatment options for treatmentrefractory ICI-induced colitis.

关键词： Immune checkpoint inhibitor Immune checkpoint inhibitor-induced colitis Infliximab Vedolizumab Graft-versus-host disease Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：