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Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate

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Synthetic and Systems Biotechnology 2018年第2期3卷 113-120页

作者： Hong Zhang Chiajung Yeh Zonglian Jin Liwei Ding Bryan Y.Liu Li Zhang H.Kathleen Dannelly Beijing Chao-Yang Hospital affiliated to Capital Medical University 8 Gongti South RoadChaoyang DistrictBeijing10020China Hangzhou Weiquan Foods Co. LTD R&D Center1688 Wu Zhong RoadMinhang DistrictShanghai201100China College of Applied Arts and Science of Beijing Union University 197 Bei Tu Cheng West RoadHaitian DistrictBeijing100108China sprim china 100 Zunyi RoadChangning DistrictShanghai200336China Indiana State University Department of Biology600 Chestnut StreetTerre HauteIN 47809USA

The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity,metabolism,development,and behavior of the *** organisms are claimed to offer several functional properties including stimulation of immune *** purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past *** study is a single center,doubleblind,randomized,controlled,prospective *** received a probiotic drink containing Lactobacillus paracasei(at least 3×10^7 colony forming units(CFU)ml^-1),Lactobacillus casei 431®(at least 3×10^7 CFU ml1)and Lactobacillus fermentium PCC®(at least 3×10^6 CFU ml^-1)or an identical placebo without probiotics for a 12-week study *** consumption of probiotics significantly reduced the incidence of upper respiratory infection(p<0.023)and flu-like symptoms with an oral temperature higher than 38℃(p<0.034)as compared to the placebo *** that consumed probiotics demonstrated a significantly higher level of IFN-g in the serum(p<0.001)and sIgA in the gut(p<0.010)as compared to the placebo group and a significant higher level of serum IFN-g(p<0.001)and gut sIgA(p<0.001)as compared to their baseline test *** contrast,there were no significant differences in the serum IL-4,IL-10,IgA,IgG or IgM between the probiotics and the placebo *** of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system.

关键词： Probiotics Upper respiratory infections Human microbiota IFN-g sIgA

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The efficacy of a novel tomato extracts formulation on skin aging and pigmentation:A randomized,double-blind,parallel-controlled trial

Journal of Dermatologic Science and Cosmetic Technology

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Journal of Dermatologic Science and Cosmetic Technology 2024年第1期1卷 13-20页

作者： Silu Zhang Shan Lu Yun Wang Jiayi Ni Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering Co.Ltd.Shenzhen 518116China Department of Dermatology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China sprim(china)Consulting Co.Ltd. Shanghai 201201China

Background:Oxidative stress is a significant factor in skin aging and pigmentation,which can be precipitated by various *** and tyrosinase inhibitors,such as carotenoids,yeast extract(glutathione),sodium hyaluronate,astaxanthin,and niacin,can individually protect the skin against aging through distinct *** mechanisms potentially enhance the skin barrier and improve signs of aging and ***,the synergistic effects of these compounds,as found in a golden tomato extract formulation,have been scarcely ***:To evaluate the effects of an orally administered formulation on the skin aging and *** and Methods:In this study,a randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLAB?Tomato Niacinamide *** of all participants,62 volunteers completed the experiment and were included in the statistical ***:The results indicated that after eight weeks of consuming the research product,there were no significant changes in the skin indicators within the placebo *** contrast,the treatment group receiving the sample formulation exhibited a 35.63%increase in stratum corneum hydration and a 29.39%reduction in transepidermal water loss(TEWL),suggesting enhanced skin *** assessments revealed improvements in skin color and gloss index by 15.03%and 11.41%,respectively,in the treatment ***,the skin gloss and individual typology angle(ITA)value increased by 18.59%and 6.36%,respectively,leading to a lighter skin *** enhancements were also observed in skin pigmentation,color uniformity,and *** eight weeks of intervention with the sample,blood levels of superoxide dismutase(SOD)and glutathione peroxidase(GPx)increased,while malondialdehyde(MDA)levels ***:These findings confirm that continuous intake of the tomato extract formulation over eight weeks effectively improved the volunteers'skin w

关键词： Skin whitening Skin aging Antioxidant Gold tomato extracts Combination effect

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Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women

Journal of Dermatologic Science and Cosmetic Technology

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Journal of Dermatologic Science and Cosmetic Technology 2024年第2期1卷 26-37页

作者： Shan Lu Silu Zhang Yun Wang Jiayi Ni Tiantian Zhao Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering CoLtd.Shenzhen 518116China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural affairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhouGuangdong 510610China Department of Dermatology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China sprim(china)Consulting Co.Ltd. Shanghai 201201China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901United States

Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging *** positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain ***:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged *** and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide *** consumed the drink over an 8-week ***:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(P<0.05).Conclusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关键词： Collagen tripeptides Elastin peptides Anti-aging Skin protection Peptide absorption

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