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Leukocyte-specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

Research 2024年第2期2023卷 123-137页

作者： Di Xiang Lei Jiang Qiong Yuan Yang Yu Ruiming Liu Meiting Chen Zheng Kuai Wendy Zhang Fan Yang Tingting Wu Zhiyu He Zuhui Ke Wanzi Hong Pengcheng He Ning Tan Yeying sun Zhen shi Xuebiao Wei Jianfang Luo Xiaoqiu Tan Yuqing Huo Gangjian Qin Chunxiang Zhang Department of Cardiology Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular ResearchThe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhouSichuan 646000China Department of Biomedical Engineering School of Medicine The University of Alabama at BirminghamBirminghamAL 35233USA Department of Cardiology.Guangdong Cardiovascular institute Guangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial Institute of Geriatric MedicineGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100China vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including *** non-coding RNAs(lncRNAs)are a group of protein expression regulators;however,the roles of monocyte-lncRNAs in macrophage differentiation and its related vascular diseases are still *** study aims to investigate whether the novel leukocyte-specific lncRNA Morrbid could regulate macrophage differentiation and *** identified that Morrbid was increased in monocytes and arterial walls from atherosclerotic mouse and from patients with *** cultured monocytes,Morrbid expression was markedly increased during monocyte to M0 macrophage differentiation with an additional increase during M0 macrophage-to-M1 macrophage *** differentiation stimuli-induced monocyte-macrophage differentiation and the macrophage activity were inhibited by Morrbid ***,overexpression of Morrbid alone was sufficient to elicit the monocyte-macrophage *** role of Morrbid in monocyte-macrophage differentiation was also identified in vivo in atherosclerotic mice and was verified in Morrbid knockout *** identified that PI3-kinase/Akt was involved in the up-regulation of Morrbid expression,whereas s100a10 was involved in Morrbid-mediated effect on macrophage *** provide a proof of concept of Morrbid in pathogenesis of monocyte/macrophage-related vascular disease,we applied an acute atherosclerosis model in *** results revealed that overexpression of Morrbid enhanced but monocyte/macrophage-specific Morrbid knockout inhibited the monocytes/macrophages recruitment and atherosclerotic lesion formation in *** results suggest that Morrbid is a novel biomarker and a modulator of monocyte-macrophage phenotypes,which is involved in atherogenesis.

关键词： inhibited Mor markedly

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Antenatal Noninvasive Fetal Electrocardiography:A Literature Review

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Maternal-Fetal Medicine 2024年第3期6卷 178-189页

作者： Claire Pegorie Becky Liu Basky Thilaganathan Amar Bhide Department of Obstetrics and Gynaecology St George’s University Hospitals NHS Foundation TrustLondon SW170QTUnited Kingdom vascular Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’s University of LondonLondon SW170QTUnited Kingdom

Fetal heart rate(FHR)monitoring is one of the central parts of obstetric ***-based technologies such as cardiotocography(CTG)remain the most common method for FHR *** CTG’s limitations,including subjective interpretation,high interobserver variability,and the need for skilled professionals,led to the development of computerized CTG(cCTG).While cCTG demonstrated advantages,its superiority over visual interpretation remains *** has prompted the exploration of alternatives like noninvasive fetal electrocardiography(NIFECG).This review explores the landscape of antenatal FHR monitoring and the need for remote FHR monitoring in a patient-centered care ***,FHR monitoring needs to evolve from the traditional approach to incorporate artificial intelligence and machine *** review underscores the importance of aligning fetal monitoring with modern healthcare,leveraging artificial intelligence algorithms for accurate assessments,and enhancing patient *** physiology of FHR variability(FHRV)is explained emphasizing its significance in assessing fetal *** measures of FHRV and their relevance are *** delves into the promising realm of NIFECG,detailing its history and recent technological *** potential advantages of NIFECG are objective FHR assessment,beat-to-beat variability,patient comfort,remote prolonged use,and less signal loss with increased maternal body mass *** its promise,challenges such as signal loss must be *** clinical application of NIFECG,its correlation with cCTG measures,and ongoing technological advancements are *** conclusion,this review explores the evolution of antenatal FHR monitoring,emphasizing the potential of NIFECG in providing reliable,home-based monitoring *** research directions are outlined,urging longitudinal studies and evidence generation to establish NIFECG’s role in enhancing fetal well-being assess

关键词： Ambulatory monitoring Noninvasive fetal electrocardiography Fetal heart-rate monitoring Fetal heart rate variability

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Longitudinal associations of cardiovascular health and vascular events with incident dementia

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stroke & vascular Neurology 2024年第4期9卷 418-428,I0066-I0130页

作者： Ya-Nan Ou Kevin Kuo Liu Yang Ya-Ru Zhang shu-Yi Huang shi-Dong Chen Yue-Ting Deng Yu Guo Rui-Qi Zhang Bang-sheng Wu Lan Tan Qiang Dong Jian-Feng Feng Wei Cheng Jin-Tai Yu Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandongPeople's Republic of China Department of Neurology and National Center for Neurological Disorders Huashan HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiPeople's Republic of China institute of science and Technology for Brain-inspired Intelligence Fudan UniversityShanghaiPeople's Republic of China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityMinistry of EducationShanghaiPeople's Republic of China

Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented.A comprehensive study to illuminate the distinctive associations across different dementia types is still *** study is sought to:(1)determine the clinical validity of Framingham General Cardiovascular Risk score(FGCRs)for dementia assessment and(2)examine the associations between cardiovascular diseases and the risk of *** A total of 432079 dementia-free individuals at baseline from UK Biobank were *** Cox proportional hazard models were used to investigate the prospective associations for FGCRs and a series of cardiovascular diseases with all-cause dementia(ACD)and its major components,Alzheimer’s disease(AD)and vascular dementia(VaD).Results During a median follow-up of 110.1 months,4711 individuals were diagnosed with *** was associated with increased risks across the dementia *** stratification analysis,high-risk groups have demonstrated the greatest dementia burdens,particularly to *** 74 traits,9 adverse associations,such as chronic ischaemic heart disease(ACD:HR=1.354;AD:HR=1.269;VaD:HR=1.768),atrioventricular block(ACD:HR=1.562;AD:HR=1.556;VaD:HR=2.069),heart failure(ACD:HR=1.639;AD:HR=1.543;VaD:HR=2.141)and hypotension(ACD:HR=2.912;AD:HR=2.361;VaD:HR=3.315)were *** distinctions were also found,with atrial fibrillation,cerebral infarction,and haemorrhage only associated with greater risks of ACD and *** By identifying distinctive associations between cardiovascular diseases and dementia,this study has established a comprehensive‘mapping’that may untangle the long-standing *** has demonstrated its predictivity beyond cardiovascular diseases burdens,suggesting potential opportunities for implantation.

关键词： cardiovascular diseases supporting

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Music alters heart rate and psychological responses but not muscle activation during light-intensity isometric exercise

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sports Medicine and Health science 2024年第4期6卷 394-401页

作者： Andrew R.Moore Jasmin C.Hutchinson Christa Winter Paul C.Dalton Lori A.Bolgla Vincent J.Paolone Department of Kinesiology Augusta University112015th St.AugustaGA30912USA Department of Exercise science&Athletic Training Springfield College263 Alden St.SpringfieldMA01109USA Department of Psychology Springfield College263 Alden St.SpringfieldMA01109USA heart&vascular institute Penn State College of MedicinePenn State University500 HMC Crescent RoadNorth Lobby HersheyPA17033USA Department of Physical Therapy Augusta University112015th St.AugustaGA30912USA

Listening to music manipulates attention to be more externally focused,which has the potential to improve muscular *** study aimed to determine the effect of listening to music on muscle activation during an isometric exercise task,and compare this effect to those of other attentional focus *** healthy subjects(n=35;16 men/19 women)completed an isometric elbow flexion task for 1 min in three randomized and counterbalanced conditions:internal focus(INT),external focus with a simple distraction task(EXT),or listening to music(MUs).Muscle activation of the biceps and triceps brachii and heart rate(HR)were recorded throughout the exercise *** of perceived exertion(RPE),affective valence,and motivation were measured at the end of each *** was no difference in muscle activation measures among the three *** during MUs was lower than EXT at 15 s([89.4±11.8]beats/min vs.[93.1±12.9]beats/min;p=0.018)and 30 s([90.6±12.4]beats/min vs.[94.2±12.5]beats/min;p=0.026),and lower than INT at 60 s([93.3±13.3]beats/min vs.[96.7±12.0]beats/min;p=0.016).Overall RPE was higher for INT(13.4±2.2)than for MUs([12.6±2.0];p=0.020)and EXT([11.94±2.22];ps higher for MUs than for INT([2.7±1.4]vs.[2.1±1.5];p=0.011).Manipulating attentional focus did not alter muscle activation for a light-intensity isometric muscular endurance task,though MUs was reported as more positive and requiring less exertion to complete than *** music can therefore be recommended during light-intensity isometric exercise based on the psychological benefits observed.

关键词： Electromyography Attentional focus Rating of perceived exertion Elbow flexion

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safety of gastrointestinal endoscopy in patients with acute coronary syndrome and concomitant gastrointestinal bleeding

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World Journal of Clinical Cases 2021年第5期9卷 1048-1057页

作者： Ahmed A Elkafrawy Mohamed Ahmed Mohammad Alomari Ahmed Elkaryoni Kevin F Kennedy Wendell KClarkston Donald R Campbell Digestive Disease and surgery institute Cleveland Clinic FoundationClevelandOH 44195United States Internal Medicine University of Missouri Kansas City School of MedicineKansas CityMO 64108United States Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFL 33331United States Division of Cardiovascular Medicine Loyola University Medical Center and Stritch School of MedicineMaywoodIL 60153United States mid america heart institute Saint Luke's Health SystemKansas CityMO 64111United States Department of Gastroenterology Saint Luke's Hospital/University of Missouri Kansas CityKansas CityMO 64111United States

BACKGROUND Gastrointestinal bleeding(GIB)is a major concern in patients hospitalized with acute coronary syndrome(ACs)due to the common use of both antiplatelet medications and *** evaluating the safety of gastrointestinal endoscopy(GIE)in ACs patients with GIB are limited by their relatively small size,and the focus has generally been on upper GIB and esophago-gastroduodenoscopy(EGD)*** To evaluate the safety profile and the hospitalization outcomes of undergoing GIE in patients with ACs and concomitant GIB using the national database for hospitalized patients in the United *** The Nationwide Inpatient sample database was queried to identify patients hospitalized with ACs and GIB during the same admission between 2005 and *** International Classification of Diseases Code,9th Revision Clinical Modification was utilized for patient *** were further classified into two groups based on undergoing endoscopic procedures(EGD,small intestinal endoscopy,colonoscopy,or flexible sigmoidoscopy).Both groups were compared regarding demographic information,outcomes,and *** analysis was conducted to identify factors associated with mortality and prolonged length of ***-square test was used to compare categorical variables,while student’s t-test was used to compare continuous *** analyses were performed using sAs 9.4(Cary,NC,United states).REsULTs A total of 35612318 patients with ACs were identified between January 2005 and December 2014.269483(0.75%)of the patients diagnosed with ACs developed concomitant GIB during the same *** least one endoscopic procedure was performed in 68%of the patients admitted with both ACs and *** who underwent GIE during the index hospitalization with ACs and GIB had lower mortality(3.8%)compared to the group not undergoing endoscopy(8.6%,Pshorter length of stay(LOs)was observed in patients who underwent GIE(mean 6.59±7.81 d)co

关键词： Gastrointestinal endoscopy Gastrointestinal bleeding Acute coronary syndrome safety Outcomes Mortality

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Hexafluoropropylene oxide trimer acid,a perfluorooctanoic acid alternative,induces cardiovascular toxicity in zebrafish embryos

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Journal of Environmental sciences 2024年第5期139卷 460-472页

作者： sujie sun Li Zhang Xue Li Lu Zang Ling Huang Junquan Zeng Zigang Cao Xinjun Liao Zilin Zhong Huiqiang Lu Jianjun Chen Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug screening for Human Diseases Jiangxi Key Laboratory of Developmental Biology of OrgansCenter for Clinical Research Center of the Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Translational Research institute of Brain and Brain-like Intelligence Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationDepartment of PediatricsShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China state Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants School of Environmental Sciences and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Interventional and vascular surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343009China Department of Internal Medicine and Hematology Affiliated Hospital of Jinggangshan UniversityJi’an 343009China

As an increasingly used alternative to perfluorooctanoic acid(PFOA),hexafluoropropylene oxide trimer acid(HFPO-TA)has been widely detected in global water ***,little is known regarding its toxic effects on cardiovascular ***,zebrafish embryos were treated with egg water containing 0,60,120,or 240 mg/L *** showed that HFPO-TA treatment led to a significant reduction in both larval survival percentage and heart ***,HFPO-TA exposure caused severe pericardial edema and elongation of the sinus venous to bulbus arteriosus distance(sV-BA)in Tg(myl7:GFP)transgenic larvae,disrupting the expression of genes involved in heart development and thus causing abnormal heart *** sprouting angiogenesis was observed in the 120 and 240 mg/L exposed Tg(fli:GFP)transgenic ***-TA treatment also impacted the mRNA levels of genes involved in the vascular endothelial growth factor(VEGF)pathway and embryonic vascular ***-TA exposure significantly decreased erythrocyte number in Tg(gata1:DsRed)transgenic embryos and influenced gene expression associated with the heme metabolism ***-TA also induced oxidative stress and altered the transcriptional levels of genes related to cell cycle and apoptosis,inhibiting cell proliferation while promoting ***,HFPO-TA exposure may induce abnormal development of the cardiovascular and hematopoietic systems in zebrafish embryos,suggesting it may not be a suitable or safe alternative for PFOA.

关键词： Hexafluoropropylene oxide trimer acid heart development vascular development Hemopoiesis Zebrafish embryos

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Percutaneous cervical carotid artery access with stenting of the left internal carotid artery in an elderly patient

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Journal of Geriatric Cardiology 2007年第2期4卷 111-114页

作者： Matthew O'steen Kathy Dougherty Neil E. strickman Division of Cardiology Baylor College of Medicine at St. Luke's Episcopal Hospital and the Texas Heart Institute Houston TX

To describe the successful endovascular treatment in a nonagenarian with symptomatic internal carotid artery stenosis using direct carotid artery access. An independent 98 year-old man was admitted to our hospital for symptoms of progressive weakness with disorientation and dysphasia. Carotid Duplex ultrasonography was performed which revealed a totally occluded right internal carotid artery and high grade stenosis of the left internal carotid artery by velocities of 608/240 cm/sec. The patient refused surgical endarterectomy and thus he was referred for carotid artery stenting. Using the femoral artery approach and multiple catheter techniques, access to the common carotid artery could not be accomplished safely. The procedure was aborted and he was therefore brought back to the catheterization laboratory the following day for direct carotid access. Carotid artery stenting was accomplished by using of a 6F sheath percutaneously in the left common carotid, cerebral protection device (CPD) and a Nitinol stent. The patient was discharged the following day without complications. At 14 months follow-up the patient is functional and independent without recurrence of symptoms. Carotid artery stenting via direct access can be accomplished in patients when the femoral artery approach is anatomically prohibitive. In this case of advanced age and the patient’s refusal for surgery, direct carotid access was his only option.

关键词： left Percutaneous cervical carotid artery access with stenting of the left internal carotid artery in an elderly patient

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Exploring the Role of serum Cystatin C in Early Detection of Acute Kidney Injury among On-Pump Cardiac surgery Patients: A single-Center Investigation in Bangladesh

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World Journal of Cardiovascular Diseases 2024年第6期14卷 363-373页

作者： Md. Ahaduzzaman Md. Abir Tazim Chowdhury Munama Magdum Md. saiful Islam Khan satyajit sharma Monoj Tiwari Md. Abul Bashar Maruf Md. Alauddin Omar sadeque Khan Md. Mostafizur Rahman Mirza Md. Nazmus saquib Department of Cardiothoracic and vascular surgery Evercare Hospital Dhaka Dhaka Bangladesh Department of Preventive and social Medicine National Institute of Preventive and Social Medicine Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Dhaka Bangladesh Department of Cardiac surgery National Heart Foundation Hospital & Research Institute Dhaka Bangladesh Department of Cardiovascular and Thoracic surgery B.P. Koirala Memorial Cancer Hospital Bharatpur Chitwan Nepal Department of Cardiac surgery United Hospital Limited Dhaka Bangladesh Department of Cardiac surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Cardiac surgery Ibrahim Cardiac Hospital & Research Institute Dhaka Bangladesh

Background: Acute Kidney Injury (AKI) stands as a prominent postoperative complication in on-pump cardiac surgery, with repercussions on morbidity, mortality, and hospitalization duration. Current diagnostic criteria relying on serum creatinine levels exhibit a delayed identification of AKI, prompting an exploration of alternative biomarkers. Aims and Objectives: This study is designed to overcome diagnostic constraints and explore the viability of serum Cystatin C as an early predictor of Acute Kidney Injury (AKI) in individuals undergoing on-pump cardiac surgery. The investigation aims to establish the relationship between serum Cystatin C levels and the onset of AKI in patients subjected to on-pump cardiac surgery. Primary objectives involve the assessment of the diagnostic effectiveness of serum Cystatin C, its comparison with serum creatinine, and the exploration of its potential for the early identification and treatment of AKI. Methodology: Conducted as a single-center study at the cardiac surgery department of BsMMU in Bangladesh from september 2020 to August 2022, a comparative cross-sectional analysis involved 31 participants categorized into No AKI and AKI groups based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Data collection encompassed preoperative, post-CBP (cardiopulmonary bypass) conclusion at 2 hours, postoperative day 1, and postoperative day 2 intervals. statistical analyses included Chi-squared tests, independent student’s t-tests, and one-sample t-tests. significance was set at P Results: The study revealed no significant differences in baseline characteristics between the No AKI and AKI groups, except for CPB time and cross-clamp time. serum Cystatin C levels in the AKI group exhibited statistical significance at various time points, highlighting its potential as an early detector. Conversely, serum Creatinine levels in the AKI group showed no statistical significance. The Receiver Operating Characteristic (ROC) curve analy

关键词： Acute Kidney Injury (AKI) On-Pump Cardiac surgery serum Cystatin C serum Creatinine Diagnostic Biomarkers Early Detection Cardiopulmonary Bypass single-Center study Bangladesh

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selective Coronary Angiography Following Cardiac Arrest

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Cardiovascular Innovations and Applications 2019年第B7期4卷 85-98页

作者： Jayasheel O.Eshcol Adnan K.Chhatriwalla saint luke’s Hospital mid america heart institute 4330 Wornall RoadSuite 2000Kansas CityMO 64111USA University of Missouri-Kansas City School of Medicine2411 Holmes StKansas CityMO 64108USA

sudden cardiac arrest is a major cause of death predominantly caused by ventricular tachyarrhythmia in patients with coronary artery *** advancements in resuscitation care,the rate of survival after cardiac arrest remains *** is a growing body of observational data suggesting early coronary angiography reduces delay to revascularization and may improve *** survivors present comatose,and neurologic outcome is uncertain;therefore it is often challenging to identify patients who will benefit from early coronary *** variables and risk scores that predict a favorable neurologic outcome have been *** rationale and current evidence for early angiography are reviewed,and a suggested approach to the selection of patients is presented.

关键词： cardiac arrest coronary angiography percutaneous coronary intervention

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Carotid artery stenting in the elderly: the time has come

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Journal of Geriatric Cardiology 2007年第2期4卷 88-92页

作者： Dipsu Patel Neil E strickman st. luke's Episcopal Hospital/Texas heart institute Houston Texas 77030 USA

　　Introduction　　Affecting over half a million people per year, stroke is the third leading cause of death in the United states. Approximately 30% of strokes are caused by carotid occlusive disease.……

关键词： CAs Carotid artery stenting in the elderly the time has come time

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