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Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience

Chinese Medical Journal 2021年第18期134卷 2258-2260页

作者： Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang jacques Goldstein Kai Harenski Department of Nephrology West China Hospital of Sichuan UniversityChengduSichuan 610041China Department of Medicine Division of Respiratory Medicine and Critical CareYong Loo Lin School of Medicine and National University Hospital119228Singapore Intensive Care Unit Bach Mai HospitalHanoi 100000Vietnam Department of Medicine Division of NephrologyFaculty of MedicineKing Chulalongkorn Memorial HospitalBangkokThailand Excellence center for Critical Care Nephrology King Chulalongkorn Memorial HospitalBangkokThailand Critical Care Nephrology Research Unit Chulalongkorn UniversityBangkokThailand Department of Nephrology VPS Lakeshore HospitalKochi 682040India Intensive Care Unit Tuen Mun HospitalHong Kong Special Administration RegionChina Department of Critical Care Medicine Quanzhou First HospitalQuanzhouFujian 362000China Department of Nephrology Tongji Hospital Affiliated Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Jiangsu Provincial Key Laboratory of Critical Care Medicine Department of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Intensive Care Unit The Third Affiliated Hospital of Shenzhen UniversityShenzhenGuangdong 518060China Department of Anaesthesiology and Intensive Care Hospital Raja Permaisuri Bainun IpohMalaysia Department of Respiratory and Critical Care Medicine China-Japan Friendship HospitalBeijing 100029China Baxter Acute Therapies Greater ChinaBaxter International Inc.Shanghai 200031China Baxter World Trade SPRL Acute Therapies GlobalBraine-l’Alleud 1420Belgium Baxter Baxter Deutschland GmbHUnterschleissheimGermany

To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters.

关键词： sepsis cytokine acute

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Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci

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Precision Clinical Medicine 2023年第2期6卷 57-66页

作者： Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard jacques Gardon Marc Taquet André Bouville Jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire Jean-Baptiste Cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France Centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of Cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France Endocrinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fondation Jean Dausset-Centre d’Etude du Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hydrosciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for Development Center IRD on TahitiArueTahiti 98713French Polynesia National Cancer Institute(retired) BethesdaMD 20892USA Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive *** research aimed to analyze the genetic factors of DTC risk among the native FP ***:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear *** analyzed the genetic profile of our cohort to identify population *** then completed a genome-wide analysis study on the whole ***:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European *** identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and *** lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and ***:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC ***,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian ***,the functional impact of these three new loci needs to be further explored and validated.

关键词： differentiated thyroid cancer population genetics genetic susceptibility

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Erratum to:Forecasts on CMB lensing observations with AliCPT-1

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中国科学:物理学、力学、天文学英文版 2023年第9期66卷 200-200页

作者： Jinyi Liu Zeyang Sun Jiakang Han Julien Carron jacques Delabrouille Siyu Li Yang Liu Jing Jin Shamik Ghosh Bin Yue Pengjie Zhang Chang Feng Zhi-Qi Huang Hao Liu Yi-Wen Wu Le Zhang Zi-Rui Zhang Wen Zhao Bin Hu Hong Li Xinmin Zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai200240China Division of Astronomy and Astrophysics Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai200240China D´epartement de Physique Th´eorique et CAP Universit´e de Gen`eveGen`eve CH-1211Switzerland CNRS-UCB International Research Laboratory Centre Pierre Bin´etruyCPB-IN2P3Berkeley IRL2007USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing100101China School of Physics and optoelectronics engineering Anhui UniversityHefei 230039China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai519082China CSST Science center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China Theoretical devision Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

One of the authors regrets that there was an omission of affiliation in this published article[1].The affiliation information of author Yi-WenWu only included the institution name for the author,and it is advised to a... 详细信息

关键词： observations CPT CMB

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