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Growing Knowledge of Stem Cells as a Novel Experimental Model in Developmental Toxicological Studies

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Chemical Research in Chinese Universities 2023年第3期39卷 342-360页

作者： REN Zhihua KU Tingting REN Mengyao LIANG Jiefeng NING Xia XU Hanqing REN Danqin ZHOU Qunfang SANG Nan College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuan030006P.R.China State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085P.R.China Shandong key laboratory of environmental Processes and Health School of Environmental Science and EngineeringShandong UniversityQingdaoQingdao266237P.R.China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou325035P.R.China

The increasing production and extensive application of chemicals have led to their unintended release and contamination in the environment,posing a hazardous threat to wildlife and human *** studies have demonstrated that developmental toxicity could be induced by various emerging chemicals,causing abnormal embryonic and placental development,adverse pregnancy outcomes,obesity,and dysfunction of lipid metabolism in *** the currently-available experimental technology for developmental toxicological studies,an in vitro model based on stem cells showed promising performance in high-throughput screening of the early-stage developmental toxicity of emerging *** this review,the deleterious effects of environmental pollutants on stem cells were systemically assorted from the aspects of cytological dysfunction,self-renewal impairment,perturbation in embryoid body(EB)formation,and disruption of committed lineage *** toxicological data on the molecular level,including the altered expressions of gene and protein biomarkers,epigenomic regulation,and enhanced oxidative stress,were collected and summarized to provide the mechanism explanation for the link between environmental pollutant exposure and unfavorable phenotypes in stem *** advantage of the stem cell model in developmental toxicological studies was specifically *** the perspectives for stem cells were ultimately highlighted in the research field of environmental toxicology,especially developmental toxicology during the early stage of life.

关键词： environmental pollutant Developmental toxicology Stem cell Early-stage life Health effect

Preparation of Fe–Co based MOF-74 and its effective adsorption of arsenic from aqueous solution

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Journal of environmental Sciences 2019年第6期31卷 197-207页

作者： Jianqiang Sun Xiaobing Zhang Anping Zhang Chunyang Liao key laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province College of Environment Zhejiang University of Technology State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

To obtain a cost-effective adsorbent for the removal of arsenic in water,a novel nanostructured Fe–Co based metal organic framework(MOF-74)adsorbent was successfully prepared via a simple solvothermal *** adsorption experiments showed that the optimal molar ratio of Fe/Co in the adsorbent was 2:*** Fe_2Co_1MOF-74 was characterized by various techniques and the results showed that the nanoparticle diameter ranged from60 to 80 nm and the specific surface area was 147.82 m^2/*** isotherm and kinetic parameters of arsenic removal on Fe_2Co_1MOF-74 were well-fitted by the Langmuir and pseudo-second-order *** maximum adsorption capacities toward As(III)and As(V)were 266.52 and 292.29 mg/g,*** presence of sulfate,carbonate and humic acid had no obvious effect on arsenic ***,coexisting phosphate significantly hindered the removal of arsenic,especially at high concentrations(10 mmol/L).Electrostatic interaction and hydroxyl and metal–oxygen groups played important roles in the adsorption of ***,the prepared adsorbent had stable adsorption ability after regeneration and when used in a real-water *** excellent adsorption performance of Fe_2Co_1MOF-74 material makes it a potentially promising adsorbent for the removal of arsenic.

关键词： Fe-Co MOF-74 Adsorbent Arsenite Arsenate Removal

Occurrence of Human Exposure to Benzothiazoles and Benzotriazoles in Indoor Dust in Suizhou and Beijing,China

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Chemical Research in Chinese Universities 2023年第3期39卷 508-515页

作者： ZHU Qingqing LIAO Chunyang JIANG Guibin State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085P.R.China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049P.R.China Institute of Environment and Health Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024P.R.China Hubei key laboratory of environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan430056P.R.China

Benzothiazoles(BTHs)and benzotriazoles(BTRs)are an important group of industrial *** to large scale and long-term applications,they have been released to various environmental media,including indoor dust,and subsequently elicited a variety of toxic *** this study,the concentrations and composition profiles of BTHs and BTRs in indoor dust from Suizhou and Beijing,China,were *** median concentrations ofΣ_(6)BTHs in indoor dust samples from Suizhou and Beijing were 133 and 439 ng/g dw,respectively,whereas theΣ5BTRs concentrations from Suizhou and Beijing were 28.4 and 40.1 ng/g dw,respectively(dw=dry weight).BTH,2-OH-BTH,1-H-BTR,and 5-Me-1-H-BTR were the predominant compounds in the *** exposure to such chemicals was further *** intake for the population in Suizhou(0.163–0.939 ng/kg bw/day)and Beijing(0.0347–0.200 ng/kg bw/day)was minor(bw=body weight).The obtained results in this study will be able to add insight into human exposure to BTHs and *** study will help to identify the behavior and fate of BTHs and BTRs in the environment,and thus to scientifically assess their risk of exposure.

关键词： Benzothiazole Benzotriazole Dust Distribution Human exposure

One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles

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Chinese Science Bulletin 2009年第15期54卷 2620-2626页

作者： ZHANG Qin HUANG RongFu GUO Liang-Hong State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-environmental Sciences ChineseAcademy of Sciences Beijing 100085 China

Silica nanoparticles are most commonly modified with amino-silanes, followed by post-modification activation for protein immobilization. In this work, epoxy-functionalized silica nanoparticles were prepared by modification with glycidyloxypropyl trimethoxysilane (GPTMS) for direct protein immobilization. Silica nanoparticles possessed an average size of 46 nm, but increased to 63 nm after GPTMS modification. Reaction time, reaction temperature and GPTMS content had no significant effect on particle size. Zeta potential of SiO2 changed from ?26mV to +38mV after modification. Fourier-transformed infrared spectroscopy revealed alkyl C-H bending and stretching bands at 2944 cm-1, 1343 cm-1 and 1465 cm-1, respectively, for the modified nanoparticles. Fluorescein cadaverine was found to bind to GPTMS-modified SiO2, but not to bare SiO2, indicating the chemical reactivity of epoxy groups on the modified nanoparticle with amines. Finally, fluorescently labeled bovine serum albumin (BSA) was used as a model protein to investigate the capacity of epoxy-SiO2 nanoparticles for protein immobilization. The results showed that more proteins were immobilized on the particle with longer reaction time, higher NaCl concentration, lower pH, and less GPTMS content. More importantly, proteins bound to epoxy-SiO2 nanoparticle were highly stable. Under optimized reaction conditions, as much as 25 mg BSA/g nanoparticle was covalently attached to the nanoparticle. The epoxy silane modification of silica nanoparticles offers a reactive surface for one-step and high-density protein immobilization.

关键词：二氧化硅制备方法反应条件纳米粒子

Levels and distributions of polychlorinated naphthalenes in sewage sludge of urban wastewater treatment plants

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Chinese Science Bulletin 2008年第4期53卷 508-513页

作者： GUO Li ZHANG Bing XIAO Ke ZHANG QingHua ZHENG MingHui State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental Sciences ChineseAcademy of Sciences Beijing 100085 China

Over seventy congeners of polychlorinated naphthalenes(PCNs) in sewage sludge of 8 urban waste-water treatment plants(WWTPs) in Beijing were analyzed by isotope dilution,and high resolution gas chromatography/high resolution mass spectrometry(HRGC/HRMS) *** total PCN concentrations determined in the samples range from 1.48 to 28.21 ng/g dw(dry weight) with TEQ concentrations of 0.11―2.45 pg/g *** levels were lower than those found in other *** and TrCNs were the most dominant homologues of *** similar congener profiles in all the samples suggest the similarity in certain *** from industrial input might be the most significant source of PCNs in the sludges in this study,and thermal processes such as waste incineration and coal combustion may be another source of the PCNs contamination.

关键词：污水污泥萘高分辨质谱法高分辨气相色谱分析城市污水处理厂

Combination of biodiesel-ethanol-diesel fuel blend and SCR catalyst assembly to reduce emissions from a heavy-duty diesel engine

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Journal of environmental Sciences 2008年第2期20卷 177-182页

作者： SHI Xiaoyan YU Yunbo HE Hong SHUAI Shijin DONG Hongyi LI Rulong State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental of Sciences Chinese Academy of Sciences Beijing 100085 China State key laboratory of Automotive Safety and Energy Tsinghua University Beijing 100084 China

In this study, the efforts to reduce NOx and particulate matter （PM） emissions from a diesel engine using both ethanol-selective catalytic reduction （SCR） of NOx over an Ag/Al2O3 catalyst and a biodiesel-ethanol-diesel fuel blend （BE-diesel） on an engine bench test are discussed. Compared with diesel fuel, use of BE-diesel increased PM emissions by 14% due to the increase in the soluble organic fraction （SOF） of PM, but it greatly reduced the Bosch smoke number by 60%-80% according to the results from 13-mode test of European Stationary Cycle （ESC） test. The SCR catalyst was effective in NOx reduction by ethanol, and the NOx conversion was approximately 73%. Total hydrocarbons （THC） and CO emissions increased significantly during the SCR of NOx process. Two diesel oxidation catalyst （DOC） assemblies were used after Ag/Al2O3 converter to remove CO and HC. Different oxidation catalyst showed opposite effect on PM emission. The PM composition analysis revealed that the net effect of oxidation catalyst on total PM was an integrative effect on SOF reduction and sulfate formation of PM. The engine bench test results indicated that the combination of BE-diesel and a SCR catalyst assembly could provide benefits for NOx and PM emissions control even without using diesel particle filters （DPFs）.

关键词： diesel engine biomass fuel selective catalytic reduction NOx particulate matter (PM)

Contamination trends of polybrominated diphenyl ethers, organochlorine pesticides and heavy metals in sediments from Dagu Drainage River estuary, Tianjin

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Chinese Science Bulletin 2007年第10期52卷 1320-1326页

作者： LU JianXia WANG YaWei ZHANG QingHua GAO ErLe JIANG GuiBint State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental Sciences ChineseAcademy of Sciences Beijing 100085 China

Concentrations of polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs) and heavy metals in two sediment cores, taken from the Dagu Drainage River, were determined. The contamination trends of these three kinds of compounds were obtained. The results showed that concentrations of PBDEs increased in recent years; there were new contamination sources for OCPs in this area; contamination levels of heavy metals had no significant change in the last several years. Comparing the results of these two cores, erosion and dilution of seawater had different effects on the transportation of these compounds.

关键词：天津大沽河口沉积物多溴联苯醚有机氯农药重金属污染趋势

Accumulation of polybrominated diphenyl ethers in breast milk of women from an e-waste recycling center in China

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Journal of environmental Sciences 2017年第2期29卷 305-313页

作者： Xinghong Li Yuan Tian Yun Zhang Yujie Ben Quanxia Lv State key laboratory of environmental chemistry and ecotoxicology Research Center of Eco-Environment SciencesChinese Academy of Sciences Department of environmental Science and Engineering Beijing Technology and Business University

Polybrominated diphenyl ethers（PBDEs） can be transferred to infants through the ingestion of breast milk, resulting in potential health risk. In this study, PBDEs, hydroxylated polybrominated diphenyl ethers（OH-PBDEs） and 2,2′,4,4′,5,6′-hexachlorobiphenyl（CB-153）in human milk from women living adjacent to e-waste recycling sites of Wenling,China, were investigated. The median level of PBDEs in samples from residents living in the e-waste recycling environment 〉 20 years（R20group, 19.5 ng/g lipid weight（lw））was significantly higher than that for residents living in Wenling 〈 3 years（R3group,3.88 ng/g lw）（p 〈 0.05）, likely ascribable to specific exposure to PBDEs from e-waste recycling activities. In the R20 group, most congeners（except for BDE-209） were correlated with each other（p 〈 0.05）. Moreover, CB-153 showed significant association with most PBDE congeners, rather than BDE-209. The relationship indicated that most BDE congeners other than BDE-209 shared common sources and/or pathways with CB-153, e.g., dietary ingestion. The correlations between BDE-209 and other congeners were different in the two groups, likely suggesting their different exposure sources and/or pathways for *** estimated dietary intake of PBDEs for infants via breast milk was lower than the minimum value affecting human health, the PBDE exposure of infants should be of great concern because of their potential effect on the development of neonates over long-term exposure. OH-PBDEs were not detected in the collected samples, which is in accordance with reports in published literature, likely indicating that they were not apt to be accumulated in human milk.

关键词： PBDEs OH-PBDEs Human milk E-waste

Selected dark sides of biomass-derived biochars as environmental amendments

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Journal of environmental Sciences 2017年第4期29卷 13-20页

作者： Zien Chen Lei Luo Diyi Xiao Jitao Lv Bei Wen Yibing Ma Shuzhen Zhang State key laboratory of environmental chemistry and ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

With the rapid increase in the application of biochars as amendments, studies are needed to clarify the possible environmental risks derived from biochars to use safely the biomass resources. This work reported selected dark sides of maize straw-and swine manurederived biochars pyrolyzed at 300 and 500°C. During the pyrolysis processes, total heavy metals in the biochars were enriched greatly accompanying with considerable emission of the heavy metals into atmosphere and the trends became increasingly obvious with pyrolysis temperature. Meanwhile, the biochars showed distinctly decreased available heavy metals compared with raw feedstocks, which could be mainly attributed to the sorption by the inorganics in the biochars. The water-and acid-washing treatments significantly increased the releasing risks of heavy metals from biochars into the environments. Electron paramagnetic resonance analysis indicated that persistent free radicals, emerged strongly in the biochars as a function of the aromatization of biomass feedstocks, were free from the influence of water-, acid-, or organic-washing of the biochars and could remain stable even after aged in soils for 30 days. Dissolved biochars, highly produced during pyrolysis processes, showed distinct properties including lower molecular weight distribution while higher aromaticity compared with soil dissolved organic *** results of this study provide important perspectives on the safe usage of biochars as agricultural/environmental amendments.

关键词： Biochar Swine manure Heavy metal Free radical Dissolved biochar