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2002年IEEE十区计算机、通信、控制和电机工程会议

作者： Kao-Shing Hwang Jeng-Yih Chiou Electrical Engineer Department National Chung Cheng University 160 san-hsing Ming-Hsiung Chia-Yi Taiwan China Electrical Engineer Department National Chung Cheng University 160 san-hsing Ming-Hsiung Chia-Yi Taiwan China

Based on the feedback linearization theory,this paper demonstrates how a reinforcement learningscheme, adopted to construct an artificial neural networks(ANNs), can linearize a nonlinear system more effectivelyand cancel the effect of nonlinearity of a plant. Theproposed Reinforcement Linearization Learning System(RLLS) consists of two sub-systems: one is a long-termpolicy selector, Evaluation Predictor (EP) element, and theother is a short-term action selector, consisting ofLinearizing Control (LC) and Reinforce Predictor (RP)elements. In addition, a affine linear reference modelplays a role of the environment (instructor), whichprovides the reinforcement signal in the linearizingprocess. Simulation results demonstrate that the proposedscheme has the better performance of reliability androbustness of the controlled structure than conventionalANNs schemes.

关键词： Adaptive Linearization Control Based on Reinforcement Learning

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Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis

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Neural Regeneration Research 2023年第3期18卷 469-473页

作者： Christopher T.Rhodes Chin-hsing Annie Lin Eunice Kennedy Shriver National Institute of Child Health and Human Development(NICHD) National Institutes of Health(NIH)BethesdaMDUSA Department of Integrative Biology University of Texas at San AntonioSan AntonioTXUSA University of Texas at san Antonio Neurosciences Institute San AntonioTXUSA

Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative *** influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic *** present an overview of epigenetic mechanisms including chromatin structure and histone modifications;and discuss novel roles of two histone modifiers,Ezh2 and Suv4-20h1/Suv4-20h2(collectively referred to as Suv4-20h),in neurodevelopment and *** review will focus on broadly reviewing epigenetic regulatory components,the roles of epigenetic components during neurogenesis,and potential applications in regenerative medicine.

关键词： adult neurogenesis epigenetic Ezh2 histone co-regulation histone modification neurodevelopment neurogenesis regenerative medicine Suv4-20h

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Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1309-1320页

作者： Vincent Blay Mu-Chun Li Sunita P.Ho Mashall L.Stoller hsing-Pang Hsieh Douglas R.Houston Division of Biomaterials and Bioengineering School of DentistryUniversity of California San FranciscoSan FranciscoCA 94143USA Department of Urology School of MedicineUniversity of California San FranciscoSan FranciscoCA 94143USA Institute of Biotechnology and Pharmaceutical Research National Health Research InstitutesZhunanTaiwan 350China University of Edinburgh Institute of Quantitative BiologyBiochemistry and BiotechnologyEdinburghScotlandEH93BFUK

Hepsin,a transmembrane serine protease abundant in renal endothelial cells,is a promising therapeutic target against several cancers,particularly prostate *** is involved in the release and polymerization of uromodulin in the urine,which plays a role in kidney stone *** this work,we design new potential hepsin inhibitors for high activity,improved specificity towards hepsin,and promising ADMET *** ligands were developed in silico through a novel hierarchical *** pipeline explicitly accounts for off-target binding to the related serine proteases matriptase and HGFA(human hepatocyte growth factor activator).We completed the pipeline incorporating ADMET properties of the candidate inhibitors into custom multi-objective optimization *** ligands designed show excellent prospects for targeting hepsin via the blood stream and the urine and thus enable key experimental *** computational pipeline proposed is remarkably costefficient and can be easily adapted for designing inhibitors against new drug targets.

关键词： Virtual screening Docking Library Hepsin Tamm-Horsfall protein Biomineralization

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A Dual-Mode Step-up DC/DC Converter IC with Current-Limiting and EMI Reduction Techniques

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Journal of Electronic Science and Technology of China 2008年第3期6卷 279-283页

作者： Wan-Rone Liou Ping-hsing Chen Marynelle L. Z. Rosales Yeh Chun-Ting Kuo Mei-Ling Yeh the Graduate Institute of Electrical Engineering National Taipei University San Shia Taipei 23741 Taiwan China the Department of Electrical Engineering National Taiwan Ocean University Keelung Taiwan China

This paper presents a novel dual-mode step-up （boost） DC/DC converter. Pulse-frequency modulation （PFM） is used to improve the efficiency at light load. This converter can operate between pulse-width modulation （PWM） and pulse-frequency modulation. The converter will operate in PFM mode at light load and in PWM mode at heavy load. The maximum conversion efficiency of this converter is 96%. The conversion efficiency is greatly improved when load current is below 100 mA. Additionally, a soft-start circuit and a variable-sawtooth frequency circuit are proposed in this paper. The former is used to avoid the large switching current at the start up of the converter and the latter is utilized to reduce the EMI of the converter.

关键词： Boost converter dual-mode converter integrated power management pulse-frequency modulation (PFM) pulse-width modulation (PWM)

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