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Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells

Chinese Journal of Cancer Research 2015年第5期27卷 491-496页

作者： Chiara Nicolazzo Isabella Massimi Lavinia V.Lotti Simone Vespa Cristina Raimondi Fabio Maria Pulcinelli Angela Gradilone Paola Gazzaniga dipartimento di Medicina Molecolare Sapienza Università di Roma dipartimento di Medicina Sperimentale Sapienza Università di Roma

Background： Circulating tumor cells （CTCs） are often undetected through the immunomagnetic epithelial cell adhesion molecule （EpCAM）-based CellSearch~ System in breast and colorectal cancer （CRC） patients treated with bevacizumab （BEV）, where low CTC numbers have been reported even in patients with evidence of progression of disease. To date, the reasons for this discrepancy have not been clarified. This study was carried out to investigate the molecular and phenotypic changes in CRC cells after chronic exposure to BEV in vitro. Methods： The human CRC cell line WiDr was exposed to a clinically relevant dose of BEV for 3 months in vitro. The expression of epithelial and mesenchymal markers and EpCAM isoforms was determined by western blotting and immunofluorescence. To evaluate the impact of EpCAM variant isoforms expression on CTC enumeration by CellSearch, untreated and treated colon cancer cells were spiked into 7.5 mL of blood from a healthy donor and enumerated by CellSearch. Results： Chronic exposure of CRC cell line to BEV induced decreased expression of EpCAM 40 kDa isoform and increased expression EpCAM 42 kDa isoform, together with a decreased expression of cytokeratins （CK）, while no evidence of epithelial to mesenchymal transition （EMT） in treated cells was observed. The recovery rate of cells through CellSearch was gradually reduced in course of treatment with BEV, being 84% , 70% and 40% at l, 2 and 3 months, respectively. Conclusions： We hypothesize that BEV may prevent CellSearch from capturing CTCs through altering EpCAM isoforms.

关键词： Circulating tumor cells (CTCs) epithelial cell adhesion molecule (EpCAM) isoform bevacizumab(BEV) colorectal cancer (CRC)

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The race for quantum supremacy: pushing the classical limit for photonic hardware

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National Science Review 2019年第1期6卷 2-3页

作者： Nicolò Spagnolo Fabio Sciarrino Quantum Lab Dipartimento di FisicaSapienza Università di Roma

The strong efforts towards the realization of scalable quantum computing are motivated by the promise of super-polynomial speed-up in several computational tasks.A first fundamental step in this route is to provide concrete evidence of ‘quantum supremacy’. Such a regime is obtained when a quantum device is capable of solving a specific problem faster than the best classical hardware. A serious attempt to provide a first demonstration of quantum speed-up with affordable resources is represented by boson sampling [1,2],

关键词： The race for quantum supremacy pushing the classical limit for photonic hardware

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Convective Transport in Rectangular Cavities Partially Heated at the Bottom and Cooled at One Side

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Journal of Thermal Science 2013年第1期22卷 55-63页

作者： C.Cianfrini M.Corcione E.Habib A.Quintino diAEE Sezione Fisica Tecnica Sapienza Università di Roma

Laminar natural convection heat transfer inside air-filled, rectangular enclosures partially heated from below and cooled at one side is studied numerically. A computational code based on the SIMPLE-C algorithm is used for the solution of the system of the mass, momentum, and energy transfer governing equations. Simulations are performed for a complete range of heater size, for Rayleigh numbers based on the height of the cavity ranging from 10~3to 10~6, and for height-to-width aspect ratios of the cavity spanning from 0.25 to 4. It is found that the heat transfer rate increases with increasing the heater size and the Rayleigh number, while it decreases with increasing the aspect ratio of the cavity. dimensionless heat transfer correlations are also proposed.

关键词： natural convection enclosure partial heating numerical analysis dimensionless correlations

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Effect of Heat Loss on Laminar Flamelet Species Concentration

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Journal of Thermal Science 2016年第5期25卷 418-423页

作者： Marco Boccanera diego Lentini dipartimento di Ingegneria Meccanica e Aerospaziale Sapienza Università di Roma

The effects of heat loss on the structure of laminar flamelets,which are the constitutive elements of turbulent flames under the most common operating conditions,are investigated for typical aeronautical gas-turbine operating conditions at *** magnitude of heat loss is quantified via the "enthalpy defect" measured with respect to an adiabatic flame.A procedure to generate laminar flamelets with an assigned enthalpy defect at the boundaries is devised and applied to nonpremixed propane/air flames,as propane reproduces the essential features of higher hydrocarbon *** is found,contrary to commonly held beliefs,that the enthalpy defect has a significant effect on the concentration not only of minor species,but also of main reaction *** effects are found in general to be more pronounced for fuel-rich *** impact is anticipated on the formation rate of nitric *** effects of scalar dissipation rate are also discussed.

关键词： Turbulent Combustion Heat Transfer Laminar Flamelets Hydrocarbon Combustion Aeroengines Gas Turbines

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KLOE results on light mesons

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Chinese Physics C 2010年第9期34卷 1379-1382页

作者： S.Fiore dipartimento di Fisica Sapienza Universitàdi Roma

The KLOE collaboration has recently published new results concerning scalar and pseudoscalar *** the φ → a 0 （980）γ → ηπ 0 γ decay analysis and the search for the φ → K 0 K 0 γ decay are discussed,together with the η → π ＋ π-e ＋ edecay measurements annd the new results for the pseudoscalar mixing angle and gluonium content of the η’ meson.

关键词： KLOE light mesons

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Lectures on Wonderful Varieties

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Acta Mathematica Sinica,English Series 2018年第3期34卷 417-438页

作者： Guido PEZZINI dipartimento di Matematica "Guido Castelnuovo" "Sapienza" Università di Roma

These notes are an introduction to wonderful varieties. We discuss some general results on their geometry, their role in the theory of spherical varieties, several aspects of the combinatorics arising from these varie... 详细信息

关键词： Wonderful varieties spherical varieties reductive groups

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KLOE results on scalar and pseudoscalar mesons

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Chinese Physics C 2010年第6期34卷 632-637页

作者： P.Gauzzi sapienza università di roma and INFN Sezione di roma P.le A.Moro

The data collected by the KLOE Collaboration at the Frascati φ-factory DAФNE from 2001 to 2006 have been used for extensive studies in meson spectroscopy. The decays of the scalar mesons a0（980） and f0（980） into two pseudoscalar mesons have been exploited to measure the relevant parameters of those resonances. The radiative decays φ →ηγ and η＇γ have been used for the determination of the pseudoscalar mixing angle and to search for a possible gluonium content in the η＇. The dynamics of the η → 3π decay has been studied and the Dalitz Plot parameters have been measured. The large amount of η mesons produced allowed also to study interesting rare η decays.

关键词： e^+e^- interactions φ-factory scalar mesons pseudoscalar mesons

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Changes in nutritional status after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10682-10690页

作者： Michela Giusto Barbara Lattanzi Vincenza di Gregorio Valerio Giannelli Cristina Lucidi Manuela Merli Ⅱ Gastroenterologia Dipartimento di Medicina Clinica "Sapienza" Università di Roma00185 Roma Italy

Chronic liver disease has an important effect on nutritional status, and malnourishment is almost universally present in patients with end-stage liver disease who undergo liver transplantation. During recent decades,a trend has been reported that shows an increase in number of patients with end-stage liver disease and obesity in developed countries. The importance of carefully assessing the nutritional status during the workup of patients who are candidates for liver replacement is widely recognised. Cirrhotic patients with depleted lean body mass(sarcopenia) and fat deposits have an increased surgical risk; malnutrition may further impact morbidity, mortality and costs in the post-transplantation setting. After transplantation and liver function is restored, many metabolic alterations are corrected,dietary intake is progressively normalised, and lifestyle changes may improve physical activity. Few studies have examined the modifications in body composition that occur in liver recipients. During the first 12 mo, the fat mass progressively increases in those patients who had previously depleted body mass, and the muscle mass recovery is subtle and non-significant by the end of the first year. In some patients, unregulated weight gain may lead to obesity and may promote metabolicdisorders in the long term. Careful monitoring of nutritional changes will help identify the patients who are at risk for malnutrition or over-weight after liver transplantation. Physical and nutritional interventions must be investigated to evaluate their potential beneficial effect on body composition and muscle function after liver transplantation.

关键词： Liver transplantation Sarcopenia Malnutrition Obesity Metabolic syndrome Outcome Survival

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Hydrogen breath test for the diagnosis of lactose intolerance,is the routine sugar load the best one?

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World Journal of Gastroenterology 2008年第40期14卷 6204-6207页

作者： Fiorenza Argnani Mauro di Camillo Vanessa Marinaro Tiziana Foglietta Veronica Avallone Carlo Cannella Piero Vernia Gastroenterologia A e Scienza dell'Alimentazione Sapienza Università di Roma

AIM: To evaluate the prevalence of lactose intolerance (LI) following a load of 12.5 g in patients diagnosed as high-grade malabsorbers using the hydrogen breath test (HBT)-***: Ninety patients showing high-grade malabsorption at HBT-25 were submitted to a second HBT with a lactose load of 12.5 *** hydrogen production,area under the curve of hydrogen excretion and occurrence of symptoms were ***: Only 16 patients (17.77%) with positive HBT-25 proved positive at *** production was lower as compared to HBT-25 (peak value 21.55 parts per million (ppm) ± 29.54 SD vs 99.43 ppm ± 40.01 SD; P dictive value (0.84) for a negative low-dose *** presence of symptoms during the first test was not useful for predicting a positive low-dose test (positive predictive value 0.06-0.31).CONCLUSION: Most patients with a positive HBT-25 normally absorb a lower dose of lactose and a strict lactose restriction on the basis of a "standard" HBT is,in most instances,***,the 25 g lactose tolerance test should probably be substituted by the 12.5 g test in the diagnosis of LI,and in providing dietary guidelines to patients with suspected lactose malabsorption/intolerance.

关键词： Lactase deficiency Lactose malabsorption Lactose intolerance Hydrogen breath test

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A classification of induced seismicity

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Geoscience Frontiers 2018年第6期9卷 1903-1909页

作者： C.Doglioni dipartimento Scienze della Terra UniversitàSapienza di RomaItaly Istituto Nazionale di Geofisica e Vulcanologia RomaItaly

In order to adopt the best safety procedures, man-made earthquakes should be differentiated as a function of their origin. At least four different types of settings can be recognized in which anthropogenic activities may generate seismicity:(I) fluid removal from a stratigraphic reservoir in the underground can trigger the compaction of the voids and the collapse of the overlying volume, i.e., graviquakes; the deeper the reservoir, the bigger the volume and the earthquake magnitude;(II) wastewater or gas reinjection provides the reduction of friction in volumes and along fault planes, allowing creep or sudden activation of tectonic discontinuities, i.e., reinjection quakes;(III) fluid injection at supra-lithostatic pressure generates hydrofracturing and micro-seismicity, i.e., hydrofracturing quakes;(IV) fluid extraction or fluid injection,filling or unfilling of artificial lakes modifies the lithostatic load, which is the maximum principal stress in extensional tectonic settings, the minimum principal stress in contractional tectonic settings, and the intermediate principal stress in strike-slip settings, i.e., load quakes; over given pressure values, the increase of the lithostatic load may favour the activation of normal faults, whereas its decrease may favour thrust faults. For example, the filling of an artificial lake may generate normal fault-related ***, each setting has its peculiarities and the knowledge of the different mechanisms may contribute to the adoption of the appropriate precautions in the various industrial activities.

关键词： Anthropogenic seismicity Graviquakes Reinjection quakes Hydrofracturing quakes Load quakes

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