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Vascular anomaly in the levator aponeurosis of neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 656-657页

作者： Satoru Kase Toshiya Shinohara Mika Noda Susumu Ishida Manabu Kase Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811 Japan Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo 060-8638 Japan Department of Surgical Pathology Teine Keijinkai HospitalSapporo 006-0811 Japan

Dear Editor,I am Satoru Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,sapporo City,Japan.I write to present a case of neurofibromatosis type 1（NF1）... 详细信息

关键词： Vascular anomaly in the levator aponeurosis of neurofibromatosis type 1 NF Figure type

Differential Responses of NHX1 and SOS1 Gene Expressions to Salinity in two Miscanthus sinensis *** with Different Salt Tolerance

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Phyton-International Journal of Experimental Botany 2021年第3期90卷 827-836页

作者： Qian Sun Toshihiko Yamada Yulai Han Tetsuo Takano Asian Natural Environmental Science Center(ANESC) The University of TokyoTokyo188-0002Japan College of Health Science and Environmental Engineering Shenzhen Technology UniversityShenzhen518118China Field Science Center for Northern Biosphere Hokkaido UniversitySapporo060-0811Japan

The lignocellulosic crop Miscanthus *** been identified as a good candidate for biomass *** responses of Miscanthus sinensis *** salinity were studied to satisfy the needs for high yields in marginal areas and to avoid competition with food *** results indicated that the relative advantages of the tolerant accession over the sensitive one under saline conditions were associated with restricted Na^(+)accumulation in *** of two accessions(salt-tolerant‘JM0119’and salt-sensitive‘JM0099’)were subjected to 0(control),100,200,and 300 mM NaCl stress to better understand the salt-induced biochemical responses of genes involved in Na^(+)accumulation in *** adaptation responses of genes encoding for Na^(+)/H^(+)antiporters,NHX1 and SOS1 to NaCl stress were examined in JM0119 and *** cDNA sequences of genes examined were highly conserved among the relatives of *** based on the sequencing on approximate 600 bp-long cDNA fragments obtained from degenerate *** salt-induced variations of gene expression investigated by quantitative real-time PCR provided evidences for insights of the molecular mechanisms of salt tolerance in *** expression of NHX1 was up-regulated by salt stress in JM0119 shoot and root ***,it was hardly affected in JM0099 shoot tissue except for a significant increase at the 100 mM salt treatment,and it was salt-suppressed in the JM0099 root *** the root tissue,the expression of SOS1 was induced by the high salt treatment in JM0119 but repressed by all salt treatments in ***,the remarkably higher expression of NHX1 and SOS1 were associated with the resistance to Na^(+)toxicity by regulation of the Na^(+)influx,efflux,and sequestration under different salt conditions.

关键词： Salinity Miscanthus sinensis NHX1 SOS1

Formation for Vinyl Allenes from 1-Lithio-1,3-Butadienyl Phosphine Oxides and Aldehydes

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Formation for Vinyl Allenes from 1-Lithio-1,3-Butadienyl Pho...

中国化学会第十三届金属有机化学学术讨论会

作者： Tamotsu Takahashi Catalysis Research Center Hokkaido UniversitySapporo 060-0811Japan

＜正＞ Vinyl allenes bearing a cumulenic and conjugated vinyl functionality have become versatile precursors or intermediates in organic synthesis. Therefore, development ofsynthetically useful methods for the formation of vinyl allenes continues to be a very attractive area. We have recently investigated these reactions of 1-lithio-1,3-dienes and unsaturated substrates. Treatment of l-lithio-l,3-dienes with aldehydes or ketones can afford stereodefined

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β-Hydride Abstraction from α-Positioned Methyl Group of Bicycliczirconacyclopentanes Assisted by Coordination of Aldehyde

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β-Hydride Abstraction from α-Positioned Methyl Group of Bi...

中国化学会第十三届金属有机化学学术讨论会

作者： Tamotsu Takahashi Catalysis Research Center Hokkaido UniversitySapporo 060-0811Japan

＜正＞ β-Hydride abstraction is one of the fundamental reactions of organometallic compounds and has been accepted as one of the most attractive approaches in synthetic chemistry. The β-hydrogen of linear alkyl groups in organometallic compounds as 1 easily undergo β-hydride abstraction （eq 1）. The type of β-hydrogen in bicyclicorganometallic compounds 2 is also known to undergo abstraction reactions （eq 2）. However, although the type of bicyclicorganometallic compounds 3 can be readily prepared and have been used in organic synthesis. P-hydride abstraction from the α-positioned alkyl groups has not been reported.

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An Efficient Method for Preparation of Thiophenes by the Direct Reaction of Zirconacyclopentadienes and Sublimed Sulfur

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An Efficient Method for Preparation of Thiophenes by the Dir...

中国化学会第十三届金属有机化学学术讨论会

作者： Tamotsu Takahashi Catalysis Research Center Hokkaido UniversitySapporo 060-0811Japan

＜正＞ Thiophenes have long played an important role in pharmaceutical chemistry and material science. Therefore, new methods of higher efficiency and greater generality are in great demand, although many means for the preparation of thiophenes have appeared. Metallacycle transfer from zirconacyclopentadienes to main group elements is an alternative method to synthesize heterocyclic compounds （eq 1）. Generally, the heteroatom compound must bear

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Unprecedented Double C-C Bond Cleavage of a Cyclopentadienyl Ligand in Titanacyclopentadiene

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Unprecedented Double C-C Bond Cleavage of a Cyclopentadienyl...

中国化学会第十三届金属有机化学学术讨论会

作者： Tamotsu Takahashi Catalysis Research Center Hokkaido UniversitySapporo 060-0811Japan

＜正＞ For more man 50 years, the cyclopentadienyl （Cp） ligand has been extensively utilized as a famous stable ligand in organometallic chemistry. It is the η5-Cp binding mode that makes the Cp ligand act as "spectator", staying unchangeable throughout the course of the reaction. In this contribution, we wish to report an unprecedented double C-C bond cleavage reaction of a cyclopentadienyl ligand.

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MicroRNA-31 expression in colorectal serrated pathway progression

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World Journal of Gastroenterology 2014年第34期20卷 12346-12349页

作者： Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura Center for Gastroenterology Teine-Keijinkai HospitalSapporo 006-0811Japan Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of MedicineSapporo 060-8543Japan Department of Gastroenterology Rheumatology andClinical ImmunologySapporo Medical University School of MedicineSapporo 060-8543Japan Department of Pathology Teine-KeijinkaiHospitalSapporo 006-0811Japan Department of Molecular Biology SapporoMedical University School of MedicineSapporo 060-8543Japan Division of Gastroenterology and Hepatology Department of Internal MedicineSt. Marianna University School of MedicineKawasaki 216-8511Japan

MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in ***,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated *** a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated *** specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP *** miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression.

关键词： BRAF Colorectal carcinoma MicroRNA-31 MLH1 Microsa

Surface-Enhanced Infrared Study of Hydrogen Bonding between Complimentary Bases at the Electrochemical Interface

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Surface-Enhanced Infrared Study of Hydrogen Bonding between ...

2～(nd) Spring Meeting of the International Society of Electrochemistry

作者： Y Sato H.Noda F.Mizutani M.Osawa National Institute of Advanced Industrial Science and Technology 1-1-1 Higashi Central 6 Tsukuba Ibaraki 305-8566 Japan Catalysis Research Center Hokkaido University sapporo 060-0811 Japan National Institute of Advanced Industrial Science and Technology 1-1-1 Higashi Central 6 Tsukuba Ibaraki 305-8566 Japan Catalysis Research Center Hokkaido University sapporo 060-0811 Japan CREST Japan Science and Technology Agency Kawaguchi 332-0012 Japan

In recent years, a great interest is focused on molecular recognition using weak intermolecularinteractions. Among the weak interactions, hydrogen bond interaction betweencomplementary bases plays decisive roles in biological recognition systems. There exist greatefforts to use hydrogen bond interactions for biosensors. In earlier studies, it was assumed thatA-T and G-C types hydrogen bond pairs found in biological systems are formed also in theartificial molecular recognition systems. Nevertheless, very limited studies have confirmed

关键词： Surface-Enhanced Infrared Study of Hydrogen Bonding between Complimentary Bases at the Electrochemical Interface

Endoscopic management of foreign bodies in the upper gastrointestinal tract:A review

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World Journal of Gastrointestinal Endoscopy 2014年第10期6卷 475-481页

作者： Choichi Sugawa Hiromi Ono Mona Taleb Charles E Lucas The Michael and Marian Ilitch Department of Surgery Wayne State University Detroit MI 48201 United States Department of Internal Medicine Seiwa Memorial Hospital Sapporo 063-0811Japan

Foreign body ingestion is a common condition, es-pecially among children who represent 80% of these emergencies. The most frequently ingested foreign bodies in children are coins, toys, magnets and batter-ies. Most foreign body ingestions in adults occur while eating, leading to either bone or meat bolus impaction. Flexible endoscopy is the therapeutic method of choice for relieving food impaction and removing true foreign bodies with a success rate of over 95% and with mini-mal complications. This review describes a comprehen-sive approach towards patients presenting with foreign body ingestion. Recommendations are based on a review of the literature and extensive personal experi-ence.

关键词： Foreign body Endoscopic management Esophageal stricture Food bolus impaction True foreign body