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Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients:A singlecenter study

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World Journal of Gastroenterology 2021年第29期27卷 4890-4899页

作者： Valentina Guatibonza-García Paula Valentina Gaete Agustín Pérez-Londoño Danna Kathalina Puerto-Baracaldo Sebastián Antonio Gutiérrez-Romero Carlos O Mendivil Monica Tapias School of Medicine Universidad de los AndesBogotá110111Colombia Section of Endocrinology Department of Internal MedicineFundación Santa Fe de BogotáBogotá110111Colombia Department of Hepatology Fundación Santa Fe de BogotáBogotá110111Colombia

BACKGROUND Primary biliary cholangitis(PBC)is a serious disease that causes significant *** is confirmed with liver biopsy but autoantibodies are frequently used as proxies for *** performance of autoantibodies for the diagnosis of PBC seems to vary widely across *** To assess the diagnostic performance of several autoantibodies for the diagnosis of PBC in Latin American *** We studied 85 female adult Colombians,43 cases with biopsy-confirmed PBC and 42 controls in whom a liver biopsy ruled out *** anti-mitochondrial antibodies(AMAs),anti-smooth muscle antibodies(ASMAs)and anti-nuclear antibodies(ANAs),as well as total immunoglobulin(Ig)M and IgG were determined using immunofluorescence or enzyme-linked immunosorbent assay in all study participants within 1 year of the *** all variables,values analyzed were those closest to the date of the *** with viral or alcoholic hepatitis were *** Mean age at diagnosis was 58.7 years for cases and 56.9 years for controls,and the body mass index was lower among *** cases received ursodeoxycholic acid,while most controls received vitamin ***ögren syndrome and Hashimoto’s thyroiditis were the most frequent autoimmune comorbidities of *** prevalence of AMA positivity among PBC cases was unexpectedly *** sensitivity and specificity values were respectively 44.2%and 76.2%for AMA,74.4%and 38.1%for ANA,14.0%and 73.8%for ASMA,26.7%and 80.0%for IgG,and 57.1%and 85.7%for *** combination of positive AMA plus positive IgM had 91%positive predictive value for *** AMA-negative cases,the most prevalent antibodies were ANA(87.5%).In all,62%of AMA-positive and 84.6%of IgM-positive individuals had fibrosis in their *** AMA positivity was very low among female Latin American patients with *** performance of all antibodies was quite *** results highlight the urgent need for better PBC biomarkers.

关键词： Primary biliary cholangitis Antibodies Anti-mitochondrial antibodies Latin America Anti-smooth muscle antibodies

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Improved stability of superelasticity and elastocaloric effect in Ti-Ni alloys by suppressing Lüders-like deformation under tensile load

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Journal of Materials Science & Technology 2023年第15期146卷 154-167页

作者： Pengfei Dang Jianbo Pang Yumei Zhou Lei Ding Lei Zhang Xiangdong Ding Turab Lookman Jun Sun Dezhen Xue State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China AiMaterials Research LLC Santa FeNM 87501USA

Functional stability of superelasticity is crucial for practical applications of shape memory *** is degraded by a Lüders-like deformation with elevated local stress concentration under tensile *** increasing the degree of solute supersaturation and applying appropriate thermomechanical treatments,a Ti-Ni alloy with nanocrystallinity and dispersed nanoprecipitates is *** contrast to conventional Ti-Ni alloys,the superelasticity in the target alloy is accompanied by homogeneous deformation due to the sluggish stress-induced martensitic *** alloy thus shows a fully recoverable strain of 6%under tensile stress over 1 GPa and a large adiabatic temperature decrease of 13.1 K under tensile strain of 4.5%at room ***,both superelasticity and elastocaloric effect exhibit negligible degradation in response to applied strain of 4%during *** attribute the improved functional stability to low dislocation activity resulting from the suppression of localized deformation and the combined strengthening effect of nanocrystalline structure and ***,the design of such a microstructure enabling homogeneous deformation provides a recipe for stable superelasticity and elastocaloric effect.

关键词： Ti-Ni alloys Superelasticity Elastocaloric effect Martensite band Functional stability

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Are we ready for telemonitoring inflammatory bowel disease?A review of advances,enablers,and barriers

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World Journal of Gastroenterology 2023年第7期29卷 1139-1156页

作者： Javier Del Hoyo Mónica Millán Alejandro Garrido-Marín Mariam Aguas Department of Gastroenterology La Fe University and Polytechnic HospitalValencia 46026Spain Department of Surgery La Fe University and Polytechnic HospitalValencia 46026Spain Health Research institute La fe La Fe University and Polytechnic HospitalValencia 46026Spain

This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered telemonitoring implementation. We performed a literature search in Pub Med, EMBASE, MEDLINE, Cochrane Database, Web of Science and Conference Proceedings. Titles and abstracts published up to September 2022 were screened for a set of inclusion criteria: telemonitoring intervention, IBD as the main disease, and a primary study performed. Ninety-seven reports were selected for full review. Finally, 20 were included for data extraction and critical appraisal. Most studies used telemonitoring combined with tele-education, and programs evolved from home telemanagement systems towards web portals through m Health applications. Web systems demonstrated patients’ acceptance, improvement in quality of life, disease activity and knowledge, with a good cost-effectiveness profile in the short-term. Initially, telemonitoring was almost restricted to ulcerative colitis, but new patient reported outcome measures, home-based tests and mobile devices favoured its expansion to different patients’ categories. However, technological and knowledge advances led to legal, ethical, economical and logistic issues. Standardization of remote healthcare is necessary, to improve the interoperability of systems as well as to address liability concerns and users’ preferences. Telemonitoring IBD is well accepted and improves clinical outcomes at a lower cost in the short-term. Funders, policymakers, providers, and patients need to align their interests to overcome the emerging barriers for its full implementation.

关键词： Inflammatory bowel disease Telemedicine Telemonitoring Information and communication technology Crohn´s disease Ulcerative colitis

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Metabolic dysregulation in term infants from SARS-CoV-2-infected mothers

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World Journal of Pediatrics 2023年第9期19卷 912-917页

作者： Mari Merce Cascant-Vilaplana Inmaculada Lara-Cantón Victoria Ramos-Garcia Alejandro Pinilla-González Álvaro Solaz-García Guillermo Quintás Purificación Marín-Reina Marta Aguar Laura Torrejón-Rodríguez Máximo Vento Julia Kuligowski María Cernada Neonatal Research Unit Health Research Institute Hospital La FeUniversity Polytechnic Hospital La FeAvda.Fernando Abril Martorell 10646026ValenciaSpain Leitat Technological Center ValenciaSpain Analytical Unit Health Research Institute La FeValenciaSpain Division of Neonatology University and Polytechnic Hospital La FeValenciaSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a novel beta coronavirus that causes coronavirus disease 2019(COVID-19),a severe infectious respiratory *** January 2020,the World Health Organization(WHO)d... 详细信息

关键词： mother respiratory acute

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SEMICONDUCTING AND METALLIC POLYMERS:THE FOURTH GENERATION OF POLYMERIC MATERIALS

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Chinese Journal of Polymer Science 2001年第6期19卷 545-572页

作者： AlanJ.Heeger Department of Physics Materials Department Institute for Polymers and Organic Solids University of California Santa Barbara Santa Barbara CA 93106 USA

INTRODUCTIONIn 1976, Alan MacDiarmid, Hideki Shirakawa and I, together with a talented group of graduate students andpost-doctoral researchers discovered conducting polymers and the ability to dope these polymers over the fullrange from insulator to metal. This was particularly exciting because it created a new field of research on theboundary between chemistry and condensed matter physics, and because it created a number of opportunities:

关键词： Poly SEMICONDUCTING AND METALLIC POLYMERS

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A cloud-based platform to predict wind pressure coefficients on buildings

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Building Simulation 2022年第8期15卷 1507-1525页

作者： Facundo Bre Juan M.Gimenez Centro de Investigacion de Metodos Computacionales(CIMEC) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and improve indoor air ***,accurate modeling of the NV effects is a basic requirement to include this technique during the building design ***,there is an important lack of wind pressure coefficients(CP)data,essential input parameters for NV *** this,there are no simple but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which means a significant limitation to NV modeling in real *** this reason,the present contribution proposes a novel cloud-based platform to predict wind pressure coefficients on *** platform comprises a set of tools for performing fully unattended computational fluid dynamics(CFD)simulations of the atmospheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are implemented to automatize the generation of the computational domain,the meshing procedure the solution stage,and the post-processing of the *** evaluate the performance of the platform,an exhaustive validation against wind tunnel experimental data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreement with experimental data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform introduced shows being a reliable and practical C_(P) data source for NV modeling in real building design scenarios.

关键词： natural ventilation building simulation airflow network model EnergyPlus wind pressure coefficient computational fluid dynamics

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Gastrointestinal manifestations of systemic sclerosis:An updated review

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World Journal of Clinical Cases 2021年第22期9卷 6201-6217页

作者： Adan Luquez-Mindiola Alexis Javier Atuesta Andres Jose Gómez-Aldana Department of Gastroenterology Gut MédicaBogota 11711 Colombia Department of Internal Medicine Universidad Nacional de ColombiaBogota 11711Colombia Department of Endoscopy Santa Fe Foundation of Bogotá(Fundación Santa Fe de Bogotá)Bogotá11711Colombia Faculty of Medicine Universidad de los AndesBogota 11711Colombia

Systemic sclerosis is an autoimmune disease characterized by vascular disease,fibrosis of the skin,and internal organ *** involvement is the most frequent complication of internal organs,impacting up to 90%of *** involvement can affect any region of the gastrointestinal tract from the mouth to the anus,with a predominance of disorders being observed at the level of the upper digestive *** gastrointestinal involvement primarily involves the esophagus,small bowel,and *** severity of gastrointestinal involvement affects quality of life and is a marker of worse prognosis and mortality in these *** this review,we describe the current findings regarding gastrointestinal involvement by this entity.

关键词： Systemic sclerosis Gastrointestinal Diagnosis Treatment

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How to avoid overtreatment of benign colorectal lesions:Rationale for an evidence-based management

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World Journal of Gastroenterology 2022年第47期28卷 6619-6631页

作者： Marco Bustamante-Balén Gastrointestinal Endoscopy Unit Gastrointestinal Endoscopy Research GroupHospital Universitari Ⅰ Politècnic La FeHealth Research Institute Hospital La Fe(ⅡSLaFe)Valencia 46026Spain

Implementing population-based screening programs for colorectal cancer has led to an increase in the detection of large but benign histological ***,endoscopic mucosal resection can be considered the standard technique for the removal of benign lesions of the colon due to its excellent safety profile and good clinical ***,several studies from different geographic areas agree that many benign colon lesions are still referred for ***,the referral rate to surgery is not decreasing over the years,despite the theoretical improvement of endoscopic resection *** article will review the leading causes for benign colorectal lesions to be referred for surgery and the influence of the endoscopist experience on the referral *** will also describe how to categorize a polyp as complex for resection and consider an endoscopist as an expert in endoscopic *** finally,we will propose a framework for the accurate and evidence-based treatment of complex benign colorectal lesions.

关键词： Colorectal polyps Endoscopic mucosal resection Colorectal surgery

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Jackknife and Bootstrap Tests of the Composition Vector Trees

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Genomics, Proteomics & Bioinformatics 2010年第4期8卷 262-267页

作者： Guanghong Zuo1,2, Zhao Xu1,3, Hongjie Yu1,4, and Bailin Hao1,5,6 1T-Life Research Center & Department of Physics, Fudan University, Shanghai 200433, China 2Shanghai institute of Applied Physics, Chinese Acadamy of Sciences, Shanghai 201800, China 3Applied Biosystems, Inc., Beijing 100027, China 4Fudan-VARI Center for Genetic Epidemiology, Fudan University, Shanghai 200433, China 5institute of Theoretical Physics, Chinese Acadamy of Sciences, Beijing 100190, China 6santa fe institute, santa fe, NM 87505, USA. [a] T-Life Research Center & Department of Physics Fudan University Shanghai 200433 China [b] Shanghai institute of Applied Physics Chinese Acadamy of Sciences Shanghai 201800 China [c] Applied Biosystems Inc. Beijing 100027 China [d] Fudan-VARI Center for Genetic Epidemiology Fudan University Shanghai 200433 China [e] institute of Theoretical Physics Chinese Acadamy of Sciences Beijing 100190 China [f] santa fe institute santa fe NM 87505 USA

Composition vector trees （CVTrees） are inferred from whole-genome data by an alignment-free and parameter-free method. The agreement of these trees with the corresponding taxonomy provides an objective justification of the inferred phylogeny. In this work, we show the stability and self-consistency of CVTrees by performing bootstrap and jackknife re-sampling tests adapted to this alignment-free approach. Our ultimate goal is to advocate the viewpoint that time-consuming statistical re-sampling tests can be avoided at all in using this alignment-free approach. Agreement with taxonomy should be taken as a major criterion to estimate prokaryotic phylogenetic trees.

关键词： composition vector phylogeny topological distance bootstrap jackknife CVTree

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Prokaryotic branch of the Tree of Life： A composition vector approach

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植物分类学报 2008年第3期46卷 258-262页

作者： Bai-Lin HAO Lei GAO T-Life Research Center Fudan University Shanghai 200433 China institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080 China santa fe institute Santa Fe NM 87501 USA Present： Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

The Composition Vector Tree (CVTree) is a parameter-free and alignment-free method to infer pro-karyotic phylogeny from their complete genomes. It is distinct from the traditional 16S rRNA analysis in both the input data and the methodology. The prokaryotic phylogenetic trees constructed by using the CVTree method agree well with the Bergey’s taxonomy in all major groupings and fine branching patterns. Thus, combined use of the CVTree approach and the 16S rRNA analysis may provide an objective and reliable reconstruction of the prokaryotic branch of the Tree of Life.

关键词：原核生命物种向量合成法分析方法

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