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Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis

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World Journal of Clinical Cases 2024年第18期12卷 3332-3339页

作者： Debmalya Sanyal Pradip Mukhopadhyay Sujoy Ghosh Department of Endocrinology NHRTIICS&KPC Medical CollegeKolkata 700032West BengalIndia Department of Endocrinology IPGME&R and SSKM HospitalKolkata 700020West BengalIndia Department of Endocrinology IPGME&RKolkata 700020West BengalIndia

BACKGROUND Primary hyperaldosteronism(PH)is considered to contribute to increased risk of developing type 2 diabetes mellitus(T2DM)and *** PH and DM are associated with increased risk for hypertension,cardiovascular diseases,and chronic kidney ***,data on prevalence of T2DM and prediabetes in PH,and impact of T2DM and prediabetes on presentation and cardio renal complications in PH at presentation is *** To determine the prevalence of T2DM and prediabetes in PH at diagnosis and impact on presentation and complications of *** A retrospective cohort study was conducted in tertiary care settings in individuals with confirmed diagnosis of PH at *** variables,clinical presentations,duration and degree of hypertension,complications,laboratory parameters including sodium,potassium levels,plasma aldosterone concentration(PAC),plasma renin activity(PRA),and aldosterone to renin ratio(ARR)and cardio-renal parameters were *** was done between three groups:PH with no DM(Group A)or with pre-diabetes(Group B)or with T2DM(Group C).P<0.05 was statistically *** Among 78 individuals with confirmed PH,62%had pre-diabetes or diabetes;with 37%having *** duration of T2DM was 5.97±4.7 *** mean levels of glycaemic parameters among the group A vs B vs C individuals were fasting plasma glucose(mg/dL):87.9±6.5,105.4±9.02,130.6±21.1;post prandial plasma glucose(mg/dL):122.7±9.8,154.9±14,196.7±38.0;glycated haemoglobin(%)(5.3±0.2,5.9±0.2,7.5±0.6,P<0.05),*** was no significant difference in the biochemical parameters(PAC,PRA,ARR,sodium,potassium levels),presentation and complications between the *** renal parameters or degree and duration of hypertension were comparable between the *** Significant prevalence of T2DM and prediabetes in PH at diagnosis does not impact its presentation or *** screening for undetected PH in T2DM and prediabete

关键词： Primary hyperaldosteronism Diabetes Prediabetes Hypertension Aldosterone Aldosterone to renin ratio

Membranous nephropathy associated with tuberculosis-a case report

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Asian Pacific Journal of Tropical Medicine 2022年第4期15卷 183-185页

作者： Madhumita Pal Moumita Sengupta Keya Basu Arpita Roychowdhury Department of Pathology IPGME&R and SSKM HospitalKolkataIndia Department of Nephrology IPGME&R and SSKM HospitalKolkataIndia

Rationale:Genitourinary tuberculosis can develop during the disease course of disseminated disease and the distinctive histological finding is epithelioid granuloma with or without caseation and accompanied Langhans-type giant ***,the lesion is only restricted to kidney involving both glomerular and extraglomerular *** with immune complex-mediated glomerulonephritis has been sparsely reported in the *** concern:A 42-year-old non-diabetic,non-hypertensive male presented with generalized body swelling and frothing of urine for 3 ***:Membranous nephropathy with tuberculous interstitial ***:Anti-tuberculous therapy for extrapulmonary tuberculosis was administered along with low dose ***:Reduction of proteinuria was achieved at one month follow-up ***:Tuberculosis should be considered as a potentially treatable cause of secondary membranous nephropathy as pharmacotherapy greatly helps improve the outcome.

关键词： Tuberculosis Membranous nephropathy Renal biopsy

Poncet's disease: An unusual presentation of tuberculosis in a diabetic lady

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World Journal of Clinical Cases 2015年第4期3卷 385-388页

作者： Partha Pratim Chakraborty Sayantan Ray Chitra Selvan Rana Bhattacharjee Sanjay Kumar Mandal Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Medical College and Hospital

Authors describe a 53-year-old woman who presentedto their diabetes clinic with a three week history of multiple painful and swollen joints. She had been diagnosed with type 2 diabetes 5 years back. On examination, both knee joints and left ankle were swollen. A soft tissue swelling appeared over the medial end of the left clavicle few days later. Rheumatoid arthritis, collagen vascular diseases and other common causes of polyarthritis were ruled out by appropriate investigations. Non steroidal anti-inflammatory drugs failed to give satisfactory pain relief and the arthritis persisted. Conventional cultures of synovial fluid samples including cultures for tuberculosis were negative. Computed tomography showed a space occupying lesion involving the left sternoclavicular joint. Fine needle aspiration from the lesion was performed and acidfast bacilli were demonstrated in the smear using ZiehlNeelsen stain. The explanation of her arthritis was therefore tuberculous arthritis in left sternoclavicular joint and reactive arthritis in the rest of the joints. A diagnosis of Poncet's disease was considered in her case. We treated her with standard anti-tuberculosis drugs and the arthritis resolved within a few days. She remained symptom-free at her 2 years' follow-up.

关键词： Poncet’s disease Diabetes Tuberculous arthritis Reactive arthritis Acid-fast bacilli

Correlation of Serum Uric Acid with Disease Activity and C-Reactive Protein in Patients Suffering from Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2016年第3期6卷 79-84页

作者： Biswadip Ghosh Debasish Baidya Pampa Halder Shamash Mandal Department of Rheumatology IPGME&R and SSKM Hospital Kolkata India Marwari hospital and Research Centre Guwahati India Department of Ophthalmology RG Kar Medical College Kolkata India Department of Medicine BS Medical College Bankura India

Rheumatoid Arthritis is characterized by increased cardiovascular morbidity and mortality that cannot be fully explained by the presence of classical cardiovascular disease (CVD) risk factors suggesting that novel risk factors may play a role. Evidence accumulated over the past decade points that uric acid (UA) may be one such novel CVD risk factor in rheumatoid arthritis, and therefore one may hypothesize that UA may contribute to the increased CVD burden in RA. The current study attempted to correlate the levels of clinical disease activity index (CDAI), high sensitivity C reactive protein (hs-CRP) and uric acid in DMARD naive non-diabetic, non-hypertensive, euthyroid patients with normal lipid profile suffering from early and established Rheumatoid Arthritis before and after 3 months of DMARD therapy. It showed a positive and significant correlation among uric acid levels and CDAI and hs-CRP levels at diagnosis. There was significant reduction in the levels of CDAI, hs-CRP and UA after 3 months of DMARD therapy with significant correlation among the changes in the 3 parameters and the change in Uric Acid also correlated with the levels of CDAI and hs-CRP at diagnosis. We propose to measure uric acid both as acute phase reactant and marker for cardiovascular morbidity in patients suffering from Rheumatoid Arthritis.

关键词： Uric Acid Rheumatoid Arthritis CDAI CRP

Liver abscess caused by Burkholderia pseudomallei in a young man: A case report and review of literature

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World Journal of Clinical Cases 2014年第10期2卷 604-607页

作者： Partha Pal Sayantan Ray Avijit Moulick Subhasis Dey Anirban Jana Kokila Banerjee Department of General Medicine Calcutta National Medical College and Hospital Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Bankura Sammilani Medical College and Hospital Department of Microbiology Drs. Tribedi and Roy Diagnostic Laboratory

Pyogenic liver abscess is a common entity in Indian subcontinent and is mostly caused by gram negative bacteria. Melioidosis is not commonly seen in India and only a few cases are reported. It can give rise to multiple abscesses at different sites including liver. We report a case of isolated liver abscess caused by Burkholderia pseudomallei(B. pseudomallei) in a 29-yearold recently diagnosed diabetic, immunocompetent male. Diagnosis was made by imaging and culture of pus aspirated from the abscess and he was treated with percutaneous pigtail catheter drainage followed by antibiotics(meropenem and trimethoprim-sulphmethoxazole). Melioidosis is an emerging infection in India and has high mortality rate, so early diagnosis and promptmanagement is warranted which requires clinical vigilance and an intensive microbiological workup. Clinicians should be aware of isolated liver abscess caused by B. pseudomallei in appropriate clinical settings.

关键词： Liver abscess Diabetes Burkholderia pseudomallei Emerging infection India

Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer

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World Journal of Gastroenterology 2023年第15期29卷 2241-2260页

作者： Akash Bararia Prosenjeet Chakraborty Paromita Roy Bitan Kumar Chattopadhay Amlan Das Aniruddha Chatterjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkata 700108India Department of Molecular Biosciences SVYASA School of Yoga and NaturopathyBangalore 560105India Department of Pathology Tata Medical CenterKolkata 700160India Department of General Surgery IPGMER&SSKM HospitalKolkata 700020India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9061New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

A global increase in the incidence of pancreatic cancer(PanCa)presents a major concern and health *** traditional tissue-based diagnostic techniques provided a major way forward for molecular diagnostics;however,they face limitations based on diagnosis-associated difficulties and concerns surrounding tissue availability in the clinical *** disease development with asymptomatic behavior is a drawback in the case of existing diagnostic *** capability of cell free markers in discriminating PanCa from autoimmune pancreatitis and chronic pancreatitis along with other precancerous lesions can be a boon to ***-stage diagnosis of PanCa can be achieved only if these biomarkers specifically discriminate the non-carcinogenic disease stage from malignancy with respect to tumor *** this review,we comprehensively described the non-invasive disease detection approaches and why these approaches are gaining popularity for their early-stage diagnostic capability and associated clinical feasibility.

关键词： Non-invasive biomarkers Cell free biomarkers Proteomic biomarkers Liquid biopsy-based diagnostics Pancreatic cancer biomarkers

A multicentric clinical study to evaluate the efficacy and tolerability of LL -2123 HP, a polyherbal formulation, in antitubercular drug induced hepato-toxicity

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A multicentric clinical study to evaluate the efficacy and t...